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Cisplatin이독성의 NO에 의한 매개:기니픽에서 L-NAME과 MK-801을 이용한 연구
이정구,오양희,전상준,정상용,오충훈 대한이비인후과학회 2002 대한이비인후과학회지 두경부외과학 Vol.45 No.8
Background & Objectives:Nitric oxide has been sugested to play an important role in the pathogenesis of cisplatin ototo-(NG-Nitroarginine Methyl Ester) is an inhibitor of nitric oxide synthase. MK-801 (Dizocilpine Maleate) is a NMDA receptor antagonist. To evaluate a role of nitric oxide in cisplatin ototoxicity, we investigated whether L-NAME and MK-801 can block the cisplatin ototoxicity in guinea pigs. Materials & Method:In the Group 1, normal saline was in-jected intraperitonealy as a control group. Group 2, 3, 4, and 5 were injected intraperitonealy as described in the folowing:Group 2, cisplatin only; + cisplatin;Group 4, MK-801+ cisplatin;Group 5, L-NAME+ MK-801+ cis-platin. Using an auditory brainstem response, hearing threshold was tested before cisplatin administration and 5 days after cisplatin injection in each group. The morphological changes of the cochlea were observed by scanning electron microscopy. Results:In the Group 2, a significant hearing loss was observed comparing to Group 1. In contrast, Group 3, 4, and 5 did distorsion and loss of stereocilia of the hair cells. However, the Group 1, 3, 4, and 5 demonstrated well preserved cochlear hair cell morphology. Conclusion:Hearing loss induced by ototoxicity of cisplatin was prevented by L-NAME and MK-801. This study suggests that NO may mediate cisplatin ototoxicity. (Korean J Otolaryngol 2002;45:741-6)
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고빌리루빈혈증성 감각신경성 난청 병력을 가진 환아의 청력 추적 관찰
전상준,오양희,이정구 대한이비인후과학회 2002 대한이비인후과학회지 두경부외과학 Vol.45 No.9
Background and Objectives:In neonates with hyperbilirubinemic sensorineural hearing loss, the lesion site is supposed to be confined to the retrocochlea. The purpose of this study is to investigate the changes of hearing level and the progression of the lesion site involving cochlear area after a lapse of time in the patients with hyperbilirubinemic sensorineural hearing loss. Materials and Method:ABR, TEOAE and IA tests were performed on 11 neonates with severe hyperbilirubinemia with exchange transfusion in the period of neonates. After more than 4 years, follow-up ABR, TEOAE, and IA tests were carried out in the same 11 children. Results:In the initial ABR test, 4 neonates showed abnormal or no response and the other 7 neonates demonstrated normal response. All 11 neonates passed TEOAE and showed A type in IA In the follow-up tests after more than 4 years, 7 children who had shown normal ABR, TEOAE and IA test results as neonates showed normal ABR, TEOAE, and IA. In 4 children who had abnormal ABR results, showed decreased ABR thresholds. In TEOAE, 3 children showed bilateral failures and 1 child showed unilateral failure. Conclusions:The results of this study suggests that the sites of lesion in hearing loss caused by hyperbilirubinemia were at the retrocochlear location as neonates. But the lesions may affect the cochlear lesions after a lapse of time. And some residual hearing may be preserved. (Korean J Otolaryngol 2002;45:858-61)
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레이저를 이용하여 후두미세수술을 시행한 환자에서 음성치료를 시작한 시기에 따른 음성 호전 결과에 관한 연구
김한균,정필상,오양희,김영훈 대한후두음성언어의학회 2001 대한후두음성언어의학회지 Vol.12 No.1
Backgrounds and Objectives : There have been reported many studies which evaluate the effectiveness of combined laryngomicrosurgery(LMS) and voice therapy for the patients with benign vocal cord lesions. But the difference of voice improvement by onset time of voice therapy has not been reported. The purpose of this study is to analyze the differences of voice improvement by voice analysis test between the two groups with different onset time of voice therapy. Materials and Methods : Two groups, each of which comprises 15 patients, were analyzed. For the one group, the voice therapy was initiated 1 day after LMS. For the other, the therapy was initiated 1 week after LMS. Voice analytic parameters of the two groups were statistically analized to identify difference in voice improvement. Results : All measured parameters improved after voice therapy in two groups and showed no significant difference between two groups. Conclusions : The onset time of voice therapy after LMS has no significant impact on post-operative voice quality in the patients with benign vocal cord lesions. Early onset of post-operative voice therapy may serve as treatment modality for patients with benign vocal cord lesions.
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신생 흰쥐 난형낭의 조직 배양 모델에서 저출력 레이저의 Gentamicin 이독성 예방과 치료 효과
김정범,정재윤,안진철,이정구,오양희 대한이비인후과학회 2009 대한이비인후과학회지 두경부외과학 Vol.52 No.1
Background and Objectives:The purpose of this study was to investigate the effects of low level laser for the prevention and treatment of aminoglycoside-induced vestibular ototoxicity. Materials and Method:An organotypic culture of 2 to 4 days old rat utricular maculae was established. Rats were divided into 6 groups according to the treadtment of the utricles:G (gentamicintreated), L (laser-irradiated), LG (laser-irradiated and gentamicin-treated), GL (gentamicin-treated and laser-irradiated), LGL (gentamicin-treated during laser-irradiated) and C (control). After organotypic culture, the utricles of 6 groups were examined by confocal laser scanning electron microscope and scanning electron microscope. The results of each group were compared with each other by statistical methods. Results:The number of vestibular hair cells of the group G was smaller compared to that of the group C. The group L had no difference compared with the group C. The groups LG and GL showed more vestibular hair cells compared with the group G. The group LG showed more vestibular hair cells than the group GL. The group LGL showed most vestibular hair cells compared to that of the groups G, LG, and GL. Conclusion:The most effective treatment of aminoglycosideinduced vestibular otoxicity is the irradiation of low level laser before and after the insult of the aminoglycoside. Further clinical studies using low level laser were needed to prevent aminoglycoside-induced ototoxicity and to promote the regeneration of vestibular hair cells.
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