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우성일,Jung Min Sohn,Kwang Seok Oh 한국화학공학회 2004 Korean Journal of Chemical Engineering Vol.21 No.1
A catalyst library consisting of 20 catalysts with different metal and weight fraction-doped TiO2 was prepared at one time for discovering the novel metal-doped TiO2 photocatalyst, which is active under visible light irradiation. Combinatorial microbeam XRD and UV-vis spectrometer were used for analysis of crystal structure and photoactivity of 20 catalysts in the library, respectively. Photodecomposition of phenol was chosen as a probe reaction. The library preparation, XRD characterization and reaction test for 20 catalysts were completed within 48 hours. Among the catalysts in the library, 1.5 wt% Co/TiO2 showed the best activity for phenol degradation.
메타콜린 기관지유발검사 시행방법: 대한천식알레르기학회 의견서
손경희 ( Kyoung-hee Sohn ),김환수 ( Hwan Soo Kim ),김병근 ( Byung-keun Kim ),김주희 ( Joo-hee Kim ),이상민 ( Sang Min Lee ),이재현 ( Jae-hyun Lee ),우성일 ( Sung-il Woo ),김철홍 ( Cheol Hong Kim ),정재원 ( Jae Won Jung ),김세훈 ( 대한천식알레르기학회 2023 Allergy Asthma & Respiratory Disease Vol.11 No.2
메타콜린 기관지유발검사는 천식의 감별 진단 및 기관지과민증을 측정하기 위해 널리 시행되어온 검사이다. 정확한 진단을 위해 표준화된 프로토콜로 검사가 이루어져야 하나, 최근 검사 장비의 변경 및 2017년 ERS가이드라인에서 프로토콜이 변경되었음에도 불구하고, 진료 일선에서는 과거 프로토콜이 여전히 사용되고 있다. 현재 국내에서 사용 가능한 APS 장비에서는 기존 KoKo dosimeter에서 사용되던 프로토콜을 적용할 수 없으므로 더 간소화되고 고도화된 프로토콜을 제안한다. 학회는 본 전문가 의견서를 통해 새로운 메타콜린 기관지유발검사 프로토콜을 제시하였으며, 개정된 프로토콜의 타당성과 정확성에 대해서는 향후 전향적인 다기관연구가 필요하다. The Korean Academy of Asthma, Allergy, and Clinical Immunology task force report aims to provide new protocols for methacholine challenge test (MCT). Although new devices have different delivery system compared to old ones, previous protocols are still used, which cannot guarantee adequate diagnoses of asthma. Another important issue is the recent recommendation in European Respiratory Society (ERS) technical standard guideline to use a delivered methacholine dose that causes a 20% decrease in forced expiratory volume in 1 second (FEV<sub>1</sub>) (PD<sub>20</sub>). Although the previous protocol based on the methacholine concentration causing a 20% decrease in FEV<sub>1</sub> (PC<sub>20</sub>) has been used globally, several studies have reported that PD<sub>20</sub> is more reliable and applicable for new protocols of MCT. Indeed, a tidal breathing inhalation protocol using a breath-actuated or continuous nebulizer is recommended. Herein, we recommend 3 protocols for the MCT using new devices and provide a brief summary of the change in strategy based on the updated ERS guideline. (Allergy Asthma Respir Dis 2023;11:56-62)