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자궁내막암과 비정형 복잡성 자궁내막증식증에서의 E-cadherin과 catenin (α-, β-catenin) 단백의 발현
양용재 ( Yong Jae Yang ),이희중 ( Hee Joong Lee ),이근호 ( Keun Ho Lee ),이윤영 ( Yoon Young Lee ),장은덕 ( Eun Duk Jang ),이진우 ( Jin Woo Lee ),남궁성은 ( Sung Eun Namkoong ),박태철 ( Tae Chul Park ) 대한산부인과학회 2005 Obstetrics & Gynecology Science Vol.48 No.6
자궁경부암 환자에서 Cisplatin에 의한 방사화학요법과 방사선요법의 효과의 비교
김정자,이지현,김수평,이헌영,양용재,임희경,한구택,남정,류진희,유기성 대한부인종양 콜포스코피학회 1998 Journal of Gynecologic Oncology Vol.9 No.3
We compared the therapeutic effects of concomitant chemoradiotherapy (CRT) using cisplatin to single radiotherapy (RT) in uterine cervical cancer. 34 cases of non-operable uterine cervical cancer were reviewed retrospectively from Mar, 1993 to May, 1996 in St. Mary' s Hospital. The patients were randomly selected to compare the effects of both methods. 22 patients were included in CRT group and 12 patients in RT group. The results were as follows: 1. The decrease of tumor size was not significant (2.17 cm in CRT and 1.95 cm in RT) (p=0.61), but the number of responders of CRT group was larger than that of RT group significantly (p <0.05). 2. The tumor markers showed no significant difference between CRT and RT groups (p >0.05) 3. The overall survival rate showed no difference between two groups (p >0.05). The disease-free survivals for 38 months were 17.02% in CRT and 11.36% in RT, but it was not significant (p >0.05). In conclusion, concomitant chemoradiotherapy showed better rate of response, but size omor decrease and tumor markers showed no difference. CRT might improve the overall survival and disease-free survival, although it was not significant in this study. The clinical significance of CRT remains to be determined in large randomized clinical trial.
김기홍(Ki Hong Kim),서상용(Sang Yong Seo),김재훈(Jae Hoon Kim),양용재(Yong Jae Yang),박동춘(Dong Choon Park),이형근(Hyung Gun Lee),정대영(Dae Young Chung),장은덕(Eun Deok Chang),유영옥(Young Ok Lew),김대훈(Dae Hoon Kim),남궁성은(Sung 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.9
A 41-year-old woman was operated under the impression of ovarian malignancy. The ovarian mass was diagnosed as a non-Hodgkin's lymphoma, diffuse large cell type of B lineage pathologically. Because regional lymph nodes and bone marrow were not involved and Ga67 whole body bone scan was normal, we suspected that ovary was a primary site of lymphoma. After six cycles of CHOP (cyclophosphamide, adriamycin, vincristine, prednisone) chemotherapy, complete remission status was maintained for 16 months. We report a case of primary ovarian lymphoma with a review of literatures.
임신오조증으로 발생한 Wernicke`s Encephalopathy 1 예
김수평(Soo Pyung Kim),유영옥(Young Oak Lew),김대훈(Dae Hoon Kim),양용재(Yong Jae Yang),이형근(Hyung Gun Lee),임채춘(Chae Chun Rhim),나순숙(Soon Sook Nah),박동춘(Dong Chun Park),정대영(Dae Young Jeong),김재훈(Jae Hoon Kim) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.1
Hyperemesis gravidarum is a complication defined as nausea and vomiting during early pregnancy. Wernickes encephalopathy is an illness of acute onset characterized by mental disturbance, paralysis of eye movements, and ataxia of gait cause by thiamine deficiency. We recently experienced a case of Wernickes encephalopalhy due to hyperemesis gravidarum, which is treated by administration of thiamine even though outcome of serious healthy problem to both mother and fetus, and reported it with a brief review of the literature.
