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이력 데이타베이스의 어그리게이트 정보를 지원하기 위한 그래픽 인터페이스의 구현
안태호(Tae Ho Ahn),양영주(Young Joo Yang),김진호(Jin Ho Kim),이윤준(Yoon Joon Lee) 한국정보과학회 1988 한국정보과학회 학술발표논문집 Vol.15 No.2
실세계의 많은 응용들은 현재 자료 뿐만 아니라 과거에 발생했던 자료도 필요로 한다. 이런 응용들을 지원하기 위한 데이타베이스를 이력 데이타베이스라 한다. 대부분의 응용들은 자료의 이력들을 분석하여 미래를 예측하는데 이용되므로, 이력 데이타베이스에서 이러한 분석과 예측을 지원하기 위한 기능을 첨가하는 것이 필요하다. 따라서 본 연구에서는 이력 데이타베이스에 대한 어그리게이트 정보를 추출하는 함수를 제공하고 그 정보를 쉽게 분석할 수 있도록 그래픽 디스플레이로 출력하는 시스템을 구현하였다. 본 시스템에서는 어그리게이트 정보에 대한 테이블, 다이어그램, 그리고 그래프 형태의 디스플레이를 제공한다. 본 시스템은SUN Workstation의 42 BSD UNIX 시스템하에서 구현되었다.
림프종으로 오인된 댑손에 의한 drug reaction with eosinophilia and systemic symptoms 증후군 1예
신보미 ( Bo Mi Shin ),박소영 ( So Young Park ),윤선영 ( Sun Young Yoon ),신은혜 ( Eun Hye Shin ),양영주 ( Young Joo Yang ),조형진 ( Hyung Jin Cho ),장일영 ( Il Young Jang ),강동욱 ( Dong Uk Kang ),김태범 ( Tae Bum Kim ),조유숙 ( Y 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 1991 소아알레르기 및 호흡기학회지 Vol.1 No.4
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a life-threatening adverse drug reaction with systemic manifestations. Dapsone is known to be useful for treatment of leprosy and various dermatologic conditions. We report a patient with prurigo pigmentosa who developed DRESS syndrome after dapsone treatment. She presented with lymphadenopathy, fever, eosinophilia, skin rash, and elevated liver enzymes. Initial lymph node and skin biopsy was suggestive of peripheral T-cell lymphoma. Initially, she was treated with chemotherapy. A week later after complete remission of skin symptoms, new skin lesions recurred. TCR-gene rearrangement was examined to show negative results and she was diagnosed as dapsone induced DRESS syndrome. This case emphasizes the importance of differential diagnosis of lymphoma and DRESS syndrome. (Allergy Asthma Respir Dis 2013;1:400-404)
림프종으로 오인된 댑손에 의한 drug reaction with eosinophilia and systemic symptoms 증후군 1예
신보미 ( Bo Mi Shin ),박소영 ( So Young Park ),윤선영 ( Sun Young Yoon ),신은혜 ( Eun Hye Shin ),양영주 ( Young Joo Yang ),조형진 ( Hyung Jin Cho ),장일영 ( Il Young Jang ),강동욱 ( Dong Uk Kang ),김태범 ( Tae Bum Kim ),조유숙 ( Y 대한천식알레르기학회(구 대한알레르기학회) 2013 Allergy Asthma & Respiratory Disease Vol.1 No.4
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a life-threatening adverse drug reaction with systemic manifestations. Dapsone is known to be useful for treatment of leprosy and various dermatologic conditions. We report a patient with prurigo pigmentosa who developed DRESS syndrome after dapsone treatment. She presented with lymphadenopathy, fever, eosinophilia, skin rash, and elevated liver enzymes. Initial lymph node and skin biopsy was suggestive of peripheral T-cell lymphoma. Initially, she was treated with chemotherapy. A week later after complete remission of skin symptoms, new skin lesions recurred. TCR-gene rearrangement was examined to show negative results and she was diagnosed as dapsone induced DRESS syndrome. This case emphasizes the importance of differential diagnosis of lymphoma and DRESS syndrome.
