강광에 의한 인삼 잎의 엽록체 미세구조 및 틸라코이드 막 (膜) 단백질의 변화

안정숙(Joung Sook Ahn),조병구(Byung Goo Cho),박훈(Hoon Park),김우갑(Woo Kap Kim) 한국식물학회 1994 Journal of Plant Biology Vol.37 No.3

Ultrastructural changes in Panax ginseng C. A. Meyer mesophyll chloroplasts and variation of thylakoid membrane proteins in responce to the light intensity were studied in leaves of two-y-old plants exposed to two different light intensities under conditions. The leaves were allowed to function for three months after emergence under two contrasting light conditions. The ginseng chloroplasts of 5% light were filled with highly stacked grana of condensely arrayed thylakoids, so that the stroma space was hardly observed. In contrast, chloroplasts from leaves at 100% sunlight had fewer thylakoid membranes and smaller grana stacks. The number of osmiophilic globules increased. Total Chl content and Chl b content were lower at 100% sunlight than 5% sunlight. The thylakoid membrane proteins in the leaves grown at 100% sunlight showed lower CPIa, LHCⅡ^* and CP29 than those with 5% sunlight. This effect was most obvious for LHCⅡ^*. Polypeptides showed major bands at 90, 64, 29-30, 22 and 14 kD, and minor bands at 59, 58, 54, 52, 49, 46, 44, 35, 23, 21 and 18-19 kD. All these bands were lower in intensity in the leaves exposed to 100% sunliht. Moreover, the bands at 58-59, 46-47 and 23 kD disappeared.

전반적 발달장애의 한국형 치료 권고안

안정숙(Joung-Sook Ahn),구영진(Young-Jin Koo),손정우(Jung-Woo Son),유한익(Hanik K. Yoo),유희정(Hee-Jeong Yoo),정운선(Un-Sun Chung),조인희(In-Hee Cho),안동현(Dong-Hyun Ahn) 대한소아청소년정신의학회 2007 소아청소년정신의학 Vol.18 No.2

모성음주와 여자청소년의 정신병리

안정숙(Joung-Sook Ahn),장형민(Hyung-Min Jang),김민혁(Min-Hyuk Kim),김혜지(Hae-Ji Kim),신정호(Jongho Shin) 한국중독정신의학회 2008 중독정신의학 Vol.12 No.2

Once females drink alcohol, they are more apt to become alcohol-dependent than males and respond poorly to intervention. Therefore, gender-specific approaches to drinking prevention and treatment are clearly needed. The aims of this article are to investigate the relationship between maternal problem-drinking, substance use, and psychopathology of female adolescents and to compare the maternal problem-drinking group with paternal, parental problem-drinking groups and controls. Ninth grade (N= 420) and 11th grade (N=353) females were divided into maternal drinking groups and controls with the score of Children of Alcoholics Screening Test (CAST) for mother. Two groups were compared for their environmental and substance-related variables, and psychopathology was measured with the Strengths and Difficulties Questionnaire (SDQ-SR). Then the subjects were divided into four groups with scores of CAST for mother and father separately and compared the same way. Female adolescents with drinking mothers showed a younger age of first drink-ing, absence of family norms for TV watching, a lot of smoking friends, problem-drinking, and higher scores in the ‘hyperactivity-inattention’ and ‘total difficulties’ sections of the SDQ-SR. ‘Parental drinking’ was the worst condition for adolescent fe-males, followed by ‘maternal drinking only’ and ‘paternal drink-ing only’, successively. However, emotional symptoms were more prevalent in cases of ‘maternal drinking only’. We suggested that the dyad of problem-drinking mother and adolescent female should be a focus of family intervention programs against drinking.

