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영지버섯 균사체 (Ganoderma lucidum IY009)로부터 추출한 단백다당체의 항암활성
백성진(Seong Jin Baek),김용석(Yong Seok Kim),용환미(Hwan Mee Yong),채주병(Ju Byung Chae),윤환민(Hwan Min Yun),박동우(Dong Woo Park),김동연(Dong Yeon Kim),이정옥(Jeong Ok Lee),이준우(June Woo Lee),박승국(Seung Kook Park) 대한약학회 2001 약학회지 Vol.45 No.6
In this study, the antitumor activities were investigated using β-Immunan, a proteoglycan obtained from cultured mycelia of the IYO09 strain of Ganoderma lucidum IY009belonging to basidiomycetes. The result showed the significant effect of cytotoxicity test against murine sarcoma 180 and murine Iymphocytic leukemia L1210 using immunized macrophage cultures by β-Immunan. When intraperitoneally injected at 40 mg/kg/day daily for 10 days, β-Immunan inhibited the growth of sarcoma 180 solid tumor in ICR mice by 88.8% (p<0.05). It was also observed that β-Immunan increased life span by 85.2% (p<0.01) after treatment of 100 mg/kg/day in BDFI mice bearing Iymphocytic leukemia L1210. And combination therapy with cisplatin (dosage: 4 mg/kg) increased life span by 140.4% (p<0.05) after treatment of 100 kg/mg/day in BDFI mice bearing Iymphocytic leukemia L1210.
영지버섯 균사체 ( Ganoderma lucidum IYO09)로부터 추출한 단백다당체의 전이암 억제 효과
백성진(Seong Jin Baek),김용석(Yong Seok Kim),용환미(Hwan Mee Yong),채주병(Ju Byung Chae),이선애(Sun Ae Lee),배우철(Woo Chul Bae),박동우(Dong Woo Park),김동연(Dong Yeon Kim),이준우(June Woo Lee),박승국(Seung Kook Park) 대한약학회 2002 약학회지 Vol.46 No.1
β-Immunan, a proteoglycan, was isolated from the mycelium of Ganoderma lucidum which belongs to a medicinal mushroom. The effects of β-Immunan on cell- cell and cell-matrix interactions mediated by carbohydrate-recognition and the mechanism responsible for the inhibition of experimental metastasis of Bl6-FIO and B16/BL6 murine melanoma were studied. The results showed that Ganoderma lucidum-Immunan inhibited Bl6-Fl melanoma cell's adhesion to laminin and asialofetuin-induced homotypic aggregation and reduced invasion against Bl6-FIO murine melanoma cells through matrigel in vitro assay: When β-Immunan was intraperitoneally administrated to C57BL/6 mice bearing B16/BL6 murine melanoma cells, it was decreased the number of pulmonary metastatic colony by the dose dependent manner ranging from 20 to 100 mg/kg/day, The results indirectly indicate that clinical treatment with β-Immunan might be expected to exhibit anti-metastatic effect. In the put-monary metastasis, the number of pulmonary metastatic colony of melanoma when β-Immunan was intraperitoneally aduunistrated to C57BL/6 mice bearing Bla/BL6 murine melanoma cells by intravenous injection were decreased by the dose dependent manner ranging from 20 to 100 mg/kg/day.