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신실,홍재익 대한피부과학회 1971 大韓皮膚科學會誌 Vol.9 No.2
One case of malignant acanthosis nigicans associated with gastric adenocarcinoma (scirrhous type) and papilloma on the oral mucosa is presented. The patient, 36 year old Korean male, visited S.N.U.H, complaining of sore-mouth and sore-tongue of 20 days duration. He had been affected with severe papillomatosis on the oral mucosa and with hyperkeratosis on the periorbital area, the perioral area, the neck, the axillae, the palms, the umbilical area, the inguinal area, the anogenital area and the soles which were moderately hyperpigmented with grayish to brown color. He had not been complaining of G-I troubles except sore-mouth and sore-tongue, but he was diagnosed as stomach carcinoma by gastroendoscopy, He got an operation of extended total gastrectomy with isoperistaltic jejunal interposition. Post-operative histopathologic examination rvealed well differentiated adenocarcinoma of the stomach which had already metastasized to the neighboring lymph nodes. After operation the papillomatosis on the oral mucosa and skin eruptions had been improved but becarne aggravated again one and half month after discharge.
신실,손숙자,최달용 대한피부과학회 1981 大韓皮膚科學會誌 Vol.19 No.1
Epidermolysis bullosa aimplex is a dominantly inherited syndrome characterized by the dissolution of the basal epidermal cells with mechanical stress. A 23 year-old man developed recurrent bullous eruptions with pain on hands, feet and face since childhood, which healed spontaneously without scarring. Grandmother of his father's side, father, aunt of his father's side and two of his three brothers had suffered similar skin lesions. Light and electron microscopy showed degeneration and bulla formation in the basal cell layer of epidermis and intact basement membrane attached to dermis.
급성 발열성 호중구성 (好中球性) 피부병 ( Sweer 증후군 ) 의 2 예
신실,손숙자,조낙준,최달용 대한피부과학회 1980 大韓皮膚科學會誌 Vol.18 No.5
Acute febrile neutrophilic dermatosis, which was introduced to the dermatologic literature by Sweet in 1964, is characterized by persistent high fever and preceding upper respiratory infection like symptoms, polymorphonuclear leukocytosis in the peripheral blood, raised painful plaques on the limbs, face and neck, histologically a dense dermal infiltration with polymorphonuclear leukocyte, dramatic response to corticosteroids, and the absence of scarring. Case 1 was a 35 year-old female who had suffered from malaise, sore throat, and fever 3 to 7 days before the each episode of the cutaneous manifestation. Painful, red, raised, well-demarcated plaques appeared on the face with tendency of recurrences, and was accompanied by a few, small, shallow ulcerations on the lower Iip and tongue, and conjunctivitis. Polymorphonuclear leukocytosis (10400 with 65%, 11600 with 75%) and elevated ESR(23mm/hr, 19mm/hr) were found on two occasions. Histologically a dense inflammatory cell infiltration composed predominantly of polymorphonuclear neutrophils, small round cells, and a few eosinophils were seen in the dermis and subcutis, especially around the dermal capillaries. Alao there were many nuclear debris and marked endothelial cell proliferations. Case 2 was a 41 year-old housewife who experience mild fever and sore throat one week before the onset of cutaneous manifestations. Skin manifestations showed vesicular eruption on erythematous infiltrated base on neck and Rt. forearm, and erythematous tender subcoutaneous nodules, some of which coalesced to form erythematous plaque on the both pretivial regions. At that times, knee and ankle joint arthralgias were accompanied. Polymorphonuclear elukocytosis(11500 with 93%) and elevated ESR(105mm/hr) were found. Skin biopsy from vesiculopapular eruption on Rt. forearm showed acnathosis, spongiosis and exocytosis in the epidermis, and a dense inflammatory cell infiltration composed predominantly of PMNL and a few eosinophils in the dermis and subcutis. However, biopsy from the plaque lesion on lower leg showed mild perivascular inlammatory cell infiltration on the dermis and subcutis, chiefly of the lymphohistiocytic cells. And sweeling of the endothelial cells were found. The symtoms and signs of our cases were responded well to orally administered prednisolone.
신실,김이중,조낙준 대한피부과학회 1978 대한피부과학회지 Vol.16 No.5
Pyogenic granuloma is not an uncommon oral cavity lesion and is a benign soft tissue tumor arising from the connective tissue of the skin or mucous membrane. We have reported a pedunculated tumor on the junctional area of the left side of upper lip and buccal mucosa which was developed without any history of trauma and clinically it was composed with condyloma acuminatum. Histopathological findings showed many newly formed blood vessels with marked endothelial swelling and collarette formation of rete ridges of epidermis. The lesion was completely subsided after surgical excision.