경추에 발생한 원발성골육종 1례

안계훈,장석정,신호 中央醫學社 1991 中央醫學 Vol.56 No.2

Primary osteosarcoma of cervical spine is extremely rare. The case of a 61-year-old woman with severe neck pain and both arm radiating pain is presented in which histological examination showed that the compressed C7 vertebral body was osteosarcoma. In this case of tumor focus was controlled with palliative surgery for decompression of neural component and relief of severe pain. Because of this rarity, this case of primary osteosarcoma of cervical spine is reported.

Chiari기형(Type Ⅰ)을 동반한 경수 및 흉수부에 발생한 척수공동증 치험 1례

안계훈,양의중,김충현,장석정,신호 대한신경외과학회 1990 Journal of Korean neurosurgical society Vol.19 No.6

We have recently managed a case of syringomyelia associated with Chiari ⅠType malformation. The syrinx was found at C₂ level to T_(10) level. And the patient complained left forearm pain and paresthesia in left shoulder, arm with segmental dissociated sensory loss. The cranio-vertebral decomression(suboccipital craniectomy, cervical laminectomy) and the shunting procedures were performed. Postoperative course was not uneven, the clinical and neurological improvement was observed. M.R.I. permitted rapid, exact diagnosis including localization of syrinx and information of associated anormaly.

제3뇌실내 낭미충증 1례

안계훈,양의중,김충현,장석정,안태형,도성신,신호 대한신경외과학회 1990 Journal of Korean neurosurgical society Vol.19 No.3

Cerebral cysticercosis is relatively common disease in Korea. But cysts in the ventricular system are rare form. In the ventricular system, they occur most frequently in the 4th ventricle, more rarely in the lateral and 3rd ventricle. We have recently experienced a case of cerebral cysticercosis which involved the 3rd ventricle. A sixty-year old man was admitted because of generalized seizure attack followed by drowsy mentation. On admission, there were no specific localizing and lateralizing neurological abnormalities except bilateral, mild degree optic papilledema. Brain CT scan after intraventricular metrizamide administration disclose a cystic mass in the third ventricle. And the serum ELISA test was positive(patient' s titer : 0.31, normal : below 0.18). Anterior trancallosal approach was performed and cystic mass was removed from the third ventricle. Pathological diagnosis of the specimen was cysticercosis. Following surgery, the patient's symptom cleared up and papilledema disappeared gradually.

소아뇌졸중의 보험의학적 고찰

안계훈,Ahn, Gye-Hoon 한국생명보험의학회 2010 保險醫學會誌 Vol.29 No.2

Moyamoya disease (MMD) is a progressive occlusive disease of the cerebral vasculature with particular involvement of the circle of Willis and the arteries that feed it. MMD is one of cerebrovacular accident,which is treated with sugical maeuver in pediatic neurosurgery. Moyamoya (ie, Japanese for "puff of smoke") characterizes the appearance on angiography of abnormal vascular collateral networks that develop adjacent to the stenotic vessels. The steno-occlusive areas are usually bilateral, but unilateral involvement does not exclude the diagnosis. The exact etiology of moyamoya disease is unknown. Some genetic predisposition is apparent because it is familial 10% of the time. The disease may be hereditary and multifactorial. It may occur by itself in a previously healthy individual. However, many disease states have been reported in association with moyamoya disease, including the following: 1) Immunological - Graves disease/thyrotoxicosis 2) Infections - Leptospirosis and tuberculosis 3) Hematologic disorders - Aplastic anemia, Fanconi anemia, sickle cell anemia, and lupus 4) Congenital syndromes - Apert syndrome, Down syndrome, Marfan syndrome, tuberous sclerosis, Turner syndrome, von Recklinghausen disease, and Hirschsprung disease 5) Vascular diseases - Atherosclerotic disease, coarctation of the aorta and fibromuscular dysplasia, 6)cranial trauma, radiation injury, parasellar tumors, and hypertension etc. These associations may not necessarily be causative but do warrant consideration due to impact on treatment.(Mainly neurosurgical operation.) The incidence of moyamoya disease is highest in Japan. The prevalence of MMD is 1 person per 100,000 population. The prevalence and incidence of moyamoya disease in Japan has been reported to be 3.16 cases and 0.35 case per 100,000 people, respectively. With regard to sex, the female-to-male ratio is 1.4:1. A bimodal peak of incidence is noted, with symptoms occurring either in the first decade(5-10yr) or in the third and fourth decades (30-40yr)of life. Mortality rates of moyamoya disease are approximately 10% in adults and 4.3% in children. Death is usually from hemorrhage. In aspect of life insurance, MR is 1700%, EDR is 16 per 1000 persons. Children and adults with moyamoya disease (MMD) may have different clinical presentations. The symptoms and clinical course vary widely from asymptomatic to transient events to severe neurologic deficits. Adults experience hemorrhage more commonly; cerebral ischemic events are more common in children. Children may have hemiparesis, monoparesis, sensory impairment, involuntary movements, headaches, dizziness, or seizures. Mental retardation or persistent neurologic deficits may be present. Adults may have symptoms and signs similar to those in children, but intraventricular, subarachnoid, or intracerebral hemorrhage of sudden onset is more common in adults. Recently increasing diagnosis of MMD with MRI, followed by surgical operation is noted. MMD needs to be considered as the "CI" state now in life insurance fields.

