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유상훈,정성희,어규식,홍정표,전양현,Yoo, Sang-Hoon,Jung, Sung-Hee,Auh, Q-Schick,Hong, Jung-Pyo,Chun, Yang-Hyun 대한안면통증구강내과학회 2008 Journal of Oral Medicine and Pain Vol.33 No.1
Purpose : To investigate the actual conditions of diagnosis and treatment of oral medicine inpatient with systemic disease. Methods : A total of 110 subjects, inpatient due to systemic disease for diagnosis and treatment of oral disease was requested to answer the medical history and dental treatment record. Results : Systemic disease is composed of Non-insulin-dependent diabetes mellitus 26%, Cerebral infarction 25.2%, Intracerebral hemorrhage, Polyarthrosis, Coxarthrosis 4.7%, Nerve root and plexus disorders, Hypertensive heart and renal diseases, Ankylosing spondylitis 2.4%. Chief complain of oral disease is composed of toothache 28.6%, routine check 23%, tooth mobility 8.7%, hypersensitivity 7.1%, periodontal bleeding 6.4%. Oral disease is composed of Gingivitis and periodontal diseases 28.9%, Dental caries 17.1%, Diseases of pulp and periapical tissues 15.1%, Diseases of salivary glands 10.5%, Other diseases of hard tissues of teeth 8.6%, Within Normal Limit 5.3%. Treatment of oral disease is composed of periodontal treatment 17.95%, rejection of treatment 16.67%, medication for halitosis & dry mouth 13.46%, extraction 12.18%, prosthetic treatment 8.97%. Chief complain in oral medicine is composed of oral soft tissue problem 6.4%, craniomandibular disorders 5.6%, halitosis 4%, total 16%. Conclusion : These findings indicate that inpatient due to the systemic disease is significantly correlated to the oral disease. The patients of oral disease interrelationship between inpatient and outpatient of systemic disease should be validated by future research.
Effect of Masticatory Muscle Pain Control by Morphine
유상훈,김민재,장주연,강수경,어규식,홍정표,전양현,Yoo, Sang-Hoon,Kim, Min-Jae,Chang, Joo-Yeon,Kang, Soo-Kyung,Auh, Q-Schick,Hong, Jung-Pyo,Chun, Yang-Hyun The Korean Academy of Orofacial Pain and Oral Medi 2012 Journal of Oral Medicine and Pain Vol.37 No.3
이 연구는 Morphine을 이용한 저작근통증의 조절 효과를 확인하기 위해서 시행되었으며, 경희대학교 치과대학병원 구강내과에 내원한 환자 중 RDC/TMD로 진단된 지원자를 saline 주사군, lidocaine 주사군, morphine 주사군 각각 10명씩 배정하였다. 통증부위에 주사 전, 주사 후 10분, 30분, 60분에 각각 주관적인 통증 평가인 시각유추척도검사, 맥길통증설문지검사 그리고 통증부위표시검사와 객관적인 통증 평가인 압력통증역치검사와 압력통증한계검사를 실시하였다. 검사 후 평가된 자료를 통계 처리하여 다음과 같은 결과를 얻었다. 1. 주관적인 통증 평가와 객관적인 통증 평가 모두 집단 내 효과가 있었다. (p<0.001) 2. 주관적인 통증 평가인 통증부위표시검사(p<0.001)에서 집단 간 효과가 있었다. 3. 객관적인 통증 평가인 압력통증역치검사(p=0.025)에서 집단 간 효과가 있었다. 4. 주관적인 통증 평가인 통증부위표시검사는 morphine 주사군(p=0.001)이 saline 주사군에 비해서 효과가 있었다. 이상의 연구결과로 저작근에 통증이 있는 환자에게 morphine 주사 시 60분 이내에는 주관적인 평가에서 통증 조절 효과가 있었으며, 향후 시간 연장에 따른 지속적인 추가 연구가 필요 할 것으로 생각된다. This study was designed to evaluate the pain control effect by morphine injection to masticatory muscle pain patients. Patients with masticatory muscle pain visited the Department of Oral Medicine, Kyung Hee University Dental Hospital were recruited to this study and diagnosed by RDC/TMD. Experimental group were divided into three group; saline injection group(n=10), lidocaine injection group(n=10) and morphine injection group(n=10). Evaluation list was the subjective pain evaluation(visual analogue scale, Mc Gill pain questionnaire, pain drawing) and the objective pain evaluation(pressure pain threshold, pressure pain tolerance) and evaluation time was injection before, after 10min, 30min, 60min and then it was analyzed statistically. The results were as follows : 1. The subjective pain evaluation and the objective pain evaluation were significantly different statistically in within subject effects(p<0.001). 2. The subjective pain drawing evaluation(p<0.001) were significantly different statistically in between subject effects. 3. The objective pressure pain threshold evaluation(p=0.025) were significantly different statistically in between subject effects. 4. The morphine injection group(p=0.001) were more significantly different than the saline injection group statistically in the subject pain drawing evaluation. Therefore, it was considered that the morphine injection was effective to pain control for masticatory muscle pain patients within 60 minute.