강광에 (强光) 의한 인삼잎 엽록체의 호 (好) 오스뮴성 소구체의 (小球體) 형성에 관한 미세구조적 연구

안정숙(Joung Sook Ahn),이창섭(Chang Seop Lee),박훈(Hoon Park),김우갑(Woo Kap Kim) 한국식물학회 1995 Journal of Plant Biology Vol.38 No.3

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강점.난점설문지의(SDQ-Kr)의 임상 활용도

신정수,안정숙,최영훈,김혜지,Shin, Jong-Soo,Ahn, Joung-Sook,Choi, Young-Hun,Kim, Hae-Ji 한국정신신체의학회 2009 정신신체의학 Vol.17 No.2

연구목적 : 소아정신과의사의 진료가 개설되지 않은 일반정신과 외래 및 소아과 외래에서 아동의 정신과적 장애를 선별 진단하는 목적으로 한국어판 강점 난점설문지(Korean version of Strengths and Difficulties Questionnaire : SDQ-Kr)가 활용될 수 있는지 알아보기 위하여 아동 정신병리의 표준진단도구인 아동행동조사표 (Korean version of Childhood Behavior Checklist : K-CBCL)와 비교 분석하였다. 방법 : 부모용 SDQ-Kr과 K-CBCL을 정신과 외래아동 313명, 정신과로 진료의뢰된 소아과 자문아동 91명, 소아과 외래아동(대조군) 93명의 부모에게 시행하였다. 이들은 모두 4~11세였고, 정신과아동은 ADHD, 정서장애, 또는 품행장애 중 하나로 진단되었다. SDQ-Kr과 K-CBCL의 대응되는 소척도 평균점수에서 세 집단간 차이가 있는지 성별을 나누어 비교하였다. 또한 두 설문지의 대응하는 소척도 점수들간 상관계수를 산출함으로써 SDQ-Kr의 구인타당도를 조사하였다. 정신과아동과 소아과아동에 대한 두 설문지의 집단 판별력을 비교하기 위해 AUC를 산출하고, 또한 정신과아동에 대한 두 설문지의 진단예측도를 비교하였다. 결과 : SDQ-Kr과 K-CBCL의 소척도 모두에서 정신과아동이 가장 높은 점수를 보였고 소아과 자문아동, 소아과 대조아동 순서로 나타났다. 두 설문지의 대응되는 소척도들은 유의하게 상관되었으며, 모두 정신과아동과 소아과아동의 집단 판별력이 우수한 것으로 나타났으나 SDQ-Kr이 더 나은 결과를 보였다. 정신과아동의 진단 예측도에서도 SDQ-Kr이 높은 예측력을 나타냈다. 결론 : 이 연구 결과는 SDQ-Kr이 소아과 외래에서 정신과적 진료가 필요한 아동을 선별하고, 일반정신과에서 소아정신과적 진단을 내리는데 일차적인 진단도구로 활용될 수 있음을 시사한다. Objectives : This study aimed to evaluate the clinical usefulness of Korean version of Strengths and Difficulties Questionnaire(SDQ-Kr) by comparing with Korean version of Childhood Behavior Checklist (K-CBCL). Methods : The parent version of SDQ-Kr and K-CBCL were administered to parents of 313 children in psychiatric clinic, 91 children referred for psychiatric consultation from pediatric clinic and 93 control children in pediatric clinic. All children aged 4-11 years old. Children in psychiatric clinic were diagnosed with one of followings;ADHD, emotional disorders and oppositional/conduct disorder. Mean scores were compared among three groups by gender. Coefficients were calculated for corresponding problem scales and total scores of both questionnaires. ROC analysis was performed for discriminant validity to distinguish psychiatry and pediatrics samples, and also to distinguish diagnostic groups of psychiatry sample. Results : The psychiatry sample showed highest means of problem scales and total scores, followed by consultation and control sample of pediatrics. SDQ-Kr and K-CBCL were significantly correlated, and equally able to distinguish those samples with SDQ-Kr showing better results. Within the psychiatry sample, SDQ-Kr had higher predictive power for all diagnostic groups. Conclusion : This study supports clinical usefulness of SDQ-Kr. We suggest that SDQ-Kr could be used not only as a diagnostic tool for children in psychiatric clinic but also as an effective and efficient screening instrument for children in need for psychiatric evaluation in pediatric clinic.