김사진 ( Sa Jin Kim ),신종철 ( Jong Chul Shin ),윤철구 ( Chul Gu Yoon ),양용재 ( Yong Jae Yang ),이근호 ( Keun Hoo Lee ),박태철 ( Tae Chul Park ),나종구 ( Jong Gu Rha ),김수평 ( Soo Pyung Kim ),이희중 ( Hee Joong Lee ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.12
목적 : 임신 말기에 필요에 따라 프로스타그란딘 E1 유도체인 미소프로스토롤을 질 경내에 투여해서 자궁경관을 숙화시킨 후 정상 질식 분만한 산모 중에서 두 군으로 나누어 이의 결과를 비교하였다. 연구 방법 : 유도 분만을 위한 자궁 숙화가 필요한 37주 이상의 정상 만삭 임신산모에서 무작위로 35명에서는 미소프로스톨 50㎍, 32명에게는 미소프로스톨 100㎍을 질 경내에 4시간마다 최고 6회까지 투여하였고 규칙적인 진통이 없거나 진통이 있더라도 자궁경관 Objective : The purpose of this study was to compare the efficacy and the safety of two different dose regimens of intravaginal misoprostol for labor induction. Methods : Sixty-seven consenting women with maternal or fetal indication for labor and no prio
자궁경부 종양 환자에서 세포진 검사, 질확대경조준하생검, 원추절제술의 진단적 정확도와 원추절제술 후 잔류 종양의 예측인자
길기철(Ki Cheol Kil),허수영(Soo Young Hur),이귀세라(Gui Se Ra Lee),양용재(Yong Jae Yang),이지현(Jee Hyun Lee),이희중(Hee Joong Lee),김사진(Sa Jin Kim),김은중(Eun Jung Kim),송승규(Seung Kyu Song),남궁성은(Sung Eun NamKoong),김수평(Soo P 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.9
목적: 세포진 검사, 질확대경 검사, 질확대경 조준하생검, 원추절제술 및 자궁적출술을 연속적으로 시행한 자궁경부 종양 환자에서 각각의 검사 결과를 조직병리학적으로 비교하여 상호간의 정확도를 분석하고 원추 절제술 후 잔류 종양의 예측 인자를 조사하여 자궁경부 초기암 환자의 진단과 치료 관리에 도움을 주고자 본 연구를 시작하였다. 연구방법: 1993년 1월부터 1998년 8월까지 가톨릭대학교 의과대학 부속 성가병원 산부인과를 방문하여 자궁경부 세포진 검사 및 질확대경 검사에서 이상 소견을 보이는 환자 중에서 질확대경 조준하생검 후, 적응증에 따라 연속적으로 원추 절제술과 자궁적출술을 시행한 167명을 대상으로 하였다. 결과: 세포진 검사의 진단적 정확도(완전 일치율)는 59.3%(99/167), 질확대경 조준하생검의 진단적 정확도(완전 일치율)는 71.3%(119/167), 원추 절제술과 자궁적출술 후 조직 소견을 비교한 결과 자궁적출술 조직 소견 중 51예(30.1%)에서 잔류 종양이 확인되었는데, 동일한 병변이 잔류한 것이 46예(90.2%), 원추절제술보다 낮은 병변이 잔류한 경우가 4예(7.8%)이었고 더 진행된 병리 소견을 보이는 경우는 1예(2.0%)이었다. 원추절제술 후 조직의 절제면에서 종양 세포의 침범 유무와 추후 실시한 자궁적출술 후 조직병리검사에서 잔류 종양 유무와의 상관관계를 관찰한 바 침범이 있었던 군에서 잔류 종양이 더 많음을 확인할 수 있었다(P<0.001). HPV 16 혹은 18 DNA 검출과 잔류 종양의 존재와는 관계가 없었다. 결론: 세포진 검사와 질확대경 조준하생검이 자궁경부 종양 환자의 진단에 유용하지만 자궁경부 상피내종양 III 또는 미세침윤암이 의심되는 경우에는 원추절제술을 시행하여 병변을 정확히 판단하여야 하며 원추절제술 후 절제면에서 종양 침범이 발견된 경우 잔류 종양의 가능성이 높으므로 보다 적극적인 치료가 필요 할 것으로 생각된다. Objective: This study was performed to evaluate the diagnostic accuracy of cytology, colposcopically directed biopsy and conization and to analyze predictive factors for residual tumor after conization in patients with cervical neoplasia. Methods: We reviewed 167 patients who had undergone cytology, colposcopically directed biopsy and conization followed by subsequent hysterectomy depending on their current disease status at the Department of Obstetrics & Gynecology, Catholic University of Korea Medical College, Holy Family Hospital from January, 1993 to August, 1998. The diagnostic accuracy of cytology, colposcopically directed biopsy and conization were investigated. Also, we investigated the significance of the margin status and the presence of HPV which were used to predict residual tumors in hysterectomy specimens after conization. Results: The results of each methods were analyzed with regard to the histopathologic findings of the surgical specimen. The accuracy rates of cytology, and colposcopically directed biopsy were 59.3% (99 of 167) and 71.3% (119 of 167), respectively. After conization, residual tumors were found in 30.1% of subsequent hysterectomized specimens (51 of 167). Underestimation by conization occurred in 2.0% of cases (1 of 51) and overestimation in 7.8% (4 of 51). Residual tumors were significantly more frequent in patients with positive conization margins than in those with negative margins (P<0.001). But the presence of HPV was not significant. Conclusion: These results suggest that diagnostic conization seems to be essential procedure in patients showing abnormal results by cytology and colposcopically directed biopsy, especially in those with CIN III or microinvasion, for the further proper management of cervical neoplastic lesion and margin status is useful in predicting residual tumor after conization.
