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- 저자 : 우두현 ( Doo Hyun Woo ) (검색결과 5 건)
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송란 ( Ran Song ),우두현 ( Doo Hyun Woo ),이연아 ( Yeon Ah Lee ),이상훈 ( Sang Hoon Lee ),이향이 ( Hyang Ie Lee ),신준범 ( Joon Beom Shin ),홍승재 ( Seung Jae Hong ),한정수 ( Chung Soo Han ),유명철 ( Myung Chul Yoo ),양형인 ( Hyu 대한내과학회 2007 대한내과학회지 Vol.73 No.2
목적: Methotrexate (MTX)로는 충분한 질병활성억제를 보지 못했거나, 부작용으로 인해 MTX를 사용할 수 없었던 류마티스 관절염 환자에서 mizoribine의 치료효과를 알아보고자 하였다. 방법: Mizoribine (100 mg/day)을 투여 받은 류마티스 관절염 환자 50명을 대상으로 MTX와 mizoribine의 병합 치료군과 mizoribine 단독 치료군으로 나누어 분석하였으며, mizoribine 투여 전과 16주간의 투여 이후 평가된 질병 활성도와 부작용 등을 비교하였다. 결과: 임상지표를 보면 MTX와 mizoribine 병합 치료 군에서 VAS, 압통관절의 수, 종창관절의 수, DAS28이 치료 전에 비해 유의하게 감소하였으나 mizoribine 단독 치료 군에서는 VAS만이 유의한 차이를 보였다. 또한, 검사실 소견에서는 병합 치료 군에서 치료 후 ESR과 CRP가 유의하게 감소하였다. 치료 약제와 관련된 부작용은 위장장애가 가장 많았고, 기타 다른 부작용도 관찰되었지만 대부분 경미하였으며 부작용으로 인해 투약을 중단한 사례는 없었다. 결론: MTX에 충분한 반응을 보이지 않는 류마티스 관절염 환자에서 mizoribine은 비교적 안전한 치료 약제이며, MTX에 효과가 불충분했을 경우 mizoribine를 추가하면 질병활성도 억제에 좀 더 효과적임을 알 수 있었다. Background: This retrospective study was performed to investigate the clinical effects of mizoribine with using methotrexate (MTX) or mizoribine alone on those patients with rheumatoid arthritis (RA) who showed an ineffective response or intolerance to the MTX. Methods: The patients were divided into two groups: (1) combination therapy of mizoribine with MTX and (2) mizoribine alone. All the patients took 100 mg mizoribine daily for at least 16 weeks. Before and after administration of mizoribine for 16 weeks, we assessed the clinical variables such as the visual analogue pain scale (VAS), the tender joint counts (TJC), and the swollen joint counts (SJC). At each time, the laboratory parameters including the ESR, CRP, complete blood count (CBC), liver enzymes and creatinine were also measured. Disease activity scores (by the DAS28) and the adverse effects were determined at baseline and after 16 weeks. Results: Fifty patients were recruited in this study (mizoribine plus MTX group: n=35, mizoribine group: n=15). There were no significant differences in the initial laboratory values between the two treatment groups. After treatment for 16 weeks, the DAS28 was decreased significantly in the mizoribine plus MTX group (4.7±1.14 vs. 3.9±0.97, respectively, p<0.05). Yet the mizoribine alone group did not showed any significant change of the DAS28 (4.3±0.56 vs. 3.9±0.37, respectively, p=0.076). Mild gastrointestinal disturbance was the most common adverse effect. The incidence of adverse effects was similar in both treatment groups (20% vs. 27%, respectively). Conclusions: Mizoribine in combination with MTX was effective for RA patients who showed an ineffective response or intolerance to MTX. Furthermore, this treatment can be considered to be relatively safe.(Korean J Med 73:192-199, 2007)
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한국인에서의 PDCD1 다형성과 강직성 척추염의 연관성
이상훈 ( Sang Hoon Lee ),이연아 ( Yeon Ah Lee ),우두현 ( Doo Hyun Woo ),송란 ( Ran Song ),김영훈 ( Young Hoon Kim ),박은경 ( Eun Kyung Park ),유미현 ( Mi Hyun Ryu ),김경수 ( Kyoung Soo Kim ),홍승재 ( Seung Jae Hong ),유명철 ( Myu 대한내과학회 2007 대한내과학회지 Vol.72 No.4
목적: Programmed death 1 (PD-1) 단백질은 활성화된 T세포를 비활성 시키거나 증식을 억제하는 것으로 알려져 있고, 이 물질의 유전자 다형성이 전신 루푸스 질환이나 류마티스 관절염과 같은 자가면역질환과 관련이 있다는 보고가 있었다. 따라서 자가면역 질환으로 생각되는 강직성 척추염과도 관련성이 의심되고 아직까지 연구된 바가 없어 본 연구를 시행하였다. 방법: 경희의료원 류마티스 내과에 2004년 3월부터 2005년 2월까지 방문하여 변경된 New York 진단 기준에 따라 진단 받은 강직성 척추염 환자를 대상으로 하여 대조군과의 유전자 다형성 차이를 알아 보았다. 유전자는 PDCD1의 exon 5의 1.9 위치에서의 다형성을 확인하였다. 결과: PD-1.9 유전자의 T 대립 염기가 강직성 척추염 환자에서 21.0%, 대조군에서 6.9%로 교차비가 1.89(95% 신뢰구간, 1.483-2.408)로 강직성 척추염 환자에서 통계적으로 유의하였다. 