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Singapore시민 및 집쥐의 신증후 출혈열 병원체에 대한 혈청역학적 조사
유상렬 고려대학교 의과대학 1987 고려대 의대 잡지 Vol.24 No.1
Korean hemorrhagic fever (KHF) came to the attention of Western medicine during the Korean War when it was a major source of morbidity and mortality among the United Nations troops in Korea. Clinically similar diseases to KHF have been known for several decades under different names in many regions of Euro-Asia continent. In 1982, the World Health Organization adopted the term Hemorrhagic fever with renal syndrome (HFRS) to designate KHF and other diseases with compatible clinical syndrome. The causative agent of KHF was first isolated in 1976 from the rodent Apodemus agrarius and in 1978 from patient's sera from KHF by Lee and Lee. The agent was named Hantaan virus after Hantaan river in 1981, and also discovered another agent similar to Hantaan virus in house rat captured in Seoul city and named it Seoul virus. Geographically HFRS is sporadically epidemic throughout the Euro-Asia continent. HFRS has not been reported yet in tropical areas such as Singapore and Malaysia. Recent seroepidemiologic surveys show that agents antigenically similar to Hantaan virus are widely distributed throughout much of the world, to a much greater geographic extent than previously recognized. This study was conducted for seroepidemiologic survey of sera from residents, laboratory rats and urban rats against the etiologic agent of HFRS in Singapore. The results are as follows: 1. 8 out of 261 patients of suspected Leptospirosis exhibit seropositive against Hantaan and Seoul viruses, and one case was confirmed as HFRS patient. 4 out of 176 acute nephritis patients exhibit seropositive against Hantaan virus. 2. 143 (43.37%) out of 330 laboratory rats in Singapore University had antibodies to Hantaan virus, but 26 research workers who had worked in this laboratory showed seronegative. 3. 14 (24.6%) out of 57 urban rats in Singapore city showed seropositive against Hantaan virus. Among 66 rats lungs were examined, one was found to have massive viral antigen in lung tissues. The above results indicate for the first time that virus similar to Hantaan virus or Seoul virus was distributed in house rats and laboratory rats in Singapore, and the possibility of existence of many HFRS patients in Singapore.
Mlc 조절단백질이 대장균의 pts 유전자 발현에 미치는 영향
유상렬 서울대학교 농업개발연구소 1999 농업생명과학연구 Vol.3 No.-
Products of the pts operon of Escherichia coli have multiple physiological roles and the operon is controlled by two promoters, P0 and P1. Expression of the pts P0 promoter that is increased during growth in the presence of glucose is also activated by CRP-cAMP. The effects of the Mlc on the pts P0 expression were studied. In vivo transcription assay using wild type and Mlc strains grown in the presence and absence of glucose indicate that Mlc negatively regulates expression of P0, and Mlc-dependent repression is relieved by glucose in the growth medium. In vitro transcription assay using purified Mlc showed that Mlc repressed transcription from the P0 specifically.
대장균의 유전자 발현조절 : 전사와 mRNA 안정성 Transcription and mRNA Stability
유상렬 中央大學校 食糧資源硏究所 1996 食糧資源硏究所 論文集 Vol.8 No.1
Phosphoenolpyruvate : carbohydrate phosphotransferase system (PTS) catalyzes the phosphorylation and transport of its sugar substrates and acts as a major signal transduction system in bacterial cells. The ptsH, ptsI, and crr genes constitute an pts operon located at 52 min on the Escherichia coli chromosome. The pts operon is regulated in a complex fashion by at least five promoters, which are regulated by different sigma factors, several transcription factors, and DNA structure. The reason for having multiple promoters in pts operon is to respond to changes in growth condition efficiently. The balance between mRNA synthesis and decay has a significant effect on the level of gene expression and the fast turnover of mRNA is crucial for rapid changes in the pattern of gene expression. The cells maintain the basal level of pts expression through the expression of a stable mRNA from a constitutively expressed promoter, while fine modulation of pts expression is achieved through the expression of the highly unstable mRNAs from other promoters regulated by various external signals.