Mirtazepine 사용에 의한 지속성 딸꾹질의 치료

양종철 대한정신약물학회 2008 대한정신약물학회지 Vol.19 No.1

Hiccups are defined as involuntary contractions of the diaphragm and intercostal muscles. Most instances of hiccups are self-limiting, but intractable hiccups can sometimes lead to multiple problems including exhaustion. A 56-year-old female visited our psychiatric department due to persistent hiccups and insomnia. Initially, she was unsuccessfully managed using conservative methods, i.e., holding her breath, drinking water, inducing a gag reflex, and orally administering haloperidol. We administered Remeron Soltab, and the hiccups disappeared. We conclude that mirtazapine is a useful treatment for persistent hiccups. ‘지속성 딸꾹질’의 발생 기전은 명확하지 않지만 다양한 기저질환과의 관련성이 제시되었으며, 경험적인 효과에 근거한 다양한 치료 방법들이 보고되었다. 본 증례에서는‘지속성 딸꾹질’을 보인 56세 여자 환자에게 mir-tazepine을 투여하여 치료한 사례를 보고하였다. 이는 mirtazepine이‘지속성 딸꾹질’에 대한 치료 방법의 하나로 사용될 수 있음을 시사한다. 이에 대한 기전을 밝히기 위해서는 향후 더 체계적인 연구들이 필요하다고 본다.

Ziprasidone 사용 후 발생한 호중구감소증

양종철,김선영,박태원,정영철,정상근,황익근 대한정신약물학회 2007 대한정신약물학회지 Vol.18 No.4

Neutropenia and agranulocytosis are dangerous conditions seldom caused by antipsychotics. We report the case of a 35-year-old female patient who presented with neutropenia following ziprasidone administration. Ziprasidone was gradually increased to 160 mg/day in combination with escitalopram 10 mg/day. Following ziprasidone administration, her neutrophil count fell to 1700 × 103/mm3 on day 45 and to 1500 × 103/mm3 on day 57. Ziprasidone was immediately stopped, and quetiapine 25 mg was given from the next day onward, along with the escitalopram. Her neutrophil count rose to 2700 × 103/mm3 2 days later, and was maintained at 2900 × 103/mm3 at 17 days after changing medication. To the best of our knowledge, this case represents the first report of ziprasidone-induced neutropenia in Korea. Further study is necessary to determine the incidence of neutropenia and its relationship with agranulocytosis secondary to ziprasidone. 몇 항정신병 약물들은 호중구감소증을 일으킬 위험이 있는 것으로 알려져 왔다. 본 증례에서는 정신분열병의 치료를 위해 ziprasidone을 복용한 후 호중구감소증이 발생되었고, ziprasidone 복약 중단 후 호중구감소증이 회복된 35세 여자 환자를 보고한다. 본 증례에서 나타난 호중구감소증은 ziprasidone의 복용과 관계된 것으로 판단된다. 따라서 ziprasidone의 투약시 호중구감소증의 발생 가능성에 대해서 유의해야 하며, 이에 대한 임상가들의 주지와 체계적인 연구가 필요하다고 본다.

한반도 미기록속 식물: 대청지치(지치과)

양종철,하상교,이유미,박수현 한국식물분류학회 2010 식물 분류학회지 Vol.40 No.1

인천광역시 옹진군 대청도에서 발견된 지치과 미기록속의 1분류군을 한반도 미기록종으로 보고한다. 이 분류군은 중국일대에 분포하는 것으로 알려진 Thyrocarpus glochidiatus Maximowicz로서, 한국명은 발견된지역명을 따라 ‘대청지치’로 명명하였다. 이 분류군에 대한 형태적 특징을 기재하였고, 도해 및 생태 사진을제시하였다. We report for the first time a taxon of the genus Thyrocarpus (Boraginaceae) from Daecheongdo,Ongin-gun, Incheon-si in Korea. This taxon appears to be Thyrocarpus glochidiatus Maxim., previously known from China. The new Korean name, ‘Dae-Cheong-Ji-Chi’, was given considering the name of discovered location. A description, an illustration and a photograph were given.