결론: PD-1.9 단일핵산다형성이 한국인에서 강직성 척추염의 또다른 유전적 소인일 가능성이 있고, 이에 대한 대규모 연구가 필요할 것으로 생각된다. Background: The programmed death 1 (PD-1) protein, the product of the PDCD1 gene, is a negative regulator of T cells, and a genetic association of PDCD1 in systemic lupus erythematosus and rheumatoid arthritis (RA) in Caucasians has been reported. However, there have been no studies on the association of this gene and ankylosing spondylitis (AS). The aim of this study was to investigate the association of PD-1 polymorphisms with ankylosing spondylitis in the Korean population Methods: One single-nucleotide polymorphism PD-1.9 T/C were genotyped in 95 patients with AS and 130 healthy controls in a case-control association study. We analyzed this SNP by use of a PCR-RFLP assay using genomic DNA. Results: The T allele of the PD-1.9 polymorphism was significantly more frequent in a Korean male population with AS than in Korean male controls (21.0% versus 6.9%; odds ratio[OR] 1.89; 95% confidence interval [95% CI] 1.483-2.408). Conclusions: We demonstrated the presence of the PD-1 polymorphism in Korean AS patients. This finding suggests a genetic association between the PD-1 polymorphism and AS susceptibility. (Korean J Med 72:393-399, 2007)
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증례 : 청소년 류마티스 관절염 환자에서 출혈성 위장관염으로 나타난 Henoch-Schonlein 자반증 1예
신준범 ( Joon Beom Shin ),이연아 ( Yeon Ah Lee ),문수영 ( Soo Young Moon ),우두현 ( Doo Hyun Woo ),이상훈 ( Sang Hoon Lee ),홍승재 ( Seung Jae Hong ),양형인 ( Hyung In Yang ) 대한내과학회 2007 대한내과학회지 Vol.73 No.4
저자들은 청소년 류마티스 관절염을 진단받고 항류마티스 약물을 복용 중이던 24세 남자에서 IgA 신병증과 심한 출혈성 위장관 증상을 동반한 HSP를 진단하였고 이를 corticosteroid 치료로서 호전시켰기에 보고하는 바이다. Henoch-Schonlein purpura (HSP) is a systemic vasculitis with IgA dominant immune complex deposits that affect the small vessels in the skin, joints, gastrointestinal tract and kidneys. Gastrointestinal symptoms are common and the manifestations include abdominal pain, bleeding, bowel infarction, intussusceptions or even perforation. Polyarticular onset juvenile rheumatoid arthritis (JRA) is a rare form of arthritis that affects children and young adults. The relationship between HSP and JRA is uncertain. We report on a 24-year-old man with a history of polyarticular onset JRA and HSP that was complicated by hemorrhagic gastroenteritis. The gastroscopy and colonoscopic findings showed extensive hemorrhagic inflammatory changes of the gastric and intestinal mucosa. The patient had severe bloody diarrheal symptoms, abdominal pain and gross hematuria. The 24 hours urine chemistry profile showed the proteinuria was greater than 4.5 g/day, and immunofluorescent staining of the renal biopsy specimen showed diffuse granular mesangial deposits of IgA and C3. The abdominal manifestations and proteinuria were improved after methylprednisolone therapy.(Korean J Med 73:453-456, 2007)
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김용남 ( Yong Nam Kim ),이향이 ( Hyang Ee Lee ),이상훈 ( Sang Hoon Lee ),이연아 ( Yeon A Lee ),우두현 ( Doo Hyun Woo ),황보영 ( Young Hwangbo ),조경삼 ( Kyung Sam Cho ),박용구 ( Yong Koo Park ),양형인 ( Hyung In Yang ) 대한류마티스학회 2005 대한류마티스학회지 Vol.12 No.3
Plasmacytomas are tumors composed of plasma cells of variable maturity, which are histologically identical to those seen in multiple myeloma. Ankylosing spondylitis is a chronic inflammatory disease, probably resulting from the interaction of a genetic predisposition involving HLA-B27 with an environmental event such as enteric bacterial infection. Multiple myeloma has been intermittently reported in patients with ankylosing spondylitis. It has been proposed that the protracted stimulation of immunocytes by inflammatory lesions on the mucosal surfaces of the gastrointestinal, respiratory tracts may be implicated in the pathogenesis of multiple myeloma in some patients. We observed a 23 year old male patient with a history of plasmacytoma who subsequently developed ankylosing spondylitis. He was diagnosed as plasmacytoma 4 years ago and took a radiation therapy. There was no previous report of ankylosing spondylitis following plasmacytoma. The relationship between two diseases is uncertain until now and further study should be needed.
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