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진성 성조숙증 환아에서 Gonadotropin-Releasing Hormone Agonists의 치료가 최종 성인 신장에 미치는 영향 및 이와 관련된 인자들에 관한 연구
안성연,류재호,신충호,양세원 대한소아청소년과학회 2004 Clinical and Experimental Pediatrics (CEP) Vol.47 No.6
Purpose:The aim of this study was to evaluate the effects of treatment with GnRH agonists on final height(FH) and the influencing factors on height gains. Methods:Twenty-five girls and five boys with true precocious puberty, who were treated with GnRH agonists for more than one year and had attained final height, were evaluated retrospectively. We analysed auxological parameters at diagnosis, at the end of treatment, and at the attainment of final height, and calculated height gains. Results:FH SDS was significantly higher than predicted adult height(PAH) SDS at diagnosis (-0.91±1.32, vs. -1.80±1.39, P<0.01). A group of initial PAH below the range of target height(TH) attained significantly more height gains and increments of height SDS than those in a group of initial PAH within the range of TH(8.37±2.56 cm vs. 1.38±6.42 cm, P<0.01; 1.30±0.74 vs. 0.35±1.28, P<0.05). Height gains were positively correlated with bone age advancement at diagnosis and height velocity during the first year of treatment(r=0.528, P<0.01 and r=0.454, P<0.05), while height gains were negatively correlated with initial PAH and bone age increments during treatment(r=-0.485, P< 0.05 and r=-0.613, P<0.01). Conclusion:This study suggests that GnRH agonist therapy for children with true precocious puberty improves the final height, and height gains are positively affected by bone age advancement at diagnosis and growth velocity during the first year of therapy, and negatively affected by PAH at diagnosis and degree of bone maturation during therapy. 목 적 : 성인 신장에 도달한 진성 성조숙증 환아에서 성장 변화와 성인 신장 획득에 영향을 미치는 관련 인자에 대하여 살펴보고자 하였다.방 법 : 1989년부터 2000년까지 성조숙증을 주소로 내원한 환아들 중 진성 성조숙증으로 진단되어 GnRHa를 1년 이상 사용하였으며 최종 성인 신장에 도달한 환자 30명을 대상으로 하여, GnRHa 치료 동안과 이후에 최종 성인 신장에 이르기까지 성장변화 및 이에 영향을 끼치는 인자들에 대하여 후향적인 조사를 시행하였다.
흉벽의 림프관종증에 대한 방사선 치료 후 조절된 유미흉 1례
안성연,최봉석,박희주,김영대,권병현 대한 소아알레르기 호흡기학회 2002 Allergy Asthma & Respiratory Disease Vol.12 No.1
A Case of Chylothorax Controlled by Radiotherapy onLymphangiomatosis of ThoraxSung Ryon Ahn, M.D., Bong Seok Choi, M.D., Hee Ju Park, M.D.Young Dae Kim, M.D.* and Byong Hyon Kwon, M.D.† 저자들은 좌측 액와부와 옆구리 부위의 적색 판상 반점을 주소로 내원하여 흉곽을 전부 차지하고 있는 유미흉과 흉벽의 림프관종증을 발견하고 흉강경을 통한 흉막제거술 및 흉막유착술을 시행하였으나 호전이 없어 2주간의 10회에 걸친 방사선 치료 후 유미흉이 조절된 10세 여아를 경험하였기에 보고하는 바이다.
우리나라 증권시장에서 주가수익률의 이상현상에 관한 연구 - 1 월효과를 중심으로 -
안성연,조정원 한국기업경영학회 1997 기업경영연구 Vol.4 No.1
Recently, many market anomalies such as the size effect, the P/E effect and the January effect have been reported in the stock market. The January effect represents a strong evidence against the efficient market hypothesis. If investors are rational and the market is efficient, there can be no reason that returns in some specific months are higher than returns in other months. Nevertheless, many empirical evidences on stock return anomalies have been found in major stock markets in the world. Using Korean stock market data, Kim(1990), Jang(1991), Koh and Rho(1993) reported the January effect However, these reports have certain limitations due to the lack of both time periods and data used for the research. To get more persuasive and comprehensive evidence, this work attempts; 1. to test the existence of stock return data using monthly stock return series from January 1980 to December 1995. Both of parametric test and non-parametric test are applied. 2. to test the weekly stock return data. Therefore the number of observations has been increased. 3. to test the relationship between the stock price index by the sizes; small, middle, large and overall. The test results in this work are summarized as follows; 1. Using monthly data, the monthly effect was found in middle sized firms, while, no January effect was found. 2. Using weekly data, the monthly effect was found in middle and small sized firms and the January effect was found in small sized firms. 3. The turn-of-the year effect was not found.
