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증례 : 순환기 ; 다량의 심낭 삼출로 발현된 POEMS 증후군 1예
오창명 ( Chang Myung Oh ),방우대 ( Woo Dae Bang ),이상국 ( Sangkook Lee ),조성수 ( Sung Soo Cho ),노송미 ( Songmi Noh ),김진석 ( Jin Seok Kim ),장혁재 ( Hyuk Jae Chang ) 대한내과학회 2011 대한내과학회지 Vol.81 No.2
심낭 삼출은 악성종양, 결핵 등 다양한 원인에 의해 유발되는 질환으로 과거와는 달리 선험적인 치료에 의존하기 보다 정확한 원인 규명의 중요성이 점차 커지고 있다. 저자들은 심낭 삼출을 주된 증상으로 하면서 말초신경병증, 비장비대, 갑상샘저하증, 단세포감마글로불린병증, 피부색소침착, 다모증, 흉막 삼출, 전신 부종, 폐동맥고혈압 등을 동반한 POEMS 증후군 1예를 경험하여 문헌고찰과 함께 보고한다. 심낭 삼출의 치료에 반응이 없으면서 원인을 찾지 못하여 특발성 심낭염으로 진단한 환자의 추가적인 감별 진단의 하나로 POEMS 증후군이 고려되어야 하겠다. Pericardial effusions can be caused by a wide variety of infectious or noninfectious diseases. After a conventional diagnostic work-up, the etiology of pericardial effusion often remains idiopathic. We report a patient with POEMS syndrome whose main clinical problem was recurrent pericardial effusions. Patients with POEMS syndrome often have generalized edema and a pleural effusion, while a pericardial effusion is a very rare complication. A 44-year-old man visited our hospital because of a recurrent pericardial effusion. He was initially diagnosed with idiopathic pericarditis five months prior. We reassessed the patient meticulously and found IgG lambda type monoclonal gammopathy, polyneuropathy, lymphadenopathy, peripheral edema, pleural effusion, hypothyroidism, pulmonary hypertension, hyperpigmentation, hypertrichosis, and papilledema, which we diagnosed as POEMS syndrome. (Korean J Med 2011;81:245-250)
증례 : 순환기 ; 관상동맥 CT 혈관조영술상 정상이었으나 심혈관계 사건이 발생한 2예
최동훈 ( Dong Hoon Choi ),김광준 ( Kwang Joon Kim ),장지용 ( Ji Yong Jang ),이찬주 ( Chan Joo Lee ),장혁재 ( Hyuk Jae Chang ),오창명 ( Chang Myung Oh ),유희태 ( Hee Tae Yu ) 대한내과학회 2010 대한내과학회지 Vol.79 No.5
저자들은 관상동맥 CT 혈관조영술상 정상소견이었으나 단기 추적 중 심혈관계 사건이 발생한 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Multi-detector row coronary computed tomography (CT) angiography is an emerging noninvasive diagnostic tool for coronary artery disease. Because of the high negative predictive value of the test, coronary CT angiography is useful for ruling out significant coronary artery stenosis in patients with chest pain. Between 2003 and 2009, 2,148 (50%) of 4,337 patients who underwent coronary CT angiography had a normal coronary artery. Of the 2,148 patients, only two (0.09%) experienced cardiovascular events within three months of their index visit. One patient underwent invasive coronary angiography based on a positive exercise test result, while the second underwent invasive coronary angiography due to an episode of chest pain. Coronary angiographic examination of these two patients revealed significant luminal narrowing of the proximal left anterior descending artery; both patients underwent revascularization at the discretion of their physician. (Korean J Med 79:553-558, 2010)