5 cm 이상 크기의 부신 종물에 대한 복강경하 부신절제술

양희조,전윤수 순천향대학교 순천향의학연구소 2016 Journal of Soonchunhyang Medical Science Vol.22 No.2

Objective: The adrenal gland is small and located in difficult area to approach, anatomically. Laparoscopic adrenalectomy (LA) is considered as a best approach for the treatment for adrenal tumors. However, its role in removal of larger tumor (>5 cm) is still questioned due to concerns of complexity of procedure. We evaluate technical feasibility and analyze the outcome of LA for large adrenal masses. Methods: The data of 36 patients who underwent LA for adrenal mass were analyzed for this study. Group 1 (n=27, mean diameter= 2.43 cm) consisted of tumors smaller than 5 cm and group 2 (n=9, mean diameter=5.64 cm) consisted of larger than 5 cm. The length of operation time, estimated blood loss, analgesics usage, length of hospital stay, histopathology, tumor size, and perioperative complications were compared. Results: All operation was completed safely and no one required conversion to open surgery. Group 1 (146.48 minutes) had a significantly shorter mean operative time compared to group 2 (181.00 minutes) (P<0.05). There was no significant difference in the postoperative hospital stay, time to remove the drainage, estimated blood loss, and the number of analgesics usage. No major complication was occurred during and after operation but one case of pulmonary congestion was occurred in group 2. Histopathologic findings were 20 cortical adenomas (55.6%), 3 cystic lesions (8.3%), and 3 malignant lesions (8.3%). Conclusion: LA is safe and feasible for large adrenal tumors without local invasion. The size of an adrenal tumor should not be the primary factor in determining whether a LA should be performed.

The Effects of Short-Chain Fatty Acids in Urological Diseases

양희조,김두상 대한요로생식기감염학회 2022 Urogenital Tract Infection Vol.17 No.1

The gut microbiome, believed to serve as a second genome within the human body, is involved in the regulation of several metabolic processes. These include human gene expression, development, nutrition and homeostasis. Dysbiosis, is an imbalance in the gut microbiome, which is known to be associated with various disease conditions such as Crohn's disease and Clostridium infections. The gut microbiota communicates with the host through a variety of biomolecules, nutrient signal-independent pathways, and epigenetic mechanisms. The gut microbiota supports the digestion and absorption of food, metabolizes fiber into bioactive short-chain fatty acids (SCFA), produces vitamins and nutrients, maintains gut integrity, and modulates host immunity. Among the above, there has been great interest in SCFA in microbiome research due to its beneficial effects on the intestinal barrier function and systemic anti-inflammatory effects. Recent reports have also indicated the role of SCFA in obesity, insulin resistance, and type 2 diabetes. While SCFA are associated with reduced risk of various diseases, dysbiosis and altered SCFA fermentative pathways could result in disease. This article is a review on the role of SCFA in urological diseases.

전립선비대증에 대한 홀미움레이저 전립선절제술 후 지속되는 저장증상의 위험인자

양희조,장상훈,전윤수 순천향대학교 순천향의학연구소 2017 Journal of Soonchunhyang Medical Science Vol.23 No.1

Objective: Holmium laser enucleation of prostate (HoLEP) is as fast-paced treatment that is one of the standard treatment for benign prostate hypoplasia. However, there is a rare case that the satisfaction rate of surgery is lowered due to storage symptoms such as frequency and urgency. We investigated the risk factors of bladder irritation symptoms persisted after holmium laser enucleation of prostate. Methods: From January 2009 to December 2014, 220 patients underwent HoLEP in Soonchunhyang University Cheonan Hospital. Among them, 133 patients were selected who did not have any problem that could affect the voiding function including urologic cancer, neurogenic bladder, urinary tract infection, and bladder stone disease. At 3 months after surgery patients were divided into two groups: postoperative International Prostate Symptom Score (IPSS) storage symptom scores <8 (group I) and ≥8 (group II). The two groups were analyzed the parameters: preoperative (prostate size, uroflowmetry, IPSS, prostate calcification), intraoperative (operative time, resected prostate weight), and postoperative (IPSS, uroflowmetry). Results: Of the 133 patients, 94 patients were assigned to group I and 39 patients were group II. Age of the patients, the prostate size, and maximal urinary flow rate showed no statistical difference in both groups. Preoperative storage symptom scores were significantly higher in group II (P<0.05) and IPSS voiding-to-storage subscore ratio was lower in group II without significance (P<0.05). The prostate calcification, periurethral prostatic calcification, and intravesical prostatic protrusion was no difference in the two groups. Postoperative IPSS, maximal urinary flow rate, and post-void residual urine volume was improved in two groups but storage symptom score was not improved in group II. Operative time and resected prostate weight were not found the differences, and postoperative parameters (maximal urinary flow rate, post-void residual urine volume) were showed no difference in both groups. However all of the IPSS was higher in group II. Conclusion: Many symptom improvements after HoLEP were observed but some patients may have difficulties due to persistent bladder irritation. Because bladder irritation sign could persist after surgery if preoperative storage symptom score was higher, it is necessary for a detailed description before surgery.