판형열교환기에서 R-22 냉매의 이상 압력 손실계수 평가
유상훈(Sang Hoon Yoo),정지환(Ji Hwan Jeong) 대한기계학회 2007 대한기계학회 춘추학술대회 Vol.2007 No.5
Brazed Plate Heat Exchanger (BPHE) is a type of compact plate heat exchanger with parallel corrugated plates which are brazed together in series. Each plate hascorrugation called herringbone pattern. Inside a BPHE, hot fluid and cold fluid alternate its flow direction to establish counter current flow configuration. Two-phase flow heat transfer and pressure drop of R-22 in BPHE were experimentally measured in this study. In the present experiments, single-phase region and two-phase region coexist in a BPHE. Therefore, the inside of a BPHE have to be divided into single phase region and two phase region and analyzed accordingly. The results from the single phase flow analysis are then extended to the two phase flow analysis to correlate the condensation and evaporation heat transfer and pressure drop for the refrigerant R-22 in the BPHEs. Previous models for two- phase friction factor have been compared with the present experimental results.
고정밀 차량 궤적 추정을 위한 3차원 CSGNSS/DR 융합 시스템 개발
유상훈(Sang-Hoon Yoo),임정민(Jeong-Min Lim),전종화(Jong-Hwa Jeon),성태경(Tae-Kyung Sung) 제어로봇시스템학회 2016 제어·로봇·시스템학회 논문지 Vol.22 No.11
This paper presents a 3D carrier-smoothed GNSS/DR (Global Navigation Satellite System/Dead Reckoning) integrated system for precise ground-vehicle trajectory estimation. For precise DR navigation on sloping roads, the AHRS (Attitude Heading Reference System) methodology is employed. By combining the integrated carrier phase of GNSS and DR sensor measurements, a vehicle trajectory with an accuracy of less than 20cm is obtained even when cycle slip or change of visibility occur. In order to supplement the weak GNSS environment with DR successfully, the DR sensor is precisely compensated for using GNSS Doppler measurements when GNSS visibility is good. By integrating a multi-GNSS receiver with low-cost IMU, a precise 3D navigation system for land vehicles is proposed in this paper. For real-time implementation, a decoupled Kalman filter is employed in the integrated system. Through field experiments, the performance of the proposed system is verified in various road environments, including sloping roads, good-visibility areas, high multi-path areas, and under-ground parking areas.
증례 : 혈액종양 ; 췌장 신경 내분비종양에서 sunitinib과 고중성지방혈증
유상훈 ( Sang Hoon Yoo ),우인숙 ( In Sook Woo ),정윤화 ( Yun Hwa Jung ),김교희 ( Gyo Hui Kim ),조영윤 ( Young Yun Cho ),한치화 ( Chi Wha Han ) 대한내과학회 2015 대한내과학회지 Vol.88 No.1
Sunitinib은 multi-target tyrosine kinase 억제제로 현재 위장관 기질종양, 신장암, 췌장 내분비종양에 사용되고 있는 항종양 표적치료제 중의 하나이다. 복용 후 흔하게 호소하는부작용으로는 설사, 피로감, 구역, 구내염, 식도염, 고혈압,피부독성, 갑상선 기능 저하 등이 있다. 또한 급성비결석성담낭염, 알레르기성 간질성신염 같은 드문 부작용이 발생하였다는 보고가 있었으나 고중성지방혈증을 유발한다는 보고는 없었다. 저자들은 전이성 췌장 내분비종양 환자에서 sunitinib투여 후 고중성지방혈증이 관찰되었으며 급성췌장염도동반되었을 것으로 의심되는 증례를 경험하여 기술하였다. 정확한 기전은 아직 밝혀지지 않았지만, 저자들은 본 증례에서 sunitinib이 혈당조절 기전에 영향을 미쳤고, 환자가 췌장미부 절제술을 시행 받아 인슐린 분비능이 감소하였으며, 이로 인해 이차적으로 고중성지방혈증이 발생된 것으로 추정하였다. 또한 sunitinib 투여 후 발생한 갑상선 기능 저하증도고중성지방혈증에 연관되었을 것으로 추정하였다. Sunitinib을 비롯한 multi-target tyrosine kinase 억제제의 임상적 사용이 확대됨에 따라 새로운 부작용들이 보고되고 있으므로 고중성지방혈증을 포함하여 새롭게 발생하는 부작용들의 기전을 밝힐 수 있는 연구들이 시행되어야 하며, 부작용들을 초기에 인지하고 적절히 대처할 수 있도록 주기적인 경과 관찰이 필요하다. Sunitinib is a multi-target tyrosine kinase inhibitor used to treat gastrointestinal stromal tumors, renal cell carcinoma, and pancreaticneuroendocrine tumors. The most common adverse reactions are known to be nausea, fatigue, diarrhea, stomatitis, esophagitis,hypertension, skin toxicity (hand-foot syndrome), hypothyroidism, and reduction in the cardiac output of the left ventricle. Herein,we report the case of a 57 year-old female who visited our hospital complaining of epigastric pain. She had been taking sunitinib at25 mg/day to treat a metastatic pancreatic neuroendocrine tumor. Upon computed tomography performed on admission, we observedthat fluid had collected around the pancreas. Laboratory analysis revealed hypertriglyceridemia (triglycerides 993 mg/dL). Tyrosine kinase inhibitors are known to have limited effects on lipid metabolism. In this case, we suggest that hyperglycemia seemsto have had a limited effect on lipid levels. We are rather of the view that hyperglycemia, a history of distal pancreatectomy, and hypothyrodisim,indirectly caused the observed hypertriglyceridemia.