진폐증 입원환자에서 저산소혈증과 정신병리의 연관성

박새한,안정숙,최영훈,진세영,박기창,Park, Sae-Han,Ahn, Joung-Sook,Choi, Young-Hoon,Jin, Sae-Young,Park, Ki-Chang 대한불안의학회 2006 대한불안의학회지 Vol.2 No.2

Objective : We examined the putative association between the psychological symptoms and hypoxemia in hospitalized pneumoconiosis patients. Methods : One hundred and nine hospitalized pneumoconiosis patients were divided into two groups according to their level of hypoxemia (PaO2); hypoxemic group consisted of 47 patients with PaO2 lower than 80 mmHg, and comparative group consisted of 62 patients with higher than 80 mmHg. All of them were interviewed with the Hamilton Depression Rating Scale (HAM-D), and completed the Symptom Checklist-90items-Revised (SCL-90-R) and the State-Trait Anxiety Inventory (STAI). The medical data (PaO2, PaCO2, Hb, and Hct), number of hospital days and socio-demographic data as well as scores of the three psychological measurements were compared between the two groups. Results : Hypoxemic patients with lower PaO2 showed higher scores in the HAM-D (p=0.01) and stateanxiety subscale of the STAI (p<0.05). Values of hemoglobin and hematocrit were negatively correlated with levels of trait-anxiety (p<0.05). Thirty patients (27.5%) of total subjects suffered from depression (higher than 18 in the HAM-D), and 46.8% of hypoxemic patients were depressed, whereas 12.9% of comparative group patients were depressed (p=0.01). Conclusion : These results suggest that depression and anxiety might be associated with the hypoxemic mechanism in pneumoconiosis patients.

내재화장애 청소년의 평가에서 자기보고용 강점난점척도와 MMPI-A의 상호보완성 : 예비연구

신교정,안정숙,임지영,이진희,Shin, Kyo Jung,Ahn, Joung Sook,Lim, Jee Young,Lee, Jin Hee 한국정신신체의학회 2018 정신신체의학 Vol.26 No.1

연구목적 청소년의 내재화장애는 겉으로 표출되지 않으므로 의료서비스 이용을 결정하는 부모나 교사가 그 증상을 인지하기 어렵고 청소년 자신도 정신의학적 개입을 기피하는 경향이 있어 치료 기회를 놓치기 쉽다. 본 연구는 내재화장애 청소년의 정신병리를 자기보고식 강점난점설문지(SDQ-SR)와 MMPI-A를 사용하여 조사하고, 이 두 검사도구가 내재화장애를 진단평가하는데 상호보완성이 있는지를 규명하고자 시행되었다. 방 법 청소년 외래환자(13~17세) 91명을 임상진단에 따라 두 집단으로 나누었으며, 내재화장애집단 44명과 그 외 임상진단을 가진 비교집단 47명이 완성한 SDQ-SR과 MMPI-A 자료가 내재화장애 진단을 어느 정도로 예측할 수 있는지 분석하였다. 결 과 로지스틱 회귀분석 결과, SDQ-SR의 정서증상 소척도가 1점 상승할 때 내재화장애의 진단예측력은 2.27배 증가하였다. 또한 ROC 곡선분석에서, SDQ-SR 정서장애 소척도의 절단점수를 4점으로 했을 때 내재화장애진단의 민감도와 특이도가 각각 88.94와 78.72로 나타났다. MMPI-A에서는 A-anx 절단점수가 56이었을 때 민감도와 특이도는 각각 77.27과 74.47이었다. 그러나 이 두 검사도구 소척도들의 어떠한 조합도 SDQ-SR 정서증상 소척도가 갖는 진단예측력을 더 높이지는 못했다. 결 론 본 연구에서는 청소년의 내재화장애를 진단하는데 SDQ-SR의 정서증상과 MMPI-A의 A-anx, A-aln, A 및 INTR가 중요한 소척도임을 알 수 있었으나 이를 확정하기 위해서는 정상대조군을 포함한 대규모의 연구가 필요하다. Objectives : The aims of this study were to investigate the psychopathology in adolescents with internalizing disorder using the self-report version of Strengths and Difficulties Questionnaire (SDQ-SR) and the Minnesota Multiphasic Personality Inventory for adolescents (MMPI-A), and to explore the complementarity between these two inventories for diagnostic assessment. Methods : Ninety-one patients aged 13-17 were divided into two groups by clinical diagnosis, 44 with internalizing disorder and 47 comparison group with other disorders. The data of SDQ-SR and MMPI-A completed by them were analyzed for the ability to predict internalizing disorder. Results : The logistic regression analysis revealed that diagnostic predictability increased by 2.27 times with every 1 point of SDQ-SR emotional symptom score increment. Comparison of ROC curves for internalizing disorders showed that the SE and SP of SDQ-SR emotional symptom with score over 4 was 88.94 and 78.72, respectively. For A-anx of MMPI-A with score over 56, SE and SP was 77.27 and 74.47, respectively. However, combination of these scales could not enhance the predictability of diagnostic classification more than that of SDQ-SR emotional symptom alone. Conclusions : Emotional symptom scale of SDQ-SR and A-anx, A-aln, A and INTR of MMPI-A should be important subscales for diagnosing the internalizing disorder of adolescents, however, which needs to be examined further with a larger sample size including normal control group.