COVID-19 유행 시기의 성인 염증성 장질환 임상 진료지침: 전문가 합의 권고문
박용은 ( Yong Eun Park ),이유진 ( Yoo Jin Lee ),장지영 ( Ji Young Chang ),송현주 ( Hyun Joo Song ),김덕환 ( Duk Hwan Kim ),양영주 ( Young Joo Yang ),김병창 ( Byung Chang Kim ),이재곤 ( Jae Gon Lee ),양희찬 ( Hee Chan Yang ),최미영 대한소화기학회 2021 대한소화기학회지 Vol.78 No.2
The coronavirus disease 2019 (COVID-19) pandemic has reduced the ability to prevent or control chronic disease due to the concerns about safety in accessing health care. Inflammatory bowel disease (IBD) is a chronic condition requiring long- term sustained treatment, which is difficult in the current panedemic situation. The Korean Association for the Study of Intestinal Diseases (KASID) has developed an expert consensus statement on the clinical practice management of adult inflammatory bowel disease during the COVID-19 pandemic. This expert consensus statement is based on guidelines and clinical reports from several countries around the world. It provides recommendations to deal with the risk of COVID-19 and medication use in IBD patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and emphasizes the importance of right treatment approach to avoid worsening of the disease condition in IBD patients. (Korean J Gastroenterol 2021;78:105-116)
증례 : 신장 ; 신 이식 후 항체 매개성 거부반응 환자에서 지연성 회복을 보인 치료 1예
조형진 ( Hyung Jin Cho ),신은혜 ( Eun Hye Shin ),양영주 ( Young Joo Yang ),정지원 ( Ji Won Jung ),지원준 ( Won Jun Ji ),최영권 ( Young Kwon Choi ),박수길 ( Su Kil Park ) 대한내과학회 2014 대한내과학회지 Vol.86 No.2
항체 매개성 거부반응은 이식 신 기능상실에 중요한 원인으로 현재까지 확립된 치료방법이 없는 상태이다. 항체 매개 성 거부반응의 원인으로 생각되는 제공자 특이 항체의 경우 면역억제제를 잘 복용하지 않아서 지연성으로 발생하는 경우가 있어, 지속적인 면역억제제 복용의 교육이 필요하다. 항체 매개성 거부반응에 있어 최근 치료로 도입된 bortezomib 단독치료로서 회복을 보이지 않았던 증례에서 rituximab을 추가로 치료하여 지연성 회복을 보인 증례를 보고하며 일반적인 치료법으로도 회복되지 않는 항체 매개성 거부반응에서 rituximab과 bortezomib의 병합치료를 고려해 볼 수 있겠고 추가적인 연구가 필요할 것으로 생각된다. Antibody-mediated rejection (ABMR) in kidney transplant recipients is mediated by donor-specific antibodies. It is the major cause of graft failure in noncompliant patients and is associated with reduced long-term graft survival. We present a case of delayed recovery of renal function despite aggressive therapy after acute ABMR. A 49-year-old male on triple-drug maintenance immunosuppression (prednisolone, cyclosporine, and azathioprine), who underwent cadaveric donor renal transplantation 14 years earlier, visited our clinic with a serum creatinine level (SCr) of 1.9 mg/dL. The kidney biopsy revealed acute ABMR with diffuse C4d immunopositivity. We started steroid pulse therapy and bortezomib with plasmapheresis. Nevertheless, the SCr increased. Consequently, antithymocyte globulin (ATG) and intravenous immunoglobulin were administered. The SCr increased further to 4.1 mg/dL. Therefore, we performed a second kidney biopsy, which showed no change. Finally, we used rituximab. Fortunately, the SCr decreased gradually and returned to baseline. (Korean J Med 2014;86:237-241)
즐례 : 의인성 쿠싱 증후군 환자에서 발생한 크립토코쿠스 근육근막염 1예
정지원 ( Ji Won Jung ),전미정 ( Mi Jung Jun ),신은혜 ( Eun Hye Shin ),양영주 ( Young Joo Yang ),조형진 ( Hyung Jin Cho ),김미나 ( Mi Na Kim ),이상오 ( Sang Oh Lee ) 대한내과학회 2014 대한내과학회지 Vol.86 No.1
크립토코쿠스에 의한 피부 감염은 비교적 흔하지만 심부 연조직 감염은 매우 드물다. 저자들은 의인성 쿠싱증후군으로 진단된 72세 여자 환자에서 외상 후 Cryptococcus neoformans 에 의한 연조직염과 근육근막염을 진단하여 fluconazole을 12개월간 투약 후 호전된 1예를 경험하였기에 문헌고찰과 함께 보고한다. The skin is the third most common site of cryptococcosis after infections of the central nervous system and lungs. However, cryptococcosis rarely involves deep soft tissue. Here, we report a case of cryptococcal cellulitis and myofascitis in a 72-year-old woman with iatrogenic Cushing`s syndrome. Despite the administration of antibiotics, the patient continued to suffer from aggravated wounds and pain. Cultures of pus and an excisional biopsy of the skin revealed Cryptococcus neoformans. She was treated successfully with intravenous fluconazole (400 mg/day) for 14 days followed by oral fluconazole (400 mg/day) for 12 months. (Korean J Med 2014;86:102-105)
성인 염증성 장질환 환자에서의 SARS-CoV-2 백신 접종: 전문가 합의 권고문
이유진 ( Yoo Jin Lee ),김성은 ( Seong-eun Kim ),박용은 ( Yong Eun Park ),장지영 ( Ji Young Chang ),송현주 ( Hyun Joo Song ),김덕환 ( Duk Hwan Kim ),양영주 ( Young Joo Yang ),김병창 ( Byung Chang Kim ),이재곤 ( Jae Gon Lee ),양희찬 대한소화기학회 2021 대한소화기학회지 Vol.78 No.2
Coronavirus disease 2019 (COVID-19), caused by the novel coronavirus, is threatening global health worldwide with unprecedented contagiousness and severity. The best strategy to overcome COVID-19 is a vaccine. Various vaccines are currently being developed, and mass vaccination is in progress. Despite the very encouraging clinical trial results of these vaccines, there is insufficient information on the safety and efficacy of vaccines for inflammatory bowel disease (IBD) patients facing various issues. After reviewing current evidence and international guidelines, the Korean Association for the Study of Intestinal Diseases (KASID) developed an expert consensus statement on COVID-19 vaccination issues for Korean IBD patients. This expert consensus statement emphasizes that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination be strongly recommended for IBD patients, and it is safe for IBD patients receiving immunomodulatory therapy. (Korean J Gastroenterol 2021;78:117-128)