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      • SCOPUSKCI등재

        일부 6가 크롬 폭로 작업자의 임파구 자매염색분체교환

        신동훈,윤능기,서석권,예민해,Shin, Dong-Hoon,Yoon, Nung-Ki,Suh, Suk-Kwon,Yeh, Min-Hae 대한예방의학회 1990 Journal of Preventive Medicine and Public Health Vol.23 No.3

        1989년 11월부터 4개월간 대구시내 소재 일부, 6가 크롬(삼산화크롬)으로 피막처리하는 도금작업장의 남성근로자를 대상으로 비중격천공이 있는 근로자 12명과 비중격천공이 없는 근로자 12명을 폭로군으로 하고 크롬에 폭로된 적이 없는 정상인 20명을 대조군으로 하여 개별면담을 통해 연령, 직업력, 흡연습관을 파악하였으며, 정맥혈을 채취하여 원자화 무염광로를 부착한 원자흡광도계로 혈중 크롬농도를 측정하였으며 말초혈액 중 임파구의 자매염색분체교환의 발현빈도를 조사하고 연령, 흡연습관, 직업력 및 혈중 크롬농도 등이 임파구 자매염색분체교환의 발현빈도에 미치는 영향을 조사했다. 크롬 도금작업의 말초혈액 중 임파구 자매염색분체교환의 발현빈도는 비중격 천공이 있는 군이 $10.1{\pm}1.6$, 비중격천공이 없는 군이 $8.5{\pm}3.4$이었고 대조군 $6.1{\pm}2.1$으로 세군간에 유의한 차이가 있었으며 (p<0.01), 비중격천공 군에서 가장 높은 빈도를 보였으며, 대조군에 비해 1.7배의 높은 빈도를 나타냈다. 혈중 크롬농도는 대조군이 $0.060{\pm}0.043{\mu}g/ml$, 크롬도금 작업자 중 비중격천공이 있는 군 $0.114{\pm}0.030{\mu}g/ml$, 비중격천공이 없는 군 $0.090{\pm}0.050{\mu}g/ml$로 세군간의 차이는 유의하였다 (p<0.01). 크롬도금 작업자와 대조군 모두 연령군별, 흡연습관별 및 근속년수에 따른 자매염색분체교환의 발현빈도에는 유의한 차이가 없었다. 혈중 크롬농도와 자매염색분체교환 발현빈도의 상관성은 상관계수, r=0.007로서 상관관계가 없었다 (Y=0.638 X+0.191, r=0.007. p>0.05). SCE 평균 발현빈도를 $y=(sum\;SCE)^{\frac{1}{2}}+(sum\;SCE+1)^{\frac{1}{2}}$를 이용하여 변형한 변수 y에 대해 연령, 흡연습관, 직업 및 혈중 크롬농도의 요인들로서 설명력은 32.3%였으며 가장 중요한 변수는 직업으로 나타났다. 이상의 결과로 보아 직업적인 크롬폭로에 의한 유전적 손상의 위험성이 어느 정토 있을 것으로 추측되며 생물학적 독성검정 지표로서 유용성이 있을 것으로 생각된다. To investigate the possibility of utilizing of sister chromatid exchange(SCE) analysis in lymphocytes as an indicator which could evaluate the effects of mutagenicity after in vivo exposure to hexavalent chromium, this study was conducted using some of chromium plating workers occupationally exposed to hexavalent chromium, chromium trioxide ($CrO_3$) in Taegu city. The study population was 12 Cr platers with perforation of nasal septum, 12 Cr platers without perforation of nasal septum and 20 controls. The SCE in peripheral blood lymphocytes of the subjects was analyzed and blood chromium concentration was estimated using the atomic absorption spectrophotometer (IL551) equipped with furnace atomizer (IL755). The mean SCE frequencies for Cr platers with and without perforation of nasal septum were statistically higher than those for control. The difference in SCE frequencies by age, smoking habits were not statistically significant both in Cr platers and controls. There was no difference in SCE frequencies by career of Cr platers workers. In Cr platers, the correlation between the mean SCE frequencies and chromium concentration in blood was not statistically significant. Using the transformation $y=(sum\;SCE)^{\frac{1}{2}}+(sum\;SCE+1)^{\frac{1}{2}}$, when the data was studied by multiple regression, it appeared that the influence of the occupation was the most important. Age, smoking, occupation and CrB(blood chromium concentration) together explain only 32.3% of interpersonal variation on SCE. The results in this study suggest tt a genetic risk due to occupationally exposure to hexavalent chromium is clearly inferable and thus, SCE analysis in human lymphocytes may be used indicator of biological toxic effects of chromium. Further, populatio analysis stuies are required before SCE frequency can be used as a mutagenic indicator in human population.

