Mycoplasma pneumoniae 감염의 신속 항원 검사 키트 "Ribotest Mycoplasma^®"의 진단적 평가

양송이,한미선,김선중,이성연,최은화,Yang, Song I,Han, Mi Seon,Kim, Sun Jung,Lee, Seong Yeon,Choi, Eun Hwa 대한소아감염학회 2019 Pediatric Infection and Vaccine Vol.26 No.2

Purpose: Early detection of Mycoplasma pneumoniae is important for appropriate antimicrobial therapy in children with pneumonia. This study aimed to evaluate the diagnostic value of a rapid antigen test kit in detecting M. pneumoniae from respiratory specimens in children with lower respiratory tract infection (LRTI). Methods: A total of 215 nasopharyngeal aspirates (NPAs) were selected from a pool of NPAs that had been obtained from children admitted for LRTI from August 2010 to August 2018. The specimens had been tested for M. pneumoniae by culture and stored at $-70^{\circ}C$ until use. Tests with Ribotest $Mycoplasma^{(R)}$ were performed and interpreted independently by two investigators who were blinded to the culture results. Results: Among the 215 NPAs, 119 were culture positive for M. pneumoniae and 96 were culture negative. Of the culture-positive specimens, 74 (62.2%) were positive for M. pneumoniae by Ribotest $Mycoplasma^{(R)}$, and 92 of the 96 (95.8%) culture-negative specimens were negative for M. pneumoniae by Ribotest $Mycoplasma^{(R)}$. When culture was used as the standard test, the sensitivity and specificity of Ribotest $Mycoplasma^{(R)}$ were 62.2% and 95.8%, respectively. Additionally, the positive predictive value, negative predictive value, and overall agreement rates with Ribotest $Mycoplasma^{(R)}$ were 94.9%, 67.2%, and 77.2%, respectively. Conclusions: A positive test result of Ribotest $Mycoplasma^{(R)}$ suggests a high likelihood of culture-positive M. pneumoniae infection. However, a negative test result should be interpreted with caution because nearly one-third of negative test results reveal culture-positive M. pneumoniae infections.

중증 열대열 말라리아에 합병한 흑수열 소아 1예

양송이 ( Song I Yang ),최영준 ( Young June Choe ),이환종 ( Hoan Jong Lee ),최은화 ( Eun Hwa Choi ) 대한소아감염학회 2017 Pediatric Infection and Vaccine Vol.24 No.2

Blackwater fever is a serious clinical syndrome manifested by acute intravascular hemolysis, fever, and the passage of black or red urine, which is classically associated with falciparum malaria and irregular administration of quinine. In Korea, Plasmodium vivax is the only endemic malaria circulating; a number of imported cases of falciparum malaria have been reported in patients following return from international travel to a malaria endemic area. Therefore, it is important for health care professionals including pediatricians to be aware of the falciparum malaria and its clinical courses. Herein, we report a case of a 14-year-old girl with severe falciparum malaria that was complicated by blackwater fever.

패션 전시 공간에 적용된 오브제 연출방법에 관한 사례 연구

양송이 ( Song I Yang ),이정교 ( Jung Kyo Lee ) 한국공간디자인학회 2013 한국공간디자인학회논문집 Vol.8 No.4

(Background and Purpose) Using various objects in modern fashion exhibition spaces is helpful for building beloved brands. The purpose of this study is to observe the various kinds of objects, as well as their various uses, in fashion exhibitions where artistic and trend-leading brands succeed in boosting brand values. (Method) In this study, theoretical studies and case analyses regarding exhibition spaces of fashion brands and objects are included. Six successful exhibition spaces by top global brands have been examined to identify the reasons for their success in drawing attention and building brand values using objects. (Result) In summary, various display methods are used in fashion exhibition spaces. D?paysement: is used most often, and it is the most popular among the various methods, for creating a unique and detached sense of place. It may be concluded that placing two or more objects in one place at the same time and place is particularly useful for creating a sense of disconnection or dislocation.

Mycoplasma pneumoniae 감염의 신속 항원 검사 키트 “Ribotest Mycoplasma^®”의 진단적 평가

양송이 ( Song I Yang ),한미선 ( Mi Seon Han ),김선중 ( Sun Jung Kim ),이성연 ( Seong Yeon Lee ),최은화 ( Eun Hwa Choi ) 대한소아감염학회 2019 Pediatric Infection and Vaccine Vol.26 No.2

