만성신부전증 환자에 대한 장기혈액 투석의 문제점 - 제 2 보

김기호 ( Ki Ho Kim ),손호영 ( Ho Young Son ),민병석 ( Byung Sok Min ),박성학 ( Sung Hak Park ),김호연 ( Ho Youn Kim ),방병기 ( Byung Ki Bang ),원언식 ( Un Sik Won ),고용복 ( Yong Bok Ko ) 대한내과학회 1977 대한내과학회지 Vol.20 No.1

다양한 조성의 Sn-Ag-Cu 합금계 무연 솔더볼과 ENIG(Electroless Ni Immersion Gold), Cu-OSP(Oraganic Solderability Preservertive) 금속 패드와의 계면 반응 연구

박용성,권용민,손호영,문정탁,정병욱,강경인,백경욱,Park, Yong-Sung,Kwon, Yong-Min,Son, Ho-Young,Moon, Jeong-Tak,Jeong, Byung-Wook,Kang, Kyung-In,Paik, Kyung-Wook 한국마이크로전자및패키징학회 2007 마이크로전자 및 패키징학회지 Vol.14 No.4

In this study, we investigated the interfacial reactions between various Sn-Ag-Cu(SAC) solder alloys and ENIG(Electroless Ni Immersion Gold) and Cu-OSP(Organic Solderability Preservative) pad finish. In the case of the interfacial reaction between Sb added SAC solder and ENlf thinner P-rich Ni layer was formed at the interface. In the case of the interfacial reaction between Ni added SAC solder and Cu-OSP, the uniform $Cu_6Sn_5$, intermetallic compounds(IMCs) were formed and $Cu_6Sn_5$ grain did not grow after multiple reflows. Thinner $Cu_3Sn$ IMCs were farmed at the interface between $Cu_6Sn_5$ and Cu-OSP after $150^{\circ}C$ thermal aging.

일개 대학병원에 내원한 무증상성 열공성 뇌경색 환자와 정상인에서 비만 지수와 대사증후군 유병률 비교

정현윤(Hyun Yun Jeong),김도경(Do Kyung Kim),손호영(Ho Yong Son),신윤리(Yoon Ri Shin),이재욱(Jae Wook Lee),김경민(Kyoung Min Kim),김영균(Young Kyun Kim),권정남(Jung Nam Kwon),박선미(Sun Mi Park) 한의병리학회 2010 동의생리병리학회지 Vol.24 No.3

This clinical study was done to examine comparison the prevalence of metabolic syndrome and obesity index between patients with silent lacunar infarction and normal controls. We compared the components of metabolic syndrome and obesity index between patients silent lacunar infarction(n=62) and normal controls(n=72). The analysis of the data was done by Frequency Analysis, two sample t-test, Chi-square Test. Hypertension and diabetes mellitus was significantly higher in patients of silent lacunar infarctions. Body mass index (BMI), waist-hip ratio (WHR), body fat percentage, obesity ratio, metabolic syndrome were higher significantly in patients of silent lacunar infarctions than normal controls. Although statistically insignificant, waist circumference showed relatively higher in patients of silent lacunar infarction. This result emphasizes the importance of managing that hypertension, diabetes, body mass index (BMI), waist-hip ratio (WHR), body fat percentage, obesity ratio, metabolic syndrome in silent lacunar infarction.

유루증을 보이는 프로락틴, 성장호르몬 혼합분비 뇌하수체 미세선종

고명범 ( Go Myeong Beom ),박재한 ( Park Jae Han ),박용완 ( Park Yong Wan ),장상아 ( Jang Sang A ),민기옥 ( Min Gi Og ),서은주 ( Seo Eun Ju ),손호영 ( Son Ho Yeong ) 대한내과학회 2003 대한내과학회지 Vol.64 No.6

We report a case of galactorrhea with acromegaly from the mixed prolactin and GH secreting pituitary microadenoma managed with a successful surgical complete removal. A 31-year-old woman visited our hospital complaining galactorrhea for more than 6 months

일부 농촌지역의 대사증후군과 음주 및 흡연과의 연관성

하희승(Hee Sung Ha),임현우(Hyeon Woo Yim),박용문(Yong-Moon Park),이진희(Jin-Hee Lee),이승환(Seung-Hwan Lee),권혁상(Hyuk Sang Kwon),윤건호(Kun-Ho Yoon),손호영(Ho-Young Son),강무일(Moo-Il Kang),이원철(Won Chul Lee) 한국역학회 2008 Epidemiology and Health Vol.30 No.2

