Effect of anticancer drug methortrexate on the biliary excretion kinetics of the reudced folate derivatives in rats

신호철,차신우,배주현,김현주,정태천,박종일,윤종만,김계웅,김진석,한상섭,Shin, Ho-chul,Cha, Shin-woo,Bae, Ju-hyun,Kim, Hyun-ju,Jeong, Tae-cheon,Park, Jong-il,Yoon, Jong-man,Kim, Gye-woong,Kim, Jin-suk,Han, Sang-seop The Korean Society of Veterinary Science 1996 大韓獸醫學會誌 Vol.36 No.1

Dihydrofolate reductase(DHFR) 억제제는 혈중활성엽산유도체의 농도저하를 초래하는데 이에 대한 기전을 밝히고자 DHFR 억제제의 대표적 약물로서 항암치료에 널리 사용되고 있는 methotrexate를 0.3 및 10mg/kg의 용량으로 랫드에 정맥주사한 후 활성엽산유도체의 담즙배설동태를 검토하였다. 임상적용 용량을 상회하는 용량임에도 불구하고 methotrexate에 의한 환원형엽산유도체의 담즙배설은 유의적 감소를 나타내지 않았다. 이러한 결과는 methotrexate에 의한 엽산유도체의 혈중농도저하가 활성엽산유도체의 담즙배설저하에 직접 관련되지 않는 것을 나타낸다. 따라서 장간순환계가 체내 엽산대사 및 항상성 유지에 중심기구임을 고려해 볼 때 DHFR 억제제에 의한 활성엽산유도체의 혈중농도저하는 담즙배설의 변화에 의한 것 보다는 소화관에 배설된 후 재흡수의 저하에 의해 초래될 가능성이 높은 것으로 사료된다. The biliary excretion kinetics of the active folate derivatives were examined after an intravenous injection of methotrexate at doses of 0.3 and 10mg/kg to clarify the mechanism of the acute decrease in the plasma folate by the dihydrofolate reductase inhibitors. Even at a higher dose than used in the clinical therapy, methotrexate did not cause any acute depletion of folate denvatives in the excreted bile. Therefore, the decrease in the plasma folate appeared not to be related with the biliary excretion process of folates. A factor responsible for the plasma folate depletion by DHFR inhibitors may be due to the malabsorption of folate derivatives excreted into the small intestine.

Chemical components of aqueous humor in Korean native cattle and Holstein-friesian cattle

신호철,Shin, Ho-chul The Korean Society of Veterinary Science 1996 大韓獸醫學會誌 Vol.36 No.3

가축 특히 대동물에 있어서 전방수의 화학조성에 관한 보고는 극히 드물다. 따라서 본 연구에서는 한우 및 유우(Holstein)를 대상으로 전방수에 대해 화학조성을 검토하였다. 유의의 protein, urea nitrogen, creatinine, cholesterol, calcium, sodium, potassium과 chloride 등이 분석 검출되었다. 이러한 조성분포는 혈장에서 보다는 수액(cerebrospinal fluid)의 조성에 더 유사한 것으로 나타났으며, 한우 및 유우에 있어서 조성에 관한 차이는 거의 인정되지 않았다. Chemical components of bovine aqueous humor were analyzed. Significant levels of protein, urea nitrogen, creatinine, cholesterol, calcium and electrolytes including sodium, potassium and chloride were detected. The composition of bovine aqueous humor is similar to that of cerebrospinal fluids, rather than that of plasma. It was also found that there is no significant difference in most components between aqueous humor of Korean native cattle and that of Holstein-Friesian cattle.

