Estimation of radionuclides leaching characteristics in different sized geopolymer waste forms with simulated spent ion-exchange resin

신영림,김병관,강재혁,마현민,엄우용 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.10

This study presents a method to solidify spent ion-exchange resin (IER) in a metakaolin-based geopolymer and shows results of mechanical strength, immersion, leaching, irradiation, and thermal cycling tests for waste acceptance criteria (WAC) to repository. The geopolymer waste form with 20 wt% of simulated spent IER met the WAC in South Korea (ROK), and the leaching tests of various sized-waste forms up to 15.0 30.0 cm and waste loadings up to 20 wt% for 1e5 d and 1e90 d achieved a leachability index, Li > 6. In a leaching test for 5 d, the cumulative fraction leached (CFL) for Cs, which leached the most, was linearly correlated with the square root of leaching time for all waste forms, and Li increased as the size of the waste form increased. The CFL was also correlated with elapsed time in the 90 d leaching test. The correlations among CFL, time, and volume-to-surface area ratio of waste forms used to estimate the Li of Cs of a 200-L sized geopolymer with 15 wt% IER showed the Li values as 14.73 (5 d) and 17.71 (90 d), respectively, indicating that the large-sized geopolymer waste form met the WAC.

불소용액양치 및 불소이온도입법에 의한 불소도포가 초기법랑질탈회병소의 재석회화에 미치는 영향

신영림,송근배,김교한 ( Young Lim Shin,Keun Bae Song,Kyo Han Kim ) 대한예방치과·구강보건학회 1994 大韓口腔保健學會誌 Vol.18 No.2

특발 저생식샘자극호르몬생식샘저하증의 유전학적인 특징

신영림 대한소아내분비학회 2010 Annals of Pediatirc Endocrinology & Metabolism Vol.15 No.3

Idiopathic hypogonadotropic hypogonadism (IHH) is defined by delayed or absent sexual development associated with inappropriately low gonadal sexual hormone and gonadotropin levels in the absence of anatomical or functional abnormalities of the hypothalamic-pituitary-gonadal axis. IHH has been divided into those associated with anosmia /hyposomia, known as Kallmann syndrome and those occurring in normosmic IHH. Recently, mutations in a number of genes associated with IHH have been identified, including: GNRH1, GNRHR, KISS1R, TAC3, TACR3, KAL1, FGF8, FGFR1, PROK2, PROKR2, and CHD7. These genes encode proteins which are involved in the regulation of gonadotropin releasing hormone (GnRH) neuronal development, migration of GnRH neurons, GnRH secretion or GnRH action. This review discusses the human genetic mutations associated with IHH and their molecular mechanism.

경상북도 전원지역 주민의 치과보철치료실태 및 수요도조사

신영림,김동응 慶北大學校 齒科大學 1993 慶北齒大論文集 Vol.10 No.2

저자는 농어촌지역주민들의 치아보철치료현황과 보철물수요정도를 조사하여 구강건강계획수립에 필요한 기초자료를 마련하기 위하여 경상북도 8개군을 임의 선정하고 각군에서 1개면 및 1개 자연부락을 무작위로 추출하여 1141명을 구강검진과 설문조사하여 다음과 같은 결론을 얻었다. 1. 상악보철물보유현황은 단순금관이 조사대상자 1인당 0.38개, 계속가공의치보유율은 28%, 국소의치보유율은 7.10%, 총의치보유율은 9.38%, 무치악율은 4.47%이었다. 2. 하악보철물보유현황은 단순금관이 조사대상자 1인당 0.39개, 계속가공의치보유율은 26%, 국소의치보유율은 8.76%, 총의치보유율은 5.61%, 무치악자율은 3.42%이었다. 3. 학력과 구강내보철현황과의 관계에 있어서 단순금관보유율은 학력이 높아질수록 낮아지는 경향이 있었고, 계속가공의치보유현황은 국졸군에 있어서 가장 높게 나타났고 국소의치보유율, 총의치보유율 및 무치악율에 있어서는 학력이 높아질수록 감소하는 경향을 나타내어 전체적으로 학력이 높을수록 보철장착율이 낮아지는 경향이었다. 4. 보철치료필요정도는 단순금관경우 1인당 1.05개, 계속가공의치의 경우 1인당 0.85개, 국소의치의 경우 58.6%가 새로 제작하거나 필요로 하는 것으로 조사 되었고 총의치의 경우 24.8%가 필요한 것으로 나타났다. 5. 보철치료필요정도는 단순금관의 경우 상악에서 50-59세가 하악에서는 40-49세가 가장 높았고 30-39세가 상,하악 공히 가장 낮았다. 계속 가공의치의 경우 상, 하악 모두 50-59세가 가장 높았고 상악에서는 30세 미안이 가장 낮았으며 하악에서는 30-39세가 가장 낮게 나타났다. 국소의치의 경우 상,하악 모두 60-69세에서 가장 높은 수요도를 나타내었고 30세미만이 가장 낮은 수요도를 나타내었다. 총의치에 있어서는 상하악 모두 연령이 증가함에 따라 수요정도가 높아지는 것으로 조사되었다. In order to collect the basic data for the dental prosthetic treatment status and the needs of prosthetic treatment in the fishing and farming villages. We selected 8 myeons in Kyung-Pook province and take a random sample of 1141 observations. The author had a detail oral examination and questionnaire. The results of these were summarized as follows; 1. In the maxillary prosthetic treatment status, simple crown was 0.38 unit per person, crown & bridge wearing rate was 28%, partial denture wearing rate was 7.10%, complete denture wearing rate was 9.38% and edentulous rate was 4.47%. 2. In the mandibular prosthetic treatment status, simple crown was 0.39 unit per person, crown & bridge wearing rate was 26%, partial denture wearing rate was 8.76%, complete denture wearing rate was 5.61% and edentulous rate was 3.42% 3. In the interrelationship between a school career and dental prosthetic treatment status, generally, it had tendency that the higher a school career, the lower the dental prosthetic treatment status was. 4. In the needs of prosthetic treatment, there was found that the needed simple crown was 1.05unit per person, crown & bridge was 0.85unit per person, new or needed partial denture was 58.6%, and needed complete denture was 24.8%.

