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        • KCI등재

          1980년대 문고본 로맨스의 독자 상정과 출판 전략 연구—‘하이틴’ 기호를 중심으로

          손진원 대중서사학회 2019 대중서사연구 Vol.25 No.3

          This paper looks at the readers and publishing strategies of paperback romance novels in the the 1980s based on the ‘high-teen’ concept. The purpose of this article is to examine the meaning the ‘high-teen’ concepts as expressed in the media through the publication of paperback romance series in the 1980s. Among paperback romance series, this paper was based on pirated/licensed version of novels published by Harlequin, a Canadian publisher, and the magazine media’s advertising promotional phrases that were published targeting the same readers. Since the 1970s, mass media have referred to teenagers as high-teens and called them important consumers. High-teen was a term referring to teenagers in school uniforms, mostly girls, and in the 1980s, ‘high-teen’ was also introduced as a new consumer market, and the publishing market put forward a number of publishing strategies to attract them. The paperback romance, including <high-teen romance>, has identified ‘high-teen’ readers as late-teen girls, sensitive consumers for best-sellers/million-sellers, readers with a tendency to read stories of love, and readers that favor American and Western culture. Since the 1980s, the market for paperback romance has been in the recession, but readers have kept the romance genre alive by accepting and localizing the Harlequin series. With the rise of a new form of media called the ‘Web Novel’, interest in the romance genre is increasing, and we hope this study will serve as a starting point for a variety of discussions with (women) readers about romance reading/enjoyment. 본고는 1980년대 문고본 로맨스 소설의 독자 상정과 출판 전략을 ‘하이틴’이라는 기호로 살펴보려 한다. 저널리즘에서 사용되었던 ‘하이틴’이라는 기호에 어떤 함의가 포함되어 있는지, 1980년대 문고본 로맨스 시리즈의 출판 현상을 통해 확인하는 것이 이 글의 목적이다. 문고본 로맨스 중에서도 캐나다 출판사 ‘할리퀸(Harlequin)’의 로맨스 시리즈의 해적판/정식판본과, 같은 독자를 상정하고 출간되었던 잡지 매체의 광고 홍보 문구를 토대로 연구를 진행하였다. 1970년대부터 대중매체는 10대 청소년을 하이틴으로 바라보고 이들을 중요한 소비주체로 호명한 바 있다. 하이틴이 교복을 입은 10대 청소년, 그중에서도 주로 여학생을 일컫는 용어였다면 1980년대 ‘하이틴’ 역시 새로운 소비주체로 상정되었고, 출판 시장에서는 이들을 포섭하기 위한 여러 출판 전략을 내세웠다. 『하이틴 로맨스』를 비롯한 문고본 로맨스는, ‘하이틴’이라는 독자들을 10대 후반 여학생, 베스트셀러/밀리언셀러에 민감한 소비주체, 사랑과 연애 이야기를 독서하는 취향을 가지며, 미·서구 문화에 호의적인 독자로 상정하였다. 1980년대 이후 문고본 로맨스 시장은 침체되었지만, 독자들은 ‘할리퀸’ 시리즈를 수용-로컬화하여 ‘로맨스’라는 장르소설의 명맥을 계속해서 유지해왔다. 웹소설이라는 새로운 매체가 부상함에 따라 로맨스 장르에 대한 관심이 폭증하는 현재, 이 연구가 (여성)독자와 로맨스 독서/향유에 대한 다양한 논의를 이끌어내는 시작점이 될 것이라 기대한다.

        • KCI등재

          Reconstruction of Blood Vessel Model with Adventitia from CT and IVUS Images for FSI Analysis

          손진원,최영,Qianqian Zhang 한국정밀공학회 2013 International Journal of Precision Engineering and Vol. No.

          In achieving 3D model of blood vessel from computed tomography (CT), it is not easy to separate intima and adventitia since the portion of the blood vessel in a CT volume data is relatively too small and does not have sufficient resolution nor distinctive voxel intensity. In case of using vascular contrast agent, detection of the intima is feasible but detection of adventitia is still difficult. This paper proposes a 3D reconstruction process of blood vessel from CT images with intravascular ultrasound (IVUS) images. The shape of intima is achieved from CT data and then converted to polygonal data with iso-surface extraction. A representative shape of the polygonal data is approximated into a B-spline curve. If adventitial shape from IVUS image is appropriately positioned on the curve at the location of the IVUS data acquisition, the cross section shape of adventitia on the location is defined. The 3D surface model of intima and adventitia is constructed from the series of cross section contours.

