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새로운 Diazinon 입제의 제조 및 담수토양중의 잔류특성에 관하여
이규승,최종우,류종국,신동린 한국환경농학회 1992 한국환경농학회지 Vol.11 No.1
농약분해에 관여하는 monooxygenase와 esterase의 활성을 저해하는 것으로 알려진 PBO와 TPP를 첨가하여 제조한 新다이아지논입제에 대하여 벼멸구에 대한 살충률을 조사하였고, 아울러 新다이아지논 입제와 두효소를 저해하는 작용기작을 가지고 있는 tricyclazole, carbofuran 그리고 EPN을 혼합하여 제조한 혼합다이아지논입제에 대하여 담수토양중의 잔류경향을 조사하였다. 1. 살균토양과 비살균토양에서 新다이아지논 입제(0.1% 첨가)의 반감기는 4.53일과 2.33일 이었고, 시판품에 비하여 각각 0.74일과 0.45일 주성분의 분해가 지연되었다. 2. 新다이아지논입제(0.1% 첨가)의 벼멸구에 대한 살충률은 추천량에서는 12%, 추천 1/2량에서는 30∼60%가 증가되었다. 3. 新다이아지논 입제 (1%)중 PBO 첨가는 토양중 반감기가 0.44일 그리고 PBO-TPP첨가로 0.65일 지연되었다. 4. 혼합다이아지논 입제는 시판품에 비하여 tricyclazole, carbofuran 그리고 EPN첨가로 반감기가 2.61일, 1.04일 그리고 0.43일 지연되었으며, EPN+carbofuran을 첨가하여 제조한 혼합다이아지논 입제는 2.7일 연장되었다. New formulation of diazinon as granule preparing with piperonyl butoxide(PBO) and triphenyl phosphate(TPP) known as the inhibitor of monooxygenase(mo) and esterase was tested with the mortality of rice leaf hopper. Also, the mixed formulation of diazinon with tricyclazole, carbofuran and EPN were investigated about the residual pattern of diazinon in submerged soil condition at 30±2℃. Although the mortality about rice leaf hopper was higher only 10% on new formulation of diazinon than commercial at recommended dose but was 30-60% at half dose. Half life of diazinon in the formulation with 0.1% of PBO+TPP was 4.53 days in sterilized soil and 2.33 days in non-sterilized soil, and it was delayed about 0.74 and 0.45 respectively in contrast with the commercial granule. Also, half life of the new formulation with 1% PBO and PBO+TPP was delayed 0.44(PBO) and 0.65day(PBO+TPP) in non-sterilized soil condition, respectively. Half life of mixed formulation with tricyclazole, carbofuran, EPN or EPN+Carbofuran was delayed 2.61, 1.04, 0.43 or 2.7 days, respectively. As a result, the persistence rate of new formulation and mixed formulation was increased by inhibition of two enzymes affecting to the dgradation of diazinon in submerged soil.
3 - Phenyl - 1 -(2 - furyl) propenone 유도체의 항균 활성과 정량적 구조 - 활성관계(QSAR)
맹주양,성낙도,강희덕,신동린 한국농화학회 1991 Applied Biological Chemistry (Appl Biol Chem) Vol.34 No.2
일련의 3-phenyl-1-(2-furyl)propenones(1) 및 3-phenyl-1- (2-furyl) -3-thio-phenylpropenones(2) 유도체들을 합성하고 한천 희석법으로 측정된 잿빛 곰팡이균(B. ceneria, BC), 사과 부란병균(V. ceratosperma, VC), 고추 역병균(P. oapsici., PC) 및 마늘균핵병균(S. cepirorum, SC)에 대한 항균활성(obs. pI_50)과 치환기(X)들의 physicochemical parameters로 부터 정량적 구조 활성 관계(QSAR)를 검토한 결과, BC와 VC에 대하여는 electronic effect(σ)와 hydrophobic effect(π) 그리고 PC와 SC에 대하여는 steric factor인 STERIMOL parameter (L₁ 및 B₁)와 steric effect(Es)가 항균활성에 주로 영향을 미침을 알 수 있었으며, SC>BC>VC 및 PC의 순서로 (2) 보다는 (1) 에 의하여 약간 큰 항균활성을 나타내었다.
3 - ( 치환 ( X ) - phenyl ) - 1 - ( 2 - furyl ) propenone 유도체의 항균활성
성낙도(Nack Do Sung),강희덕(Hee Deog Kang),맹주앙(Joo Yang Maeng),신동린(Dong Rin Shin) 한국응용생명화학회 1994 Applied Biological Chemistry (Appl Biol Chem) Vol.37 No.4
New 3-phenyl-1-(2-furyl)propenones, 1 and 3-phenyl-1-(2-furyl)-3-thiophenyl-propanone, 2 derivatives were synthesized, and their fungicidal activities in vitro against Botrytis cineria (BC), Valsa ceratosperma (VC), Scelerotium cepivorum (SC) and Phytophthora capsici (PC) were investigated using a generalized structure-activity relationship (SAR). The activity of 1 was superior to those of 2, and nonsubstituent, 1a and chloro group substituent, 1d of E (Syn) conformer were the most effective (EC_(50)=10∼12 ppm) compound to BC. Antifungal activities were able to predict to depend essentially on the β carbon and their positive charge from the results that the good correlation (r²= 0.90) was observed between hydrolysis rate constant (logk) of 1 and the electronic parameter (σ) of X-substituent on the β-phenyl ring.