우울장애와 불안장애 환자들에서 자살관련 행동의 비교

신호철,임세원,오강섭,Shin, Ho-Chul,Lim, Se-Won,Oh, Kang-Seob 대한불안의학회 2007 대한불안의학회지 Vol.3 No.1

Objectives : By comparing the prevalence rates of suicide-related behaviors (suicide ideation, plan and attempt) between depressive disorder and anxiety disorder patients, we tried to find the characteristics of suicide-related behaviors in these patients. Methods : Four hundred-three patients participated in the study and the prevalence rates of suicide-related behaviors were investigated using Korean version of Mini International Neuropsychiatric Interview plus. Pearson Chi-Square test was used to find the association between depressive or anxiety disorders and suiciderelated behaviors. Results : Statistically significant differences were found between depressive disorder group and anxiety disorder group in terms of suicide ideation ($X^2$=6.173, df=1, p=0.013) and suicide attempt ($X^2$=8.008, df=1, p=0.005). We also found that patients in depressive disorder group were more likely to have suicide ideation (Odds Ratio=2.049, 95% Confidence Interval=1.155-3.635), and attempt suicide (Odds Ratio=4.970, 95% Confidence Interval=1.466-16.845) than patients in anxiety disorder group. Conclusion : These findings suggest that suicide ideation and suicide attempt rates are higher in depressive disorders than in anxiety disorders.

폴리옥시에틸렌 - 무수말레인산 공중합 고분자 수식셀룰라아제의 당화 반응속도론에 관한 연구

신호철,전영호,박진원 ( Ho Chul Shin,Young Ho Jhon,Jin Won Park ) 한국화학공학회 1996 화학공학의이론과응용 Vol.2 No.2

Active metabolites in rat bile after intravenous injection of [³H] pteroylglutamic acid

신호철,시모다 미노루,코쿠에 에이치,Shin, Ho-chul,Shimoda, Minoru,Kokue, Eiichi The Korean Society of Veterinary Science 1993 大韓獸醫學會誌 Vol.33 No.4

항암치료의 조절인자로서 중요시되는 활성엽산대사물의 장간(腸肝)순환동태를 규명하기 위해 랫드에 $[^3H]pteroylglutamic$ acid(PteGlu)를 정맥주사한 후 고성능 액체 크로마토그래피법(HPLC)을 이용해 담즙중 활성대사물에 관해 조사하였다. HPLC-liquid scintillation counting법의 분석결과, 현저한 다섯개의 방사활성 피크가 출현, 이들은 $H_4PteGlu$, $10-HCO-H_4PteGlu$, $5-CH_3-H_4PteGlu$와 paraaminobenzoyl glutamate(pABG), PteGlu로 각각 동정되었다. 전자 3물질의 활성엽산대사물의 동정은 표준물질과의 비교분석에 의해 HPLC-전기화학검출기를 이용한 retention time profile 및 hydrodynamic, Voltammogram의 일치성 그리고 HPLC-photodiode array분석에 의한 흡광스펙트럼의 일치성에 근거하였다. 후자 그 물질의(pABG 및 PteGlu) 동정은 흡광스펙트럼의 일치성에 근거하였다. 랫드 담즙중$[^3H]PteGlu$의 활성엽산대사물로서 $H_4PteGlu$의 존재가 처음으로 밝혀졌다. Active metabolites in rat bile after an intravenous injection of $[^3H]$ pteroylglutamic acid(PteGlu)were studies using high-performance liquid chromatography(HPLC). Predominant four radioactive metabolites and parent compound PteGlu were detected on the chromatogram of HPLC with liquid scintillation counting system. These metabolites were identified as tetrahydrofolate, 10-formyltetrahydrofolate, 5-methyltetrahydrofolate and para-aminobenzoyl glutamate. The identification of active folate metabolites was based on the consistency of retention time profiles and hydrodynamic voltammograms which were obtained by HPLC with the electrochemical detection system, and characteristics of UV absorbance spectra obtained by HPLC with photodiode array detection system.

