식이중 지방함량이 성장기 쥐의 뇌 mitochondrial monoamine cxidase 확성도에 미치는 영향

여의주,최혜미,최명언 한국영양학회 1984 총회 및 학술대회 Vol.- No.19

청과류 포장 형태에 따른 소비자 구매행동

여의주,문정훈,안희경,정재석 한국유통학회 2015 한국유통학회 학술대회 발표논문집 Vol.2015 No.11

중국 스타트법률사무소 인터뷰

여의주,권현정 아주대학교 법학연구소 2015 중소기업과 법 Vol.7 No.1

Effect of Duck Feet Gelatin on Physicochemical, Textural, and Sensory Properties of Low-fat Frankfurters

여의주,김현욱,황고은,송동헌,김용재,함윤경,Fu-Yi He,박재현,김천제 한국축산식품학회 2014 한국축산식품학회지 Vol.34 No.4

Duck feet gelatin (DFG) gel was added as a fat replacer to low-fat frankfurters and the effect of DFG on physicochemical,textural, and sensory characteristics of low-fat frankfurters was evaluated. DFG gel was prepared with a 20% duck feet gel-atin concentration (w/w). Adding DFG decreased lightness and increased yellowness of the low-fat frankfurters (p<0.05). However, DFG did not affect redness of low-fat frankfurters (p>0.05). The statistical results indicated that adding DFGimproved cooking yield of low-fat frankfurters (p<0.05). In addition, replacing pork back fat with DFG resulted in increasedmoisture content, protein content, and ash content of low-fat frankfurters, and the low-fat frankfurter formulated with 5%pork back fat and 15% DFG gel had the highest moisture content and lowest fat content (p<0.05). Adding of DFG increasedall textural parameters including hardness, springiness, cohesiveness, chewiness, and gumminess of low-fat frankfurters(p<0.05). In terms of sensory properties, the low-fat frankfurter formulated with 5% pork back fat and 15% DFG gel showedsimilar satisfaction scores for the flavor, tenderness, juiciness, and overall acceptance when compared to the regular frank-furters (20% back fat). Therefore, our results suggest that DFG could be an effective novel source, as a fat replacer, for man-ufacturing of low-fat frankfurters.

식이중 지방함량이 성장기 쥐 뇌의 Monamine Oxidase 활성도에 미치는 영향

여의주,최혜미,최명언 ( Eui Zu Yeo,Hay Mie Choi,Myung Un Choi ) 생화학분자생물학회 1985 BMB Reports Vol.18 No.2

The effect of dietary lipid on monoamine oxidase (MAO) activity was examined by feeding pregnant Sprague Dawley rats with three kinds of experimental diets containing 10, 2, and 0.5% of corn oil. A part of control group rats was fed 0.5% deficient diet at birth in order to verify the lipid effect during the lactation period. Furthermore, a part of 0.5% diet groups was rehabilitated after weaning with the control diet for comparison. Throughout the experimental periods, MAO activities of the deficient groups were significantly lower than that of the control group except the MAO activity of the group fed 0.5% diet at brith (D-0.5B). When serotonin was used as substrate, however, the MAO-A activities of the D-0.5B group rats were also significantly lower than that of the control. The results of lipid compositions of each diet groups revealed that the phospholipid/cholesterol ratio of total lipid extracted from brain mitochondria showed significant differences between the control and the deficient groups. Likewise, the p/s ratio of deficient groups were also significantly lower than that of the control group. These observations, therefore, provide an evidence that the alteration of dietary lipid can affect the lipid composition of mitochondria and in consequence the dietary lipid influenced the activity of the membrane-bound MAO.

