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      저자 : 안명천(Myoung-Chone An) (검색결과 1 건)
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        ISFET 소자를 이용한 산성-중성-알칼리성 용액 내 자성나노입자 분포에 따른 pH 특성 연구

        안명천(Myoung-Chone An),최종구(Jong-Gu Choi),이상석(Sang-Suk Lee) 한국자기학회 2020 韓國磁氣學會誌 Vol.30 No.2

        Magnetic nanoparticles have not only been required for biological DNA isolation, detection and purification, but also have been studied steadily until recently as medical chemical processing materials for drug delivery and release that can control cancer cells in the human body. Using a ion selective field effect transistor (ISFET) pH sensor, a pH value sensitive to the concentration of hydrogen ions (H<SUP>+</SUP>) dissolved in various liquid solutions was measured according to the behavior of magnetic nanoparticles in the external magnetic field. The magnetic nanoparticle solution of pH 7.1 was mixed with acidic, neutral, and alkaline buffer solution at a ratio of 3:1, and the acidic solution having a pH of 3.9 with respect to the change of magnetic particle distribution was found to have a change of 35 mV (0.65 pH), which is greater than the pH of the alkaline solution of pH 9.8. Some of the H<SUP>+</SUP>-ions in the solution was bound to the magnetic nanoparticles and the concentration of ions was reduced near the Si₃N₄ layer of the ion sensitive membrane, so that the change in pH value, the output voltage, was closely related to the distribution of the nanoparticles. The output voltage curves between the two terminal source and drain for the external magnetic field were symmetrical around 0 Oe, and the variation up to ±1000 Oe was greater in acidic solutions than alkaline. Because a multi-reactive polymer nanoparticles containing drugs with a pH of about 7.2 for treatment of cancer cells with a pH of 6.8 move to targets, we suggest the therapy system in which the ring of nanoparticles is decomposed by high-frequency magnetic field therapy.

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