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흉막강액에서 진단된 악성 섬유성 조직구종 - 1예 보고 -
오화은,김유훈,조성진,김영식,김인선,Oh, Hwa-Eun,Kim, Yoo-Hoon,Cho, Seong-Jin,Kim, Young-Sik,Kim, In-Sun 대한세포병리학회 1995 대한세포병리학회지 Vol.6 No.1
Malignant fibrous histiocytoma is the most common soft tissue sarcoma of late adult life, but it is rare in the pleura. We recently experienced a case of cytology of malignant fibrous histiocytoma in plural fluid. The smear revealed histiocytic malignant cells, spindle malignant cells and inflammatory cells. The histiocytic cells showed abundant, pale cytoplasm and ovoid, irregular eccentrically-placed nuclei. The spindle cells showed elongated nuclei. Intercellular collagen was also present.
자가면역 췌장염의 동반증상 없이 발생한 IgG4 연관 경화성 담관염
천송욱 ( Song Wook Chun ),최자성 ( Ja Sung Choi ),강버들 ( Beo Deul Kang ),김유진 ( Yu Jin Kim ),한기준 ( Ki Jun Han ),조현근 ( Hyeon Geun Cho ),오화은 ( Hwa Eun Oh1 ),조재희 ( Jae Hee Cho ) 대한소화기학회 2013 대한소화기학회지 Vol.62 No.1
IgG4-related systemic diseases are characterized by a diffuse or mass forming inflammatory reaction rich in lymphocytes and IgG4-positive plasma cells (lymphoplasmacytic infiltration), fibrosclerosis of variable organs and obliterative phlebitis. They usually involve various organs including the pancreas, bile duct, gallbladder, salivary gland, retroperitoneum, kidney, lung, and prostate. However, most of them are accompanied by autoimmune pancreatitis, and good response to steroid treatment is one of the hallmarks of this disease. We report a case of an 67-year-old man with IgG4 associated sclerosing cholangitis, who was diagnosed by endoscopic retrograde cholangiopancreatography and successfully treated with steroid therapy. (Korean J Gastroenterol 2013; 62:69-74)
문정석,오화은,이주한,김애리,김철환,김한겸,박미자,원남희,Moon, Jeong-Seok,Oh, Hwa-Eun,Lee, Ju-Han,Kim, Ae-Ree,Kim, Chul-Hwan,Kim, Han-Kyeom,Park, Mee-Ja,Won, Nam-Hee 대한세포병리학회 1997 대한세포병리학회지 Vol.8 No.2
Mucoepidermoid carcinoma is the most common malignant neoplasm of the salivary gland, compring between 30 and 40%. Fine needle apsiration cytology was performed in five patients with mucoepidermoid carcinoma. The patients consisted of three males aged of 42, 48, and 60 years, and two females aged 36, and 56 years. The primary tumor sites were the parotid gland in four patients and the submandibular gland in the rest one. The histologic grades were low in one patient, intermediate in two patients and high in other two. In our experience, the common cytologic findings of low grade subtype were predominent mucous cells with some intermediate cells in an abundant mucinous background. The cytologic findings of intermediate grade subtype were predominant clusters of intermediate cells with or without mucous cells in an abundant mucinous background. And the cytologic findings of high grade subtype were predominant clusters of epidermoid cells with intermediate cells in a bloody background. Cytologic pleomorphism and atypia were more severe in high grade than low and intermediate grade, and nucleoli were more frequently noted in epidermoid cells. In low grade, it is very difficult to decide the benignancy or malignancy of the tumor. In fact, the presence of mucous cells in a mucinous background should rule out any other type of well differentiated carcinoma.
자궁경부상피내종양의 원추절제술 후 절제 변연부 상태에 영향을 미치는 인자 분석
정차남 ( Cha Nam Jung ),오나정 ( Na Jung Oh ),류기영 ( Ki Young Ryu ),오화은 ( Hwa Eun Oh ),김우영 ( Woo Young Kim ) 대한산부인과학회 2011 Obstetrics & Gynecology Science Vol.54 No.12
목적 자궁경부 원추절제술 후 절제 변연부 침범 소견을 보일 때 병변의 중증도가 이에 미치는 영향에 대하여 살펴보고 절제 변연부 침범과 재발 및 잔류종양의 연관성에 대하여 알아보고자 하였다. 연구방법 2003년 11월부터 2011년 2월까지 자궁경부 원추절제술을 시행 받은 후 cervical intraepithelial neoplasia (CIN)으로 진단된 환자 202명을 대상으로 후향적 연구를 시행하였다. 원추절제술 후 환자는 자궁절제술을 시행 받거나 3-6개월 간격으로 자궁경부세포검사를 통한 추적관찰을 시행하였으며 이상 소견을 보이는 경우 질확대경하에 조직검사를 시행하였다. 재발은 CIN I 이상의 조직 소견을 보이는 경우로 정의하였다. 결과 CIN으로 진단된 환자 202명 중 CIN I은 46명(22.8%), CIN II는 35명(17.3%), CIN III는121명(59.9%)이었다. 절제 변연부 침범 소견을 보인 환자는 67명(33.2%)이었고 CIN I은 7명(10.4%), CIN II는 14명(20.9%), CIN III는 46명(68.7%)으로 CIN의 중증도가 심할수록 절제 변연부의 침범 빈도가 증가하였다(P = 0.009). 자궁절제술을 시행 받은 환자는 28명(13.9%)으로 절제 변연부 침범이 없었던 환자는 13명, 절제 변연부 침범이 있었던 환자는 15명이었고 각각 7명(53.8%)과 5명(33.3%)에서 잔류 병변이 존재하여 절제 변연부의 침범 여부와 잔류종양의 유무는 통계학적으로 유의한 상관관계를 보이지 않았다(P = 0.445). 보존적 치료를 시행한 환자는 174명으로 이 중 절제 변연부 침범을 보인 3명(3/52, 5.7%)과 절제 변연부 침범을 보이지 않은 2명(2/122, 1.6%)의 환자에서만 재발을 보였다(P = 0.335). 결론 CIN 환자에 있어 병변의 중등도가 심할수록 절제 변연부 침범이 있을 가능성이 크지만 절제 변연부의 침범이 있다 하더라도 실제적으로 잔류 병변이 없는 경우가 더 많으며 절제 변연부의 침범 여부가 재발과는 유의한 상관관계가 없는 것으로 나타났다. 따라서 변연부 침범소견을 보이는 경우라도 지속적 추적관찰만 잘 이루어 질 수 있다면 CIN의 치료로 충분하다 할 수 있겠다. 