Effect of Dietary Lipid on Monoamine Oxidase Activity of Developing Rat Brain

여의주,최혜미,최명언,Yeo, Eui-Zu,Choi, Hay-Mie,Choi, Myung-Un 생화학분자생물학회 1985 한국생화학회지 Vol.18 No.2

식이 지방함량에 의한 성장기 뇌의 monamine oxidase(MAO) 활성도에 미치는 영향을 살펴보기 위해 옥수수 기름을 각각 10, 2, 0.5% 포함한 3종류의 식이를 임신한 Sprague Dawley종의 흰쥐에게 임신말기부터 제공했다. 수유기간중의 영향을 알아보기 위해 대조군(10% 옥수수 기름) 일부에 분만후 0.5% 결핍 식이를 섭취시켰으며, 또 0.5% 식이군의 일부에 이유후부터 10% 정상식이를 주어 회복 효과를 관찰하였다. 전 실험기간동안 임신 말기부터의 결핍 식이군의 MAO활성도는 대조군에 비해 유의적으로 감소했으나 분만후부터 0.5% 결핍식이를 제공한 군에서는 차이가 없었다. 그러나 serotonin을 기질로 하여 MAO type A 활성도를 살펴본 결과 분만후의 결핍에 의해서도 대조군과 유의적인 차이를 보여 주었다. 각 군의 뇌 mitochondria의 지질조성을 살펴본 결과 결핍군에서 대조군에 비해 phospholipids/cholesterol의 비가 유의적으로 낮았고 또한 membrane fluidity의 한 지표인 p/s의 비도 유의적으로 낮았다. 이들로부터 성장 초기에 지방함량을 조절한 식이에 의해 뇌 mitochondria의 지질 조성이 크게 변함을 관찰 할 수 있었고 이에 따라 그 외막에 결합된 MAO 활성도도 유의적인 영향을 받고 있음을 알 수 있었다. The effect of dietary lipid on monoamine oxidase (MAO) activity was examined by feeding pregnant Sprague Dawley rats with three kinds of experimental diets containing 10, 2, and 0.5% of corn oil. A part of control group rats was fed 0.5% deficient diet at birth in order to verify the lipid effect during the lactation period. Furthermore, a part of 0.5% diet groups was rehabilitated after weaning with the control diet for comparison. Throughout the experimental periods, MAO activities of the deficient groups were significantly lower than that of the control group except the MAO activity of the group fed 0.5% diet at brith (D-0.5B). When serotonin was used as substrate, however, the MAO-A activities of the D-0.5B group rats were also significantly lower than that of the control. The results of lipid compositions of each diet groups revealed that the phospholipid/cholesterol ratio of total lipid extracted from brain mitochondria showed significant differences between the control and the deficient groups. Likewise, the p/s ratio of deficient groups were also significantly lower than that of the control group. These observations, therefore, provide an evidence that the alteration of dietary lipid can affect the lipid composition of mitochondria and in consequence the dietary lipid influenced the activity of the membrane-bound MAO.

노화와 암 발생 기전

여의주 생화학분자생물학회(구 한국생화학분자생물학회) 2010 생화학분자생물학회 소식 Vol.30 No.3

Effect of Dietary Lipid on Fatty acid Pattern in Developing Brain Mitochondria in Rats

여의주,최혜미,Yeo, Eui-Ju,Choi, Hay-Mie The Korean Nutrition Society 1985 Journal of Nutrition and Health Vol.35 No.9

