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장천공과 Enteritis Cystica Profunda를 동반한 Peutz-Jeghers 증후군
안기성(Ki Sung Ahn),배정동(Jung Dong Bae),김호각(Ho Gak Kim),손호상(Ho Sang Shon),최정윤(Jung Yoon Choe),김지희(Chi Hui Kim),김이근(Ih Geun Kim),김태석(Tae Sug Kim),김채기(Chae Gi Kim) 대한소화기학회 1997 대한소화기학회지 Vol.29 No.5
The Peutz-Jeghers syndrome is an autosornal dominant condition characterized by mucocutaneous pigmentation and hamartomatous polyps of the gastrointestinal tract. This syndrome is clinically important because of complications caused by gastrointestinal polyps, such as abdorninal pain, gastrointestinal bleeding and intussusception often leading to intestinal obstruction. The possibility of malignant change in the polyp has been a controversial issue. In the recent reviews of soe cases of Peutz-Jeghers syndrome, the reported lesions of small intestinal adenocarcinoma are regarded as the benign process of enteritis cystica profunda. We present herein a case of Peutz-Jeghers syndrome with small bowel perforation, a previously unreported instance, and enteritis cystica profunda. (Korean J Gastroenterol 1997; 29:677-682)
살모넬라 Group C 감염에 동반된 횡문근융해증 및 급성신부전
안기성(Ki Sung Ahn),박정기(Jeong Ki Park),여동근(Dong Keun Ye),윤원찬(Wern Chan Yoon),김학준(Hak Jun Kim),정의달(Ye Dal Jeong),조선주(Sun Ju Jo) 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.2
Rhabdomyolysis is a syndrome characterized by muscle necrosis and release of intracellular muscle constituents into the circulation. Rhabdomylosis can be precipitated by different causes, such as trauma, extraordinary physical exer- tion, metabolic disorder, drugs, toxins, infection, or endocrinopathy. Salmonellosis is another rare cause of rhabdomyolysis. We report a 62-year-old male who developed severe diarrhea and vomitting, one day after boiled pork & raw octopus ingestion. The diagnosis of rhabdomyolysis was established primarily by the elevated serum CPK and myoglobin level. There were no other traumatic, metabolic, toxic, or enzymatic causes for the rhabdomyolysis. Stool cultures received at the first day of hospitalization yielded Salmonella Group C. Salmonella sp. is suggested to cause muscle damage by direct bacterial invasion as well as by decreasing the oxidative and glycolytic enzyme activity of skeletal muscles and by activating lysosomal enzymes. We wish to draw attention to these serious complication of salmonella gastroenteritis, and to institute of prompt measures for preventing the development of ATN. We report a case of acute renal failure associated with rhabdomyolysis and gastroenteritis caused by salmonella Group C with review of literatures.
손호상(Ho Sang Sohn),안기성(Ki Sung Ahn),박정기(Jeong Ki Park),정의달(Ye Dal Jeong),조선주(Sun Joo Cho),여동근(Dong Geun Yeo),최정윤(Jung Yoon Cheo),이지현(Jee Hyen Lee) 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.3
Doxylamine succinate is common over-the-counter sleep medication that is frequently involved in accidental poisonings and suicide attempts. Doxylamine overdose is generally directed at the anticholinergic effect including autonomic,and central nervous system effect and direct cardiac toxicity. Rarely, rhabdo-myolysis has been reported with doxylamine over-dose. We experienced two cases of rhabdomyolysis with overdose of doxylamine in 17-year-old and 31-year-old male. They were diagnosed with high levels of creatine phosphokinase in serum, myoglobin in serum and urine, and increased radionuclide uptake of muscles in (99m)Tc-MDP bone scan. Patients recovered without any complications with hydration and diuresis. Clinicians should be aware of the possibility of rhabdomyolysis in patients with doxylamine overdose.
임신 중 발견되어 말기 신부전으로 진행한 수질낭성 신질환 1 예
박민식(Min Sik Park),이진배(Jin Bae Lee),임상혁(Sang Hyuk Lim),안기성(Ki Sung Ahn),이인희(In Hee Lee) 대한신장학회 2002 Kidney Research and Clinical Practice Vol.21 No.5
Medullary cystic disease (MCD) and familial juvenile nephronophthisis are inherited diseases characterized by development of small cysts at the corticomedullary borders of the kidneys. Both diseases consist of microscopic or gross cysts of the renal medullae associated with atrophy of nephrons, anemia, renal insufficiency, polyuria, and salt-wasting. We report a 27-year-old pregnant female patient with MCD which caused acute renal failure progressing to end stage renal disease during the second trimester. Hypertension, oliguria, preeclampsia, placenta abruptio, and disseminated intravascular coagulation were also accompanied. Radiologically, abdominal ultrasonography and computed tomogram showed many cysts confined only to the renal medullae, which are typical findings consistent with MCD. In spite of conservative therapy, her renal function deteriorated rapidly and uremic symptoms including pulmonary edema were aggravated. She was started on hemodialysis and she has received regular hemodialysis without recovery of renal function.