A Case Giving Proof of Pathogenesis of Abdominoscrotal Hydrocele: A Case Report

양희조,손명원,김두상 순천향대학교 순천향의학연구소 2021 Journal of Soonchunhyang Medical Science Vol.27 No.2

An abdominoscrotal hydrocele (ASH) is an uncommon condition characterized by cystic mass that occupies the scrotum and abdomen. The characteristic aspect is the presence of two hydrocele sacs in the abdominal cavity and the scrotum, and compression of one side causes enlargement of the other side, thereby connecting the two sacs. There are several hypotheses regarding the occurrence of ASH. However, the evidence of the hypotheses is lacking. The patient was a 52-year-old male. During observation of the right inguinoscrotal hydrocele, the patient complained of a palpable mass lesion on the right lower quadrant of the abdomen. Physical examination revealed ASH that occurred with the growth of the inguinoscrotal hydrocele. This was further confirmed by sequential imaging test thereby proposing the verification of cephalad extension of hydrocele. The surgical excision was recommended and inguinal exploration was performed under general anesthesia. No evidence of relapse was observed during the 2-year follow-up period after surgery. The present case proves the cephalad extension of hydrocele among other hypotheses on the etiology of ASH.

2023 Korean Association of Urogenital Tract Infection and Inflammation guidelines for gonococcal infection

양희조,이혁민,이승주,최진봉,배상락,정재흥,강태욱,황의창 대한비뇨의학회 2024 Investigative and Clinical Urology Vol.65 No.1

The incidence of gonorrhea has increased significantly in recent years in the United States, especially among sexually active twenty-year-olds. Although the incidence of gonorrhea has decreased in Korea since the early 2000s, it is still common among people in their twenties. Nucleic acid amplification test (NAAT) is the most sensitive diagnostic test for detecting gonococcal infection. Gram-staining is a simple and useful laboratory test for diagnosing symptomatic male gonococcal urethritis. Although bacterial culture can be used to detect antimicrobial susceptibility, its sensitivity is lower than that of NAAT. Treatment for uncomplicated gonorrhea infection is a single intramuscular injection of ceftriaxone 500 mg. Doxycycline (100 mg twice daily for 7 days) is added if there is a possibility of co-infection with chlamydia. If ceftriaxone is difficult to use, spectinomycin 2 g can be injected intramuscularly in Korea. Patients with gonorrhea should have repeated examinations within three months at the exposure site because of a high risk of re-infection. A person diagnosed with gonorrhea should discuss the nature of the infection, the importance of informing partners, when sexual activity can resume, and how to reduce the risk of sexually transmitted infections.

Role of microbiome and its metabolite, short chain fatty acid in prostate cancer

양희조,김재헌 대한비뇨의학회 2023 Investigative and Clinical Urology Vol.64 No.1

The microbiome which is an assembly of all microbes living inside our bodies performs a major role in maintaining human health and wellness. It has been found that the imbalance of the microbiome can cause various diseases in humans. Similarly, there is growing evidence that the microbiome largely affects a person’s chance of contracting certain cancers and how the disease develops and progresses. Studies have shown that about 15% to 20% of all cancers are caused by microbial pathogens. The prevalence of prostate cancer, which is increasing rapidly in Korea, is related to lifestyle including diet. These diets can alter the gut microbial composition, and the effect of the microbiome on prostate cancer development can be estimated. However, the microbiome associated with prostate cancer has been reported differently according to race. This means that the metabolite rather than the specific microbiome will be important. Short chain fatty acids, metabolites of the microbiome, plays an important role in the action mechanism of the microbiome. Short chain fatty acids play roles such as immunomodulation and inhibition of histone deacetylase. Here, we examined the most up-to-date literature featuring the effects of the microbiome on the risk and pathogenesis of prostate cancer.

