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성공적 공공기관 지방이전을 위한 정책지렛대 발굴과 전략개발에 관한 시뮬레이션 연구
원문호(Moonho Won),박기남(Kinam Park) 한국인터넷전자상거래학회 2014 인터넷전자상거래연구 Vol.14 No.6
This study investigates how much strength of the public sector’s relocation policy affect the performance to avoid capital congestion and to develop regional economy. For this purpose, agent-based relocation model was constructed. We divided the territory of Korea into 4 regions including capital region and gave the relocation model some constraints and conditions to process steps of simulation results are presented. The results showed the effect of public sector’s relocation policy to reduce the net immigration to the capital area and develop the regional economy was very limited. Instead of relocation policy, the effect of renovation policy about the level-up of education and the storage of high quality of knowledge and technology was very significant. In summary, relocation policy is just symbol to show the regional autonomy era and the long-term strategies for core competency of the region such as regulatory reform, education, the quality of knowledge and technology is essential to avoid the exodus from the region and to enhance the regional economy.
구본혁,이봉구,정명선,권승해,허광래,권영근,원문호,김영명,유승우 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
Arginase inhibition exhibits beneficial effects in vascular endothelial and smooth muscle cells. In human aortic smooth muscle cells (hAoSMCs), native low-density lipoprotein (nLDL) induced the production of interleukin-8 (IL-8) that is involved in the pathogenesis of cardiovascular diseases. Therefore, we examined the effect of arginase inhibition on IL-8 production and the underlying mechanism. In hAoSMCs, reverse transcription–PCR, western blotting and immunocytochemistry with MitoTracker confirmed that arginase II was confined predominantly to mitochondria. The mitochondrial membrane potential (MMP) was assessed using tetramethylrhodamine ethyl ester. The MMP decreased upon nLDL stimulation but was restored upon arginase inhibition. MMP loss caused by nLDL was prevented by treatment with the intracellular Ca2+ chelator BAPTA-AM. In mitochondrial Ca2+ measurements using Rhod-2 AM, increased mitochondrial Ca2+ levels by nLDL were inhibited upon preincubation with an arginase inhibitor. Among the polyamines, spermine, an arginase activity-dependent product, caused mitochondrial Ca2+ movement. The nLDL-induced MMP change resulted in p38 mitogen-activated protein kinase (MAPK) phosphorylation and IL-8 production and was prevented by the arginase inhibitors BAPTA and ruthenium 360. In isolated AoSMCs from ApoE− /− mice fed a high-cholesterol diet, arginase activity, p38 MAPK phosphorylation, spermine and mitochondrial Ca2+ levels and keratinocyte-derived chemokine (KC) production were increased compared with wild-type (WT) mice. However, in AoSMCs isolated from arginase II-null mice, increases in MMP and decreases in mitochondrial Ca2+ levels were noted compared with WT and were associated with p38 MAPK activation and IL-8 production. These data suggest that arginase activity regulates the change in MMP through Ca2+ uptake that is essential for p38 MAPK phosphorylation and IL-8 production.
야생등줄쥐 흑색질 및 배쪽피개의 dopamine성 신경세포
정영길,김길수,이철호,윤원기,현병화,오양석,원문호,김무강,Jeong, Young-gil,Kim, Kil-soo,Lee, Chul-ho,Yoon, Won-kee,Hyun, Byung-hwa,Oh, Yang-seok,Won, Moo-ho,Kim, Moo-kang 대한수의학회 1997 大韓獸醫學會誌 Vol.37 No.3
The distributions characteristics of neurons displaying immunoreactivity to the catecholamine synthetic enzymes, tyrosine hydroxylase(TH), dopamine-${\beta}$-hydroxylase(DBH), and phenylethanolamine-N-methyltransferase(PNMT) were examined in the adjacent sections of the substantia nigra & ventral tegmentum of the Striped Field Mouse(Apodemus agrarius coreae). None of these cell groups displayed either DBH or PNMT immunoreactivity. Many TH-immunoreactive neurons were present in the substantia nigra & ventral tegmentum. The major dopaminergic cell(TH-positive, DBH- & PNMT-negative) group in the midbrain was present in the pars compacta of substantia nigra and adjacent ventral tegmentum. And smaller dopaminergic cell groups Were found in the pars reticulata of the substantia nigra and central liner nucleus.