유방에 전이한 악성 흑색종의 세침흡인 세포학적 소견 - 1예 보고 -

오영륜,고영혜,Oh, Young-Lyun,Ko, Young-Hyeh 대한세포병리학회 1998 대한세포병리학회지 Vol.9 No.1

Although the characteristic cytologic features of melanoma have been well described the diagnosis of metastatic melanoma by fine needle aspiration cytology (FNAC) may be difficult in the case of amelanotic melanoma and in the absence of awareness of clinical history. Furthermore, when the breast is the site of initial presentation, it could simulate a primary breast carcinoma leading to misdiagnosis. The recognition of metastatic malignant melanoma in FNAC material is essential to avoid an unnecessary mastectomy and to ensure appropriate chemotherapy. We experienced a case of metastatic melanoma of breast which presented as solitary breast mass in a 56-year-old woman. She had a history of surgical excision of right foot for melanoma one year ago. The cytologic smears were composed of noncohesive epithelioid cells with round or eccentric nuclei, bi-or multi-nucleation, prominent nucleoli, fine chromatin, and intranuclear inclusions. The cytoplasm of tumor cells had scanty melanin pigment but were diffusely positive for S-100 protein.

침샘에 발생하는 고등급 악성 종양과 방추세포 병변의 세침흡인 세포소견에 대한 고찰

오영륜,Oh, Young-Lyun 대한세포병리학회 2005 대한세포병리학회지 Vol.16 No.2

Fine needle aspiration cytology (FNAC) is a very useful tool in the preoperative diagnosis of lesions of the salivary gland. Surgical therapy of high-grade malignancies (salivary duct carcinoma, mucoepidermoid carcinoma, squamous cellcarcinoma, carcinoma ex pleomorphic adenoma, small cell carcinoma, and sebaceous carcinoma) is different from that of benign lesions or low-grade malignancies. Therefore, the recognition of high-grade malignancies is important in salivary gland FNAC. Although recognition of high-grade malignancies of the salivary gland by FNAC is not difficult, precise classification of these malignancies is often impossible. Additionally, because of its rarity, FNAC of spindle cells and mesenchymal lesions of the salivary glands is a tool that is not familiar to many cytopathologists. The characteristic cytomorphologic features of these lesions are reviewed here with a discussion of specific diagnostic problems.

전이성 폐종양의 세포소견과 면역조직화학적 검사의 유용성

오영륜,Oh, Young-Lyun 대한세포병리학회 2008 대한세포병리학회지 Vol.19 No.1

The lungs are one of the most common visceral sites for metastatic disease. The identification of a metastasis from a second primary lung tumor is clinically important for patients with pulmonary metastases of an extrathoracic origin. Although the cytologic features of metastatic tumors involving the lung have been extensively described, making the cytologic diagnosis is usually not easy in the absence of clinical information. However, the immunohistochemical staining for many tumor markers and the different expressions of cytokeratin 7 and 20 are very useful in the diagnosis. This review presents the cytomorphological spectrum of metastatic tumors along with the immunohistochemical findings.

악성 침샘종양의 세침흡인 세포검사의 정도관리

오영륜,고영혜,Oh, Young-Lyun,Ko, Young-Hyeh 대한세포병리학회 2004 대한세포병리학회지 Vol.15 No.1

To evaluate the quality of fine needle aspiration cytology diagnosis on malignant salivary gland neoplasms, cytologic findings were correlated with histologic diagnosis of 56 surgically removed malignant salivary gland tumors. Seven cases (12.5%) were insufficient, 23 cases (41.1%) were diagnosed as malignant, 17 (30.4%) cases were accurately diagnosed by histologic subtype, and 9 cases (16%) were diagnosed as benign. Five out of 9 false negative cases were misdiagnosed as pleomorphic adenomas. Except the cases with insufficient specimen, overall sensitivity was 81.6%, and the sensitivity varied according to the histologic subtype; 91% in salivary duct carcinoma, 100% in carcinoma ex pleomorphic adenoma, 50% in mucoepidermoid carcinoma, 63% in adenoid cystic carcinoma, and 50% in acinic cell carcinoma. The diagnostic accuracy differed among cytopathologists irrespective of periods after acquisition of board of pathologists. These results confirm that salivary gland neoplasm can be easily misdiagnosed in fine needle aspiration cytology and a great caution should be given in diagnosing the benign appearing salivary aspirates to avoid under-diagnosis of malignant neoplasm with low grade cytologic atypia.