섬망의 운동성 아형에 따른 증상과 임상적 특징

백수현,민성호,안정숙,박기창,김민혁,Paik, Soo-Hyun,Min, Seongho,Ahn, Joung-Sook,Park, Ki-Chang,Kim, Min-Hyuk 한국정신신체의학회 2015 정신신체의학 Vol.23 No.2

연구목적 본 연구에서는 섬망의 운동성 아형 간의 증상과 임상적 특징의 차이를 알아보고자 한다. 방 법 일 대학병원에 입원하여 정신건강의학과에 협진의뢰된 환자 중 일반신체질환에 의한 섬망으로 진단된 256명을 대상으로 후향적으로 의무기록을 검토하였다. 운동성 아형은 Lipowski의 분류 체계에 따라 과활동형, 저활동형 및 혼재형으로 분류하였으며, 섬망평가척도를 이용하여 증상을 평가하였다. 결 과 과활동형이 130명(50.8%), 혼재형은 118명(46.1%), 저활동형은 118명(3.1%)이었다. 과활동형은 평균연령이 혼재형 환자보다 적었으며(p=0.022), 섬망을 치료하기 위해 항정신병 약물을 더 자주 사용하였다(p<0.001). 과활동형은 인지적 및 비인지적 증상 점수가 타 아형에 비해 높았다(각각 p=0.002, p<0.001). 결 론 섬망의 운동성 아형에 따라 증상 및 임상적 특징에서 차이가 있었다. 운동성 아형에 따라 진단 및 치료적 접근 방법을 달리하여, 특정 아형의 섬망 진단이 간과되거나 치료가 지연되지 않도록 관심을 가질 필요가 있다. Objectives : To investigate clinical and symptomatic differences among motoric subtypes of delirium. Methods : A total of 256 patients referred to psychiatric consultation services for delirium due to general medical condition were assessed retrospectively. Motoric subtypes were determined according to Lipowski's criteria for hyperactive, hypoactive and mixed subtypes. All patients were evaluated according to Delirium Rating Scale-Revised-98(DRS-98-R) by trained psychiatrists to obtain symptomatic profiles of delirium. Results : Hyperactive subtype were 50.8%(n=130), mixed 46.1%(n=118) and hypoactive 3.1%(n=8). Hyperactive patients were younger than mixed subtype($69.62{\pm}13.976$ vs. $73.97{\pm}11.569$, p=0.022) and received antipsychotics to manage symptoms of delirium more frequently(83.8% vs. 57.6%, p<0.001). Hyperactive patients had higher DRS-R-98 scores on both noncognitive($7.14{\pm}3.543$ for hyperactive, $5.62{\pm}3.279$ for mixed subtype) and cognitive subscales($10.00{\pm}3.574$ for hyperactive, $6.38{\pm}2.875$ for hypoactive, $7.43{\pm}3.771$ for mixed subtype, p<0.001). Conclusions : We demonstrated that clinical and symptomatic profiles were different across motoric subtypes in delirium. Diagnostic and therapeutic approach should be made differently according to motoric subtypes of delirium and special attention is needed not to underestimate or delay treatment in specific motoric subtype of delirium.