산전 초음파로 진단된 다낭포성 신이형성증의 임상소견 및 자연경과

신영림,원혜성,성윤종,박영서 대한소아청소년과학회 2000 Clinical and Experimental Pediatrics (CEP) Vol.43 No.7

Purpose : Multicystic dysplastic kidney(MCDK) is characterized by the presence of multiple cysts of varying sizes. It is associated with ureteral or pelviureteral atresia, and a non-functioning kidney. The purpose of this study was to examine the clinical feature and the natural history of MCDK. Methods : A study was performed in 36 children with prenatal diagnosis of MCDK from 1989 to 1999. All patients underwent renal ultrasonography and scintigraphy, and most underwent voiding cystourethrography after birth. Follow-up renal ultrasonography was performed generally every year. Results : Initial size of ultrasonography showed that MCDK was larger than normal in 27 cases, normal in 5 cases, and smaller than normal in 4 cases. Follow-up was available on 26 children during 12-78 months. In one patient, there was a complete involution of the MCDK. In 15 patients(58%), there was a reduction in size and 9 patients(35%) showed no change. One patient underwent nephrectomy for an enlarged MCDK. Voiding cystourethrography in 23 patients revealed vesicoureteral reflux in 6(26%). Other abnormalities of the contralateral kidney were detected in 3 of 36 children(8%), consisting of hydronephrosis, hydronephrosis and ureterocele, and simple cyst. Hypertrophy of the contralateral kidney was observed in 14% at birth and 50% in follow up. No renal dysfunction, hypertension and urinary tract infection were noted in all patients during follow up. Conclusion : The natural history of MCDK demonstrates a low incidence of complications and a high incidence of spontaneous regression. Therefore, uncomplicated MCDK is best managed conservatively. But further long-term follow up study is needed. 목 적 : 다낭포성 신이형성증(multicystic dysplastic kidney)은 신장이 정상 조직 없이 다양한 크기의 낭종으로 형성된 질환으로 대부분 산전 초음파에서 발견된다. 다낭포성 신이형성증은 최근 연구에 의하면 자연적으로 퇴행하는 양상을 보인다고 한다. 이에 저자들은 산전 초음파로 진단된 다낭포성 신이형성증의 임상 소견 및 추적 관찰을 통한 자연경과를 알아 보고자 하였다.방 법 : 1989년 9월부터 1999년 12월까지 10년간 서울중앙병원에서 산전 초음파로 진단된 다낭포성 신이형성증 환아 36명을 대상으로 하였다. 출생 후 신장 초음파, 배뇨성 방광 요도 조영술 및 신장 동위원소 검사를 시행하였고 1년마다 신장 초음파로 추적 관찰을 하였다.

