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침출 조건이 감잎차의 색 및 항산화 특성에 미치는 영향
안종화,김주혜,김춘영 한국식품저장유통학회 2023 한국식품저장유통학회지 Vol.30 No.2
This study was carried out to investigate the effect of the extraction conditions for persimmon (Diospyros kaki Thunb.) leaf tea (PLT) on its color quality and antioxidant properties. The amount of persimmon leaf (PL) powder and pH influenced the PLT’s color and antioxidant capacity. As the amount of PL powder in tea increased, lightness decreased while yellowness increased. The PLT with the highest amount of PL (10 mg/mL) exhibited the highest 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) radical scavenging activity and ferric reducing antioxidant power (FRAP). In addition, the PLT with the highest PL showed the highest total polyphenol and flavonoid contents. Subsequently, PLT was prepared using 10 mg/mL PL powder under varying pH conditions. As pH increased from 4 to 7, lightness decreased while redness and yellowness increased. Antioxidant capacity was determined using 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity and FRAP assay showed that lower pH exhibited higher antioxidant capacity. The PLT extracted under the lowest pH of 4 showed higher polyphenol and flavonoid contents than that extracted under higher pH conditions. Overall, PLT extraction using a solvent with pH 4.0 showed better antioxidant activities and higher amounts of polyphenolic compounds. Simultaneously, lesser lightness, redness, and yellowness were detected in PLT extracted under pH 4 conditions. In conclusion, to acquire a better functional health benefit in terms of antioxidant capacity, preparing PLT under pH 4 conditions is suggested.
젊은 성인에서 가와사키 병이 원인으로 추정되는 운동 중 심장 돌연사로 발현된 급성 심근 경색증 1예
안종화,민지현,박정랑,황석재,박용휘,곽충환,황진용 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1
서론: 가와사키 병은 주로 5세 미만의 영유아에서 이환되며, 5일 이상 계속되는 발열, 양측 결막의 충혈, 입술 및 입안의 변화, 부정형 발진, 사지 말단의 변화 및 경부 림프절 비대 등의 임상 증상을 보이는 급성 혈관 염증성 질환이다. 가와사키 병으로 이환된 환자의 약 15-25%에서 관상동맥류가 발생하고 있으며 이 중 거대 관상동맥류는 그 경과가 좋지 않아서 관상동맥의 폐쇄나 심한 협착을 일으키기 쉽고, 이는 허혈성심질환 및 심근경색 등을 유발하는 것으로 알려져 있다. 가와사키 병의 뚜렷한 증거 없이도 관상동맥 동맥류로 인한 심근 경색증이 발병했다는 보고가 있었지만, 젊은 성인에서 운동 중 심장 돌연사로 발현된 국내 보고는 아직까지 없어서 증례를 보고하는 바이다. 증례: 내원 12일전 입대한 19세 남자 훈련병으로 30분 정도 구보를 하고 난 직후 의식 소실과 심정지 상태로 발견되어 심폐소생술을 시행하였으며 약 45분후 정상 동빈맥으로 전환되었다. 동율동 회복 이후 심전도에서는 V1-3에서 비정상 Q파가 관찰되었으며 경흉부 심초음파검사에서 좌심실 전벽과 심실 중격의 저운동증이 관찰되었고 심장효소 검사에서는 CK-MB >300 ng/mL, Troponin-I >100 ng/mL으로 상승된 소견을 보였다. 의식 회복 이후에 관상동맥 조영술을 시행하였으며 좌전하행 관상동맥과 우측 관상동맥의 완전폐쇄, 주 관상동맥에 9×8 mm 크기의 거대 관상동맥 동맥류가 보였고 그 원위부에서 50%의 부분 협착을 보였다. 특징적인 형태의 관상동맥 동맥류 소견과 동반된 다발성 협착을 보여서 가와사키 병으로 인한 관상동맥 동맥류로 진단하였고 관상동맥 우회로 이식술을 시행하였다. 현재 흉통이나 특별한 수술적인 합병증 없이 외래 경과관찰 중이다.
