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안도환,박양생 고신대학교 의학부 1991 高神大學校 醫學部 論文集 Vol.7 No.1
카드뮴이 신장에 존재하는 인산염 이동계에 미치는 영향을 조사하기 위하여 2주간 체중 kg당 2 mg의 카드뮴을 쥐에게 매일 피하주사하였다. 그결과 카드뮴 만성중독 시 나타나는 다뇨, 단백뇨, 당뇨, 인산뇨 등이 관찰되었다. 카드뮴 중독을 일으킨 쥐에서 분리된 세뇨관 강막소포(BBMV)를 이용하여 인산염의 이동을 조사한 바 Na^+dependent phosphate 이동량이 시마게 감소되었다. 따라서 카드뮴 중독은 신장의 세뇨강막에 존재하는 Na^(-)-phosphate cotransport system에 손상을 입혀 인산뇨를 유발함을 알 수 있었다. Effect of cadmium intoxication on the renal cortical phosphate transport system was studied in adult Sprague-Dawley male rats. Subcutaneous injections of CdCl_(2) at a dose of 2 mg Cd/kg body weight per day for 2 weeks induced marked polyuria, glycosuria, proteinuria and phosphaturia, which are the characteristics of chronic cadmium intoxication. In the renal cortical brush-border membrane vesicles prepared from cadmium-intoxicated rats, the Na^(+)-dependent phosphate uptake was markedly attenuated, whereas the Na^(+)-independent uptake was not apparently altered. These results indicate that cadmium intoxication impairs the Na^(+)-dependent phosphate cotransport system in the brush-border membrane of renal proximal tubular cells, which leads to phosphaturia in intact animals.
자전 고온 반응 합성법에 의한 AlN 분말의 제조 II, Al 분말로부터 AlN 분말의 형성기구
안도환,전형조,김석윤,김용석 한국세라믹학회 1996 한국세라믹학회지 Vol.33 No.10
In this study the formation mechanism of AlN synthesized by SHS(Self-propagating high-temperature Syn-thesis) was studied in order to obtain uniform AlN powder size and morphology. Based on the morphology of AlN synthesized and the calculation of the temperature of Al powder as a function AlN layer thickness the formation mechanism of AlN was proposed.
안도환,박양생 고신대학교(의대) 고신대학교 의과대학 학술지 1991 고신대학교 의과대학 학술지 Vol.7 No.1
-Abstract- Effect of cadmium intoxication on the renal cortical phosphate transport system was studied in adult Sprague-Dawley male rats. Subcutaneous injections of CdCl₂ at a dose of 2 mg Cd/kg body weight per day for 2 weeks induced marked polyuria, glycosuria, proteinuria and phosphaturia, which are the characteristics of chronic cadmium intoxication. In the renal cortical brush-border membrane vesicles prepared from cadmium-intoxicated rats, the Na⁺-dependent phosphate uptake was markedly attenuated, whereas the Na⁺-independent uptake was not apparently altered. These results indicate that cadmium intoxication impairs the Na⁺-dependent phosphate cotransport system in the brush-border membrane of renal proximal tubular cells, which leads to phosphaturia in intact animals.
안도환 한국국방연구원 2023 국방정책연구 Vol.39 No.2
This study aims to analyze the discourse on cybersecurity in North Korea, examine social effects of the discourse, and figure out the intention of the North Korean power elite, generators of such discourse. To achieve these aims, the study analyzes articles related to cybersecurity published in North Korea’s two major daily newspapers, Rodong Sinmun and Minju Joseon, using Fairclough’s critical discourse analysis framework. As a result of the study, it was found that the discourse on cybersecurity in North Korea serves as a ruling strategy to create the elite’s intended cyber reality at the domestic level and to guarantee the tactical use of cyberspace aimed at gaining “attack superiority” at the external level. 본 연구의 목적은 북한의 사이버 안보 담론을 분석함으로써, 이 담론의 사회적 효과를 규명하고, 담론의 생산 주체인 북한 권력층의 의도를 파악하는 데 있다. 이를 위해 본 연구는 2000년부터 2021년까지 로동신문 과 민주조선 에 게재된 사이버 안보 관련 기사들을 페어클럽(Fairclough)의 비판적 담론분석 이론을 활용해 분석했다. 분석 결과, 북한은 권력층이 의도하는 사이버 현실을 실현하기 위해 사이버 안보 담론을 대내적 통치 기제로 활용하고 있으며, 대외적으로는 통일된 규범이 없고 세력 간 진영화가 심해지는 국제 사이버 안보 환경을 불법적, 전략적으로 활용해 자신들의 ‘공격 우위’를 확보하고 서방에 대해 반대 담론을 구축하고 있다는 결론을 도출했다.
토끼 신장의 근위곱슬세관과 근위곧은세관에 존재하는 Na-α-ketoglutarate Cotransport System의 생화학적 특성
안도환 ( Do Whan Ahn ),김경룡 ( Kyoung Ryong Kim ),박희석 ( Hee Seok Park ),박양생 ( Yang Saeng Park ) 대한신장학회 2007 Kidney Research and Clinical Practice Vol.26 No.1
Purpose: alpha-Ketoglutarate (αKG), a Krebs cycle intermediate, is extensively used in the kidney as a fuel substrate and as a counter anion for organic acid secretion. It is known to be taken up by the proximal tubule cells via the brush-border as well as basolateral membranes. We explored biochemical characteristics of the brush-border and basolateral αKG transport systems in pars convoluta and pars recta of the proximal tubule, respectively. Methods: Brush-border and basolateral membrane vesicles (BBMV and BLMV) were isolated from rabbit renal outer cortex and outer medulla by Percoll gradient centrifugation. Vesicular uptake of αKG was determined by rapid Millipore filtration method using α-14[C]KG as a substrate. Results: Both BBMV and BLMV showed a Na-gradient dependent uphill transport of αKG. The systems in both membranes were similarly inhibited by Li and activated by Na (Hill coefficient of 1.4). Kinetic analyses indicated that the Na-αKG cotransporters in the BBMV had a lower substrate affinity as compared with those in the BLMV. The transport systems in BLMVs showed a similar Km but different Vmax between the outer cortex (Km: 34 uM, Vmax: 3.3 nmol/mg protein/10s) and outer medulla (Km: 37, Vmax: 1.8). On the other hand, the systems in BBMVs were different in both Km and Vmax between the outer cortex (Km: 194, Vmax: 3.3) and outer medulla (Km: 89, Vmax: 1.7). Conclusion: The findings suggest that both axial and apical to basolateral heterogeneity of the Na-αKG cotransport system in proximal tubules may be due to a physiological adaptation to efficiently utilize αKG in the kidney.