위에 발생한 사구종양 - 보고 -

오영륜(Young Lyun Oh),김진복(Jin Pok Kim),김용일(Yong Il Kim) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.1

Submucosal tumors of the stomach are not uncommon among the primary gastric tumors, and are, if found, mostly leiomyorna/leiomyosarcoma and malignant lymphoma. Rarely are vis- ceral glomus tumors which can occur at any place of the body, and the stomach has been doc- umented with extreme rarity, and a single case has been described in Korean literature. A 34-year-old woman had intermittent epigastric pain, nausea and anorexia. An upper gastrointestinal X-ray examination revealed an intramural mass in the antrum of the stomach. The abdominal computed tomograph confirmed a well defined, multilobulated solid tumor mass density with homogeneous enhancement. Gastrectomy specimen contained a 4cm-sized submucosal mass with central mucosal ulceration in the antrum and the tumor occupied the submucosa, proper muscle and subserosal layer. The basic histologic findings were identical with those seen in other sites. Immunostainings on the turnor cells expressed alpha-smooth muscle actin and vimentin, but were negative for desmin and Factor V[I1-related antigen. Ul- trastructure showed uniformly round tumor cells containing filaments with focal condensa- tion, many pinocytotic vesicles along plasma membrane and basal lamina. To our knowledge, this is the second case of glomus tumor which can occur in a form of submucosal tumors of the stomach in Korea. (Korean J Gastroenterol 1994; 26: 188 1 90)

세침흡인 세포검사로 진단한 폐의 포상 연부육종 - 1예 보고 -

김대수,오영륜,고영혜,Kim, Dae-Su,Oh, Young-Lyun,Ko, Young-Hyeh 대한세포병리학회 1998 대한세포병리학회지 Vol.9 No.2

Alveolar soft part sarcoma(ASPS) is a rare malignant neoplasm with a distinct clinicopathologic entity of which fine needle aspiration(FNA) cytologic findings have been described in only a few reports. Although patients usually present with an isolated soft-tissue mass in the extremity, metastasis can occur in about 13 % of total cases and the most frequent metastatic site is the lung. We have recently experienced a FNA cytologic case of ASPS in the lung. A 23-year-old female patient was admitted to this hospital due to 2-month-history of cough She had been good in health before the visit. Chest computed tomography revealed multiple, variable sized, bilateral pulmonary nodules. Physical examination and other staging work up revealed no other lesions except for pulmonary nodules. A percutaneous transthoracic FNA was performed from the pulmonary nodules. The smear was cellular and most cells were arranged singly. In addition, a few clusters lined by thin-walled vasculature with a pseudoalveolar pattern were present. Some of the tumor cells were large and polygonal lo oval with abundant granular or vacuolated cytoplasm. Most cells were naked nuclei showing finely granular chromatin pattern with prominent central nucleoli.

역형성 대세포 림프종의 세침흡인 세포학적 소견 - 악성 섬유성 조직구중을 닮은 1예 보고 -

이정원,오영륜,고영혜,Lee, Jung-Won,Oh, Young-Lyun,Ko, Young-Hyeh 대한세포병리학회 1998 대한세포병리학회지 Vol.9 No.1

Anaplastic large cell lymphoma(ALCL) is an uncommon type of non-Hodgkin's lymphoma(NHL) populated with anaplastic, often bizarre cells that express CD30 (Ki-1) antigen. The unusual histologic and cytologic features may cause confusion with other neoplasms, such as poorly differentiated carcinoma, melanoma, Hodgkin's disease, or true histiocytic lymphoma. Although the cytologic features of ALCL have been well described, there are few reports about cytologic findings of the sarcomatold variant of ALCL. We experienced a case of fine needle aspiration(FNA) cytologic findings of ALCL which mimicks malignant fibrous histiocytoma. FNA cytology of chest wall mass in a 62-year-old female with a history of peripheral T-cell lymphoma(Lennert lymphoma) revealed a heterogeneous population of single cells and poorly cohesive cells with large, pleomorphic nuclei and spindle cells gathering around vascular structures within an inflammatory background. Additional features of the neoplastic cells were eccentric, multilobated nuclei with occasional 'wreath-like' configuration; abundant cytoplasm with vacuolization; and prominent nucleoli. The cytologic features suggested sarcoma, especially malignant fibrous histiocytoma. The diagnosis was made retrospectively with an aid of immunocytochemical staining.