      • KCI등재

        ZCB00 인공수정체의 부분결합간섭계와 초음파 방식의 술 후 굴절 예측치 차이

        신동훈,임동희,유자영,정의상,정태영,Dong Hoon Shin,Dong Hui Lim,Ja Young You,Eui Sang Chung,Tae Young Chung 대한안과학회 2014 대한안과학회지 Vol.55 No.4

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

        Purpose: To evaluation the accuracy of the IOL power calculation formulae measured by IOL Master<sup>® and applanation ultrasonography for the Tecnis ZCB00 IOL Methods: We performed a retrospective study of 170 eyes in 121 patients who underwent cataract surgery in our hospital with AMO Tecnis ZCB00 IOL.s. The SRK/T formula was used to predict the patient's implanted IOL power. Differences in the predicted refractive errors between IOL Master<sup>® and ultrasonography were analyzed and factors attributed to the differences were also analyzed. Three months after cataract surgery, mean numeric error and mean absolute error were analyzed. Results: SRK/II and SRK/T formulas calculated using ultrasonography showed differences compared to the same formulas calculated using IOL Master<sup>®, in which hyperopic shift was also demonstrated. No definite factor was attributed to the differences between the 2 methods. Although the 3 formulas of IOL Master<sup>® showed no significant difference in refractive errors, the SRK/T formula calculated using IOL Master<sup>® showed the least mean absolute and numeric errors. Conclusions: IOL Master<sup>® is considered more suitable when determining proper AMO Tecnis ZCB00 IOL power in cataract surgery. The hyperopic shift should be considered when calculating the IOL power using only ultrasonography. J Korean Ophthalmol Soc 2014;55(4):527-533

      • 일산화탄소흡입(一酸化炭素吸入)이 비임신(非妊娠) 토끼자궁운동(子宮運動)에 미치는 영향(影響)

        신동훈,김기곤,Shin, Dong-Hoon,Kim, Ki-Kon 대한생리학회 1975 대한생리학회지 Vol.9 No.2

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

        Adult nonpregnant female rabbits were subjected to the study of the effects of carbon monoxide inhalation on the uterine motility. Animals were anesthetized with intravenous injection of nembutal, 35 mg/kg, and the uteri were exposed. Polyethylene tubing which had a small hole near the blind tip was inserted in the loop and normal saline was infused at a constant rate of 1.5 ml/min. On the other end of the loop, an outlet of fluid was made. When a peristaltic wave proceeded to the hole, a rise of the pressure was ensued and it was transmitted to the pressure transducer, making an upward deflection of the recording pen on the physiograph. Carbon monoxide, 1,000 ppm in the concentration, was inhaled through a tracheal cannula for 30 minutes, following fresh air for 30 minutes. In some cases, pure oxygen was also supplemented for another 30 minutes. Uterine motility was expressed in terms of the impulse that was the time integral of the pressure and of the frequency of the peristaltic waves. The results obtained were as follows. 1. When 1,000 ppm carbon monoxide was inhaled for 30 minutes, the impulse dropped to $72{\pm}16.5%$ and the frequency to $75{\pm}22.7%$ of the values obtained before the gas administration. 2. By fresh air for 30 minutes, the impulse and the frequency restored to $77{\pm}25.7%$ and $92{\pm}21.1%$, respectively. 3. By the supplement of pure oxygen for 30 minutes, no remarkable improvement were revealed, showing $89{\pm}35.2%$ in the impulse and $91{\pm}10.8%$ in the frequency, respectively. 4. There was an appreciable discrepancy in the recovery courses of the impulse and the frequency, suggesting different mechanisms attributable to the alteration by carbon monoxide inhalation.