안종화,고진신,박정랑,박미정,민지현,조상영,이은주,김완철,김계환 한국심초음파학회 2012 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.20 No.2
Isolated left ventricular noncompaction (LVNC) is a rare disorder caused by embryonic arrest of compaction. LVNC is sometimes associated with other congenital cardiac disorders; however, there have been few reports of its coexistence with a left ventricular aneurysm. A 40-year-old woman was admitted to our hospital for renal infarction. She had a history of embolic cerebral infarction 10 years ago. Transthoracic echocardiography showed prominent trabeculae and deep intertrabecular recesses which are filled with blood from the left ventricular (LV) cavity. A thrombus in the akinetic apical wall was confirmed by contrast echocardiography. Using cardiac computed tomography and magnetic resonance imaging, we rejected a possible diagnosis of suspicion of coronary artery disease. She was diagnosed LVNC with a thrombus in apical aneurysm. Here, we report the first patient in Korea known to have LVNC accompanying LV congenital aneurysm presenting with recurrent embolism.
안종화,김미화,송의연,전민지,김태용,류진숙,김원배,송영기,한지민,김원구 대한내분비학회 2020 Endocrinology and metabolism Vol.35 No.4
Background: The clinical outcomes of delayed radioiodine remnant ablation (RRA) therapy in patients with low-risk papillary thyroid carcinoma (PTC) are unclear. We aimed to evaluate the clinical impact of the interval between total thyroidectomy (TT) and RRA therapy in patients with low-risk PTC. Methods: We included 526 patients who underwent TT and RRA for low-risk PTC with a primary tumor size of >1 cm between2000 and 2012. Patients were divided into the early (<90 days) and the delayed (≥90 days) RRA groups based on the interval between TT and RRA. The results of diagnostic whole-body scan (DxWBS), ongoing risk stratification (ORS; response to therapy), and disease-free survival (DFS) were evaluated before and after propensity score matching (PSM). Results: Among the 526 patients, 75 (14.3%) patients underwent delayed RRA; they had more cervical lymph node metastasis and received a higher RRA dose than those who underwent early RRA. The median follow-up period was 9.1 years after initial therapy, and the structural recurrence rate was 1.9%. In DxWBS, 60 patients had focal iodine uptake limited in operative bed, with no significant difference between groups. According to ORS, 78%, 20%, 1%, and 1% patients were classified into excellent, indeterminate, biochemical incomplete, and structural incomplete response groups, respectively. There was no significant difference in ORS or DFS between groups before and after PSM. Conclusion: The timing of the first RRA had no clinical impact in patients with low-risk PTC. Thus, the clinical decision for RRA can be determined >3 months after TT considering other prognostic factors.
안종화,전민지,송의연,김태용,김원배,송영기,김원구 대한내분비학회 2020 Endocrinology and metabolism Vol.35 No.1
Background: Recently, there has been some controversy regarding the role of radioactive iodine (RAI) ablation in the treatment oflow-risk differentiated thyroid carcinoma (DTC), especially papillary thyroid microcarcinoma (PTMC). This study aimed to compare quality of life (QoL) parameters between patients with PTMC who underwent total thyroidectomy (TT) alone and those whounderwent TT with RAI ablation. Methods: In this cross-sectional study, patients with PTMC who underwent TT with/without RAI remnant ablation were prospectively enrolled between June 2016 and October 2017. All patients completed three questionnaires: the 12-item short-form health survey (SF-12), thyroid cancer-specific quality of life (THYCA-QoL) questionnaire, and fear of progression (FoP) questionnaire. Results: The TT and TT with RAI groups comprised 107 and 182 patients, respectively. The TT with RAI group had significantlylower serum thyrotropin (TSH) levels than the TT group. However, after matching for TSH levels between the groups (n=100 in bothgroups), there were no significant differences in baseline characteristics. According to the SF-12, the score for general health was significantly lower in the TT with RAI group than in the TT group (P=0.047). The THYCA-QoL also showed a significant difference inthe “felt chilly” score between groups (P=0.023). No significant differences in FoP scores were observed between the groups. Conclusion: Patients with PTMC who underwent TT with RAI ablation experienced more health-related problems than those managed with TT alone. These findings support the idea that RAI ablation should be carefully considered in patients with low-risk DTCs.