Prevalence of Olfactory or Gustatory Dysfunction in COVID-19 Patients: An Analysis Based on Korean Nationwide Claims Data

안은진,민현진 대한이비인후과학회 2021 Clinical and Experimental Otorhinolaryngology Vol.14 No.4

Introduction to systematic review and meta-analysis

안은진,강현 대한마취통증의학회 2018 Korean Journal of Anesthesiology Vol.71 No.2

Systematic reviews and meta-analyses present results by combining and analyzing data from different studies conducted on similar research topics. In recent years, systematic reviews and meta-analyses have been actively performed in various fields including anesthesiology. These research methods are powerful tools that can overcome the difficulties in performing large-scale randomized controlled trials. However, the inclusion of studies with any biases or improperly assessed quality of evidence in systematic reviews and meta-analyses could yield misleading results. Therefore, various guidelines have been suggested for conducting systematic reviews and meta-analyses to help standardize them and improve their quality. Nonetheless, accepting the conclusions of many studies without understanding the meta-analysis can be dangerous. Therefore, this article provides an easy introduction to clinicians on performing and understanding meta-analyses.

Assessment of P values for demographic data in randomized controlled trials

안은진,김종해,김태균,박재홍,이동규,이상석,인준용,강현 대한마취통증의학회 2019 Korean Journal of Anesthesiology Vol.72 No.2

monly reported in table 1 of the article for the purpose of emphasizing the lack of differences between or among groups. As such, the authors intend to demonstrate that statistically insignificant P values in the demographic data confirm that group randomization was adequately performed. However, statistically insignificant P values do not necessarily reflect successful randomization. It is more important to rigorously establish a plan for statistical analysis during the design and planning stage of the study, and to consider whether any of the variables included in the demographic data could potentially affect the research results. If a researcher rigorously designed and planned a study, and performed it accordingly, the conclusions drawn from the results would not be influenced by P values, regardless of whether they were significant. In contrasts, imbalanced variables could affect the results after variance controlling, even though whole study process are well planned and executed. In this situation, the researcher can provide results with both the initial method and a second stage of analysis including such variables. Otherwise, for brief conclusions, it would be pointless to report P values in a table simply listing baseline data of the participants.

한국약사법에 근거한 약사보조원의 교육과 임상약제서비스 확대

안은진,황인경,강혜경 한국병원약사회 2012 病院藥師會誌 Vol.29 No.1

Hospital pharmacy practices have shifted from pharmacy outputs to patient outcomes. Unfortunately, some Korean hospital pharmacists lack the opportunities to provide patients with quality clinical pharmacy services and maintain their professional development because of a heavy workload in drug distribution and maintenance of inventory. Gyeongsang National University Hospital (GNUH) pharmacy department has changed the framework of practice to focus on quality clinical pharmacy services. An operational manual for Pharmacy Technician (PT) was developed in February 2009, which defines PT duties. Twelve pharmacists and twelve PTs in the GNUH pharmacy department were included in this practice. One year into the program, pharmacists’activities were evaluated by their clinical performance and surveys. Pharmacists and PT clearly recognized their duties involving professional judgement under the law. Pharmacists’work-hours for drug distribution and maintenance of inventory were reduced allowing them to perform clinical pharmacy services such as nutrition support consultation, anticoagulation service, IV admixture, therapeutic drug monitoring, drug information, and patient counselling. According to survey results, pharmacists enhanced their clinical capabilities by 83% and job motivation by 100%. PT clearly recognized their duties involving removing drugs from stock, placing products into containers, affixing labels to envelopes, and maintaining inventory by 96%. The operational manual allowing PT to perform non-discretionary tasks helps pharmacists to improve their focus on providing quality clinical pharmacy services.

Concepts and emerging issues of network meta-analysis

안은진,강현 대한마취통증의학회 2021 Korean Journal of Anesthesiology Vol.74 No.5

Most diseases have more than two interventions or treatment methods, and the application of network meta-analysis (NMA) studies to compare and evaluate the superiority of each intervention or treatment method is increasing. Understanding the concepts and processes of systematic reviews and meta-analyses is essential to understanding NMA. As with systematic reviews and meta-analyses, NMA involves specifying the topic, searching for and selecting all related studies, and extracting data from the selected studies. To evaluate the effects of each treatment, NMA compares and analyzes three or more interventions or treatment methods using both direct and indirect evidence. There is a possibility of several biases when performing NMA. Therefore, key assumptions like similarity, transitivity, and consistency should be satisfied when performing NMA. Among these key assumptions, consistency can be evaluated and quantified by statistical tests. This review aims to introduce the concepts of NMA, analysis methods, and interpretation and presentation of the results of NMA. It also briefly introduces the emerging issues in NMA, including methods for evaluation of consistency.

