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Clinical Features and Outcomes of Microscopic Polyangiitis in Korea
오지선,이창근,김용길,나성수,문희범,유빈 대한의학회 2009 Journal of Korean medical science Vol.24 No.2
Microscopic polyangiitis (MPA) is a systemic vasculitis affecting small vessels. To determine the clinical features and outcomes of MPA in Korean patients, we retrospectively reviewed the medical records of patients diagnosed with MPA at a single medical center in Korea between 1989 and 2006. The 18 patients who met the Chapel Hill criteria for MPA had a mean (±SD) age at the time of diagnosis of 62.4± 12.7 yr. Renal manifestations and general symptoms were the most common features of MPA, with lung involvement also very common. Antineutrophil cytoplasmic antibodies (ANCA) were present in 17 of the 18 patients (94%). Of 17 patients treated with steroids and cyclophosphamide, 11 (65%) had stable or improved course. One patient treated with steroids without cyclophosphamide showed disease progression. Ten of the 18 patients (56%) died at a median follow-up of 8 months. MPA in Korean patients was distinguished by a higher rate of lung involvement, especially alveolar hemorrhage, which was the leading cause of death in our patients. Korean patients were also older at MPA onset and were more likely positive for ANCA. Other overall clinical manifestations did not differ significantly.
청소년이 지각한 부모 양육태도, 스마트폰 과의존, 학교적응의 관계에서 회복탄력성의 매개효과
오지선,김도영 한국청소년학회 2024 청소년학연구 Vol.31 No.1
This study aims to examine the mediating effects of resilience in the relationship between youth perceived parenting styles, smartphone overuse, and school adaptation. To achieve this, we surveyed 853 students in elementary and middle schools in Jeju Special Self-Governing Province, investigating the influence of parenting styles, smartphone overuse, and resilience on school adaptation through correlation analysis, multiple regression analysis, and hierarchical regression analysis. The research findings indicate that parenting styles perceived as autonomous and supportive contribute to increased resilience and school adaptation. It was observed that resilience plays a positive role in school adaptation. Furthermore, resilience showed a partial mediating effect between parenting styles and school adaptation, while no mediating effect was found between resilience, smartphone overuse, and school adaptation. Based on these results, suggestions were provided for fostering positive parenting styles, creating an environment for responsible smartphone use, and enhancing resilience for school adaptation through support at the individual, family, school, and community levels.
Fermented Red Ginseng Extract Inhibits Cancer Cell Proliferation and Viability
오지선,Seong Bin Jeon,이유리,이혜지,김주,권보라,유강열,차정단,황승미,최경민,정용섭 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.4
Red ginseng (Panax ginseng C.A. Meyer) is the most widely recognized medicinal herb due to its remedial effects in various disorders, such as cancers, diabetes, and heart problems. In this study, we investigated the anticancer effect of fermented red ginseng extract (f-RGE; provided by Jeonju Biomaterials Institute, Jeonju, South Korea) in a parallel comparison with the effect of nonfermented red ginseng extract (nf-RGE; control) on several cancer cell lines—MCF-7 breast cancer cells, HepG2 hepatocellular carcinoma cells, and reprogrammed MCF-7 cells (mimicking cancer stem cells). Cells were cultured at various concentrations of RGE (from 0.5 up to 5 mg/mL) and their viabilities and proliferative properties were examined. Our data demonstrate the following: (1) nf-RGE inhibited cell viability at ≥ 1 mg/mL for MCF-7 cells and ≥ 2 mg/mL for HepG2 cells, (2) in the presence of a carcinogenic agent, 12-O-tetradecanoylphorbol-13-acetate (TPA), nf-RGE treatment in combination with paclitaxel synergistically decreased MCF-7 as well as HepG2 cell viability, (3) f-RGE (which contained a greater level of Rg3 content) more effectively decreased the viability of MCF-7 and HepG2 cells compared to nf-RGE, and (4) f-RGE appeared more potent for inhibiting cancerous differentiation of reprogrammed MCF-7 cells in a synergistic fashion with paclitaxel, especially in the presence of TPA, compared to nf-RGE. These findings suggest that f-RGE treatment may be more effective for decreasing cancer cell survival by inducing apoptotic cell death and also presumably for preventing cancer stem cell differentiation compared to nf-RGE.
오지선,신상훈 공주대학교 KNU 기업경영연구소 2023 기업경영리뷰 Vol.14 No.4
While the size of the legal services market in Korea has grown rapidly, the number of lawyers has also increased dramatically, leading to a saturated market. The Korean legal services market has been characterized by its conservative and closed nature, making it inaccessible to the general public, but innovation has become an essential element in the legal services industry. Therefore, this study analyzes the corporate growth and success factors based on the founding and leadership of Myeongkyeong Law Firm, one of the most active law firms in the legal services market, and recommends its implications. The research questions are as follows. 1) What are the growth factors of Myeongkyeong? 2) What are the key leadership and innovation strategies that led to the company's growth? 3) What are the implications of the findings for successful company growth in the professional knowledge service industry? The academic contributions and practical implications of this study are as follows. First, this study sheds light on real-life corporate cases based on entrepreneurial leadership, which has not been studied much in Korea and abroad. Second, the growth of medium and large law firms in Korean society has been an opportunity to provide efficient legal services by organizationally solving increasingly complex legal issues as society develops. Third, he suggested the need for innovative leadership in professional management organizations. Fourth, it provides implications for corporate growth and innovation in the management of knowledge service and specialty firms through 'entrepreneurial leadership' and 'knowledge management' of leaders with 'entrepreneurial orientation' of law firms. In practical terms, this study provides entrepreneurs and entrepreneurs who are preparing to start a business in various fields of professional fields with important field guidance on leadership, innovation strategy, and knowledge management required for top management.