대청도(옹진군)의 관속식물상

양종철,박수현,하상교,이유미 한국자원식물학회 2012 한국자원식물학회지 Vol.25 No.1

Distributional surveys for vascular plants were carried out in Daecheong island, Ongjin-gun, South Korea, from 2008 to 2010. The vascular plants recognized from the island were in tatal 402 taxa that were of 90 families, 269 genus, 350species, 3 subspecies, 43 varieties, 6 forms. Among the investigated 402 taxa, 2 Korean endemic plants, 8 rare and endangered plants which was designated by Korea Forest Service, 35 specially plants designated by the Ministry of Environment were included. The naturalized plants were identified as 40 taxa and the percentage of naturalized plants index was 9.9%. In addition, an unrecorded species, Thyrocarpus glochidiatus Maxim (Boraginaceae), was recognized from the island. 본 연구는 2008년과 2010년에 걸쳐 3차례 식물상을 조사하였으며, 전체 조사된 분류군은 90과 269속 351종 3아종 43변종 6품종등 403분류군이 확인되었다. 주요 식물들로 특산식물이 서울제비꽃 등 2분류군이 확인되었고, 산림청지정 희귀 및 멸종위기 식물이 대청부채(CR) 등 8분류군, 환경부 지정 특정식물은 금방망이(Ⅴ) 등 35분류군으로 나타났다. 또한 식물지리학적 분포특성에 있어 남방계식물과 북방계식물이 함께 확인되었다. 귀화식물은 대청가시풀 등 40분류군이 확인되었으며, 한반도 미기록종인 대청지치가 새로이 발견되었다.

미토콘드리아 DNA 분석을 통한 구상나무와 분비나무의 계통지리학적 연구

양종철,이동근,주민정,최경 한국식물분류학회 2015 식물 분류학회지 Vol.45 No.3

Genetic variations of Abies koreana and Abies nephrolepis were assessed using two mitochondrial DNA regions (nad5 intron 4 and nad5 intron 1) for 16 natural populations to understand their phylogeographical history. Seven polymorphic sites of the two combined regions resulted in the resolution of four haplotypes (M1−1M4). The average gene diversity within the population (HS) was 0.098, the total gene diversity (HT) was 0.620, and the interpopulation differentiation was GST = 0.841, NST = 0.849. The populations were divided into three groups (northern area, central area, southern area) according to their geographic locations. The populations of the northern and southern areas were mostly fixed for M1 and M2, respectively. The populations of the central area showed the highest levels of gene diversity (HT = 0.654) due to introgression from the northern area and southern area. The presence of a single mtDNA haplotype in the southern area suggests that current widespread populations have expanded to the central area from a specific refugium population after the last glacial period. 분비나무와 구상나무의 계통지리적 유연관계 파악을 위하여 16개 지역의 구상나무와 분비나무 집단에 대하여 미토콘드리아 DNA(nad5 intron 4, nad5 intron 1 지역)를 이용한 유전적 분석을 수행하였다. 그 결과 총 7 지역의 유전자 변이가 확인되었으며, 4개의 반수체형이 확인되었다. 개체군 내 평균 유전다양성(HS)은 0.098, 전체 유전다양성(HT)은 0.620으로 관찰되었으며, 개체군 간 분화값은 GST = 0.841, NST = 0.849로 확인되었다. 조사 개체의 지리적 위치에 따라 일본지역을 제외하고 3개의 그룹(북부지역, 중부지역, 남부지역)으로 나누었다. 북부지역과 남부지역은 대부분 각각 M1, M2 단일의 반수체형을 가지며, 중부지역은 북부지역과 남부지역의 분포경계에 위치하면서 유전자 유입으로 인해 유전 다양성 (HT=0.654) 이 가장 높게 나타난 것으로 판단된다. 현재 남부지역의 단일의 반수체형(M2) 분포는 빙하기 때 북부지역에서 남하한 개체군들이 지리적 격리를 통해 분화하게 되고 빙하기 이후 다시 중부지역까지 분포 확장된 결과로 추측된다.