A Case of Renal Schwannoma

양희조,이민호,김두상,이현주,이지혜,전윤수 대한비뇨의학회 2012 Investigative and Clinical Urology Vol.53 No.12

Schwannomas are benign tumors that arise from the neural sheath of Schwann cells. Renal schwannomas are extremely rare and are commonly misdiagnosed as renal cell carcinoma, which typically results in a radical nephrectomy. We present a case of a renal schwannoma that mimics a renal pelvis tumor.

식이 중 비타민 D와 칼슘이 신장결석의 형성에 미치는 영향

양희조,전윤수 순천향대학교 순천향의학연구소 2017 Journal of Soonchunhyang Medical Science Vol.23 No.2

Up to 19% of men and 10% of women in the United States will form a kidney stone at some time and recurrence rates are as high as 20%–50% after 5 years. In Korea, some studies have shown that the incidence of kidney stones is as high as 30,000 per year, although the incidence has not increased significantly during the last decade. Calcium is very important for bone health, especially after middle age, and it is also an important factor in the formation of stones. Many studies have shown that ingestion of calcium during meals reduces the formation of stones. However, calcium supplements could reduce the risk of stone formations only when taken with meals. In the case of vitamin D, the intake of vitamin D did not increase the risk of stone formation. A large-scaled prospective study is needed.

급성 단순 방광염 여성에서 삶의 불편 증상에 대한 초기 연구

양희조,김영호,김민의 대한비뇨의학회 2007 Investigative and Clinical Urology Vol.48 No.10

경제활동 인구 대상 한국형 삶의 균형 척도 타당화 연구

양희조(YANG, HEE JO),설경옥(SEOL, KYOUNG OK) 강원대학교 사회과학연구원 2020 사회과학연구 Vol.59 No.2

본 연구는 한국인의 삶의 균형을 측정하는 도구를 개발하기 위해 Matuska(2012)의 Life Balance Inventory를 번안 및 수정하여 20세-49세 경제활동 인구를 대상으로 한국형 삶의 균형 척도를 타당화하였다. 연구 1에서는 대학생과 직장인 305명(표본 1)을 대상으로 번안한 원척도 문항에 대한 예비검사를 실시하였다. 탐색적 및 확인적 요인분석 결과 원척도가 제시한 건강, 관계, 정체성, 도전의 4요인에서 보다 세분화된 9개의 요인으로 나타났다. 연구 2는 표본 1과 유사한 성격을 지닌 대학생과 직장인 310명(표본 2)를 대상으로 본 검사를 실시하였다. 확인적 요인분석 결과는 예비검사의 결과와 동일하게 9개의 요인구조가 적절한 것으로 나타났다. 구체적으로 원척도의 건강영역은 기본적 삶유지 요인, 관계영역은 안정적 관계와 새로운 관계 요인, 정체성영역은 개인적 성장과 사회적 성장 요인, 도전영역은 역량개발, 탐험, 취미 그리고 자기표현의 요인으로 세분화되어 나타났다. 준거타당도는 주관적 안녕감, 자율성 기본심리욕구, 삶의 의미발견, 삶의 만족도, 스트레스로 검증하였다. 본 연구는 삶의 균형을 연구할 수 있는 측정 도구를 한국형으로 타당화하여 우리사회에 중요한 화두인 균형있는 삶의 국내 연구 확산을 가능하게 한 의의가 있다. This study aimed to validate the Korean Life Balance scale using Matuska’s (2010) Life Balance Inventory among 20-50 years old who actively engage in economic activities. In Study 1, we performed exploratory and confirmatory factor analyses with 305 college students and employees (Sample 1) after translating and revising the original scale items in Korea. As result, a 9 factor model was supported. The 9 factor model was corresponded with the original 4 factor model. In Study 2, we cross-validated the result of study 1 with 310 college students and employees (Sample 2). A confirmatory factor analysis confirmed the 9–factor model from study 1. The criterion-related validity was confirmed: the Korean Life Balance Scale was positively correlated with subjective well-being, autonomy basic psychological need, found of meaning in life, and life satisfaction. These findings suggest that the Korean Life Balance scale is a reliable and valid measure for assessing life balance in Korea.