      • KCI등재

        154 kV XLPE 전력케이블의 부분방전 측정을 위한 FSA의 적용 및 표준화 연구

        신동훈,양종석,황두현,임종천,박노준,박대희,Shin, Dong-Hoon,Lwin, Kyawsoe,Yang, Jong-Seok,Hwang, Doo-Hyun,Lim, Jong-Chun,Park, Noh-Joon,Park, Dae-Hee 한국전기전자재료학회 2007 전기전자재료학회논문지 Vol.20 No.5

        The measuring system of the Partial discharge(PD) is very essential to investigate the hazard defects in the insulation systems of the high voltage engineering. We will discussed this research which has included two parts. The proposed method of Foil Sensor Array(FSA) and the normally used method in the practice. Firstly, it will be shown the improved sensitivity of a FSA sensor, which is our aim, compare with the existing normal foil sensor. And then, the linearity of detecting sensitivities of various kinds of FSA sensors was shown. According to our experiments, we can see that FSA sensor is more sensitivity than normal foil sensor and the linear increment property of FSA sensitivities.

      • KCI등재

        도시하천경관복원 접근방법에 관한 고찰- 청계천 복원사업을 사례로 -

        신동훈,이규석,Shin Dong-Hoon,Lee Kyoo-Seock 한국조경학회 2004 韓國造景學會誌 Vol.32 No.4

        In the 1960s, polluted urban streams were covered and paved in concrete. Rivers became sewers buried under road. As a result, wildlife habitat was lost and the open stream space was gone. In the 1990s, there was a movement for restoring urban streams to enhance the quality of life of inhabitants. Chungkye Stream, whose covering began from early 1950s and ended in 1977, is now in the process of restoration together with the Central Business District (CBD) Redevelopment Plan. However, as the construction proceeds, several problems were raised, and serious controversies resulted. Therefore, this study aims to investigate the validity of the approach of the Chungkye Stream Restoration Project through a literature survey and a site survey, and to present the improved alternative. Ultimately, the study aims to contribute to present references or guidelines for similar urban stream restoration projects. The Chungkye Stream Restoration Project has some of the following problems. First, the construction should be done based on the long-term urban redevelopment plan. Second, the construction period should be extended to restore urban streams. Third, the cultural asset conservation plan should be implemented. In order to fulfill the anticipated purpose, the above mentioned problems need to be solved.

      • KCI등재

        건강한 한국인 자원자에서 Garenoxacin 단회투여에 의한 약동학적 특성 연구

        신동훈,홍정화,이소정,김태은,장인진,신상구,유경상,Shin, Dong-Hoon,Hong, Jeong-Hwa,Yi, So-Jeong,Kim, Tae-Eun,Jang, In-Jin,Shin, Sang-Goo,Yu, Kyung-Sang 대한임상약리학회 2010 臨床藥理學會誌 Vol.18 No.1

        Background: Garenoxacin is a des-F(6) quinolone antimicrobial drug with broad-spectrum activity. We investigated the safety and pharmacokinetic (PK) characteristics of garenoxacin after a single oral dose in healthy Korean male volunteers, and compared them to those of Japanese. Methods: A parallel, single ascending dose (200, 400 and 600 mg), dose-block randomized, double-blind, placebo-controlled study was conducted in 24 healthy Korean male volunteers. Subjects were randomized into each dose group (6 for active drug, 2 for placebo). For safety assessment, vital signs, laboratory tests, 12-lead electrocardiograms and adverse events were monitored. Plasma concentrations of garenoxacin were measured till 72 hours after drug administration. Concentration-time data was analyzed by noncompartmental methods and the results were compared to Japanese data from the previous study performed under the same protocol. Results: Regarding safety, all doses of garenoxacin were well tolerated without serious adverse events or clinically meaningful changes. The mean area under the concentration-time curve from 0 hour to the last measured concentration over the limit of quantitation ($C_{last}$) ($AUC_{last}$) were 43.9, 101.8, 155.7 mg*h/L and the maximum plasma concentration ($C_{max}$) were 4.7, 8.9, 13.6 mg/L in 200, 400 and 600 mg dose groups, respectively. The range of mean elimination half-life by dose groups was 12.3 to 12.4 h. Increases in systemic exposure to garenoxacin in terms of $AUC_{last}$ and $C_{max}$ were dose proportional over the dose range of 200 to 600 mg. The geometric mean ratios (90% confidence interval) for Koreans to Japanese were 0.97 (0.87-1.08) for dose-normalized $AUC_{last}$ and 1.08 (0.96-1.22) for dose-normalized $C_{max}$. Conclusion: Single oral doses of garenoxacin were well tolerated. Systemic exposures of garenoxacin were linear according to dose increments up to 600 mg dose. Comparison of the PK between Koreans and Japanese indicates that the pharmacokinetic characteristics were similar, which suggests that no dosage adjustment is required for garenoxacin in Koreans compared to Japanese.

