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A Case of Glomus Tumor Mimicking Neuroendocrine Tumor on 68 Ga-DOTATOC PET/CT
이고은,안보경,홍승모,안지용,공정식,류진숙 대한핵의학회 2021 핵의학 분자영상 Vol.55 No.6
68 Ga-DOTA-peptide PET/CT is a valuable tool for diagnosing neuroendocrine tumors (NET). Various tumors and normalhuman tissue express the somatostatin receptor (SSTR), warranting attention to positive findings on 68 Ga-DOTA-peptidePET/CT. However, overexpression of SSTR in glomus tumors has not yet been reported. Gastric glomus tumors show manysimilar features of NET and are often misdiagnosed. We present the case of a 61-year-old male with a glomus tumor whounderwent distal gastrectomy under the pretense of an NET grade 1 because the nodule showed focal intense uptake onpreoperative 68 Ga-DOTATOC PET/CT.
김좌훈,안보경,홍승모,정훈용,김도훈,최기돈,안지용,이정훈,나희경,김종훈,김용희,김형렬,이현주,김성배,박숙련 대한암학회 2022 Cancer Research and Treatment Vol.54 No.2
Purpose This study aimed to evaluate the real-world efficacy of immune checkpoint inhibitors (ICIs), and to identify clinicolaboratory factors to predict treatment outcomes in patients with advanced esophageal squamous cell carcinoma (ESCC) receiving ICIs.Materials and Methods Sixty patients with metastatic or unresectable ESCC treated with nivolumab (n=48) or pembrolizumab (n=12) as ≥ second-line treatment between 2016 and 2019 at Asan Medical Center were included.Results The median age of the patients was 68 years (range, 52 to 76 years), and 93.3% were male. Most patients had metastatic disease (81.7%) and had been previously treated with fluoropyrimidines, platinum, and taxane. In 53 patients with measurable disease, the overall response rate and disease control rate were 15.1% and 35.8%, respectively. With a median follow-up duration of 16.0 months, the median progression-free survival (PFS) and overall survival (OS) were 1.9 months (95% confidence interval [CI], 1.54 to 2.19) and 6.4 months (95% CI, 4.77 to 8.11), respectively. After multivariate analysis, recent use of antibiotics, low prognostic nutrition index (< 35.93), high Glasgow Prognosis Score (≥ 1) at baseline, and ≥ 1.4-fold increase in neutrophil-to-lymphocyte ratio after one cycle from baseline were significantly unfavorable factors for both PFS and OS. Younger age (< 65 years) was a significant factor for unfavorable PFS and hyponatremia (< 135 mmol/L) for unfavorable OS.Conclusion The use of ICIs after the failure of chemotherapy showed comparable efficacy in patients with advanced ESCC in real practice; this may be associated with host immune-nutritional status, which could be predicted by clinical and routine laboratory factors.
Ogive-Cylinder 주위와 Venturi에서의 캐비테이션 전산 유동해석
이장춘(J.C. Lee),안보경(B.K. Ahn),김동훈(D.H. Kim),김찬기(C.K. Kim),박원규(W.G. Park) 한국전산유체공학회 2007 한국전산유체공학회 학술대회논문집 Vol.2007 No.-
A two-phase method in CFD has been developed and is applied to model the cavitation flow. The governing equation system is two-phase Navier-Stokes equation, comprised of the mixture mass, momentum and liquid-phase mass equation. It employs an implicite, dual time, preconditioned algorithm using finite difference scheme in curvilineal coordinates and Chien k-ε turbulence equation. The experimental cavitating flows around ogive-cylinder and venturi type objects are employed to test the solver. To prove the capabilities of the solver. several three-dimentional examples are presented.