Effects of Antidepressant Treatment on Sexual Arousal in Depressed Women: A Preliminary fMRI Study

양종철,Jong-Il Park,김광원,Sung-Jong Eun,Moo-Suk Lee,Kyung-Lae Han,채정호,Gwang-Woo Jeong 대한신경정신의학회 2012 PSYCHIATRY INVESTIGATION Vol.9 No.4

Objective There was a recent study to explore the cerebral regions associated with sexual arousal in depressed women using functional magnetic resonance imaging (fMRI). The purpose of this neuroimaging study was to investigate the effects of antidepressant treatment on sexual arousal in depressed women. Methods Seven depressed women with sexual arousal dysfunction (mean age: 41.7±13.8, mean scores of the Beck Depression Inventory (BDI) and the 17-item Hamilton Rating Scale for Depression (HAMD-17): 35.6±7.1 and 34.9±3.1, respectively) and nine healthy women (mean age: 40.3±11.6) underwent fMRI before and after antidepressant treatment. The fMRI paradigm contrasted a 1 minute rest period viewing non-erotic film with 4 minutes of sexual stimulation viewing an erotic video film. Data were analyzed by SPM 2. The relative number of pixels activated in each period was used as an index of activation. All depressed women were treated with mirtazapine (mean dosage: 37.5 mg/day) for 8 to 10 weeks. ResultsaaLevels of brain activity during sexual arousal in depressed women significantly increased with antidepressant treatment (p<0.05) in the regions of the hypothalamus (3.0% to 11.2%), septal area (8.6% to 27.8%) and parahippocampal gyrus (5.8% to 14.6%). Self-reported sexual arousal during visual sexual stimulation also significantly increased post-treatment, and severity of depressive symptoms improved, as measured by the BDI and HAMD-17 (p<0.05). Conclusion These results show that sexual arousal dysfunction of depressed women may improve after treatment of depression, and that this improvement is associated with increased activation of the hypothalamus, septal area, and parahippocampal gyrus during sexual arousal.

불안과 GABA 체계

양종철,Yang, Jong-Chul 대한불안의학회 2006 대한불안의학회지 Vol.2 No.2

Anxiety and anxiety disorders are related to many neurotransmitters, such as norepinephrine, serotonine, dopamine, glutamate, and Gamma-aminobutyric acid (GABA). GABA, the main inhibitory neurotransmitter of the CNS, is known to counterbalance the action of the excitatory neurotransmitters and control anxiety. GABA acts on 3 GABA receptor subtypes, $GABA_A$, $GABA_B$, and $GABA_C$. $GABA_A$ and $GABA_c$ receptors are oligomeric transmembrane glycoproteins composed of 5 subunits that are arranged around a central chloride channel. $GABA_B$ receptor comprises two 7-transmembraneis-spanning proteins that are coupled to either calcium or potassium channel via G proteins. This article highlights neurobiological interactions between anxiety and GABA system.

일반인군과 우울증 환자군에서 한국어판 사회적응 자가평가척도의 심리측정적 특성 평가

양종철,김재민,신일선,노안영,윤진상 대한신경정신의학회 2003 신경정신의학 Vol.42 No.3

Objectives:The purpose of this study is to examine the reliability and validity of the Korean version of the Social Adaptation Self-evaluation Scale (KvSASS), and to evaluate its psychometric properties. Methods:KvSASS was administered to two groups, 269 members of the general population and 52 depressive patients, and data on socio-demographic characteristics (age, gender, occupation, marital status, and level of education) and psychological assessment scales (Self-esteem Scale, Beck Depression Inventory, General Health Questionnaire/Quality of Life-12) were collected. For the patient group, data on clinical rating scales and the duration of antidepressant treatment were also obtained. Results:The evaluation of item intercorrelation by the Pearson correlation matrix showed that the number of correlation coefficients over 0.40 was nine. Internal consistency (Cronbach’s alpha), split-half reliability (Guttmans), and test-retest reliability of the KvSASS were good. Three main factors (social activity, self-value oriented activity, and work related activity) were extracted, and three clusters (highly, moderately, and poorly adaptive) emerged by factor and cluster analyses respectively. Concurrent validities with other psychological assessment scales were high. Stepwise multiple regression tests showed that KvSASS was significantly associated with Self-Esteem Scale and General Health Questionnaire/Quality of Life- 12 in the general population group, and with occupation and General Health Questionnaire/Quality of Life-12 in the depressive patient group. Conclusion:KvSASS was a reliable and valid instrument to assess social functioning in both members of general population and depressive patients, and had psychometric properties reflecting the depressive patients’ self-perception of social behavior rather than depressive symptoms themselves

정서적 불안정을 동반한 PANDAS 1예

양종철 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.3

학술연구논문 포스터발표 : 1분과: 산림환경, 산림생태, 수목확, 분류, 조림 ; 한국산 측백나무과 식물의 형태형질 연구

양종철,홍정기,오승환,이유미,허권 한국임학회 2012 한국임학회 학술발표논문집 Vol.2012 No.-