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신승현,박경준,김인주,김범수,김성장 대한핵의학회 2017 핵의학 분자영상 Vol.51 No.3
Objectives Previously published studies showed that the standard tumor-to-blood standardized uptake value (SUV) ratio (SUR) was a more accurate prognostic method than tumor maximum standardized uptake value (SUVmax). This study evaluated and compared prognostic value of positron emission tomography (PET) parameters and normalized value of PET parameters by blood pool SUV in non-small-cell lung cancer (NSCLC) patients who received curative surgery. Methods Seventy-seven patients who underwent curative resection for NSCLC between January 2010 to December 2013 were enrolled in this study. 18Fluorine-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) was performed before surgery. The mean standardized uptake value (SUVmean), SUVmax, metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of each lesion was measured, on the workstation. SURmean, SURmax, and TLGSUR were calculated by dividing each of them by descending aorta SUVmean. Cox proportional hazards regression was used to analyze the effect of age, sex, pathological parameters, and PET parameters on recurrence and death. Results In Cox regression analysis, N stage predicted for both recurrence (p < 0.0001) and death (p < 0.0001). SURmax predicted recurrence (p = 0.0014), not death. Area under the receiver operating characteristic curve of SURmax was 0.759 with cutoff value 4.004. However, SUVmax, SUVmean, MTV, TLG, SURmean, and TLGSUR predicted neither recurrence nor death. Conclusions Among PET parameters, SURmax was the independent predictor of recurrence in NSCLC patients who received curative surgery. N stage was the independent prognostic factor for both recurrence and death. Both parameters could be used to stratify the risk of NSCLC patients.
신승현,심지현 한국기업교육학회 2018 기업교육과인재연구 Vol.20 No.1
본 연구의 목적은 기업의 스마트러닝 강의를 평가하기 위한 평가도구를 개발하고, 개발된 평가지표와 도구의 신뢰도와 타당도를 검증하는 것이다. 이를 위해 본 연구에서는 이러닝, 스마트러닝, 기업교육, 강의평가 등 연구와 관련된 선행연구를 분석하여 평가지표 초안을 도 출하고, 이를 스마트러닝 교육을 시행한 경험이 있는 현장 전문가나 교육담당자들에게 검토 를 받았다. 검토한 의견을 수렴하여 평가도구 개발을 위한 설문지를 작성하였으며, 스마트러 닝 경험이 있는 학습자들을 대상으로 설문조사를 하였다. 설문 응답결과를 분석하여 평가도 구의 신뢰도를 검증하고, 탐색적 요인분석과 확인적 요인분석을 통해 평가도구의 타당도를 확인하여, 최종 평가도구를 제안하였다. 연구결과 본 연구에서 개발한 스마트러닝 강의평가 도구는 기존 e-러닝, 오프라인 강의평가와 다르게 다음과 같은 특성이 있다. 첫째, 기업에서 스마트러닝 교육을 담당한 실무자와 스마트러닝을 수강한 학습자들의 의견을 반영한 평가도 구이다. 둘째, 스마트러닝 특성이 포함된 평가도구이다. 증강현실, 지능적 맞춤화, 자기주도학 습 등 스마트러닝 환경에서만 구현하고 시행할 수 있는 부분들을 평가항목으로 제안하고 검 증하였다. This study has been conducted to develop an evaluation tool for smart learning lectures in corporations sector and to verify its validity and reliability. To that end, preceding studies on e-learning, smart learning, corporate education and lecture evaluation were analyzed to draw a draft for the evaluation index and had it reviewed by experts in the field or those in education who had experience in smart learning. The review opinions were collected to create a questionnaire for the development of evaluation tools and the questionnaire was distributed to learners who had experience in smart learning. The questionnaire responses were then analyzed to verify the reliability of the evaluation tool. Ultimately, the validity of teaching assessment toll was verified by a confirmatory factor analysis and an exploratory factor analysis to suggest the final evaluation tool.
컨테이너선 및 석유 운반선에 대한 건현 계산식 검증 및회귀분석 기초연구
신승현,구남국 한국CDE학회 2018 한국CDE학회 논문집 Vol.23 No.1
The purpose of this research is a verification of the current equation for calculating freeboard and a suggesting a method for development of a new rational equation. The equation for calculating freeboard consists of several procedures. But the equation is only based on the previous ships, so that has some weakness such as “Limited or no representation of physics”, “Based on old analysis techniques”, “Based on old (outdated) hull forms”. Therefore, SLF Sub-Committee (Sub-Committee on Stability and Load Lines and on Fishing Vessels' Safety) was established, and they studied this subject. However, it was not possible within the given time frame of the ongoing revision process to ascertain to what extent the ICLL 1966 regulations result in sufficient reserve buoyancy, it was decided at SLF 42 to leave the freeboard tables of ICLL 1966 unaltered for the moment being. So, in this research, we suggest new equations using regression analysis of existing results of the estimation for freeboard. It is expected to shorten time for calculating freeboard in very first design stage using proposed equation.
신승현,김근영,이재민,김은주,김성장,김인주,박경준,이명준 대한신경과학회 2019 Journal of Clinical Neurology Vol.15 No.1
Background and Purpose We aimed to determine the association between the annual changes in dopamine transporter (DAT) availability as measured by 123I-ioflupane (123I-FP-CIT) single-photon-emission computed tomography and single-nucleotide polymorphisms (SNPs) known to be risk factors in Parkinson’s disease (PD). Methods In total, 150 PD patients were included from the Parkinson’s Progression Markers Initiative database. Specific SNPs that are associated with PD were selected for genotyping. SNPs that were not in Hardy-Weinberg equilibrium or whose minor allele frequency was less than 0.05 were excluded. Twenty-three SNPs met the inclusion criteria for this study. The Kruskal- Wallis test was used to compare annual percentage changes in DAT availability for three subgroups of SNP. Results None of the 23 SNPs exerted a statistically significant effect (p<0.0022) on the decline of DAT availability in PD patients. However, we observed trends of association (p<0.05) between three SNPs of two genes with the annual percentage change in DAT availability: 1) rs199347 on the putamen (p=0.0138), 2) rs356181 on the caudate nucleus (p=0.0105), and 3) rs3910105 on the caudate nucleus (p=0.0374). A post-hoc analysis revealed that DAT availability was reduced the most for 1) the putamen in the CC genotype of rs199347 (vs. CT, p=0.0199; vs. TT, p= 0.0164), 2) the caudate nucleus in the TT genotype of rs356181 (vs. CC, p=0.0081), and 3) the caudate nucleus in the CC genotype of rs3910105 (vs. TT, p=0.0317). Conclusions Significant trends in the associations between three SNPs and decline of DAT availability in PD patients have been discovered.