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Production of bio-based chemicals from Klebsiella pneumonia
오민규,정무영 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.0
The fermentative production of 2,3-butanediol has been intensively studied because of the potential of these products as platform chemicals, such as polymers, fuels, and plastics. Klebsiella pneumoniae is a good host for production of 2,3-butanediol from a wide range of carbon sources. We metabolically engineered K. pneumoniae (△wabG △ldhA △pflB) to reduce the production of byproducts. In particular, the inactivation of pflB significantly improved the yield of 2,3-butanediol from glucose to 92.2% of the theoretical maximum. We also engineered Enterobacter aerogenes for efficient utilization of sugarcane molasses in 2,3-butanediol production by elimination of carbon catabolite repression. Deletion of scrR and cra as well as overexpression of scrAB improved the strain’s performance of utilizing three sugars in sugarcane molasses and producing 2,3-butanediol.
Metabolic Engineering for Utilizing Various Carbon Sources
오민규 한국공업화학회 2020 한국공업화학회 연구논문 초록집 Vol.2020 No.-
The development of industrial strains that can efficiently utilize various carbon sources has been emphasized in metabolic engineering because cheaper carbon source should be utilized in biorefinery. In case of glucose, overflow metabolism is the main problem in because high amounts of byproducts are produced. This can be significantly reduced if the glucose uptake rate is regulated in various strains. To utilize lignocellulosic biomass, the strain must be able to co-utilize glucose and xylose. This can be resolved by minimizing carbon catabolic repression (CCR), which is regulated by phosphotransferase system (PTS). Disruption of PTS was not enough so that further engineering to reduce metabolic burden was applied. Fourth generation carbon source, C1 gas, can also be utilized for PHB production. Useful metabolic engineering strategy for utilizing C1 gas in industrial strain will also presented.
신정휴손(腎精虧損)으로 변증한 파킨슨병 환자의 이상운동증 치험(治驗) 1례(例)
오민규,김태용,김동진,신현수,Oh, Min-Kyu,Kim, Tae-Yong,Kim, Dong-Jin,Shin, Hyeon-Su 대한한방내과학회 2007 大韓韓方內科學會誌 Vol.28 No.4
Objectives : This study was designed to research the effects of oriental treatment on dyskinesia with lower limbs caused by Parkinson's Disease. Methods : We prescribed Yukmijihwang-tang (六味地黃湯) and Jaumganghwa-tang (滋陰降火湯) and treated acupuncture through Shinjungkyuk (腎正格) every day. It was used to treat the Shinjeonghyuson (腎精虧損) symptoms. We analyzed the frequency of dyskinesia over one night at intervals of three days and measured the score of 'Unified Parkinson's Disease Rating Scale' every week to evaluate the entire symptom's improvement. Results and Conclusion : He had been treated with western medicine to improve the dyskinesia symptoms, but couldn't get a noticeable result. Having oriental treatment for 43 days, dyskinesia in the lower limbs mostly disappeared and all symptoms of Parkinson's disease (tremor, rigidity, dysphagia, hallucination, anorexia, etc.) improved significantly.