자궁경부암 세포의 증식에 관여하는 annexin-I의 역할
유영옥(Young Ok Lew),박태철(Tae Chul Park),남궁성은(Sung Eun NamKoong),박동춘(Dong Choon Park),김재훈(Jae Hoon Kim),김대훈(Dae Hoon Kim),양용재(Yong Jae Yang),이지현(Jee Hyun Lee),조성대(Sung Dae Cho),조형권(Hyeong Kwon Jo) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.10
목적: 인간 자궁경부암에서 annexin-I의 역할을 규명하기 위해 annexin -I의 발현과 암세포증식과의 상관관계를 조사하였다. 방법: 면역조직화학 (immunohistochemical) 염색법 과 Western blotting으로 자궁경부암 조직에서 annexin-I 발현의 정도와 분포를 조사하였다. 악성세포주인 SiHa와 HeLa 세포주를 tamoxifen, β-estradiol과 all-trans retinoic acid로 3일 또는 5일간 처리한 후 각 세포의 증식을 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT ) colorimetric assay로 측정하였고 동시에 유세포측정기(flow cytometry)로 annexin-I의 발현을 조사하였다. 결과: Annexin-1에 대한 면역조직화학 분석 결과 자궁경부암세포가 진한 과립상으로 염색되어 관찰되었으며, Western blotting 분석에서는 annexin-I의 발현이 정상이나 양성조직보다 암조직에서 증가하였다. 한편, tamoxifen, β-estradiol 또는 all-trans retinoic acid와 같은 세포증식 조절물질을 이용한 세포주 실험에서는, tamoxifen이나 β-estradiol로 SiHa와 HeLa 세포주를 증식시킨 뒤 annexin-I의 발현이 증폭되었고 all-trans retinoic acid에 의한 항증식 후 annexin-I의 발현이 감소되었다. 결론: Annexin-I의 발현은 정상조직보다 자궁경부암에서 증가되어 있었고 자궁경부암 세포주의 증식과 비례해서 annexin-I의 발현이 증가되었다 Objectives: To investigate the role of annexin-I in human cervical cancer, we evaluated the expression of annexin-I and the relation with the proliferation of cancer cells. Methods: By immunohistochemical analysis and the western blotting of annexin-I , we investigated the extent and distribution of the expression of annexin-I in cervical cancer tissues. After treating the human cancer cell lines ( SiHa and HeLa cell lines ) with tamoxifen, estradiol, and retinoic acid for 5 days to make the cells proliferate and antiproliferate, we measured the proliferation simultaneously with 3-(4,5- dimethyl thiazol- 2-yl)-2,5-diphenyl-tetr -azolium bromide (MTT) colorimetric assay and the expression level of annexin-I with flowcytometry. Results: In the immunohistochemical stains, a granular staining pattern involving the entire cytoplasm was more heavily observed in malignant lesions than in normals. In the western blotting, the antibodies against 35-kDa annexin-I appeared to react more strongly with the lysates of cancer tissues than normal and benign tissues. In SiHa and HeLa cell lines with tamoxifen and β- estradiol treatment, increased expressions of annexin-I were noted with correlated increased proliferation of cells, and with the treatments of all trans retinoic acid, decreased expressions of annexin-I were noted with correlated decreased proliferation of cells. Conclusions: The results suggest that the expression of annexin-I might correlate with cervical cancer than normal and the proliferation of cancer cells.