알코올 사용이 자살시도의 심각성과 치명도에 미치는 영향-성별 차이를 중심으로

이진희,민성호,안정숙,박기창,김민혁,김흥규,Lee, Jinhee,Min, Seongho,Ahn, Joung-Sook,Park, Ki-Chang,Kim, Min-Hyuk,Kim, Heungkyu 한국정신신체의학회 2016 정신신체의학 Vol.24 No.2

Objectives : The aim of this study was to clarify the role of alcohol use disorders and acute alcohol consumption in suicide attempts by gender. Methods : Data of 1,152 suicide attempters(487 males and 742 females) who had visited an emergency center was gathered. Suicide attempts were categorized into three groups according to alcohol use: an alcohol use disorder group(AUD), an acute alcohol use group(AAU), and a no-alcohol use group(NAU). The intent and lethality of suicide attempts were evaluated by Suicidal Intents Scale and Risk-Rescue Rating Scale. Results : For Suicidal Intents Scale score, the male AUD group revealed a significantly lower mean score than the male AAU one. However, there were no statistically significant differences for female subjects across subgroups. With regard to the Risk-Rescue Rating Scale score, there were no significant differences for males, while the AUD group showed both the lowest highest rescue scores and lowest risk-rescue scores within female groups. Conclusions : AUD in females was more likely regarding impulsive suicide attempts with high rescue chances. Consuming alcohol might have different effect on suicide attempts by gender and our study shows that alcohol use is an important risk factor according to gender, particularly with regard to female suicide attempts. 연구목적 본 연구는 자살시도에서 알코올이 자살시도의 심각성 및 치명도에 미치는 영향이 성별에 따라 차이가 있는 지 여부를 확인하고자 하였다. 방 법 총 1,152명의 자살시도자(남성 487명, 여성 742명)를 분석 대상으로 하였으며, 음주 양상에 따라 알코올사용 장애군, 급성알코올사용군, 비알코올사용군으로 나누었다. 자살시도의 심각성과 치명도는 자살의도척도및 위험-구조평가척도로 평가하였다. 결 과 남성에서는 급성알코올사용군에 비해 알코올사용장애군에서 자살의도척도의 총점이 유의하게 낮았지만, 여성에서는 각 군 사이에 유의한 차이가 없었다. 위험-구조평가척도에서 남성은 각 군간에 차이가 없었으나, 여성은 알코올사용장애군에서 가장 높은 구조도와 가장 낮은 위험도 점수를 보였다. 결 론 알코올사용장애가 있는 여성 자살시도자는 구조가 쉬운 상황에서 충동적인 자살 시도를 하는 경향이 있다면, 남성은 알코올 사용장애 환자보다 급성 알코올 중독상태일 때 자살의도가 더 강했다. 자살시도자의 알코올의 사용이 성별에 따라 다른 영향을 미칠 수 있으며, 특히 여성에서 중요한 위험 요인임을 시사하고 있다.

임상에서 부모-교사 보고의 일치

김흥규(Heung Kyu Kim),안정숙(Joung Sook Ahn),김민혁(Min Hyock Kim) 대한소아청소년정신의학회 2012 소아청소년정신의학 Vol.23 No.3

Objectives:The aims of this study were to examine agreement between parent and teacher ratings of the Korean version Strengths and Difficulties Questionnaire (SDQ-Kr) for the children’s psychopathology and to determine whether it is effective in diagnostics as the Korean version of Childhood Behavior Checklist (K-CBCL). Methods:SDQ-Kr and K-CBCL were completed by parents and teachers of 165 children aged 6-12 years. The clinical diagnosis was made by a child and adolescent psychiatrist who did not have knowledge of the outcome. Spearman’s correlations were computed for associations between parents’ and teachers’ ratings on a subscale level. The Mann-Whitney U test was performed for the influence of child’s age and sex on the results. Finally, AUC values were calculated for the diagnostic capacity and the difference between informants was tested using the z test. Results:High correlations were observed between parents’ and teachers’ SDQ-Kr on every scale. Parents were more sensitive to emotional symptoms of girls, while teachers appeared to be more responsive to externalized symptoms of boys, inattention-hyperactivity of young children, and emotional symptoms of seniors. Parents’ SDQ-Kr demonstrated the highest prediction of attention-deficit hyperactivity disorder. Conclusion:Teachers’ SDQ-Kr can be used in identification of child psychopathology when parents are absent or when their reliability is considered low.