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어지안 ( Ji An Uh ),이수경 ( Soo Kyung Lee ),이운하 ( Un Ha Lee ),김명신 ( Myoung Shin Kim ) 대한피부과학회 2023 대한피부과학회지 Vol.61 No.10
Background: Although the older adult population in Korea is growing, few studies have investigated the profile of late-onset vitiligo (onset at 50 years of age or above) to date. Objective: The present study aimed to describe the clinical characteristics and course of patients with late-onset vitiligo in Korea. Methods: The present single-center retrospective study included 132 patients with late-onset vitiligo from January 1, 2009 to November 30, 2022. We analyzed patient demographics and vitiligo characteristics. Further, we evaluated the progress of late-onset vitiligo using the Vitiligo Area Severity Index (VASI) score. Results: The study included more females (n=83, 62.9%) than males (n=49, 37.1%), with an average age of onset 60.9±7.4 years. The average duration of the disease before presentation was 15.0±27.3 months. A family history of vitiligo was identified in eight patients (6.1%), and seven patients (5.3%) had associated autoimmune diseases. Acrofacial vitiligo was the most common type (n=56, 43.1%), and the head and neck area were the commonly affected site at disease onset (n=93, 70.5%). The Koebner phenomenon was observed in seven patients (5.3%), and chemical-induced vitiligo was suspected in three patients (2.3%). Treatment was administered to 131 patients (99.2%). The VASI score decreased in 93 patients (83.0%), with an average decline rate of 58.56%. Conclusion: Late-onset vitiligo tends to be of the acrofacial vitiligo subtype in the Korean population. Patients demonstrated a strong desire to treat vitiligo, and treatment response was promising. Further larger-scale studies to elucidate the characteristics and progression of late-onset vitiligo may be needed. (Korean J Dermatol 2023;61(10): 595∼601)
김중호,어지안,이재호,김호영,이수경,김명신,이운하 대한피부과학회 2023 Annals of Dermatology Vol.35 No.1
Syringocystadenoma papilliferum (SCAP) and apocrine hidrocystoma (AH) are benign apocrineneoplasms that usually occur separately. SCAP arises predominantly in head and neck,while AH typically develop in periorbital area. We report a case of a 68-year-old male withan asymptomatic erythematous papulonodule that occurred on his back 3 years ago. Histologicexamination showed cystic invagination extending from the epidermis into the dermiswith some papillary projections. The invaginated portion was lined by epithelial bilayer composedof cuboidal and columnar cells, and decapitation secretion was observed in the innerepithelial layer. In the deep dermis, multiple cystic spaces with variable sizes were observed,and these cysts also presented double layers of the epithelium and decapitation secretion. According to such histologic features, the coexistence of SCAP and AH within a single lesionwas demonstrated. The patient was recommended to completely remove the remaininglesion after punch biopsy, but he refused further surgical management. Herein, we report anunusual case of complex apocrine tumor with a rare composition in an atypical site.
Postherpetic Trigeminal Trophic Syndrome: A Case Report
이재호,어지안,김중호,김호영,김명신,이운하,이수경 대한피부과학회 2022 Annals of Dermatology Vol.34 No.5
Trigeminal trophic syndrome (TTS) is a rare condition characterized by anesthesia, paresthesia,and facial ulceration involving the trigeminal dermatome secondary to self-manipulationof the skin after a peripheral or central injury to the trigeminal nerve or its branches. Differential diagnosis of TTS includes conditions presenting with chronic facial ulceration,such as various infectious diseases, malignancy, vasculitis, pyoderma gangrenosum anddermatitis artefacta. We report a case of postherpetic TTS and highlight the importance ofearly diagnosis and prompt treatment of this condition, which may commonly be misdiagnosed.
김중호,어지안,김호성,이수경,김명신,이운하 대한백신학회 2022 Clinical and Experimental Vaccine Research Vol.11 No.3
The cutaneous appearance of transient or persistent livedo reticularis is characterized by violaceous, mottled, ring-shaped interconnecting lesions that form a reticular or net-like pattern. It can occur physiologically in response to cold exposure, such as in cutis marmorata, but can also be induced by pathological conditions such as vascular obliterans or venodilation. We report two cases of livedo reticularis that occurred on the lower limbs of two patients post ChAdOx1 nCoV-19 vaccination. As the patients had no other likely causes of livedo reticularis, the reticular skin lesions were suspected to occur in association with the ChAdOx1 nCoV-19 vaccination. Livedo reticularis is an uncommon adverse reaction, with few cases being reported post ChAdOx1 nCoV-19 vaccination.
김중호,어지안,김호성,이수경,김명신,곽금희,이운하 대한피부과학회 2023 대한피부과학회지 Vol.61 No.5
The areola is a rare location for squamous cell carcinoma (SCC) because sunlight exposure, the main risk factor for SCC, is unusual on it. Acantholytic SCC (ASCC) is a rare histologic variant of SCC, characterized by pseudoglandular appearance with acantholytic tumor cells. A 59-year-old male presented a painful erythematous papule on his right areola. He had a history of psoralen ultraviolet A phototherapy for psoriasis in his 20s. Biopsy revealed an epithelial tumor and pseudoglandular structures with acantholytic tumor cells. In immunohistochemistry, cytokeratin 5/6, epithelial membrane antigen, and p63 were positive, while cytokeratin 7, carcinoembryonic antigen, S-100, and estrogen and progesterone receptors were negative. Periodic acid-Schiff stain was negative. Ki-67 labeling index was 79.7%. The final diagnosis was ASCC of the areola. After wide local excision, recurrence have not been reported. Here, we report a case of ASCC on the areola, focusing on its rare histologic variant and uncommon location.
김호영 ( Ho Young Kim ),어지안 ( Ji An Uh ),김중호 ( Joong Ho Kim ),이재호 ( Jae Ho Lee ),이수경 ( Soo Kyung Lee ),김명신 ( Myoung Shin Kim ),이운하 ( Un Ha Lee ) 대한피부과학회 2021 대한피부과학회지 Vol.59 No.2
Hand-foot-mouth disease (HFMD) is a viral infection that occurs commonly in children. It is characterized by vesicles with surrounding erythema on the extremities and mouth. Most common pathogens are Coxsackievirus A16 and Enterovirus 71. HFMD caused by Coxsackievirus A6 is uncommon and accompanied by more extensive and atypical eruptions. A 42-year-old man presented with erythematous papules and vesicles on the right hand which occurred 7 days prior to presentation. The rash spread extensively with high fever, chills, headache, and myalgia. He also had whitish ulcer-like lesions on the oral mucosa with swallowing difficulty. One day after hospitalization, he developed arthralgia on his shoulders, pelvis, knees, and fingers. The biopsy specimen showed an intraepidermal blister with reticular degeneration, epidermal necrosis, and neutrophilic infiltration. There were no inclusion cells or giant cells. The serum antibody titer of Coxsackievirus A6 showed a significant increase, at 64 times. He was diagnosed with HFMD caused by Coxsackievirus A6. (Korean J Dermatol 2021;59(2):132∼135)