      • KCI우수등재

        영팽창선이론(零膨脹線理論)에 의한 동적토압해석(動的土壓解析)

        신동훈,황정규,Shin, Dong Hoon,Hwang, Jung Kyu 대한토목학회 1993 대한토목학회논문집 Vol.13 No.5

        본 연구에서는 토체내에 발생하는 파괴면(破壞面)의 방향(方向)은 선형변형율증분(線形變形率增分)이 0인 영팽창선(零膨脹線)의 방향(方向)과 일치한다고 하는 Roscoe의 영팽창선이론(零膨脹線理論)과 Mononobe-Okabe의 동적(動的) 토압이론(土壓理論)을 응용(應用)하여 지진(地震)의 영향(影響)을 고려한 동적토압이론식(動的土壓理論式)을 제안하였다. 동적토압식을 유도함에 있어서 벽체는 연직이고 재하중(載荷重)이 없으며, 뒷채움면은 수평면이고 그 재료는 조밀한 비점착성(非粘着性) 사질토(砂質土)로서 지진시에도 토질정수(土質定數)는 변화되지 않는 것으로 가정하였으며, 지진에 의한 영향을 고려하기 위하여 수평방향진도(水平方向震度)만을 고려하였다. 한편, 제안된 토압식에 포함되어 있는 수평진도(水平震度), 흙의 내부마찰각(內部摩擦角), 벽마찰각(壁摩擦角) 및 다이레이션각(角)의 영향을 분석하였으며, 유도된 이론식을 Mononobe-Okabe의 토압식과 비교분석하였다. The present study was made based on the zero extension line theory and the well-known Mononobe-Okabe's to determine the dynamic earth pressures acting on the retaining walls. The zero extension line theory, which was proposed by Roscoe et al., assumes the coincidence between the loci of failure and the zero extension lines in soil mass. ln order to compute the dynamic earth pressure developed by an earthquake, it was assumed that for the vertical retaining walls with no surcharge, the backfill materials are dense and cohesionless sandy soils, there are no changes in soil parameters during earthquake, and the horizontal earthquake intensity is considered. The effects of horizontal earthquake intensity, internal friction angle of soil, wall friction angle and dilation angle, on the earth pressure coefficients were analysed. Final1y, the presented theories were successfully compared with the Mononobe-Okabe's as well.

      • KCI등재

        가시광선중합화에 따른 충전용 Glass Ionomer Cement의 물리적 성질에 관한 연구

        신동훈,권혁춘,Shin, Dong-Hoon,Kwon, Hyuk-Choon 대한치과보존학회 1992 Restorative Dentistry & Endodontics Vol.17 No.2

        The aim of this study was to investigate the physical properties of visible light curing Glass Ionomer cement for restorative esthetic filling. The control group was the autopolymerizing GC Fuji II Glass Ionomer cement (2.2: 1 P/L ratio) and the experimental groups were made by following procedure. To induce the polymerization by visible light, the powder of GC Fuji II GI cement and the liquid of Vitrabond for base & liner were mixed in an amalgam capsule with 2.5:1, 3.0:1, 3.5:1 P/L ratio (% wt/wt). After fabrication of specimens, compressive strength, fracture toughness ($K_{IC}$) Scanning Electron Microscope and X-ray Diffraction, water-leachable content, marginal leakage and surface roughness were studied. The results were as follows: 1. Only experimental No. 1 group (visible light curing) showed less compressive strength than control group 1 hour after curing. Strength was increased with aging in all groups, so the compressive strength of light curing groups was no less than that of autopolymerizing group after 3 weeks. 2. Experimental No.3 group (visible light curing) was inferior to No.2 group (visible light curing) in fracture resistance but light curing groups were more resistant to fracture than autopolymerizing group and showed ductile fracture pattern as compared with the brittle fracture pattern of autopolymerizing group. 3. From scanning electron microscopic image, various sized unreacted powder particles, surrounded by silica gel, were embedded in polysalt matrix. Light curing groups showed little crack and more dense unreacted particles than autopolymerizing group. 4. From X-ray diffraction analysis, GC Fuji II Glass Ionomer cement powder and all groups showed glassy appearance but light curing groups seemed to be more intensive in crystaline than autopolymerizing group. S. The most significant dissolution was shown in early setting period in all group. Light curing groups were dissolved less than autopolymerizing group. 6. Marginal leakage was not different significantly in case of cavity margin composed of same tooth structure (ex. only enamel margin, only dentin margin) but much more leakage was shown in dentin/cementum margin than enamel margin. In only case of only enamel margin, light curing groups were superior to autopolymerizing group. 7. All groups showed relatively smooth surface, which irregularity was less than $1{\mu}m$. Light curing groups were smoother than autopolymerizing group.

