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관동맥의 내피세포의존성 혈관이완에 대한 마그네슘의 영향
송재관(Jae Kwan Song),고문수(Moon Soo Koh),염광섭(Kwang Seoup Yeoum),이진오(Jhin Oh Lee),강태웅(Tae Woong Kang),서정돈(Jung Don Seo),이영우(Young Woo Lee),서석효(Suk Hyo Suh),김기환(Ki Whan Kim) 대한내과학회 1990 대한내과학회지 Vol.39 No.4
N/A After the historical discovery of a soluble vasodilating substance from the vascular endothelium (endothelium-derived relaxing factor, EDRF), impaired EDRF-mediated vasorelaxation is discussed as one of the main pathogenic mechanisms of coronary artery spasm. Recently, some clinical reports that hypomagnesemia may be implicated in the induction of coronary artery spasm were presented, although there are controversial reports on the effects of the extracellular magnesium ion on endothelium-dependent vasorelaxation. Isometric contraction-relaxation was recorded in the transverse strips of porcine coronary artery to clarify the exact effects of Mg2+ on tension-development by a vasoconstrictor agent and on endothelium-dependent vasorelaxation and to predict a possible mechanism of hypomagnesemia in the induction of coronary artery spasm. The results of our study were as follows: 1) Vasoconstrictor activity of PGF2α was significantly more attenuated in the endothelium-intact transverse strips of porcine coronary artery than in the endothelium-denuded strips. 2) Lowering the magnesium concentration enhanced the vasoconstrictor activity of PGF2α while a marked reduction of isometric tension was observed with the elevation of magnesium concentration. 3) Bradykinin-induced endothelium-dependent vasorelaxation is a dose-dependent manner which was completely abolished with the pretreatment of hemoglobin. 4) Endothelium-dependent vasorelaxation of bradykinin was markedly inhibited by lowering the extracellular calcium ion concentration. 5) Change of the extracellular magnesium ion concentration did not alter the IC50 (inhibitory concentration of bradykinin causing a 50% inhibition of the maximum contraction) values of bradykinin-induced endothelium dependent vasorelaxation. From these results it is concluded that if magnesium deficiency is implicated in the induction of coronary artery spasm, the main mechanism would be direct enhancement of responsiveness of the vascular smooth muscle to the vasoconstrictors. Further study with a bioassay system and more various stimulators of EDRF secretion is necessary for exact clarification of the effects of Mg2+ on endothelium-dependent vasorelaxation.
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간장 ( 肝臟 ) 및 담도 ( 膽道 ) : 간세포암에 대한 화학색전요법의 항종양 효과
현인영(In Young Hyun),이정애(Jung Ae Lee),고문수(Moon Soo Kih),은진호(Jin Ho Eun),염광섭(Kwang Seoup Yeoum),홍원선(Weon Seon Hong),이진오(Jhin Oh Lee),강태웅(Tae Woong Kang),변홍식(Hong Sik Byun),강숙욱(Sook Wook Kang),김기환(Kie Hwa 대한소화기학회 1991 대한소화기학회지 Vol.23 No.1
N/A Eighty-seven TACEs were performed in 38 patients with hepatocellular carcinoma: one in 16 patients; twice in seven patients; three times in seven patients; four times in four patients; and five times in four patients. In all patients, TACE was performed with adriamycin, mitomycin-C and lipiodol. In 21 patients, embolization with gelfoam powders were added following TACE. Six patients had the hepatocellular carcinoma of 4.0~4.9 cm in diameter: 14 patients, 5.0~9.9 cm; and 18 patients, larger than 10 cm. Response rate was evaluated in 33 patients, among whom fifteen patients (45$) achieved response (complete response, 6%; partial response, 33%). The cumulative survival rates at one year and two years for 38 patients were 55.3$ and 23.2%, respectively, with the median survival time of 12.0 months. Sex, ascites, HBsAg, esophageal varix, liver cirrhosis, gelfoam embolization, serum albumin level, size of the tumor, and a-fetoprotein were analyzed to investigate the effect of TACE on survival time, demonstrating that no significant differences in the survival times were observed between these factors except HBsAg. Theses results suggest that TACE is not curable for hepatocellular carcinoma, however prolong the life span in patients with hepatocellular carcinoma.
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