토지공급자 관점의 보금자리주택 입지선정 요인 중요도에 관한 연구

안계훈,정문오,김광호,이상엽 한국부동산학회 2010 不動産學報 Vol.42 No.-

1. CONTENTS (1) RESEARCH OBJECTIVES Minister of Land, Transport and Maritime Affairs(MLTM) presented the NEW PLUS Housing scheme for low-income families to solve unstable housing and for civilians who did not own house to stimulate their house ownership. This study is conducted to look into the importance by factor in selecting the location about release from the greenbelt for the housing project and the site designation, and further more to verify the need and the importance of differentiating site designation standards according to the characteristics of each location by applying selection cases of existing model districts. (2) RESEARCH METHOD It examined the NEW PLUS Housing policy, and carried out a survey of experts in charge of the NEW PLUS Housing on the importance of site designation factors. This study analyzed what items are important in designating the NEW PLUS Housing site through AHP method, and additionally looked into the difference by analyzing the importance of respective site designation of the firstly sold four model districts(Gangnam Segok, Secho Woomyun, Goyang, Wonheung, Hanam Misa). (3) RESEARCH FINDINGS The result of the analysis on the importance in designating the NEW PLUS Housing site has shown that environmental conditions such as conflicts with environmental groups and the recovered area of the destructed green belt are most important, and there is a difference between the importance item orders of the comprehensive importance of site designation and each model district’s due to its regional characteristics. 2. RESULTS For designating the NEW PLUS Housing site, the standards for site designation should be prepared considering the specialty ‘supplying’ through the release from the green belt. Moreover, they should be different according to unique location characteristics of each district.

두개골에 발생한 해면혈관종 : 1례 증례보고

안계훈 中央醫學社 1991 中央醫學 Vol.56 No.2

Cavernous hemangioma may occur in any region of the brain and very rare in extracerebral site. Recently we experienced a case of cavernous hemangioma in the skull (site: Lt. frontal bone). Exact preoperative diagnosis of lesion is difficult because of angiographic silence and unusual site. We performed total removal of tumor and the relevant literature is reviewed.

후측방 개흉술 접근법으로 치유한 상흉추부의 결핵성 척주염 1례

이승명,안계훈,김충현 대한신경외과학회 1992 Journal of Korean neurosurgical society Vol.21 No.7

Bone and joint involement develops in approximately 10 percent of patients with tuberculosis and half of these affected patients have tuterculosis of the spine. The goals of management are to eradicate the infection and to prevent or threat neurologic deficits and spinal deformity. An operation may be performed to drain abscess, to debride sequestered bone and disc. to decompress the spinal cord. or to stabilize the spine for the prevention or correction of deformity. But there are difficulties in approaching the upper thoracic spine(T1-T3). These vertebral bodies can be visualize through a standard thoracotomy. Access is greatly restricted, however, by the scapula and the remaining ribs, making a vertebrectomy and spinal cord decompression very difficult. Reconstruction of the vertebral defect and instrumentation to give spinal stability are equally difficult. We describe a surgical approach to the upper thoracic spine which allow an adequate exposure of the vertebral bodies from T1 to T3. The posterolateral thoracotomy approach seems to be a safe and useful method for the upper thoracic lesion, allows adequate exposure and easy reconstruction.

불안정성 흉·요추부 질환에서 Kaneda기구를 이용한 전방융합술

양의중,안계훈,김충현,장석정,안태형,도성신,신호 대한신경외과학회 1990 Journal of Korean neurosurgical society Vol.19 No.2

Recently anterior spinal device in the treatment of the unstable thoraco-lumbar spine has been used. We have experienced 11 patients of the unstable thoraco-lumbar spine, which were composed of 8 patients with burst fracture and 3 patients with tuberculous spondylitis. The 11 patients with neurological deficit were treated with an one stage anterior operation consisting of anterior decompression through vertebrectomy, realignment with Kaneda device. No patient showed neurologic deterioration after surgery. The anterior spinal instrumentation with Kaneda device affored enough stability to enable early ambulation with good alignment and solid fusion.