      • 촉지 림프절의 세침흡인 세포검사 - 단일 기관의 1,346예 경험 -

        신동훈,김지연,강현정,김익두,설미영,최경운,Shin, Dong-Hoon,Kim, Jee-Yeon,Kang, Hyun-Jeong,Kim, Ick-Doo,Sol, Mee-Young,Choi, Kyung-Un The Korean Society for Cytopathology 2007 대한세포병리학회지 Vol.18 No.2

        The aim of this study was to evaluate the diagnostic value of fine needle aspiration cytology (FNAC) for the assessment of palpable enlarged lymph nodes. The authors reviewed the results of 1,346 FNACs of palpable enlarged lymph nodes performed at Pusan National University Hospital from 1998 to 2004. Of the 1,346 cases, 1,265 (94.0%) were satisfactory and 81 (6.0%) unsatisfactory. Cytologic diagnoses were judged in 488 cases, based on subsequent histologic diagnoses, clinical follow up, or both. Global results for all malignancies (lymphoid and non-lymphoid neoplasms) based on cases with final diagnoses, showed a sensitivity of 87.4% and a specificity of 98.7%. The overall diagnostic accuracy was 93,2%, and the false negative rate reduced from 12,6% to 7,3% when lymphomatous cases were excluded. The annual data for this period showed that the number of diagnostic lymph node biopsies and the rate of inadequately sampled material markedly decreased. Gene rearrangement studies for IgH and TCR ${\gamma}$ were helful in 30 cases. FNAC is a useful initial diagnostic procedure for the evaluation of palpable enlarged lymph nodes. However, the technique should be assisted by the appropriate ancillary studies and by proper interpretation by a cytopathologist.

      • KCI등재

        대돈(大敦)·소부(少府) 사법자침(瀉法刺鍼)이 뇌혈류역학(腦血流力學) 변동(變動) 개선(改善)에 미치는 영향

        신동훈,조명래,Shin, Dong-hoon,Cho, Myoung-rae 대한침구의학회 2004 대한침구의학회지 Vol.21 No.1

        Objective: The aim of this study was to investigate anti-ischemic effect of LR1 HT8 Reduction in Acupuncture Methods: I designed to investigate whether LR1 HT8 Reduction in Acupuncture affects cerebral hemodynamics [regional cerebral blood flow(rCBF), pial arterial diameter(PAD), mean arterial blood pressure(MABP)] in normal rats and to make manifest whether LR1 HT8 Reduction in Acupuncture is mediated by cyclooxygenase or guanylate cyclase. The changes of rCBF and MABP were determinated by laser-doppler flowmetry(LDF), and the change of PAD was de terminated by video microscope and width analyzer. Results: The results were as follows; 1. LR1 Reduction in Acupuncture was increased rCBF and PAD, but decreased MABP. 2. HT8 Reduction in Acupuncture was significantly increased rCBF, but decreased MABP, and increased PAD. 3. LR1 HT8 Reduction in Acupuncture was significantly increased rCBF, PAD, but decreased MABP after withdrawing of the needle. This results suggest that LR1 HT8 Reduction in Acupuncture increased significantly rCBF by dilating PAD. 4. Pretreatment with indomethacin(1mg/kg, i,v.) was significantly inhibited LR1 HT8 Reduction in Acupuncture induced increase of rCBF and PAD, but increased LR1 HT8 Reduction in Acupuncture induced decrease of MABP after withdrawing of the needle. 5. Pretreatment with methylene blue($10{\mu}g/kg$, i,v.) was decreased LR1 HT8 Reduction in Acupuncture induced increase of rCBF and PAD, but accelerated LR1 HT8 Reduction in Acupuncture induced decrease of MABP. Conclusions: I suggest that LR1 HT8 Reduction in Acupuncture has an anti-ischemic effect through the improvement of cerebral hemodynamics, and the mechanism is mediated by cyclooxygenase.

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