면역글로불린 A 및 $G_2$, $G_4$ 결핍에 동반된 만성 난치성 설사 1례
안성연,김영미,남상욱,박재홍,이창훈,Ahn, Sung-Ryon,Kim, Young-Mi,Nam, Sang-Ook,Park, Jae-Hong,Lee, Chang-Hoon 대한소아소화기영양학회 2001 Pediatric gastroenterology, hepatology & nutrition Vol.4 No.2
저자들은 생후 2개월부터 지속되는 만성 설사를 주소로 내원한 환아에서 면역글로불린 정량 검사상 IgA의 결핍과 함께 $IgG_2$ 및 $IgG_4$ 결핍이 동반되어 있고 영아기에 빈번한 설사와 감염을 동반한 증례를 경험하였기에 보고하는 바이다. In most cases, acute diarrhea in childhood heals spontaneously, but it may become the form of chronic diarrhea in immunodeficient children and then cause weight loss, dehydration, malabsorption and malnutrition. The immunodeficient diseases associated with chronic diarrhea include severe combined immunodeficiency syndrome, common variable immunodeficiency, acquired immunodeficiency syndrome, agammaglobulinemia or selective IgA deficiency. IgA deficiency is the most common primary immunodeficiency. Because many IgA deficient individuals seem to have compensated for their deficiency with increased IgM production and various nonimmunologic factors, the incidence of gastrointestinal involvement is not prominent. Some of those with IgA deficiency and recurrent infections have been found to also have IgG subclass deficiency. IgA deficiency with $IgG_2$ and $IgG_4$ subclass deficiency have high susceptability to infection and chronic diarrhea. IgG subclass deficiency, when present, is more likely to be found in association with a partial IgA deficiency rather than complete IgA deficiency. We report a 3-month-old male with intractable diarrhea accompanied by IgA, $IgG_2$, and $IgG_4$ deficiency.
13세 여아에서 발생한 총담관낭 I형에서 기원한 담관암 1례
안성연,남상욱,박재홍,임영탁,이준우,이창훈,Ahn, Sung-Ryon,Nam, Sang-Ook,Park, Jae-Hong,Lim, Young-Tak,Lee, Jun-Woo,Lee, Chang-Hun 대한소아소화기영양학회 2002 Pediatric gastroenterology, hepatology & nutrition Vol.5 No.1
저자들은 갑작스럽게 발생한 우상복부 동통을 주소로 내원한 13세 여아에서 간에 다발성으로 전이가 된 I형 총담관낭으로부터 발생한 담관암 1례를 경험하였기에 보고하는 바이다. Choledochal cyst is a rare developmental malformation of the biliary tree and has serious problem of transformation to malignancy. The development of cholangiocarcinoma related to choledochal cyst increases as the age of patient increases and is more common in Orientals with female predominance of 2.5 times. Prevalence rate of cholangiocarcinoma is various from 2.5 to 15.6% in adult with choledochal cyst, but very low in children. We experienced a case of cholangiocarcinoma with multiple liver metastases arising from type I choledochal cyst in a 13-year-old girl who complained of sudden onset of right upper quadrant abdominal pain.
안성연,김구환,유한욱 대한소아청소년과학회 2015 Clinical and Experimental Pediatrics (CEP) Vol.58 No.8
Permanent neonatal diabetes mellitus refers to diabetes that occurs before the age of 6 months and persists through life. It is a rare disorder affecting one in 0.2–0.5 million live births. Mutations in the gene KCNJ11, encoding the subunit Kir6.2, and ABCC8, encoding SUR1 of the ATP-sensitive potassium (KATP) channel, are the most common causes of permanent neonatal diabetes mellitus. Sulfonylureas close the KATP channel and increase insulin secretion. KCNJ11 and ABCC8 mutations have important therapeutic implications because sulfonylurea therapy can be effective in treating patients with mutations in the potassium channel subunits. The mutation type, the presence of neurological features, and the duration of diabetes are known to be the major factors affecting the treatment outcome after switching to sulfonylurea therapy. More than 30 mutations in the KCNJ11 gene have been identified. Here, we present our experience with a patient carrying a novel p.H186D heterozygous mutation in the KCNJ11 gene who was successfully treated with oral sulfonylurea.