오스템퍼링 처리한 회주철의 마멸특성에 미치는 잔류 오스테나이트 조직의 영향에 관한 연구

신호철,이종훈,김홍범,김창규,최창옥 ( Ho Chul Shin,Jong Hoon Lee,Hong Beam Kim,Chang Gyu Kim,Chang Ock Choi ) 한국주조공학회 1994 한국주조공학회지 Vol.14 No.6

N/A Grey iron containing a small amount of Cu and Mo to improve the effect of heat treatment and microstructures were poured in to the mold and them austenized at 900℃. After austenitizing the specimens of castings were austempered 210℃, 250℃, 300℃ and 350℃. The effects of matrix structures, mechanical properties and wear characteristics were investigated by austempering temperatures. Tensile strength and hardness of austempered grey iron are increased and the amount of retained austenite is decreased as austempering temperature is lower even though the amount of retained autenite in it only 4%. The amount of rolling wear loss are increased as rolling revolution is increased and wear loss of austempered grey iron under dry rolling condition is characterized by three models; initial wear, stationary wear and abnormal wear. It has been found that the amount of wear loss was increased with increasing maxium compressive stress and rolling revolution.

Beagle dog에 있어서 rifapentine의 독성동태연구

신호철,이혜숙,차신우,한상섭,노정구,김진석,이원창,Shin, Ho-chul,Lee, Hye-suk,Cha, Shin-woo,Han, Sang-seop,Roh, Jung-ku,Kim, Jin-suk,Lee, Won-chang 대한수의학회 1995 大韓獸醫學會誌 Vol.35 No.4

The toxicokinetics of rifapentine was studied after an oral administration to beagle dogs. High-performance liquid chromatography(HPLC) using column-switching technique was performed to determine the serum concentrations of rifapentine. The pharmacokinetic profiles of rifapentine were analysed using one-compartment open model. Following a single oral administration of 10mg/kg, pharmacokinetic parameters were determined as follows: maximum serum concentration($C_{max}$), $28.90{\mu}g/ml$; maximum concentration time($T_{max}$), 3.7hr; elimination half-life($t_{1/2}$, 4.7hr; area under the curve(AUC), $339.0{\mu}g{\cdot}hr/ml$; volume of disiribution/bioavailability (Vd/F), 0.21 l/kg; lag time, 24min; absorption rate constant($k_a$), $0.445hr^{-1}$; elimination rate constant($k_{el}$), $0.148hr^{-1}$. After 6 month multiple oral doses of 10mg/kg/day, parameters were as follows: $C_{max}$, $34.40{\mu}g/ml$; $T_{max}$, 2.6hr; $t_{1/2}$, 6.7hr; AUC, $391.3{\mu}g{\cdot}hr/ml$; Vd/F, 0.291/kg; $k_a$, $0.976hr^{-1}$; $k_{el}$, $0.104hr^{-1}$. The consistant kinetic parameters after a single and multiple oral administration show that there was no accumulation of rifapentine after 6 month oral administration. We also simulated the concentration of rifapentine after oral multiple administration of 10 and 50mg/kg/ day, based on the parameters obtained form the single administration. The measured serum concentrations of rifapentine were well fitted to the simulated results. The simulated results show that rifapentine readily reaches to steady-state after about 3 doses and the steady-state serum concentrations($C_{ss}$) are fluctuated in between $2.2{\sim}25.2{\mu}g/ml$, and $10.6{\sim}125.2{\mu}g/ml$ at the doses of 10 and 50mg/kg/day, respectively.