흉막에 발생한 고립 섬유성 종양의 세침흡인 세포학적 소견 - 폐의 선암종으로 오진한 1예 보고 -

최윤라,오영륜,이미숙,한정호,안긍환,Choi, Yoon-La,Oh, Young-Lyun,Lee, Mee-Sook,Han, Jung-Ho,Ahn, Geung-Hwan 대한세포병리학회 2001 대한세포병리학회지 Vol.12 No.2

Solitary fibrous tumor on the pleura is rare but should be included in the differential diagnosis on a peripheral pulmonary nodule. Cytologic features of solitary fibrous tumor of the pleura is not familar to the pathologist and may be misdiagnosed as malignancy. We report fine needle aspiration cytologic(FNAC) findings of a case of solitary fibrous tumor misdiagnosed as adenocarcinoma in a 48-year-old woman. The FNAC displayed a mixture of bland-looking spindle cells and clusters of epithelioid cells, which have hyperchromatic nuclei with prominent nucleoli. The helpful finding to distinguish It from other circumscribed benign and malignant lesions is the presence of fibromyxoid matrix admixed with blood vessels and thin collagen fibers. Familiarity with these features is essential to avoid misdiagnosis and overtreatment.

Analysis of Fine Needle Aspiration Cytology and Ultrasonography of Metastatic Tumors to the Thyroid

조은윤,오영륜,Cho, Eun-Yoon,Oh, Young-Lyun The Korean Society for Cytopathology 2007 대한세포병리학회지 Vol.18 No.2

Cytologic diagnosis of the metastatic tumors to the thyroid is important in the management of the patients. There have been rare reports analyzing fine-needle aspiration (FNA) cytology of metastatic tumors to the thyroid. This study examines comprehensive cytologic findings of metastatic tumors to the thyroid with radiologic findings. The FNA cytology slides obtained from 12 cases with metastatic tumors of the thyroid; lung cancer (n=5), tongue and tonsil cancer (n=3), esophageal cancer (n=2), and breast cancer (n=2) were reviewed. Radiological study showed single mass with heterogeneous texture or multiple masses without calcification. Metastatic tumor was easily considered in a differential diagnosis of FNA cytology because they had peculiar cytological features which were not seen in primary thyroid tumor. The smear background varied from predominantly necrotic, bloody, and inflammatory to colloid. The aspirates exhibited a mixture of benign follicular cells and malignant cells in 6 cases. The characteristic cytoplasmic features of the tumor cells, such as keratin, mucin and melanin, were found in 9 cases. Although some cases mimic primary thyroid neoplasm, a careful examination of the cytological characteristics may help cytopathologists to recognize a metastatic tumor in the thyroid by FNA, and may help the clinicians to establish a proper treatment plan.

The Cytology of a Cellular Variant of Cerebellar Hemangioblastoma in Squash Preparation: Pitfalls in Diagnosis

서연림,오영륜,Suh, Yeon-Lim,Oh, Young-Lyun The Korean Society for Cytopathology 2006 대한세포병리학회지 Vol.17 No.2

Due to its nuclear pleomorphism, knowledge regarding the cytological findings of cerebellar hemangioblastoma can lead to misdiagnosis when using squash specimens, which in other circumstances serves as a useful adjunct in the diagnosis of brain tumors on frozen section. We recently experienced the cytological findings of a cellular variant of cerebellar hemangioblastoma in a 51-year-old man. Squash specimens revealed scattered single tumor cells, with pleomorphic nuclei and cytoplasmic vacuoles, on a hemorrhagic background. The cellular clusters were composed of spindle-shaped endothelial cellsin addition to densely clustered stromal cells. Intranuclear inclusions were frequently seen. The nuclear pleomorphism, bubbly cytoplasmic vacuoles and presence of intranuclear inclusions, seen in the squash specimen, may increase the difficulty of frozen section diagnosis of cerebellar hemangioblastoma. Awareness of the cytologicalfindings of hemangioblastoma is needed to avoid the pitfalls in the intraoperative diagnosis of cerebellar hemangioblastomas.