Excess of leptin inhibits hypothalamic KiSS-1 expression in pubertal mice
안성연,Sei Won Yang,이희제,Jong Seon Byun,신충호 대한소아청소년과학회 2012 Clinical and Experimental Pediatrics (CEP) Vol.55 No.9
Purpose: Leptin has been considered a link between metabolic state and reproductive activity. Defective reproductive function can occur in leptin-deficient and leptin-excessive conditions. The aim of this study was to examine the effects of centrally injected leptin on the hypothalamic KiSS-1 system in relation to gonadotropin-releasing hormone (GnRH) action in the initial stage of puberty. Methods: Leptin (1 μg) was injected directly into the ventricle of pubertal female mice. The resultant gene expressions of hypothalamic GnRH and KiSS-1 and pituitary LH, 2 and 4 hours after injection, were compared with those of saline-injected control mice. The changes in the gene expressions after blocking the GnRH action were also analyzed. Results: The basal expression levels of KiSS-1, GnRH, and LH were significantly higher in the pubertal mice than in the prepubertal mice. The 1-μg leptin dose significantly decreased the mRNA expression levels of KiSS-1, GnRH, and LH in the pubertal mice. A GnRH antagonist significantly increased the KiSS-1 and GnRH mRNA expression levels, and the additional leptin injection decreased the gene expression levels compared with those in the control group. Conclusion: The excess leptin might have suppressed the central reproductive axis in the pubertal mice by inhibiting the KiSS-1expression, and this mechanism is independent of the GnRH-LHestradiol feedback loop.
음악요법이 초산부의 경막하 무통 분만 중 분만통증, 분만경험, 자아존중감에 미치는 효과: 유사실험 연구
안성연,박은지,문유리,이보영,이은별,김동연,정성희,김진경 한국여성건강간호학회 2023 여성건강간호학회지 Vol.29 No.2
Purpose This non-randomized study was performed to evaluate the effects of music therapy on labor pain, the childbirth experience, and self-esteem in women during vaginal delivery. Methods In total, 136 primiparous women over 37 weeks of gestation receiving epidural analgesia during vaginal delivery were recruited via convenience sampling. To minimize diffusion effects, data from the control group (n=71) were collected first (April 2020 to March 2021), followed by data from the music group (n=65; April 2021 to May 2022). Participants in the music group listened to classical music during labor, while the control group was offered usual care (no music). Labor pain was measured using a numeric rating scale (NRS), and self-esteem and childbirth experience were collected using self-report questionnaires. Data were analyzed using the independent t-test, chi-square test and Cronbach’s α coefficients. Results The overall pain level (NRS) at baseline was 0 in both groups. Mothers in the music therapy group had lower levels of latent pain (t=1.95, p=.005), active pain (t=3.69, p<.001) and transition-phase pain (t=7.07, p<.001) than the control group. A significant difference was observed between the two groups, and the music therapy group expressed more positive perceptions of the childbirth experience (t=-1.36, p=.018). For self-esteem, the experimental group’s score was slightly higher, but without a statistically significant difference from the control group. Conclusion Using music therapy during labor decreased labor pain and improved the childbirth experience. Music therapy can be clinically recommended as a non-pharmacological, safe, and easy method for nursing care in labor. Purpose: This non-randomized study was performed to evaluate the effects of music therapy on labor pain, the childbirth experience, and self-esteem in women during vaginal delivery.Methods: In total, 136 primiparous women over 37 weeks of gestation receiving epidural analgesia during vaginal delivery were recruited via convenience sampling. To minimize diffusion effects, data from the control group (n=71) were collected first (April 2020 to March 2021), followed by data from the music group (n=65; April 2021 to May 2022). Participants in the music group listened to classical music during labor, while the control group was offered usual care (no music). Labor pain was measured using a numeric rating scale (NRS), and self-esteem and childbirth experience were collected using self-report questionnaires. Data were analyzed using the independent t-test, chi-square test and Cronbach’s α coefficients.Results: The overall pain level (NRS) at baseline was 0 in both groups. Mothers in the music therapy group had lower levels of latent pain (t=1.95, p=.005), active pain (t=3.69, p<.001) and transition-phase pain (t=7.07, p<.001) than the control group. A significant difference was observed between the two groups, and the music therapy group expressed more positive perceptions of the childbirth experience (t=–1.36, p=.018). For self-esteem, the experimental group’s score was slightly higher, but without a statistically significant difference from the control group.Conclusion: Using music therapy during labor decreased labor pain and improved the childbirth experience. Music therapy can be clinically recommended as a non-pharmacological, safe, and easy method for nursing care in labor.Clinical trail number: KCT008561