불소용액양치 및 불소이온도입법에 의한 불소도포가 초기법랑질탈회병소의 재석회화에 미치응 영향

신영림 慶北大學校 齒科大學 1994 慶北齒大論文集 Vol.11 No.2

불소용액양치 및 불소이온도입법에 의한 불소도포가 초기법랑질탈회병소의 재석회화에 미치는 영향에 대해 알아보고자 법랑질시편에 인위적으로 초기법랑질탈회를 유발하여 하악가철성장치물에 매식한후 4명의 대상자 구강내에서 2주동안 초기법랑질탕회병소를 노출시키면서 불소처치없이 타액에 의한 자연적인 재석회화, 매일 1회 1분동안 0.05% 불화소다용액 양치, 이온도입으로 2.0% 불화소다용액을 4분간 1회 도포한후 Vickers hardness tester로 법랑질시편의 표면미세경도, 내산성 실험후 표면미세경도를 측정하였고 주사전자 현미경으로 표면변화를 관찰하여 다음과 같은 결과를 얻었다. . 구강내노출 실험후 표면미세경도를 측정한 결과, 구강내노출군 모두 초기법랑질탈회병소에 비해 증가된 표면미세경도를 나타내었으며(p<0.01) 타액군, 불소용액양치군, 불소이온도입군의 순으로 표면미세경도가 증가하였다. . 구강내노출 실험후 내산성실험을 행하여 표면미세경도를 측정한 결과, 구 강내노출군 모두 초기법랑질탈회병소에 비해서 높은 표면미세경도를 나타내엇으며(p<0.01) 타액군, 불소용액양치군, 불소이온도입군순으로 표면미세경도가 높게 나타났다. . 표면미세경도의 변화를 초기법랑질탈회병소를 기준으로 각 실험군의 백분 율로 환산하여 비교한 결과 구강내노출 실험후에 비해 내산성실험후 타액군, 불소용액양치군, 불소이온도입군 모두 감소하였으나 불소용액양치군은 통계적으로 유의한 차이가 없었다(p>0.05). . 주사전자현미경으로 구강내노출 실험후 표면변화양상을 관찰한 결과 타액군의 경우 초기법랑질탈회병소에 비해 파괴양상이 상당히 감소되었으나 미세공과 균열부위가 여러군데 관찰되었고 불소도포군의 경우 표면구조가 비교적 매끄럽고 균일하게 회복되었다. The effect of fluoride application by mounthrinse and iontophoresis on remineralization of early caries-like lesions was investigated in vivo using acrylic mandibular removable applinance. Forty extracted third molars were collected, early caries-like lesions were created using 0.1M lactic acid-sodium hydroxide buffer(pH=4.0). A total of 7 enamel specimens with early caries-like lesions were mounted into the recesses of lingual surface of the appliance with sticky wax and 4 subjects wore the appliance for 14days without exposure to fluoride agent, with daily exposure to 0.05% NaF solution for 1 min. or one iontophresis application of 2.0% NaF solution for 4 min. Each subjects wore the appliance for three separate 14-day periods; saliva exposure. F mouthrinse, F iontophoresis test. During the intraoral periods, all subjects continued their usual dietary habits, and wore the appliance continuously except during meal times and toothbrushing, and brushed with F-free dentifrice. For analysis of remineralization effect, surface microhardness test, acid resistance test were done with Vickers hardness tester(500gm load) and the changes of enamel surface were observed with scanning electron microscope(at 20Kv). For statistical analysis, oneway ANOVA and Duncan's multiple rang test were used to test for statistical differences of surface microhardness values between early caries-like lesions and intraoral exposure(IOE) groups, and after acid resistance test(ART). The comparision of microhardnesss(%) between following IOE and after ART compared to the early caries-like lesions was determined using t-tests. The obtained results were as follows: 1. Surface microhardness value after intraoral exposure. IOE groups were found significantly higher mean value of surface microhardness than early caries-like lesions(p<0.01) and VHN was highest in fluoride iontophoresis group and lowest in saliva group. 2. Resistance to a controlled acid challenge was determined followingsurface microhardness testing after intraoral exposure. ART groups after intraoral exposure were found significantly higher mean value of surface microhardness than early caries-like lesions(p<0.01) and VHN was lowest in saliva group and highest in fluoride iontophoresis group. 3. The percent change in microhardness following intraoral exposure and after acid resistance test compared to early caries-like lesions. IOE groups were found higher mean value of surface microhardness than ART groups but no difference occured between %IOE and %ART of fluoride mouthrinse group(p>0.05). 4. The changes of surfaces were observed with SEM photographs(x2,000) after IOE and ART. Saliva group was guietly decreased the degree of destruction of enamel surface than early caries-like lesions but focal holes and small micropores were found in various place. Relatively homogeneous surface pttern was observed in fluoride application group.