인지능력과 성격이 직무성과에 미치는 결합효과(joint effects)에 관한 연구

신호철(Shin, Ho-Chul),양병화(Yang, Byunghwa) 한국인사관리학회 2013 조직과 인사관리연구 Vol.37 No.1

본 연구에서는 선발과정에서 많이 사용되는 인지능력과 성격(원만성, 성실성, 정서적 불안정성)을 예측변수로, 그리고 현직 보험회사 상담사의 상담건수, 시간, 그리고 내용의 질을 객관적으로 측정한 직무성과를 준거변수로 하여 준거관련 타당성을 검증하였다. 연구결과, 인지능력과 성격 모두 개별적으로 상담사의 직무성과를 타당하게 예측하였다. 인지능력과 성격을 예측변수로 설정하고 직무성과를 준거변수로 설정하여 그 관계성을 살펴보았을 때, 유의미한 증분타당도(incremental validity)와 상호증진작용(multiplicative interaction) 효과를 보여주었다. 즉, 인지능력과 성격이 함께 직무성과를 예측할 때, 성격의 원만성, 성실성, 그리고 정서적 불안정성은 상담사의 직무성과에 대한 인지능력의 예측력(predictive power)을 뛰어 넘어 가산적인 효과성을 보여주었다. 그리고 인지능력이 상담사의 직무성과를 예측할 때, 성격의 성실성과 정서적 불안정성은 유의미한 조절효과를 갖는 것으로 검증되었다. 이론적 측면에서 볼 때, 본 연구의 결과는 인지능력과 성격이 직무성과에 미치는 영향에 대한 개념적 이해의 폭을 넓히는데 기여하였다. 또한 상대적으로 낮은 성격 5요인의 타당성이 인지능력과의 조절효과 인해 향상될 수 있음을 보여주었다. 실무적 측면에서는, 대부분의 기업이 인사선발 과정에 둘 이상의 선발도구를 사용하고 있는 현실을 감안할 때, 본 연구의 결과는 복수의 예측변수가 서로 상관성이 거의 없으면서 각각의 예측변수가 준거변수와 관련성이 높을 때 그 효과성이 극대화될 수 있음을 시사하고 있다. 또한 인사배치 시에도 본 연구의 결과가 활용될 수 있음을 암시하고 있다. 마지막으로, 본 연구의 한계점과 후속연구에 대한 제안을 기술하였다. This study investigated the additive and multiplicative effects of the cognitive test with personality inventory as predictors of job performance for 125 life insurance's call center employees. Specifically, job performance as a criterion variable was measured by the number, time, and quality of consulting, while a cognitive ability test and a personality inventory as predictors were developed for the present study. Results revealed that both cognitive ability and personality were valid predictors of job performance. Results also indicated that cognitive ability showed incremental validities when personality (Agreeableness, Conscientiousness, and Neuroticism) predicted job performance. With respect to multiplicative interaction effects, results indicated that cognitive ability moderated the relationship of personality (Conscientiousness and Neuroticism) to job performance. In light of the fact that most companies use multiple selection tools, these results demonstrate that personnel selection systems need to incorporate cognitive ability tests in conjunction with personality inventories as predictors of job performance. Thus, in order to predict job performance more effectively, the use of multiple predictors simultaneously rather than the use of either predictor alone is recommended. Theoretical and practical implications were discussed, and limitations of the present study and suggestions for future study were addressed.

독성동태시험의 개요

신호철(Ho-Chul Shin),김은주(Eun-Joo Kim),한상섭(Sang-Seop Han) 한국실험동물학회 2000 Laboratory Animal Research Vol.16 No.2

