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This first article in a series of descriptions of devices and methods in the field of automated information processing depicts two machines representing a. certain type of documentation systems which use micro-images and coding of documents in an unalterable sequence, namely on 16mm filmrolls.
This first part of a series provides some data on the quick growth, high importance and increasing cost of scientific research which leads to a doubling of the amount of research literature in about every eight years. The importance of periodicals is emphasized and some figures on the growth of abstract journals demonstrate how difficult it has become for the scientist to keep up with the current development in his subject field without using documentation. The second part, in KORSTIC's next issue, deals with the scope and methods of scientific documentation, the third part with the devices and machines for information processing and with the problem of automation, whilst the fourth part throws some light on the organization of documentation work all around the world.
The solubility and stability of ondansetron hydrochloride (OS) in various vehicles were determined. The effect of cyclodextrins (CD) on the solubility of OS in water was determined by equilibrium solubility method. The solubility of OS at 32℃ increase in the rank order of isopropyl myristate (IPM)<propylene glycol laurate (PGL)《 propylene glycol monolaurate<propylene glycol monocaprylate (PGMC)<poly(ethylene glycol) 400<diethylene glycol mono ethyl ether (DGME)<ethanol<poly(ethylene glycol) 300<water(36.1㎎/ml)《 propylene glycol (PG) (283㎎/ml). The addition of PG or DGME to non-aqueous vehicles such as IPM, PGL and PGMC markedly increased the solubility of OS. The addition of CDs in water increased the solubility. Apparent stability constant for the CD complexation with OS was calculated to be 25.5M^-1 for 2-hydroxypropyl-β-CD(2HPβCD0. Twenty mM β-CD, 69.4mM sulfobutyl ether β-CD and 115.4mM 2HPβCD increased the aqueous solubility of OS 1.27, 2.18 and 1.85 times, respectively. OS was stable in buffered aqueous solution (pH 5.0). However, OS was relatively unstable in non-aqueous vehicles in the order of PG<DGME<PGMC-DGME(60:40) co-solvent<PGMC. The degradation of OS in these vehicles was accelerated, depending on temperature.