흰쥐 뇌에서 Tyrosine Hydroxylase분비세포의 출현시기 및 분포에 관한 면역조직화학적 연구

정윤영,선희매,김영택,김남훈,안계훈,장인엽,김종중,문정석,강양수 조선대학교 부설 의학연구소 1999 The Medical Journal of Chosun University Vol.24 No.1

The immunohistochemical (ABC method) studies on the ontogeny and localization of the catecholamine-synthesizing enzyme tyrosine hydroxylase (TH) were examined in rat brain from the 12th fetal day until the 9th postnatal day. The results obtained were as follows : 1. Tyrosine hydroxylase was first detected immunohistochemically at embryonic day 13(E13). At this stage, the TH-containing neurons were still migrating and cytologically immature. 2. The changes occuring from the early to the late prenatal stages of development appeared to be the result of an increase in the number and size of the TH-containing cells and in the length of nerve fibers. 3. The distribution of the TH-containing neurons at embryonic day 19(E19) more closely resembled catecholaminergic neurons in the adult rat brain : 1) a rhombencephalic group became the A1-7 ; 2) a ventral mesencephalic group became A8-10 ; 3) a ventral prosencephalic group and a few neurons ventral to the striatum became A11-14 ; and 4) the cells of the olfactory bulb corresponded to the A15. 4. The cytodifferentiation of the TH-immunoreactive neurons was accompanied by continued migration to form the collective catecholaminergic groups during ontogenesis. In addition, the morphology of the TH-immunoreactive neurons in the late prenatal stage resembled in the adult rat brain.

개 앞띠겉질에서 parvalbumin과 calbindin D-28k 양성반응세포의 출생후 발달에 관한 연구

윤상필(Sang-Pil Yoon),안계훈(Gye-Hoon Ahn),문정석(Jeong-Seok Moon),김종중(Jong-Joong Kim),유호진(Ho-Jin You),김진호(Jin-Ho Kim),장인엽(In-Youb Chang) 대한해부학회 2002 Anatomy & Cell Biology Vol.35 No.2

출생시부터 출생후 180일까지 개의 앞띠겉질에서 칼슘결합단백인 parvalbumin과 calbindin D-28k 양성반응세포의 출현 시기, 분포양상, 발생양상을 확립하기 위하여 면역조직화학적 방법을 이용한 실험 결과 다음과 같은 결론을 얻었다. Parvalbumin 면역반응은 출생후 7일에 VI층 뭇극세포에서 처음 관찰되었다. GABA계 사이신경세포에서 parvalbumin 면역 반응은 안쪽에서 바깥쪽으로 퍼져나가는 현상을 보였고, 출생후 180일에 성숙형과 유사한 분포상을 보였다. 면역반응은 주로 발생중인 비피라밋세포에서 나타났으나 parvalbumin에 양성반응을 보이는 V층의 피라밋세포가 출생후 14일부터 90 일까지 일시적으로 관찰되었다. Calbindin D-28k 면역반응은 parvalbumin 면역반응과는 차이가 있었다. Calbindin D-28k 면역반응은 출생시 V층 피라밋세포에서 처음 나타났고, 이 양상은 출생후 90일까지 지속되었다. Calbindin D-28k에 양성반응을 보이는 사이신경세포는 출생시 속과립층 아래 영역과 백색질에 분포하였고, 출생후 14일가 되어서는 속과립층의 위∙아래 영역 모두에서 증가하였으며, 성숙형과 유사한 분포상은 출생후 180일에 확립되었다. 이상의 결과로 미루어 미성숙한 상태의 사이신경세포 뿐만 아니라 미성숙 피라밋세포에서 칼슘결합단백이 일시적으로 발현되는 것은 칼슘의 증가에 의한 손상으로부터 신경세포를 보호하는 칼슘결합단백의 기능과 연관이 있는 것으로 사료된다. We have examined the ontogeny of parvalbumin and calbindin D-28k immunoreactivities in the canine anterior cingulate cortex from the day of birth (P0) through P180. At P7, parvalbumin immunoreactivity appears firstly in layer VI multipolar cells. The parvalbumin immunoreactivity in GABAergic interneurons appears to follow an ‘inside-out’gradient of radial mergence and reaches an adult-like pattern by the end of the 6th postnatal month. Immunoreactivity is limited mainly to developing nonpyramidal cells, whereas pyramid-like parvalbumin immunoreactive cells are transiently observed in layer V from the P14 to the P90. The developmental pattern of calbindin D-28k immunoreactivity differs from that of parvalbumin immunoreactivity. Calbindin D-28k immunoreactivity develops firstly in layer V pyramidal cells from P0, which continues through the third postnatal month. Calbindin D-28k immunoreactive interneurons are located in the infragranular layers and white matter at P0 and increase in both the supragranular and infragranular layers by P14. This is followed by an adult-like pattern at the P180. These data suggested that parvalbumin and calbindin D-28k may play a role in protecting immature neurons from intracelluar calcium influx during postnatal development.