식이 중 지방함량이 성장기 뇌의 미토콘드리아 지방산 조성에 미치는 영향을 살펴보기 위해 옥수수기름을 각각 10, 2, 0.5% 포함한 3종류의 식이를 임신한 Sprague Dawley종의 흰쥐에게 임신말기부터 제공했다. 수유기간 중의 영향을 살펴보기 위해 대조군(10%옥수수기름 섭취)의 일부에 분만 후 0.5% 결핍식이를 섭취시켰고, 또 이유후부터 0.5% 결핍식이군의 일부에 10% 정상식이를 주어 회복효과를 관찰하고자 하였다. 전 실험기간 동안 체중과 뇌 무게, 단백질 함량을 측정하였고 뇌에서의 미토콘드리아를 분리하여 지방산 조성을 관찰하였다. 출생후 수유기간 동안에는 대조군에 비해 지방결핍식이군에서 체중과 뇌의 무게가 다소 높았으나 이유 후 부터 점점 감소하여 유의적인 차이를 볼 수 없었고 특히 0.5% 식이군의 체중은 생후 6주와 7주에 유의적인 감소를 보였다. 그러나 체중에 대한 뇌무게와 뇌의 단백질 함량에 있어에는 대조군과 결핍군 사이에 유의적인 차이를 볼 수 없었다. 따라서 지방결핍이 뇌 성장에 미치는 영향은 다른 영양소에 비해 크지 않음을 알 수 있었다. 뇌 미토콘드리아의 지방산 조성은 나이와 식이에 따라 변하였다. 나이를 먹음에 따라 단쇄 포화 지방산은 감소하고 다 불포화 지방산의 함량은 증가하였다. 또한 결핍식이군과 대조군 사이에 뇌 미토콘드리아 지방산조성을 살펴 본 결과 지방 결핍의 좋은 지표가 되고 불포화도, triene 과 tetraene의 비, 그리고 ${\omega}-6$ 계열과 ${\omega}-9$ 계열의 비에 있어서 큰 차이를 볼 수 있었다. 이들로 부터 성장초기에 지방함량을 조절한 식이에 의해 뇌 미토콘드리아 지질 조성이 크게 변하고 이에따라 미토콘드리아의 기능도 유의적인 영향을 받고 있음을 알 수 있었다.

한국어교육용 어휘 선정 쟁점 연구 -선행 연구 검토 및 전문가 인식 조사를 바탕으로-

여의주,강현화 한국언어문화교육학회 2023 언어와 문화 Vol.19 No.2

The purpose of this study is to examine the issues of selecting and grading Korean language education vocabulary in existing studies, and to propose proper approaches for selecting desirable vocabulary. Firstly, for the unit of vocabulary selection, a meaning-centered unit was proposed that combined high-frequency productive affixes such as `-하다' and `-되다' in the `lemma' unit. Secondly, the study also examined problems of the previous studies regarding the corpus and stressed the need for constructing a balanced and representative corpus. Thirdly, the study confirmed the necessity of artificial vocabulary grading for educational efficiency through a survey. Fourthly, the study identified problems in the previous methodology of vocabulary selection and proposed alternatives, suggesting that criteria related to the applicability of the curriculum, in addition to frequency, should be considered. Finally, the study emphasized the importance of judgment based on objective indicators in the compromise vocabulary selection method. Ultimately, the study provides valuable insights into the selection and grading of Korean language education vocabulary and serves as a reference for future studies in this field. .

Hypoxia and aging

여의주 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-

Eukaryotic cells require sufficient oxygen (O2) for biological activity and survival. When the oxygen demand exceeds its supply, the oxygen levels in local tissues or the whole body decrease (termed hypoxia), leading to a metabolic crisis, threatening physiological functions and viability. Therefore, eukaryotes have developed an efficient and rapid oxygen sensing system: hypoxia-inducible factors (HIFs). The hypoxic responses are controlled by HIFs, which induce the expression of several adaptive genes to increase the oxygen supply and support anaerobic ATP generation in eukaryotic cells. Hypoxia also contributes to a functional decline during the aging process. In this review, we focus on the molecular mechanisms regulating HIF-1α and aging-associated signaling proteins, such as sirtuins, AMP-activated protein kinase, mechanistic target of rapamycin complex 1, UNC-51-like kinase 1, and nuclear factor κB, and their roles in aging and aging-related diseases. In addition, the effects of prenatal hypoxia and obstructive sleep apnea (OSA)- induced intermittent hypoxia have been reviewed due to their involvement in the progression and severity of many diseases, including cancer and other aging-related diseases. The pathophysiological consequences and clinical manifestations of prenatal hypoxia and OSA-induced chronic intermittent hypoxia are discussed in detail.