Purpose: Prevalence of metabolic syndrome is increasing markedly in rural area of Korea. Alcohol drinking and smoking are the main risk factors which shows the highest prevalence rate among the risk factors of metabolic syndrome. The aim of this study was to investigate the association between metabolic syndrome and alcohol drinking and smoking histories in a rural area of Korea. Methods: Data was obtained from 1,332(507 men, 825 women) individuals aged over 40 years who lived in rural area of Chungju city in 2007. Metabolic syndrome was defined by NCEP ATP criteria and waist circumference was defined by WHO-APR(Asia Pacific Region). Data analysis was carried out using SAS version 8.02. Results: In men, adjusted odds ratio for metabolic syndrome was 2.78(1.09-7.05) for current alcohol drinker, 2.75(1.38-5.51) for past alcohol drinker, 3.25(1.58-6.67) for under 21 years old at start of alcohol drinking, 2.62(1.12-6.11) for light alcohol drinker, 6.01(2.65-13.64) for heavy alcohol drinker. In women, all the alcohol related risk factors were not statistically significant with metabolic syndrome. For all the smoking related risk factors were not statistically significant with metabolic syndrome in men and women. Adjusted odds ratio of alcohol drinking habits for each components of diagnostic criteria of metabolic syndrome was significant for high blood pressure, high fasting glucose and hypertriglyceridemia in men and abdominal obesity in women. Adjusted odds ratio of cigarette smoking habits for each components of diagnostic criteria of metabolic syndrome was significant for abdominal obesity in women. Conclusion: Controlling alcohol drinking habits in men should be reinforced in order to prevent the metabolic syndrome in a rural area of Korea.

알코올성 간염의 변증설문 개발에 관한 연구

김정은(Jung Eun Kim),박상은(Sang Eun Park),이재왕(Jae Wang Lee),손호영(Ho Young Son),이병권(Byung Gwon Lee),신철경(Cheol Kyung Sin),이수영(Su Young Lee),김원일(Won IL Kim),홍상훈(Sang Hoon Hong),김보경(Bo kyong Kim),지규용(Gyu yong J 한의병리학회 2009 동의생리병리학회지 Vol.23 No.5

Alcoholic hepatitis is a serious liver disease that may lead to cirrhosis and carcinoma, and the short-term mortality rate is fairly high in severe patients. This study was conducted to develop the instrument of pattern identification for alcoholic hepatitis. We made the pattern identification questionnaire and symptoms indicator through reviewing traditional oriental medical literatures and got advices from the advisor committee with Delphi technique. The advisor committee on this study was organized by 10 professors of internal medicine of oriental medical colleges nationwide. The questionnaire was composed of questions about 6 pattern identification - dampness, heat, liver, spleen, cold and dryness. We gave importance to each symptoms of 6 pattern identification which had been scored on a 5-point scale. We surveyed two groups: 36 male alcoholic hepatitis patients whose Alcohol Use Disorder Identification Test(AUDIT) scores were over 12 and who drank alcohol over 40 g per day were allocated to the hepatitis group. Forty three men who did not drink alcohol were allocated to the normal group. Alcoholic hepatitis had relativities to dampness, heat among cause of disease and liver, spleen among viscera. There were statistical significances between the hepatitis group and the normal group in dampness, heat, liver questionnaire. As a result of this study we suggest that the questionnaire would be effective instruments of pattern identification for alcoholic hepatitis.

알코올성 간질환자를 대상으로 한 증상개선 측정도구의 타당성 연구

김정은(Jung Eun Kim),박상은(Sang Eun Park),이승연(Seung Yeon Lee),손호영(Ho Young Son),홍상훈(Sang Hoon Hong),강창완(Chang Wan Kang),김보경(Bo Kyung Kim),지규용(Gyoo Yong Chi) 한의병리학회 2010 동의생리병리학회지 Vol.24 No.2

Alcoholic hepatitis is an acute and severe liver disease associated with high mortality rate. This study was conducted to develop the instrument of criterion for symptoms improvement after temperance. We made the symptoms improvement questionnaire for alcoholic hepatitis patients through reviewing traditional oriental medical literatures and got advices from the advisor committee with delphi technique. The advisor committee on this study was organized by 10 professors of internal medicine of oriental medical colleges nationwide. The questionnaire was composed of questions about 10 symptoms - fatigue, pain, anorexia, abdominal bloat, heaviness of the body, itch, nausea, sleep, dryness in the mouth and stools. We named it Alcoholic Hepatitis Symptoms Improvement Questionnaire(AHSIQ). We surveyed 65 male alcoholic hepatitis patients and checked liver function profile and AHSIQ before and after temperance four times for six weeks. As a result of factor analysis the scales of AHSIQ had content validity and construct validity. And internal consistency reliability was good(Cronbachs alpha=0.768-0.871). The total scale scores were statistically significant in gamma-GTP related validity. We suggest that AHSIQ would be effective for measuring symptoms improvement degree in alcoholic hepatitis patients through further investigations with larger clinical trials.

