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반하(半夏)가 다낭성 난소 증후군이 유발된 흰쥐의 난소 조직에 미치는 영향
여은주 ( Eun Ju Yeo ),조성희 ( Sung Hee Jo ),양승정 ( Seung Jung Yang ),박경미 ( Kyung Mi Park ) 대한한방부인과학회 2012 大韓韓方婦人科學會誌 Vol.25 No.2
Objectives: This study was designed to investigate the effects of PR on ovarian tissue in PCOS rats through measurement of morphological and histo-pathological observations, ovarian size. In addition, effects on expression levels of Insulin like Growth Factor Receptor(IGFR) were also investigated to elucidate related mechanisms. Methods: PCOS was induced by single intermuscular injection with β-Estradiol 17-Valerate(EV) in female rats. Normal group(NOR, n=8) were injected with sesame oil and administrated hard food for five weeks. Control group(CTL, n=8) were injected with EV and administrated hard food for five weeks. CR group(n=8) were injected with EV and administrated hard food mixed CR for five weeks. Then, we measured weights of body and ovary, uptakes of food and water. And we observed morphological and histo-pathological changes of ovary, levels of IGFR. Results: In this experiments, single injection of Estradiol Valerate(EV) induced suppression of weight gain, formation of cysts, increase of IGFR expression. Oral administration of PR prevent decrease of ovarian size significantly. Further more, formation of cystic follicles induced by EV injection is suppressed by PR treatment. Conclusions: These results suggest PR can be used for patients with PCOS to prevent formation of cystic follicles and malfunction of ovary.
김지은 ( Ji Eun Kim ),양승정 ( Seung Jeong Yang ),조성희 ( Seong Hee Cho ),여은주 ( Eun Ju Yeo ),박경미 ( Kyung Mi Park ),김경옥 ( Kyung Ok Kim ) 대한한방부인과학회 2012 大韓韓方婦人科學會誌 Vol.25 No.4
Objectives: This case is that of a woman in her late forties who was diagnosed as conversion disorder. She suffered the climacteric while being treated with conversion disorder and the respective symptoms got worse. We investigated whether Korean traditional treatment is effective in patient with conversion disorder and menopausal symptoms. Methods: The prescription of Banhabaekchulchunma-tang, Gamisoyo-san, Bunsimgieum, acupuncture therapy and moxibustion therapy were used for the treatment. Results: After treatment, the chief complaint and accompanying symptoms were reduced to 40% compared with first visit day. Conclusions: We may conclude that Korean traditional treatment is effective in patients with conversion disorder and menopausal symptoms.
한국에서 사용 중인 개 파보바이러스 백신의 유효성 확인
양동군 ( Dong Kun Yang ),김명수 ( Myung Soo Kim ),이경우 ( Kyung Woo Lee ),여은주 ( Eun Ju Yeo ),김영은 ( Young Eun Kim ),허원 ( Won Hur ),최환원 ( Hwan Won Choi ),김채현 ( Chae Hyun Kim ),장현 ( Hyun Jang ),오은미 ( Eun Mi Oh ) 한국예방수의학회(구 한국수의공중보건학회) 2011 예방수의학회지 Vol.35 No.2
Canine parvovirus (CPV) type 2a (CPV-2a) has recently been identified as the main genotype circulating in the dog population in South Korea. Although CPV vaccines protect domestic dogs from CPV-2 infection, the efficacy of commercial live or inactivated CPV vaccines against CPV-2a has not been reevaluated. In this study, dogs were immunized with one of 7 commercial CPV vaccines (4 modified live and 3 inactivated vaccines) followed by challenge with CPV-2a strain, KV0901 that had been isolated from naturally infected dog in 2009. All dogs vaccinated twice with 4 commercial modified live CPV vaccines were seroconverted (geometric mean HI titer >190.2) and most of dogs were completely protected against virulent CPV-2a strain infection. The dogs inoculated with 3 commercial inactivated CPV vaccines were also seroconverted and showed a slight loss of appetite and light diarrhea for 4 days after challenge and returned to normal at 5 days post challenge. However, the non-vaccinated dogs revealed the typical clinical signs of CPV infection including haemorrhgic diarrhea. In conclusion, the 4 live CPV vaccines licensed in Korea cross-protected dogs against virulent challenge with CPV-2a and are applicalble to pet dogs for the prevention of CPV infection.
이현철,여은주,조완섭,김학용,유재수 충북대학교 컴퓨터정보통신 연구소 2004 컴퓨터정보통신연구 Vol.12 No.1
단백질 간의 상호작용에 대한 연구는 생물학적 프로세스를 이해하기 위해 중요한 부분이다. 이 논문의 목적은 생물학적 내용을 담고 있는 연구논문으로부터 단백질간의 상호작용을 추출하는 확장성을 가진 텍스트 마이닝 기법을 제안하는데 있다. 단백질 간의 상호작용에 대한 정보는 주로 생명과학 관련 연구논문에 존재하지만 컴퓨터로 자동으로 처리하여 상호작용에 관한 정보를 추출할 수 있기 위해서는 텍스트 마이닝 기술이 적용되어야 한다. 바이오 텍스트 마이닝에서 대두되고 있는 중요한 쟁점은 대용량의 연구논문에서 필요한 정보를 어떻게 효율적으로 정확하게 추출할 것인가에 대한 내용이다. 또한, 관심이 있는 단백질의 종류나 상호작용에 대한 관련성을 나타내는 문장내 패턴의 다양성을 수용하기 위하여 시스템의 확장성을 높이는 것도 소프트웨어 공학적인 측면에서 중요한 이슈이다. The research for protein-protein interactions remains an important part to understand the biological process. This paper suggests a text mining technique with extensibility, which extracts the protein-protein interaction from the biological research papers. There is much information related to the protein-protein interactions in plentiful biological research papers, we need the text-mining technique to extract the protein-protein interaction information automatically and rapidly. The main issue in bio-textming lays how to extract the necessary information efficiently and correctly. In addition, it is a significant issue to accommodate the concerned kinds of proteins and the diversity patterns in sentences with the relevance about protein-protein interactions in order to increase system extendibility in aspect of software engineering.