Purpose: Early detection of Mycoplasma pneumoniae is important for appropriate antimicrobial therapy in children with pneumonia. This study aimed to evaluate the diagnostic value of a rapid antigen test kit in detecting M. pneumoniae from respiratory specimens in children with lower respiratory tract infection (LRTI). Methods: A total of 215 nasopharyngeal aspirates (NPAs) were selected from a pool of NPAs that had been obtained from children admitted for LRTI from August 2010 to August 2018. The specimens had been tested for M. pneumoniae by culture and stored at -70°C until use. Tests with Ribotest Mycoplasma^® were performed and interpreted independently by two investigators who were blinded to the culture results. Results: Among the 215 NPAs, 119 were culture positive for M. pneumoniae and 96 were culture negative. Of the culture-positive specimens, 74 (62.2%) were positive for M. pneumoniae by Ribotest Mycoplasma®, and 92 of the 96 (95.8%) culture-negative specimens were negative for M. pneumoniae by Ribotest Mycoplasma^®. When culture was used as the standard test, the sensitivity and specificity of Ribotest Mycoplasma^® were 62.2% and 95.8%, respectively. Additionally, the positive predictive value, negative predictive value, and overall agreement rates with Ribotest Mycoplasma^® were 94.9%, 67.2%, and 77.2%, respectively. Conclusions: A positive test result of Ribotest Mycoplasma^® suggests a high likelihood of culture-positive M. pneumoniae infection. However, a negative test result should be interpreted with caution because nearly one-third of negative test results reveal culture-positive M. pneumoniae infections.

소아 폐쇄세기관지염에 대한 새로운 관점

양송이 ( Song-i Yang ) 대한천식알레르기학회 2022 Allergy Asthma & Respiratory Disease Vol.10 No.2

수두-대상포진 바이러스에 노출된 소아 환자의 예방 조치

양송이 ( Song I Yang ),임지희 ( Ji Hee Lim ),김은진 ( Eun Jin Kim ),박지영 ( Ji Young Park ),윤기욱 ( Ki Wook Yun ),이환종 ( Hoan Jong Lee ),최은화 ( Eun Hwa Choi ) 대한소아감염학회 2016 Pediatric Infection and Vaccine Vol.23 No.3

Purpose: This study described the post-exposure prophylaxis (PEP) and secondary varicella infection in children inadvertently exposed to varicella zoster virus (VZV) in the hospital. Methods: We retrospectively analyzed data from patients with VZV infection who were initially not properly isolated, as well as children exposed to VZV at the Seoul National University Children`s Hospital between January 2010 and December 2015. The PEP measures were determined by the presence of immunity to VZV and immunocompromising conditions. Patient clinical information was reviewed via medical records. Results: Among 147 children hospitalized between 2010 and 2015, 13 inadvertent exposures were notified due to VZV infection. Five index children had a history of VZV vaccination. Eighty-six children were exposed in multi-occupancy rooms and 62.8% (54/86) were immune to VZV. The PEP measures administered to 27 exposed patients included varicella zoster immunoglobulin and VZV vaccination. Four children developed secondary varicella, which was linked to a single index patient, including one child who did not receive PEP and three of the 27 children who received PEP. The rates of secondary varicella and prophylaxis failure were 4.7% (4/85) and 11.1% (3/27), respectively. The secondary varicella rates were 1.9% (1/54) and 9.7% (3/31) among immunocompetent and immunocompromised children, respectively. Conclusions: Delayed diagnosis of VZV infection can lead to unexpected exposure and place susceptible children and immunocompromised patients at risk for developing varicella. The appropriateness of the current PEP strategy based on VZV immunity may require re-evaluation.

한국 소아의 식품 의존성 운동유발 아나필락시스: 단일 기관 후향적 연구

양송이 ( Song I Yang ),이은 ( Eun Lee ),유진호 ( Jin Ho Yu ),조유숙 ( You Sook Cho ),김태범 ( Tae Bum Kim ),홍수종 ( Soo Jong Hong ) 대한천식알레르기학회 2015 Allergy Asthma & Respiratory Disease Vol.3 No.3

Purpose: Food-dependent exercise-induced anaphylaxis (FDEIA) is a specific clinical syndrome requiring both ingestion of an allergenic food and exercise to induce anaphylaxis. It may be underdiagnosed due to insufficient history taking in terms of the causes of anaphylaxis. This study aims to describe clinical characteristics and diagnostic results of FDEIA in children. Methods: We retrospectively reviewed the medical records of patients under 18 years old who were diagnosed with FDEIA at Asan Medical Center between January 2003 and August 2014. Results: Of the 170 children with anaphylaxis, 11 (6.5%) had FDEIA. The mean age at the onset of symptoms was 14.8±1.5 years. The causative foods were: wheat (n=4), meat (n=1), mung beans (n=1), rice (n=1), celery (n=1), cabbage (n=1), fish (n=1), and soy (n=1). The numbers of symptom development were: 7 (n=1), 6 (n=1), 3 (n=4), 2 (n=2), and 1 (n=3). The geometric mean (range of 1 standard deviation) of total serum IgE levels was 131.6 kU/L (53.5.324.2 kU/L). The skin prick test and immununoCAP were positive for causative foods in 3 of 6 patients (50.0%) and 7 of 10 patients (70.0%), respectively. The provocation test was performed in 8 of 11 patients and showed positive results except 1 patient. The interval between exercise and symptoms was 21.6±7.3 minutes. Conclusion: It is important to suspect FDEIA and take a detailed history in children with anaphylaxis. Provocation test should be considered to confirm the diagnosis. Further studies on disease course and long-term prognosis are warranted.(Allergy Asthma Respir Dis 2015;3:194-199)

