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The new cephamycin-type antibiotic, cefotetan is very stable to β-lactamase, it possesses a good antibacterial activity on aerobic and anaerobic gram-negative cocci and bacilli. Clinical values of cefotetan were evaluated in 26 patients with a clinical diagnosis of bacterial infection of the urinary, respiratory and gastrointestinal tract. The drug was administered intravenously in dose of 1∼4g per day for 1 to 16 days. The clinical response was satisfactory in 11(100%) patients with urinary tract infections, 8(61.5%) of 13 patients with respiratory tract infections, 2(100%) patients with gastrointestinal tract infections. Overall, cefotetan was effective in 21(80.8%) of all patients treated. During the treatment 5 patients showed adverse effects including nausea, diarrhea, skin rash, drug fever. And elevation of hepatic enzyme levels occured in 1 of all patients treated. But the majority of adverse effects disappeared within 2∼3 days.
A clinical study of 45 patients admitted with a diagnosis of small and non-small cell lung cancer to the Kang Nam St. Rlarys Hospital from NOV. 1982 to Dec. 1984 revealed the following results. 1) Among the 45 patients, 11 patients were classified as small cell cancer and 34 patients as non-small cell cancer with the highest incidence in the 6th to 8th decade. 2) The male/female ratio in small cell cancer and non-small cell cancer was 10: 1 and 2. 1: 1 respectively showing male predominance in small cell cancer. The smoker/mon-smoker ratio in small and non-small cell cancer was 4: 1 and 2.1: 1respectively showing smoker predominance in small cell cancer. 3) Coughing was the most common symptom in both small and non small cell cancer, but symptom due ta regional spread was not statistically different between two groups. 4) In the location of tumor, 72.7% of small cell cancer and 58.1% of non-small cell cancer were located in the central area showing more central distribution in small cell cancer. 5) Metastasis ta the bone and brain wzs more freguent in small cell cancer, but metastasis to the lymph node and bone marrow was more frequent in non-small cell cancer, although which was not statistically significant 6) 8 cases(72%) of small cell cancer and 17 cases(50M) of non-small cell cancer were diagn- ased by bronchoscopy showing higher rate of detection by broochoscopy in small cell cancer. And 2 cases(18.2%) of small cell cancer and 10 cases(29.4%) of non-small cell cancer were diagnosed by lymph node biopsy showing higher rate of detection by lymph node biapsy in non-small cell cancer. 7) Among the 5 cases of limited type-small cell cancer, partial and complete remission occurred in 3 cases(60%), 2 cases(40%) respectively showing mean survival of more than 14. 3 months. And among the 4 cases of extensive type-small cell cancer, 2 cases(50%) who showed partial remission lived 6 months and 2 cases(50%) who showed no response lived 3.5 months. 8) 29 cases(85.3%) of non-small cell cancer were stage g at the time of diagnosis in which 13 cases(81%) of squmaus cell cancer, 9 cases (82%) of adenocarcinoma and 7 cases(100%) of undifferentiated cell cancer were being included. 9) In the review of survival duration of non-small cell cancer, 10 cases(76. 9%) of response group showed mean survival of more than 7 months and R cases(23.1%) of non-response group lived 2. 2 months.
61 year-old man with malnutrition and ascite was diagnosed to have Menetrier's disease by gastrofiberscopy and UGIS. Work-up showed classic menetriers disease with enlarged gastric rugae and hypoalbuminemia due to protein-losing gastropathy. 50 days after medical conservative treatement, total gastrectomy was performed in order to improve hypoalbuminemia. Microscopically there was a increased number of mucous cell involving the parietal and chief cell. We consider it mixed mucous-glandular cell type hyperplasia by Mings classification. The pathogenesis and pathophysiology of the disease are poorly understood. Indeed, there is sti]1 controversy regarding its classification, cause and management. A brief review of classification, etiology, pathophysiology, classical pictures and management of Menetriers disease is presented.
This is a report of two cases of adenocarcinoma in ileum of the small intestine. Ileal adenocarcinoma has been noted at its rarity, etiology, distribution, and poor prognosis. Recently we experienced two interesting cases. One dveloped in 25 year-old rnan, and the other in 42 year old man, vho had treated by segmental resection and chemotherapy, was followed by development of gastric carcinoma after 8 year-survival.
Raynaud`s phenomenon is a disorder characterized by digital vasospasm, with sequential phases of digital pallor, cyanosis and erythema generally precipitated by exposure to cold or emotional stimuli. It is well known that Raynaud phenomenon is a frequent, early, premonitory symptom often associated with scleroderma. So we studied 26 cases of connective tissue diseases associated with Raynaud phenomenon to define the features of patients with Raynaud phenomenon that predict the evolution of connective tissue diseases especially scleroderma, The results were as follows: 1) The male/female incidence was 1 and 25 cases respectively, with the mean age of 34.2 years. 2) In 26 cases, systemic lupus erythematosus were 16 cases(56.5%), progressive systemic sclerosis were 8 cases(34.7%) and rheumatoid arthritis and cutaneous vasculitis were 1 cases respectively. 3) Fluorescent antinuclear antibody(FANA) revealed 8 cases(30.8%) of homogenous pattern, 8 cases(30.8) of speckled pattern, 1 case(3.8%) of nucleolar pattern and 4 cases(15.4%) of negative results. 4) The common symptoms and signs of systemic lupus erythematosus associated with Raynaud's phenomenon were renal involvement, CNS involvement, A-V conduction defect, pulmonary infiltration, serositis and liver function abnormalities. It was noticeable that Raynaud phenomenon was a major or initial manifestation in 3 cases(19.8%) of systemic lupus erythematosus. 5) The clinical manifestation of scleroderma were cutaneous manifestation, pulmonary infiltration, esophageal dysfunction, dryness of mouth, bone tuft resorption, proteinuria and calcinosis. 6) The average duration of Raynaud's phenomenon before evolving into clinical scleroderma was 4.3 years. 7) FANA pattern of scleroderma revealed speckled pattern(57%), hemogenous(14%), nucleolar (14%) and negative result(14%). 8) Hypergammaglobulinemia(33%), rheumatoid factor(38%), cryoglobulinemia(13%) were also found in scleroderma. 9) Skin biopsy of scleroderma revealed 2 cases of mild perivascuar mononuclear cell infiltration and 1 case of increased collagen bundle associated with flattening of epidermis under light microscopic examination. Immunofluorescent examination revealed 1 case of linear deposit of IgM along the- dermal-epidermal junction and 1 case of diffuse- nuclear deposit in epidermis.