Radiation Therapy for Pituitary Adenoma

윤세철(Sei Chul Yoon),장홍석(Hong Suck Jang),김성환(Song Hwan Kim),신경섭(Kyung Sub Shinn),박용휘(Yong Whee Bahk),손호영(Ho Young Son),강준기(Joon Ki Kang) 대한방사선종양학회 1991 대한방사선종양학회지 Vol.9 No.2

가톨릭의대 강남성모병원 방사선치료실에서는 1983년 3월부터 1990년 4월 사이 7년여 동안에 뇌하수체선종으로 확진되었던 74명의 환자(7~65세, 평균 37세, 남:여=39:35)에 대하여 뇌하수체 부위에 외부방사선치료를 하였다. 방사선치료는 6MV 선형가속기를 사용하여 선원중심축거리 80cm, 4×4×4~8×8×8㎤ 조사야로 3문조사를 하였다(180cGy/일, 5회/주, 20~65Gy). 5예에서는 정위다방향고선량단일조사 (15~25Gy/1회)를 실시하였다. 이 환자들의 수술전후 및 방사선치료 후에 복합뇌하수체자극검사를 실시하여 종양의 호르몬분비에 따른 분류와 방사선치료가 호르몬분비에 미치는 영향을 추적조사하였다. 호르몬분비에 따른 뇌하수체선종의 분류는 프로랙틴종 23예(29%), 성장호르몬분비종 20예(26%), 부신피질자극호르몬분비종 6예(8%) (쿠싱병 4예와 넬슨증후군 2예)였으며 4예(5%)에서는 프로랙틴과 성장호르몬을 동시에 분비하였다. 한편, 호르몬분비기능없는 종양이 29예(37%)였다. 23예의 프로랙틴종 중 15예(65%)와 20예 성장호르몬분비종 중 3예(15%)에서는 방사선치료 2~3년 후 정상 호르몬 수치로 전환되었다. 부신피질자극호르몬분비종은 6예 중 1예를 제외한 전예에서 치료 후 모두 정상이되었다. 방사선치료에 따른 부작용으로서 범하수체기능저하증 및 갑상선기능저하증이 각각 7예(9%)씩 그리고 성선기능저하증 2예(3%) 등이 관찰되었다. 전예 중 15예(20%)에서는 정기적인 호르몬 추적검사를 실시하지 못하였다. Seventy four patients with pituitary adenoma received radiation therapy (RT) on the pituitary area using 6 MV linear accelerator during the past 7 years at the Division of Radiation Therapy, Kangnam St. Mary's Hospital Catholic University Medical Colleage. Thirty nine were men and 35 were women. The age ranged from 7 to 65 years with the mean being 37 years. Sixty five (88%) patients were treated postoperatively and 9(12%) primary RT. To evaluate the effects of RT, we analyzed the series of endocrinologic studies with prolactin (PRL), growth hormone (GH), adrenocorticotrophic hormone (ACTH), leuteinizing hormone (LH), follicular stimulating hormone(FSH) and thyroid stimulating hormone(TSH) etc after RT. All but one with Nelson's syndrome showed abnormal neuroradiologic changes in the sella turcica with invasive tumor mass around supra- and/orparasella area. The patients were classified as 23(29%) prolactinomas and 20(26%) growth hormone(GH) secreting tumors, and 6(8%) ACTH secreting ones consisting of 4 Cushing's disease and 2 Nelson's syndrome. Twentynine(37%) had nonfunctioning tumor and four(5%) of those secreting pituitary tumors were mixed PRL-GH secreting tumors. The hormonal level in 15 (65%) of 23 PRL and 3 (15%) of 20 GH secreting tumors returned to mormal by 2 to 3 years after RT, but five PRL and five GH secreting tumors showed high hormonal level requiiring bromocriptine medication. Endocrinologic insufficiency developed by 3years after RT in 5 of 7 panhypopituitarisms, 4 of seven hypothyroidisms and one of two hypogonadisms, respectively. Fifteen (20%) patients were lost to follow up after RT.

뇌하수체선종

윤세철(Sei Chul Yoon),권형철(Hyung Chul Kwon),오윤경(Yoon Kyeong Oh),박용휘(Yong Whee Bahk),손호영(Ho Young Son),강준기(Joon Ki Kang),송진언(Jin Un Song) 대한방사선종양학회 1985 Radiation Oncology Journal Vol.3 No.1