10학년 과학교과서와 차세대 과학교과서의 지구 영역 비교 분석

조규성 ( Kyu Seong Cho ),양송이 ( Song I Yang ),김재영 ( Jae Young Kim ),정주상 ( Ju Sang Jeong ) 전북대학교 과학교육연구소 2012 과학과 과학교육 논문지 Vol.37 No.-

The purpose of this research is to compare and analyze the earth science domain of a next-generation science textbook with that of a 10th grade science textbook in order to study possible improvements that can be made. The results of this research are as follows: According to the results of analyzing the load of chapters on Earth out of all the chapters the ratio was 26.93% with the new-generation science textbooks which showed a high value relative to previous textbooks. And the results of studying the ratio of diagrams tables and supplementary documents regarding the total number of pages on the Earth domain the ratios of diagrams and tables have decreased for the next-generation science textbook while the ratio of supplementary data has increased. Furthermore the next-generation textbooks provide clearer photographs and more diverse terms in comparison to the existing textbooks.

호흡기바이러스감염과 알레르겐 감작에 의한 소아 천식 악화의 계절적 변동

김유진 ( Yoo Jin Kim ),양송이 ( Song-i Yang ) 대한천식알레르기학회 2021 Allergy Asthma & Respiratory Disease Vol.9 No.4

Purpose: Acute asthma exacerbations in children have seasonal variations and occur frequently in fall. Respiratory viral infections and environmental allergens are associated with asthma exacerbation. This study aimed to identify seasonal trends of asthma exac-erbation and the effects of respiratory viral infection and allergen sensitization on the seasonality of asthma exacerbation in children. Methods: Children under the age of 18 years who visited to the Emergency Department or hospitalized for acute asthma exacerba-tions from 2011 to 2019 were included. We reviewed medical records, including demographics, date of asthma exacerbation, results of respiratory virus and allergen sensitization, and they were analyzed to identify the seasonal trends of asthma exacerbation. Results: A total of 320 asthma exacerbations were included, with the highest frequency in fall. Human rhinovirus was positive in 64.7% and 60.0% in fall and spring exacerbations, respectively. House dust mite sensitization was highest in fall at 78.5%, while food sensitization was highest in spring at 76.9%. In patients who were sensitized to house dust mites or food allergens, respiratory viral infections further increased asthma exacerbation in fall and spring, respectively. Conclusion: Respiratory virus may be associated with asthma exacerbation in fall and spring. House dust mite and food sensitiza-tions may be associated with fall and spring asthma exacerbations by worsening the severity of asthma symptoms caused by respi-ratory viral infections. In childhood asthmatic patients with allergen sensitization, avoidance of sensitized allergens, prevention of viral infection, and more active treatment of viral infection may help prevent acute asthma exacerbations. (Allergy Asthma Respir Dis 2021;9:238-244)

1기 위암의 재발에 대한 임상적 고찰

백상현(Sang Hyun Baik),양송이(Song I Yang),신연명(Yeon Myeong Shin) 대한외과학회 2010 Annals of Surgical Treatment and Research(ASRT) Vol.79 No.1

Purpose: Recently, diagnosis of stage 1 gastric cancer has increased in number and prognosis is excellent when proper treatment is done. However, some patients have recurrence and their prognosis is poor. Thus, we investigated the risk factors of recurrence in stage 1 gastric cancer patients. Methods: From January 2004 to December 2008, a total of 1,241 number patients were operated on for stage 1 gastric cancer at the Department of General Surgery, Kosin University Gospel Hospital. We reviewed the characteristics of all patients retrospectively and compared them to recurred group (n=24) and non-recurred group (n=1,114). We analyzed the risk factors associated with recurrence. Results: Twenty-four patients with stage 1 gastric cancer were recurred after radical gastrectomy. Recurrence rate was 2.05%. The most common pattern of recurrence was hematogenous (41.7%), and lymphatic (20.8%), peritoneal seeding (16.7%), combined form (12.5%), and locoregional (8.3%). Five-year survival rate was 50.08% of recurrence group. Of clinicopathological factors, depth of invasion, lymph node metastasis, lymphatic involvement and tumor marker were statistically significant between recurred and other group. Conclusion: In this study, tumor marker, tumor depth, node status, lymphatic channel involvement were possible risk factors of recurrence for stage 1 gastric cancer. More intensive follow up and care is needed for those with such risk factors.