또한 절제 변연부의 침범이 없는 경우에도 잔류종양이 남아 있을 가능성이 있으므로 주의 깊은 추적관찰이 필요할 것으로 생각된다. Objective The aim of this study was to evaluate the correlation between resection margin status after conization and severity of dysplasia and to evaluate the risk of residual disease and recurrence for positive resection margin after conization. Methods We retrospectively reviewed the medical and histopathological records of 202 patients who underwent conization that revealed cervical intraepithelial neoplasia (CIN) at Myongji Hospital, Kwandong University College of Medicine between November 2003 and February 2011. Patients were followed up every three to six months with cervicovaginal smears, and suspected cases of recurrence were subjected to colposcopy and biopsy. Results A total of 202 patients underwent conization (46 [22.8%] with CIN I, 35 [17.3%] with CIN II, 121 [59.9%] with CIN III) and were enrolled this study. The cone resection margin involved in 33.2% (67/202) of the patients (7/67 [10.4%] with CIN I, 14/67 [20.9%] with CIN II, 46/67 [68.7%] with CIN III). The frequency of resection margin involvement after conization was higher with increasing severity of CIN (P = 0.009). Hysterectomy was performed in 28 patients (13.9%). The incidence of residual disease was 53.8% (7/13) in resection margin free group and 33.3% (5/15) in resection margin involvement group (P = 0.445). There were three (3/52, 5.7%) recurrence in resection margin involvement group and two (2/122, 1.6%) recurrence in resection margin free group (P = 0.335). Conclusion The risk of resection margin involvement after conization increased with increasing severity of CIN. However, the women with involvement of resection margin after conization often have no residual disease and there was no difference in recurrence between the resection margin status. Therefore, patients whose resection margins were involved after conization could be managed conservatively.
쌍태 임신에서 한 명의 태아 사망으로 인한 생존아의 다낭성 뇌연화증
류기영(Ki Young Ryu),최병민(Byung Min Choi),송순영(Soon Young Song),오화은(Hwa Eun Oh) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.3
The antepartum death of a fetus in a twin pregnancy may cause significant risk of mortality and morbidity in the surviving infant. Especially, one fetal demise of a twin pregnancy in the second or third trimester is an uncommon and difficult problem in the management of pregnancy. In this report, we present a case of single intrauterine death in a twin gestation diagnosed in the 27th week of pregnancy and the surviving fetus exhibits multicystic encephalomalacia three weeks later, antenatally.
Diclofenac 주사 후 발생한 Nicolau 증후군
고재완 ( Jae Wan Go ),김신한 ( Shin Han Kim ),노병인 ( Byung In Ro ),오화은 ( Hwa Eun Oh ),조한경 ( Han Kyoung Cho ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.9
Nicolau syndrome or embolia cutis medicamentosa is a rare complication of a still largely unidentified pathogenesis at the site of intramuscular injections of various drugs. It is characterized by development of an acute, severe pain around the injection site followed by a localized erythema, a reticular rash, a hemorrhagic patch and varying degrees of tissue damage. The disease outcomes vary from atrophic ulcers and pigmentation to lower limb paralysis and limb amputation. We describe a 34-year-old woman with the diagnosis of this syndrome after she received an intramuscular diclofenac-beta-dimethyl-aminoethanol injection to the lateral aspect of the right upper buttock. The patient was treated by surgical debridement with concomitant primary closure. (Korean J Dermatol 2010;48(9):786~789)
가상 현미경을 이용한 병리학 실습 교재의 시험적 제작과 적용
송지선(Ji Sun Song),이상엽(Sang Yeop Yi),오화은(Hwa Eun Oh) 한국의학교육학회 2006 Korean journal of medical education Vol.18 No.2
Purpose: Learning the concepts of pathology can be facilitated by repeated learning situations with illustrative pathology images. Virtual microscopes are digital facsimiles of glass slides that can be viewed on a computer screen. This study was designed to evaluate the possibility of using virtual microscopes as a teaching modality in the pathology laboratory. Methods: The virtual microscope was produced from high resolution images scanned by an exclusive slide scanner from newly made teaching glass slides. The final teaching material was put up on personal computers in the computer laboratory, classroom, and medical library. Results: This material was easily accessed by exclusive viewers. The students readily adapted to the use of virtual microscopes. The quality of the images in this material was appropriate for viewing. The response from the students displayed highly significant differences between the traditional and virtual microscopes, with the virtual microscope being preferred. Conclusion: The virtual microscopes in this study were helpful for medical students studying pathology. The results of this implementation suggest that virtual microscope technology may be extended to other educational venues where traditional microscopes and photomicrographs are currently used.