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병원 내 심장정지 환자의 목표체온조절에 관한 연구: 연구자주도 단일기관 무작위배정 평가자맹검 예비 임상 연구 프로토콜
TTM-36 IHCA Trial 연구자,전상범 대한신경집중치료학회 2016 대한신경집중치료학회지 Vol.9 No.1
Background:Targeted temperature management (TTM) has neuroprotective effects in comatose patients despite restoration of spontaneous circulation (ROSC) after out-of-hospital cardiac arrest. However, no TTM trials have been performed for in-hospital cardiac arrest (IHCA). Methods:We aim to enroll 60 comatose adults with ROSC after IHCA. Eligible patients are randomly assigned in a 2:1 ratio to either the intervention group or the control group with stratification according to the electrocardiography rhythm. Core body temperature is maintained at 36 °C for the initial 72 hours (TTM-36) in the intervention group. Fever control using conventional methods is attempted in the control group. The primary efficacy outcome is Cerebral Performance Category (CPC) of 3-5 at 180 days. The secondary efficacy outcomes include CPC of 3-5 at 7 days and 30 days; modified Rankin Scale of 4-6 at 7 days, 30 days, and 180 days; daily measured serum levels of neuron specific enolase for the first 5 days; predefined electroencephalography patterns suggesting poor prognosis; repeated measurements of brain MRI including diffusion-weighted imaging, fluid attenuated inversion recovery, susceptibility-weighted imaging, high resolution T1-weighted imaging, diffusion tensor imaging, and resting state functional MRI at 4 days, 30 days, and 180 days; detailed neuropsychological tests; questionnaire for depression, quality of life, activities of daily living, and neuropsychiatric symptoms; and scales for parkinsonism and ataxia. The safety outcomes include cardiac re-arrest, arrhythmia, pneumonia, septic shock, infection, bleeding, and shivering. Results:We are currently recruiting the study patients. Conclusion:The results of this trial are expected to provide evidence for feasibility, safety, and efficacy of TTM-36 in patients with IHCA.
3-D Perpendicular Assembly of SWNTs for CMOS Interconnects
김태훈,Cihan Yilmaz,Sivasubramanian Somu,Ahmed Busnaina,연구자TEST 대한금속·재료학회 2013 ELECTRONIC MATERIALS LETTERS Vol.9 No.6
Due to their superior electrical properties such as high current density and ballistic transport, carbon nanotubes (CNT) are considered as a potential candidate for future very large scale integration (VLSI) interconnects. However,direct incorporation of CNTs into a complimentary metal oxide semiconductor (CMOS) architecture by the conventional chemical vapor deposition (CVD) growth method is problematic because it requires high temperatures that might damage insulators and doped semiconductors in the underlying CMOS circuits. In this paper, we present a directed assembly method to assemble aligned CNTs into pre-patterned vias perpendicular to the substrate. A dynamic electric field with a static offset is applied to provide the force needed for directing the SWNT assembly. It is also shown that by adjusting assembly parameters the density of the assembled CNTs can be significantly enhanced. This highly scalable directed assembly method is conducted at room temperature and pressure and is accomplished in a few minutes. I-V characterization of the assembled CNTs was conducted using a Zyvex nanomanipulator in a scanning electron microscope (SEM) and the measured value of the resistance was 270 kΩs.