소아청소년 시기의 갑상선질환

신영림 대한의사협회 2018 대한의사협회지 Vol.61 No.10

Thyroid hormones play an important role in normal growth and development throughout infancy, childhood, and adolescence. Abnormalities of thyroid function during the fetal period and infancy result in impaired development of the brain and skeleton. In childhood and adolescence, thyroid disorders can negatively affect normal growth and pubertal development. Therefore, early diagnosis and treatment of thyroid disorders are essential for obtaining excellent outcomes. Because most pediatric patients with thyroid disorders need long-term therapy, and can experience adverse effects or have an unfavorable prognosis, physicians should provide professional treatment and monitoring.

새로운 ABCD1 유전자의 돌연변이를 가지는 소아 대뇌형 부신백질이영양증 1례

신영림,Shin, Young-Lim 대한유전성대사질환학회 2012 대한유전성대사질환학회지 Vol.12 No.1

X 연관 부신백질이영양증(adrenoleukodystrophy, ALD)은 과산화소체베타산화과정(peroxisomal ${\beta}$-oxidation)의 장애로 매우긴사슬지방산(very long chain fatty acids, VLCFA)이 신경계의 백질과 부신피질 및 고환에 축척된다. 이 질환은 과산화소체막단백질(peroxisomal membrane protein)을 형성하는 Xq28에 위치하는 ATP-binding cassette, subfamily D, member 1 (ABCD1) 유전자 돌연변이에 의해 주로 발생한다. X 연관 ALD는 다양한 임상양상을 보이는데 전형적인 소아대뇌형 부신백질이영양증은 10세 이전의 남아에서 대뇌백질에 빠르게 진행하는 탈수초현상을 보인다. 8세 된 남자 환아로 정상발달과정을 보이던 중 초등학교 입학 후에 집중장애와 산만한 모습으로 인해 주의력결핍과다활동장애로 진단받고 치료를 받았었다. 환아는 내원 8개월 전부터 말이 어눌해 지고 걸을 때 오른 발을 끌며 자주 넘어지는 모습을 보여 내원하였고 오른쪽 상, 하지의 근력이 떨어지는 양상이 관찰되었다. 검사상 부신기능저하증 소견을 보였으며 혈청 지방산 분석검사에서는 C26:0, C42:0/C22:0, C26:0/C22:0가 증가하였다. 뇌 자기공명영상에서는 T2와 FLAIR 강조영상에서 양측의 두정후두부의 백질과 소뇌의 백질에서 대칭적으로 고신호강도를 보였다. 환아는 부신백질이영양증로 진단하였고 ABCD1 유전자 분석 검사에서 새로운 c.983delT (p.Met329CysfsX7) 돌연변이가 확인되었다. X 연관 ALD는 유전자형과 표현형에 연관성이 없으며 다양한 임상양상을 보이기 때문에 환자들마다 임상증상을 잘 관찰해야 하며 향후 유전자 기능을 좀 더 파악하고 임상증상에 영향을 주는 다른 요소에 대한 연구가 필요할 것이라 사료된다. X-linked adrenoleukodystrophy (ALD) is a rare inherited metabolic disease which results in impaired peroxisomal ${\beta}$-oxidation and the accumulation of very long chain fatty acids (VLCFA) in the adrenal cortex, the myelin of the central nervous system, and the testes. X-linked ALD is caused by mutations in the ABCD1 gene encoding an ATP-binding cassette transporter superfamily located in the peroxisomal membrane. This disease is characterized by a variety of phenotypes. The classic childhood cerebral ALD is a rapidly progressive demyelinating condition affecting the cerebral white matter before the age of 10 years in boys. We report the case of a 8-year-old with childhood cerebral X-linked ALD who developed inattention, hyperactivity, motor incoordination and hemiparesis. We diagnosed ALD with elevated plasma very long chain fatty acid level and diffuse high signal intensity lesions in both parieto-occipital white matter and cerebellar white matter in brain MRI. We identified a novel c.983delT (p.Met329CysfsX7) mutation of the ABCD1 gene. There is no correlation between X-ALD phenotype and mutations in the ABCD1 gene. Further studies for searching additional non-genetic factor which determine the phenotypic variation will be needed.

한국인의 Metachromatic Leukodystrophy의 효소 및 DNA 진단

신영림,유한욱,Sin, Yeong-Rim,Yu, Han-Uk 대한유전성대사질환학회 2003 대한유전성대사질환학회지 Vol.3 No.1

The Timing of Rapid Infant Weight Gain in Relation to Childhood Obesity

신영림 대한비만학회 2019 The Korean journal of obesity Vol.28 No.4