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Objectives : The purpose of this study is to review the effect of Guaruhaebaekbaekju-tang (GHBJ), Guaruhaebaekbanha -tang (GHBH) and Jisilhaebaekgyeji-tang (JHGJ) by summarizing Korean and English articles. Methods : The study was based on 23 papers published since 1995. Papers were searched on seven domestic electronic databases including Koreantk, NDSL, RISS, KISS, OASIS, Koreamed and Library of Korea University and three international electronic databases including PUBMED, Embase and Science Direct. Results : 1. 23 research papers were collected, including 13 in vitro studies, 6 in vivo studies, 2 case reports and 2 literature studies. 2. GHBJ, GHBH and JHGJ showed significant myocardial protective and anti-hyperlipidemic and anti-inflammatory effects. In addition, researches on anti-oxidant, thrombosis, and atherosclerosis have been conducted in various ways. 3. It can be confirmed that these studies are related to Chest and back pain (胸背痛), Insomnia by chest paralysis (胸痺不得臥), Stabbing pain that radiates from chest to back (心痛徹背), Chest numbness (心中痞), Obstruction of qi in the chest (留氣結在胸), Fullness sensation in chest (胸滿) among the <Geumgyeyoryak> terms. Conclusion : Through these results, close association was found between classic description and modern research about GHBJ, GHBH and JHGJ, and the possibility of providing objective evidence was confirmed. To improve the quality of the study, large scale studies will be required to evaluate the authority of GHBJ, GHBH and JHGJ.
오원종 ( Won Jong Oh ), 고은정 ( Eun Jung Ko ), 최선영 ( Sun Young Choi ), 박귀영 ( Kui Young Park ), 이갑석 ( Kapsok Li ), 김범준 ( Beom Joon Kim ), 서성준 ( Seong Jun Seo ), 김명남 ( Myeung Nam Kim ), 홍창권 ( Chang Kwun Hong ) 대한피부과학회 2015 大韓皮膚科學會誌 Vol.53 No.7
Sorafenib is an oral multi-kinase inhibitor with effects on tumor cell proliferation and tumor angiogenesis. The drug is associated with a relatively high incidence of dermatologic adverse events. Frequently observed clinical presentations include skin rash, a hand-foot skin reaction, alopecia, splinter subungual hemorrhages, and xerosis. There have been few reports of erythema multiforme or leukocytoclastic vasculitis related to sorafenib use. We report a case of a 72 year-old male diagnosed with renal cell carcinoma with distant metastasis, who developed an erythema multiforme-like drug eruption on his trunk and extremities after use of sorafenib. (Korean J Dermatol 2015;53(7):542∼545)
Objectives : The purpose of this study is to review herbal treatment for diabetic neuropathy by summarizing Korean clinical studies. Methods : The study was based on 8 papers published in Korea since 1997. The papers were searched on six domestic electronic databases including RISS, NDSL, Koreantk, KMBASE, Koreamed and OASIS. Results : 1. The average age of the subjects was 50.6 years. In sexual proportion, male is 72.7% and female is 28.3%. The average duration of diabetic neuropathy was 4.5 years. 2. The most frequent Pattern identification was Eumhu(陰虛). 3. In administration of Korean herbal medicine, UchaShinki-hwan(牛車腎氣丸) was the most frequently used to treat diabetic neuropathy and the next was Yukmijihwang-tang(六味地黃湯), Bogan-tang(補肝湯) and Gamisamul-tang(加味四物湯). 4. The average period of treatment was 43 days and the most frequent used evaluation index was VAS or NRS score. 5. The effects of treatment were evaluated based on VAS, NRS score, FBS, pp2hr and other evaluation indexes. In all studies, VAS or NRS score decreased to 1-3, and FBS, pp2hr and other indicators were significantly more effective than before treatment. Conclusion : To improve the treatment of diabetic neuropathy in Korean herbal medicine, large scale studies will be required to evaluate the authority of Korean medical treatment for diabetic neuropathy.
본 연구에서는 생쥐 섬유아 세포주인 LP1-1 세포의 세포 주기를 분석하고 G1기를 조절하는데 관여하는 D-type cyclins인 cyclin D1과 D3의 발현을 조사하였다. 세포를 G1/S 경계에 synchronization 시킨 후 풀어준 LP1-1 세포의 세포주기는 6시간까지는 S기, 10시간 까지는 G2, 10시간에서 12시간까지는 G2/M 전환기이며, 12시간 이후에는 G1기임을 알 수 있었다. 전체 세포주기에서 cyclin D1 및 D3 유전자 발현을 조사한 결과 cyclin D1은 G1기 중기에서 유도되어 G1기 후기까지 증가하다가 S기에서 가장 낮은 발현 수준을 나타내었고, cyclin D3는 S기까지 증가하다가, G2/M기에 발현이 감소하였다. 또한 G1기에서 cyclin D1 및 D3 유전자의 발현 수준을 조사하였더니, cyclin D1의 유전자 발현이 D3에 비해 빨리 유도됨을 알 수 있었다. The present study examines cell cycle distribution ad expression of G1 cyclins in LP1-1 cells. The cell cycle distribution of LP1-1 cells analyzed by ³H-thymidine incorporation rate and FACS showed 0-6 hr in S, 6-10 hr in G2 and 10-12 hr in G2/M phases after release from G1/S boundary. At each phase of cell cycle, expression of cyclin D1 and D3 were examined. Expression of cyclin D1 was induced in mid-G1 and increased with time until 8 hr and then decreased at a corresponding to S phase. The level of cyclin D3 mRNA was elevated until S phase and declined at G2/M phase. The order of expression of cyclin D1 and D3 in G1 phase was different; cyclin D3 mRNA expression was induced slower than that of cyclin D1 in LP1-1 cells.
Moisturizers are the most prescribed products in dermatology. Treatment with moisturizers aims to maintainskin integrity and overall well-being by providing a healthy appearance. Moisturizers perform very important functionsin baby care; however, there are few studies on the effects of moisturizers on the skin of infants. To investigate theeffects of moisturizers on the skin of healthy full-term infants and toddlers, thirty-one healthy, full-term, 6- to36-month-old infants and toddlers without any dermatologic conditions received moisturizer applied to the whole bodyexcept the eyes and diaper area after bathing twice daily for 4 weeks. Clinical assessments were conducted before treatment, immediately after the treatment period, and 1 and 4 weeks after treatment. At all visits, skin hydration, transepidermal water loss (TEWL), skin pH, and skin roughness were measured, the skin surface was photographed, andany adverse events were recorded. After using moisturizer, skin hydration significantly increased and TEWL and roughness significantly decreased. The skin pH was modified to mildly acidic and the skin surface was visually smootherthan before treatment. There were no statistical significant differences of effects of moisturizers according to age and sex, and adverse events were not observed. The results of moisturizer application on the skin were increased skin hydration, recovery of barrier function, balancing skin pH within a mildly acidic range, and increasing the smoothness ofthe skin surface for 4 weeks.