일반손해보험의 도약을 위한 보험중개사의 역할과 법적 쟁점

신호철(Shin Ho Chul) 한국보험법학회 2016 보험법연구 Vol.10 No.2

우리나라 일반손해보험은 세계보험시장에서 18위(장기보험을 생명보험으로 합산 시) 수준으로 생명보험의 7위와 비교할 때 초라한 위상을 보이고 있다. 향후 일반손해보험의 건실한 발전과 지속적인 성장을 도모하기 위해서는 유통구조의 선진화가 급선무이고 이를 위해서는 보험선진국에서 유용성과 효율성이 널리 검증된 보험중개사의 역할과 비중이 획기적으로 증대되어야 할 것이다. 본고에서는 우리나라 보험중개업의 현황을 먼저 살펴보고 일반손해보험 특히 위험인수의 전문성 및 고도성으로 인해 보험중개사의 기능이 절대적으로 요구되는 기업보험에서의 중개사의 기능과 관련된 사례를 열거 하였다. 선진국에서 보험모집의 핵심으로 위상을 공고히 하고 있는 보험중개사가 우리나라에서는 시장점유율이 1%도 채안 되는 미미한실적을 보이고있는데 앞으로 보험중개업이제 기능을 수행하고 보험 산업의 발전에 기여해 나가려면 무엇보다도 법적인 측면에서의 불안정성과 미비점이 해소되어야 한다고 보았다. 이를 위해 여러 가지 방안을 구체적으로 제시하였는데 먼저 보험중개업을 보험업법상 별도편제로 독립·구분하여 보험중개업의 위상을 제고해야 되고 중개사협회 내에 윤리위원회를 두어 회원사의 모집질서 위반행위를 효과적으로 제재할 수 있는 근거조항도 필요하다고 하였다. 또한 보험중개사의 영업기준을 보완 강화하여 중개사의 부실가능성을 사전에 차단하는 방안, 중개사에 보험료 수령권, 고지와 통지수령권을 부여하여 업무의 효율성을 제고하고 손해사정업 겸업을 허용하는 방안 등도 제시하였다. 그리고 ‘국가를 당사자로 하는 계약에 관한 법률’을 개정하여 국·공기업의 보험 입찰시 보험중개사도 차별 없이 참여할 수 있도록 해 중개사의 업무영역에 대한 제약을 철폐할 것도 제안하였다. 국내일반보험시장에서 보험중개사의 기능과 역할은 재론의 여지없이 필수적이다. 모집채널 중 전문성과 고도성을 지니고 기업 편에서 보험회사와 효율적인 협상을 할 수 있는 조직은 보험중개사가 유일하기 때문이다. 국내보험산업이 한 차원 높은 성장을 추구하고 보험선진국과 대등한 위치에서 경쟁을 해 나가려면 보험중개사가 법적인 미비점 없이 원활한 영업활동을 전개할 수 있도록 당국의 세심한 측면지원이 절실히 필요하다고 본다. The Korean commercial insurance market is ranked 18th (if you count long-term insurance as life insurance) in the world insurance market, which is disappointing when compared with the 7th place ranking of Korean life insurance. Top priority must go to the advancement of the insurance solicitation structure in order to encourage the robust development and persistent growth of the future Korean commercial insurance market. in order to achieve this, the focus needs to be on the role and importance of the insurance broker, as is the situation in developed countries, where the broker’s usefulness and efficiency has been extensively proven. This paper discusses the current situation in the Korean insurance broking business and enumerates the cases related to the function of the commercial insurance broker, which is an essential role when dealing with the professional and highly advanced nature of underwriting in the commercial insurance. The Korean insurance broking business takes a meager domestic market share, even falling short of 1 percent whereas the insurance brokers in developed countries retain a dominant market position as being core to insurance solicitation. In the future, for a Korean insurance broker to conduct its deserved function, thus contributing to the development of the insurance industry, the instability and insufficiency of the Korean legal framework must be addressed. For this, we have proposed a variety of specific measures: ㆍIn the first instance, we propose that the articles of the insurance broking business stated in the Insurance Business Act(IBA) should be separately categorized as an independent and divided section, in order to enhance the status of the insurance broker. ㆍOur next proposal is that the grounds articles, which enables The Korean Insurance Brokers Association (KIBA) to effectively discipline the soliciting violations of KIBA member brokers, should included in regulation, such as ‘Regulation on supervision of insurance business’providing a foundation in IBA to form an ethics committee within KIBA. Our other proposals include: ㆍmeasures of preventing the possibility of the insolvency of insurance brokers by supplementing and/or reinforcing business standards for certified insurance brokers (article 36 of enforcement decree of IBA). ㆍmeasures of enhancing the efficiency of insurance brokers by granting the insurance brokers the rights to receive premiums and the insured’s notification prior to making an insurance contract and during the policy period. ㆍmeasures of allowing the insurance broker to conduct loss adjusting business as a supplementary job. ㆍmeasures of repealing the restraints on the insurance brokers’ business scope by allowing the insurance broker to participate in the tender of insurance of government and public sector without discrimination, by revising ‘Act on contracts to which the state is a party’. It goes without saying that the role and function of the insurance broker is essential to the Korean commercial insurance market, This is, because an insurance broker is the sole organization on the side of the insured (a corporate), who is able to carry out the efficient negotiation with an insurance company, armed with professional and highly advanced knowledge of underwriting within the insurance soliciting channels. In order for the Korean insurance industry to pursue a cut above growth and compete on an equal footing with the insurance market within developed countries, we opine that the considerate side supports of concerned authorities are direly needed so that the insurance brokers may conduct a business smoothly without gaps in the insurance legal process.