연관규칙 탐사를 이용한 우리나라 농촌 성인의 식이섭취평가

심재은,백희영외2명 한국역학회 1997 Epidemiology and Health Vol.19 No.2

Facial Diplegia in Plasmodium vivax Malaria

심재은,최영철,김원주 대한신경과학회 2010 Journal of Clinical Neurology Vol.6 No.2

Background Facial diplegia has diverse etiologies, including viral and bacterial infections such as diphtheria, syphilis and Lyme disease, and also protozoal infection in very rarely cases. Case Report A 20-year-old male patient was admitted to our hospital due to bilateral weakness of the upper and lower facial muscles. Examination revealed that the patient had a facial diplegia of the peripheral type. A peripheral blood smear demonstrated the presence of the asexual trophozoite stage of Plasmodium vivax with ring-form trophozoites, which led to a diagnosis of malaria. A serum work-up revealed increased IgG titers of antibodies to myelin-associated glycoprotein and ganglioside GD1b. The patient was administered antimalarial treatment, 1 week after which he showed signs of recovery. To our knowledge, this is the first case of facial diplegia after malaria infection, providing evidence that the mechanism underlying the condition is related to immune-mediated disease. Conclusions Facial diplegia can manifest after P. vivax infection.

유아의 식생활 평가를 위한 식품섭취빈도 조사지의 타당성 증진 질적 연구: 응답과정 인지면접

심재은,장주영 동아시아식생활학회 2020 동아시아식생활학회지 Vol.30 No.5

Food frequency questionnaire (FFQ) is a useful tool for the assessment of usual intake in epidemiological research and is usually completed by participants themselves. In this study, participants were interviewed to explore the cognitive process underlying a care-givers’ response to a self-administered FFQ for the dietary evaluation in children in the 1∼5 year age group. A total of 10 participants were recruited voluntarily. Both of think-aloud interviewing and verbal probing techniques were applied. The major components of a 4-stage cognitive model were applied as a coding scheme for the transcribed interview, and cognitive problems were explored. In the comprehension stage, “passing over the survey instruction”, “misunderstanding frequency response category”, “unfamiliar food name”, and “similar food items” were the observed issues. In the retrieval stage, “lack of information on non-family meals”, and “forward telescoping error” and in the judgement stage, “discrepancy between consumption and presented portion in the unit” and “overestimation or underestimation of staple dishes” appeared to be the issues; while the response stage had issues regarding “confusion in the mapping of estimation” and “social desirability”. The cognitive problems revealed through the interview set the direction for an improvement in the questionnaire design. The other results of the exploration of the cognitive process could be utilized in improving the instructions for respondents and in the researcher’s guidelines which could enhance the accuracy of the survey.

Clinical Characteristics and Molecular Genetic Analysis of Korean Patients with GNE Myopathy

심재은,남태승,박형준,신하영,김승민,최영철 연세대학교의과대학 2013 Yonsei medical journal Vol.54 No.3

Purpose: Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (GNE) myopathy is an autosomal recessive neuromuscular disorder characterized by early adult-onset weakness of the distal muscles of the lower limbs. The clinical spectrum of GNE myopathy varies, and it is not clear how the same GNE gene mutations can result in different phenotypes. Here, we present clinical, pathological and genetic characteristics of twenty-one Korean patients with GNE myopathy. Materials and Methods: Twenty-one GNE myopathy patients were included in this study, conducted from 2004 to 2011. Based on medical records, patients’ gender,onset age, family history, clinical history, serum creatine kinase (CK) level, neurologic examination, findings of muscle biopsy, muscle imaging findings and electrophysiologic features were extensively reviewed. Mutation of the GNE gene (9p13.3) was confirmed by DNA direct sequencing analysis in all patients. Results: The mean onset age was 23.8±8.8 years (mean±SD). Patient serum CK levels were slightly to moderately elevated, ranging from 41 to 2610 IU. Among the patients, twelve patients were female and nine patients were male. Except for eight patients, all of the patients presented initially with only distal muscle weakness in the lower extremities. The most common mutation was V572L, followed by C13S. Conclusion:The clinical manifestations of our patients with GNE mutations varied. Among twenty-one patients, thirteen patients showed the typical GNE myopathy phenotype. There was no relationship between clinical features and site of mutation. Therefore, we suggest that neither homozygous nor compound heterozygous models are correlated with disease phenotype or disease severity.

A Case of GNE Myopathy Presenting a Rapid Deterioration during Pregnancy

심재은,홍지만,서경임,조한나,박경석,손은희,최영철 대한신경과학회 2013 Journal of Clinical Neurology Vol.9 No.4

Background GNE myopathy is characterized by early-adult-onset distal myopathy sparing quadriceps caused by mutations in the GNE gene encoding UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, an enzyme in the sialic-acid synthesis pathway. Case Report A 27-year-old Korean woman presented a rapid deterioration in strength of the distal lower limbs during her first pregnancy. She was diagnosed with GNE myopathy and carrying the compound heterozygous mutations of the GNE gene (D208N/M29T). Conclusions This is a representative case implying that an increased requirement of sialic acid during pregnancy might trigger a clinical worsening of GNE myopathy.