Twenty-four cases of pituitary adenoma, 13 males and 11 females with the age ranging from 11 to 65 years, received radiation therapy(RT) on the pituitary area with 6MV linear accelerator during past 25 months at the Division of Radiation Therapy, Kangnam St. Mary's Hospital, Catholic Medical College. Of 24 cases of RT, 20 were postoperative and 4 primary. To evaluate the effect of RT, we analysed the alteration of the endocrinologic tests, neurologic abnormalities, major clinical symptoms, endocrinologic changes and improvement in visual problems after RT. The results were as follows ; 1. Major clinical symptoms were headache, visual defects, diabetes insipidus, hypogonadisms and general weakness in decreasing order of frequency. 2. All but the one with Nelson's syndrome showed abnormal neuroradiologic changes in the sella turcica with an invasive tumor mass around supra· and para-sellar area. 3. Endocrinological classifications of the patient were 11 prolactinoma, 4 growth hormone -secreting tumors, 3 ACTH-secreting tumors consisting of one Cushing's disease and two Nelson's syndrome, and 6 nonfunctioning tumors. 4. Eleven of 14 patients, visual problems were improved after treatment but remaining 3 were unchanged. 5. Seven of 11 prolactinomas returned to normal hormonal level after postoperative and primary RT and 3 patients are being treated with bromocriptine (BMCP) but one lost case. 6. Two of 4 growth hormone·secreting tumor returned to normal level after RT but the remaining 2 are being treated with BMCP, as well.

보리 흰가루병 곰팡이 Fusarium graminearum에 대한 산초 추출물의 항진균 활성

김범수(Byum Soo Kim),장한수(Han-Su Jang),최충식(Chung-Sig Choi),김종식(Jong Sik Kim),권기식(Gi-Seok Kwon),권인숙(In-Sook Kwun),손건호(Kun Ho Son),손호영(Ho-Yong Sohn) 한국생명과학회 2008 생명과학회지 Vol.18 No.7

흰가루병은 거의 모든 식물재배에서 나타나며, 다양한 곰팡이에 의해 발병한다. 본 연구에서는 천연물 추출물을 이용한 식물병원성 곰팡이 제어가능성을 검토하기 위해, 보리 흰가루병에서 분리된 Fusarium graminearum을 대상으로 900여종의 천연물 추출물의 항진균 활성을 평가하였다. 먼저 포자발아억제 활성평가 결과 산초, 당귀, 미국가막사리, 까마중, 오수유, 윤판나물, 미치광이풀, 때죽나무, 백선, 방기, 정향, 멍석딸기, 호장근, 천황련, 작약, 대황, 모란, 달맞이꽃, 대극, 개박하 추출물을 1차 선별하였으며, 균사 생육억제 활성 원재료 확보 용이성 및 실제 적용 가능성 등을 고려하여 산초 추출물을 최종 선정하였다. 산초 추출물 조제 시 methanol 추출이 효율적이며, 순차적 유기용매 분획물의 경우 물 잔류물에서 항진균 활성이 나타났다. 그러나 methanol 추출물에 비해 분획물의 활성이 다소 감소하여 다양한 물질이 보완적으로 항진균 활성을 나타냄을 추측할 수 있으며, 미약하지만 methanol 추출물 및 분획물에서 항세균 활성도 확인하였다. 토마토 묘목을 이용한 산초 추출물의 활성 분획물의 약해평가 결과 1,000 ㎍/ml 농도 처리 시에도 특이한 약해는 나타나지 않았다. 본 연구결과는 F. graminearum에 의해 나타나는 흰가루병 제어에 산초 추출물이 유용함을 제시하고 있다. The powdery mildew, a fungal plant disease found in varieties of plant cultures, is occurred by attack with Fusarium sp., Sphaerotheca sp., Leveilluna sp., and Eryshipe sp.. In this study we investigated the control of Fusarium graminearum, a barley powdery mildew fungus, by natural plant extracts. Among the 900 plant extracts tested, Zanthoxylum schinifolium, Ligusticum acutilobum, Bidens frondosa L., Dictamnus dasycarpus, Evodia officinalis, Disporum sessile, Scopolia japonica Max., Styrax japonica S. et Z., Dictamnus dasycarpus Turcz., Sinomenium acutum Rehder et Wils., Eugenia aromaticum, Rubus parvifolius L., Reynoutria elliptica, Coptis chinensis, Paeonia lactiflora Pall., Rheum undalatum, Paeonia suffruticosa, Oenothera odorata Jacq., Euphorbia pekinensis Rupr., and Nepeta cataria were selected based on spore germination inhibition assay. Further mycelial growth inhibition assay with economical and safety considerations led us to finally select Z. schinifolium (sancho) for control of F. graminearum. To produce antifungal sancho extract, methanol was suitable for extraction and subsequent fractionations of the extract showed that the water residue mainly had antifungal activity. The sancho extract and its fractions showed minor antibacterial activity against different pathogenic or food spoilage bacteria, but they did not show any harmful effects against young tomato plant by treatment of 1,000 ㎍/ml in green chamber test. These results suggested that the extract of sancho has high potentials on control of a powdery mildew fungus, F. graminearum.