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알지네이트가 가교된 소장점막하조직 스폰지의 생체적합성 평가
송인범 ( In Bum Song ),이민숙 ( Min Suk Lee ),김문석 ( Moon Suk Kim ),강길선 ( Gil Son Khang ),이해방 ( Hai Bang Lee ) 한국조직공학과 재생의학회 2006 조직공학과 재생의학 Vol.3 No.3
Porcine small intestine submucosa(SIS), mainly composed of collagen and glycosaminoglycan, has been widely used as a material for organ and tissue reconstruction without immuno-rejection responses. Chemicallycrosslinked SIS sponges were prepared and characterized for bio-interactive wound dressings and tissue engineered scaffolds. SIS powder were reacted in aqueous solution of 3% acetic acid and 0.1% pepsin for 48 hrs and the prepared SIS solution was poured into mold and fabricated by freeze-drying method. The crosslinking reaction was performed using 1-ethyl-(3-3-dimethyl aminopropyl) carbodiimide hydrochloride(EDC) solution(distilled water(D.W.) : ethanol = 5 : 95) of 50, 100 and 200 mM concentration for 24 hrs. Then 1 wt% alginate solution was pass through the SIS sponge and lyophilzed. 102 mM calcium chloride(CaCl2) was used as crosslinking agent. The prepared sponges were characterized by scanning electron microscopy(SEM). The biocompatibility of NIH/3T3 fibroblast with these SIS sponges was found to be acceptable at a cell density of 2×104 cell/cm2. We investigated biodegradation of SIS sponge, MTT assay and H&E stain. From the MTT assay results, the biocompatibility of the crosslinked SIS sponge with NIH/3T3 fibroblast was confirmed. It was confirmed that SIS consists of organic components like tissue and showed inter-connective pores for adhesion and growth of cell. As a result of this study, we suggest that crosslinked alginate-SIS sponges fulfil many critical elements desirable in the application of wound dressing and tissue regeneration material.
최성촌(Seong-Chon Choi),정두용(Doo-Yong Jung),송인범(In-Bum Song),이수원(Su-Won Lee),원충연(Chung-Yuen Won) 한국조명·전기설비학회 2011 한국조명·전기설비학회 학술대회논문집 Vol.2011 No.5월
This paper proposes the bi-directional isolated DC-DC converter for a charger in electric vehicle. Unlike a common load, the battery absorbs converter output current ripple because it has a large capacitance. The converter out current ripple causes the battery to generate heat, reduce lifecycle and the efficiency of the system.. The system selects isolated bi-directional full-bridge. constant current / constant voltage charging control method guarantee improvement of output current ripple and the ZVS(Zero Voltage Switching) is implemented by applying phase-shift strategies. The system is carried out with the software PSIM 9.2.
폴리(에틸렌글라이콜), 폴리카프로락톤, 및 폴리(락타이드-co-글라이콜라이드)로 구성된 트리블록 공중합체의 합성과 임계 마이셀 농도 결정
조영호 ( Young Ho Cho ),현훈 ( Hoon Hyun ),이재호 ( Jae Ho Lee ),정성찬 ( Sung Chan Jeong ),송인범 ( In Bum Song ),이봉 ( Bong Lee ),김문석 ( Moon Suk Kim ),강길선 ( Gil Son Khang ),이종문 ( John M. Rhee ),이해방 ( Hai Bang Lee 한국조직공학과 재생의학회 2005 조직공학과 재생의학 Vol.2 No.4
To use macroinitiator, methoxy poly(ethylene glycol)-block-polycaprolactone (MPEG-PCL) diblock copolymer was synthesized by the ring opening polymerization of CL with MPEG as an initiator. Also, MPEG-PCL diblock copolymer as a macroinitiator was synthesized by the ring-opening polymerization of CL under the existence of HCl·Et2O at room temperature. Successively, we synthesized triblock copolymers, methoxy poly(ethylene glycol)-block-polycaprolactone-block-polycaprolactone (MPEG-PCL-PCL), methoxy poly(ethylene glycol)-blockpolycaprolactone- block-poly(L-lactic acid) (MPEG-PCL-PLLA), and methoxy poly(ethylene glycol)-block-polycaprolactone- block-poly(L-lactide-co-glycolide) (MPEG-PCL-PLGA (mole ratio 50:50)). The properties of synthesized triblock copolymer were analyzed by 1H-NMR, GPC, FT-IR, DSC, and XRD. Critical micelle concentration (CMC) of these triblock copolymer was determined by fluorescence spectrophotometer. Micelle formation of these triblock copolymer using D2O was confirmed by 1H-NMR. The diameter and shape of micelle was measured by ELS and AFM. In conclusion, we could prepare the triblock copolymer with different polyester blocks and found the dependance of CMC with respect to characteristic polyester blocks.