Phrenic nerve palsy after internal jugular venous catheter placement

안은진,백종화,신화용,강현,정용훈 대한마취통증의학회 2012 Korean Journal of Anesthesiology Vol.63 No.2

건설사업 참여주체(발주자, CMr, 설계자, 시공자) 관점에서 건설사업관리 성과측정에 관한 연구

안은진,유병기,이윤선,김재준,Ahn, Eun-Jin,Yoo, Byeong-Gi,Lee, Yoon-Sun,Kim, Jae-Jun 한국건설관리학회 2008 건설관리 : 한국건설관리학회 학회지 Vol.9 No.3

건설업은 일반 제조업의 생산과정과는 달리 다양한 참여주체들이 모여 프로젝트 성공이란 하나의 목표아래 정보를 공유하며 업무를 진행하므로 한 프로젝트마다 일시적인 팀워크가 형성된다. 다양한 참여주체들은 건설공사의 단계별 역할이 다르며, 업무 및 이에 따른 이해관계 역시 복잡하게 얽혀있다. 건설프로젝트의 효율적인 관리와 경영의 최적화를 위하여 CM제도가 도입이 되었다. 따라서 CM제도의 성공을 위해서는 주요 참여주체(발주자, CMr, 설계자, 시공자)의 협력관계가 요구된다. CM제도가 도입된 이래 성공적으로 사업을 수행하기 위한 일환으로 CM성과측정에 대한 많은 노력이 있었으나, 발주자의 입장에서만 바라본 항목으로 측정되고 있다. 이에 본 연구에서는 CM성과를 객관적으로 측정하기 위해서 건설프로젝트의 주요 참여주체인 발주자, CMr, 설계자, 시공자의 균형적인 시각을 바탕으로 한 성과측정 항목의 필요성을 제기 하고자 한다. 건설프로젝트의 주요 참여주체인 4자(발주자, CMr, 설계자, 시공자)의 협력관계를 살펴본 뒤 각 주체에 따라 성과항목에 대한 인식차이가 있다는 것을 검증하였다. The production process of construction industry is different from thing of the general manufacturing, likewise various participants make temporary teamwork for success of the project through sharing of information. But, the each role of participants is Individually changed to step in construction process stage and moreover it has complicated, entangled interests. The CM(so it called Construction Management as an abbreviation word) system was inducted for the effective management and operation of construction project. The key of the CM success depends on the cooperative relationship relation to major participants. There are lots of studies and efforts for the performance measures of the CM, however existing performance index is only measured as the viewpoint of project owner. Therefore it needs to make up for balanced view through combination of the four-way view of participants. In this study, we should search for cooperative relationship of project participants, and then we should suggest to define the difference of project in their viewpoints.

건설사업 참여주체(발주자, CMr, 설계자, 시공자) 관점에서 건설사업관리 성과측정에 관한 연구

안은진,김재준,유병기,이윤선 한국건설관리학회 2008 한국건설관리학회 논문집 Vol.9 No.3

The production process of construction industry is different from thing of the general manufacturing, likewise various participants make temporary teamwork for success of the project through sharing of information. But, the each role of participants is individually changed to step in construction process stage and moreover it has complicated, entangled interests. The CM(so it called Construction Management as an abbreviation word) system was inducted for the effective management and operation of construction project. The key of the CM success depends on the cooperative relationship relation to major participants. There are lots of studies and efforts for the performance measures of the CM, however existing performance index is only measured as the viewpoint of project owner. Therefore it needs to make up for balanced view through combination of the four-way view of participants. In this study, we should search for cooperative relationship of project participants, and then we should suggest to define the difference of project in their viewpoints.

Identification of possibility of Glycyrrhiza uralensis as an allergen by protein analysis

안은진,김강훈,이인승,박지영,김유미,정우상,권대호,장형진 한국바이오칩학회 2018 BioChip Journal Vol.12 No.1

Various secondary metabolites derived from plants are useful for humans to preserve their health. For this reason, medical herbs have been consumed universally without deep research about the dangerousness of these substance. However, they can produce unexpected adverse reactions in humans. Among these side effects, allergic reactions involving human immunoglobulin E can occur due to antimicrobial or antibacterial substances in plants. Glycyrrhiza uralensis has been prescribed for the treatment of numerous diseases given its multiple types of pharmaceutical efficacy, including its antimicrobial and antibacterial activities. Therefore, we researched whether Glycyrrhiza uralensis, which has antimicrobial ability, can cause allergic reaction in humans. To test the hypothesis devised here, we conducted proteomic level experiments. We utilized SDS-PAGE using a protein extract of Glycyrrhiza uralensis, with Coomassie blue staining to confirm the protein pattern and western blotting to identify Human IgE binding proteins in Glycyrrhiza uralensis. Among the many candidate sera, these methods detected three positive sera. Moreover, an identified protein section with reactivity associated with Human IgE was analyzed by LC-MS/ MS. Our experimental data provide a basis for testing the possibility of Glycyrrhiza uralensis as an allergen by identifying the reactivity between human Immunoglobulin E and proteins of Glycyrrhiza uralensis.

Introducing big data analysis using data from National Health Insurance Service

안은진 대한마취통증의학회 2020 Korean Journal of Anesthesiology Vol.73 No.3

Among the different providers of health care big data in Korea, the data provided by the National Health Insurance Database include the medical information of all the citizens who have subscribed to medical insurance. As such, the data have representativeness and completeness. In order to conduct research using these National Health Insurance Database data, it is necessary to understand the characteristics of the claim data to avoid various biases, and to control confounding variables when making various operational definitions in the planning stage of the research. Moreover, without a proper understanding of the big data, it is possible during the analysis and data interpretation to mistakenly interpret the correlation between variables as a causal relationship. Therefore, in order to help advanced medical science, which reflects the medical reality such as medical expenses and number of hospital visits by clearly recognizing and analyzing the characteristics and limitations of health care big data, this author has dealt with the use of data sharing services provided by the National Health Insurance Database.