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RISS 인기검색어
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- 저자 : 원하경 ( Ha Kyeong Won ) (검색결과 2 건)
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Cetuximab에 의한 아나필락시스를 보인 환자에서 성공적인 탈감작 적용 1예
원하경 ( Ha Kyeong Won ),문성도 ( Sung Do Moon ),심지수 ( Ji Su Shim ),정수지 ( Soo Jie Chung ),김건우 ( Gun Woo Kim ),김수정 ( Su Jeong Kim ),박한기 ( Han Ki Park ),강혜련 ( Hye Ryun Kang ) 대한천식알레르기학회 2015 Allergy Asthma & Respiratory Disease Vol.3 No.4
Cetuximab, a chimeric mouse-human immunoglobulin, is an antiepidermal growth factor receptor monoclonal antibody. It has been approved by the U.S. Food and Drug Administration for the treatment of metastatic colorectal and head/neck cancer, but can cause fatal hypersensitivity reactions in some patients. A 66-year-old male with metastatic sigmoid cancer had cetuximab-induced anaphylaxis when the first dose of cetuximab was administered. Cetuximab was safely readministered for another 15 cycles based on the rapid desensitization protocol. We experienced a case of cetuximab-induced anaphylaxis on the first exposure which was successfully managed by rapid desensitization. (Allergy Asthma Respir Dis 2015;3:294-296)
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이차 항결핵제에 약물과민반응증후군을 보인 다제내성 결핵 환자에서 급속 탈감작요법에 준한 항결핵제 재투여 1예
문성도 ( Sung Do Moon ),원하경 ( Ha Kyeong Won ),조재영 ( Jae Young Cho ),강민구 ( Min Koo Kang ),김주영 ( Ju Young Kim ),박한기 ( Han Ki Park ),김수정 ( Sujeong Kim ),강혜련 ( Hye Ryun Kang ) 대한천식알레르기학회 2015 Allergy Asthma & Respiratory Disease Vol.3 No.4
For the treatment of multidrug-resistant (MDR) tuberculosis, maintenance of appropriate antituberculous agents is essential because of its low cure rate and high dropout rate. Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe drug-induced systemic hypersensitivity response resulting in cessation of causative agents. In cases of second-line antituberculous agent-induced DRESS, it is extremely difficult to find other replacement medications to cure MDR tuberculosis. A 53-year-old male who had taken the second-line antituberculous agents (cycloserine, streptomycin, p-aminosalicylic acid, and prothionamide) as well as pyrazinamide for 5 weeks experienced DRESS syndrome accompanying hepatic coma. His symptoms improved with discontinuation of antituberculous agents and administration of high-dose methylprednisolone for 1 month. To resume the antituberculous medication, second-line antituberculous agents were administered one by one using a rapid desensitization protocol. While kanamycin, levofloxacin, and cycloserine were successfully readministered, p-aminosalicylic acid- and prothionamide-induced cutaneous hypersensitivity symptoms were relatively mild compared to previous reactions. Herein, we report a case of successfully treated MDR tuberculosis having a history of fatal DRESS syndrome to antituberculous agents using the rapid desensitization protocol. (Allergy Asthma Respir Dis 2015;3:297-301)
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