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- 저자 : 유경훈(Kyong Hoon You) (검색결과 2 건)
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한국인에서의 Paraoxonase Gene Polymorphism 과 관동맥 질환과의 관계
유경훈(Kyong Hoon You),김석연(Seok Yeon Kim),김효수(Hyo Soo Kim),손대원(Dae Won Sohn),오병희(Byung Hee Oh),이명묵(Myoung Mook Lee),박영배(Young Bae Park),최윤식(Yun Shik Choi),이영우(Young Woo Lee) 대한내과학회 1998 대한내과학회지 Vol.55 No.6
N/A Objectives: Paraoxonase is a high density lipoprotein (HDL)-associated enzyme, which has been implicated in preventing low density lipoprotein-cholesterol (LDL-C) from oxidation. The human paraoxonase gene is codominantly expressed as allele A and B. The A allele codes for glutamine(A subtype) and the B allele for arginine(B subtype) at codon 192 of the paraoxonase enzyme. This genetic polymorphism divides the enzyme into high and low activity form It has been believed that this difference of specific activity might change the metabolism of cholesterol and the prevalence of coronary artery disease. The present study investigated the association among the paraoxonase gene polymorphism and the level of plasma lipoprotein and coronary artery disease. Methods: The 416 subjects who have undergone coronary angiography in SNUH were recruited. 7he patients(n=251) had >50% stenosis of at least one of the major coronary arteries. To identify the genotype of paraoxonase, we amplified the target region in the paraoxonase gene by PCR(polymerase chain reaction) and electrophoresed the products. Results: There was no difference between the two groups in the allele frequency (A: B = 0.41: 0.59 in patients, A: B = 0.37: 0.63 in controls; p=0.21) or in the genotype frequency (AA:AB:HB= 45:116:90 in patients, AA:AB:BB=22:77:66 in controls; p=0.41). There was no association of the paraoxonase genotype with serum lipoprotein level and acute coronary syndrome in this study. The B allele was not an independent risk factor for coronary artery disease in this study. Conclusion: The paraoxonase gene 192 polymorphism was not an independent risk factor for coronary artery disease in this study.
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후천성 면역부전증에 병발한 원발성 중추신경계 림프종 1예
이은봉,유경훈,유창달,김남중,오명돈,신형식,백한주,지제근,허대석,최강원 대한감염학회 1996 감염 Vol.28 No.4
저자들은 인간면역부전바이러스 검사 양성, cryptosporidiosis로 후천성면역부전증을 진단받은 환자에서 나타난 원발성 중추신경계 림프종을 경험하였기에 이를 보고한다. A 43-year old man with acquired immunodeficiency syndrome was admitted to this hospital because of cognition defect. The patient with a history of homosexual behaviour developed acquired immunodeficiency syndrome seven months before this admission, when he was positive for HIV test, had cryptosporidiosis and suspicious pulmonary tuberculosis. One week before admission, fever, cognition defect, including inappropriate response and memory disturbance, and ptosis of the left eye developed. Brain MRI showed an ill-defined, rim enhancing lesion in the left mid brain and both thalami. Stereotaxic brain biopsy showed malignant lymphoma with monoclonal T cell phenotype on nested PCR and immunohistochemistry. Brain radiotherapy of 6120 rad was delivered, which resulted in stable disease. We report the first case with acquired immunodeficiency syndrome and primary central nervous system lymphoma in Korea.
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