Dietary Risk Factors for Hypertension among Korean Adult Men

심재은,Jiyoung Park,백희영 대한지역사회영양학회 2006 Journal of community nutrition Vol.8 No.4

24시간 회상법으로 조사된 영양섭취 상태와 신체계측결과 비교분석 : 98 국민 건강·영양 조사

심재은,문현경 대한영양사협회 2004 대한영양사협회 학술지 Vol.10 No.2

This analysis was performed to investigate the relationship between nutrition and anthropometric indices using the data from a cross-sectional survey of a large national sample, '98 Korean national health and nutrition examination survey. Subjects were selected by stratified multistage probability sampling design and completed dietary questionnares including food intakes for one day by 24-hour recall method. For this analysis, 6566 subjects were selected by age(over 20 years old). For anthropometry, height, weight, and waist- and hip- circumference were measured. They were classified by body mass index(BM1, weight(Kg)/height²m²)) and waist-hip ratio(WHR, waist circumference(cm)/hip circumference(cm)). The nutrients intake of subjects were compared with the recommended daily allowances(RDA). Mean adequacy ratio(MAR) was calculated. Mean heights, weights, BMIs were higher in the groups with nutrient intake over 125% of RDA than the lower intake groups for most nutrients. However, Mean WHR was the highest in the groups with nutrient intake under 75% of RDA for most nutrients excluding iron intake of women aged 20-64 years. Among women aged 20-64 years, means of MAR were 0.71 for obese individuals (BMI>30), 0.72 for subjects with underweight(BMI<18.5), and 0.76 for subjects with normal weight( 18.5 ≤BMK<2.5). Normal subjects has statistically significantly higher MAR than those of other groups. However, among elderly people aged over 65 years, obese group had the highest MAR, 0.68. Women with abdominal obesity(WHR> 0.9) had lower MAR, 0.71 than those with normal weight(MAR=0.76). From these results, obesity and abdominal obesity seems to be the results of malnutrition including both undernutrition and overnutrition rather than simple problem of excess energy intake. Obesity in elderly people needs to be handled differently from adults.

A Case of Acute Disseminated Encephalomyelitis Associated with Hepatitis C Virus Infection

심재은,이경열,이준범,조유나,서상현,김자경 연세대학교의과대학 2012 Yonsei medical journal Vol.53 No.4

Acute disseminated encephalomyelitis (ADEM) is a monophasic autoimmune demyelinating disease of the central nervous system, which typically follows acute viral or bacterial infection or vaccination. We report a case of ADEM associated with hepatitis C virus (HCV) infection with positive serum and cerebrospinal fluid (CSF) anti-HCV antibody. After steroid treatment, neurologic symptoms were improved. Virus triggers autoimmunity or direct viral invasion plays a part in the genesis of ADEM. This is the first reported case of ADEM with anti-HCV antibody in the CSF.

코팅된 구의 고유함수 해를 이용한 완전도체구의 전파흡수체의 설계

심재은,전중창,김효태 대한전자공학회 1999 電子工學會論文誌, D Vol.d36 No.4

본 논문에서는 완전도체구의 전파흡수제를 설계하는 방법을 제시하였다. 코팅된 구의 역산란파는 반사파와 creeping wave의 합으로 표현된다. 현재는 곡률을 가진 산란체의 경우일지라도 단순히 반사파의 반사계수를 0이 되게 하는 저파흡수제를 설계하였다. 크기가 작은 완전도체구의 전파흡수체를 설계하기 위해서는 반사파 뿐만 아니라 회절파인 creeping wave에 의한 영향도 함께 고려해 주어야 한다. 이를 위해 코팅된 구의 고유함수해의 역산란파가 0이 되는 조건을 Newton-Raphson 수치 해석 방법을 이용하여 전파흡수체를 설계하였다. 본 연구에서 제안한 방법으로 전파흡수체를 설계하여 크기가 작은 완전도체구에 코팅하였을 경우 기존의 무한 평면으로 가정하여 구한 전파흡수체 보다 우수한 흡수 성능을 보였다. The design method of a wave absorber for a perfectly conducting sphere is presented. The backscattered field from a coated sphere can be represented as the sum of the reflected field and the creeping wave. The wave absorber for a curved surface has been designed from that the reflection coefficient of the reflected field is zero. For the design of wave absorber for a small sized conducting sphere, the creeping wave should be considered as well as the reflected field. The perfect absorbing conditions are numerically searched using the Newton-Raphson method from the backscattered field of the eigenfunction series solution from a coated sphere. The wave absorber designed by this method exhibits a superior performance of absorption to that designed from the plate type absorbing condition.

유아기 까다로운 식습관과 성장상태 간의 연관성

심재은,백희영,윤지현,김기준 한국영양학회 2013 Journal of Nutrition and Health Vol.46 No.5

This study was conducted in order to investigate the association between picky eating behaviors of preschool children and growth outcomes. In this study, picky eating behaviors were defined as containing four constructs of ‘eating a small amount (ES),’ ‘neophoic behavior (NB),’ ‘refusal of specific food groups (RF),’ and ’preference for specific food-preparation methods (PP).’ A 7-point scale was used for the multi-item questionnaire, which consisted of 21 items (three items for ES, two items for NB, nine items for RF, and seven items for PP), in order to evaluate picky eating behaviors of children. Subjects were recruited among visitors at a medical clinic in Seoul. A total of 150 self-administered survey responses from parents of preschool children were analyzed in order to investigate the association between picky eating behaviors of preschool children and growth outcomes. Height for age (HFA) and weight for height (WFH) z-scores were used for assessment of preschool children’s growth. The prevalence of ES, NB, RF, and PP was 44%, 57%, 73%, and 53%, respectively. Children with ES had lower HFA (p < 0.05) and WFH (p < 0.0001) than those without ES, while children with NB, RF, or PP had HFA and WFH were similar to their counterparts. The mean HFA z-score of children with ES was less than 0 (p < 0.05) and the mean WFH z-scores of children with ES, NB, RF, or PP were less than 0 (p < 0.05). According to the study results, related growth outcome differed depending on constructs of picky eating behaviors. In particular, picky eating of ES showed a risk of faltering height growth in preschool children. Further comprehensive studies on the reason for ES and intervention approach is warranted.