        • KCI등재

          산화적 스트레스로 유도된 간손상에 대한 소음인보중익기탕 열수추출물의 간세포보호효과

          손진원,정지윤,김광연,황보민,박정아,조일제,백영두,정태영,김상찬,지선영 대한한의학방제학회 2017 大韓韓醫學方劑學會誌 Vol.25 No.4

          Background and objectives : Soeumin Bojungykgi-tang (seBYTE) has been used to supplement qi in Korean medicine. It has been demonstrated to possess various biological functions such as anti-cancer, anti-aging and anti-inflammatory effects. The present study evaluated the protective roles of seBYTE in hepatotoxic in vitro and in vivo model. Methods : To investigate cytoprotective effect of seBYTE, HepG2 cells were pretreated with seBYTE and then subsequently exposed to 10 ㎛ AA for 12 h, followed by 5 ㎛ iron. Cell viability was examined by MTT assay, and expression of apoptosis-related proteins was evaluated by immunoblot analysis. For responsible molecular mechanisms, ROS production, GSH contents, and mitochondrial membrane potential were measured. In addition, hepatoprotective effect of seBYTE in vivo was assessed in CCl4-induced animal model. Results : seBYTE prevented AA + iron-induced cytotoxicity in concentration dependent manner. In addition, ROS production, GSH depletion, and mitochondrial dysfunction induced by AA + iron were significantly reduced by seBYTE pretreatment. Furthermore, seBYTE recovered expression of the pro-apoptotic proteins such as PARP and pro-caspase-3. In animal experiment, plasma ALT and AST levels were significantly elevated in CCl4 treatment, but seBYTE significantly decreased the ALT and AST levels. Moreover, seBYTE alleviated the numbers of histological activity index, percentages of degenerative regions, degenerated hepatocytes, infiltrated inflammatory cells, nitrotyrosine- and 4-hydroxynonenal-positive cells in liver. Conclusions : These results showed that hepatoprotective effect of seBYTE against on CCl4-induced hepatic damages is partly due to antioxidative and anti-apoptotic process.

        • KCI등재

          죽엽 열수추출물의 염증억제 효과

          손진원,박상미,정지윤,황보민,조일제,정태영,박정아,김상찬,지선영,Son, Jin Won,Park, Sang Mi,Jung, Ji Yun,Hwangbo, Min,Cho, Il Je,Jung, Tae Young,Park, Chung A,Kim, Sang Chan,Jee, Seon Young 대한한의학방제학회 2016 大韓韓醫學方劑學會誌 Vol.24 No.4

          Objectives : Phyllostachys Folium is leaves of Phyllostachys nigra var. henesis $S_{TAPF}$. In the East Asian traditional medicine, the herb has been used to treat nasal bleeding, dysuria, epilepsy and etc. The present study was conducted to evaluate the anti-inflammatory effects of the Phyllostachys Folium water extracts (PFE) in vitro and in vivo model. Methods : Cell viability was measured by MTT assay after the treatment of PFE and NO production was monitored by measuring the nitrite content in culture medium. iNOS, COX-2, $I{\kappa}B$, $p-I{\kappa}B{\alpha}$ amd $NF{\kappa}B$ were detected by immunoblot analysis, and levels of cytokine were analyzed by sandwich ELISA kit. Anti-edema effect of PFE was determined in the carrageenan-induced paw edema model in rats. Results : LPS increased NO and cytokines levels compared with control, these increases were attenuated by PFE. In addition, LPS-induced pro-inflammatory proteins such as iNOS, COX-2 were down regulated by PFE. These anti-inflammatory effect of PFE results from inhibition of phosphorylation of $I{\kappa}B$ and translocation of $NF-{\kappa}B$. Conclusion : These results show that PFE has some anti-inflammatory effects which might play a role in gram-negative bacterial infection inflammation and $NF{\kappa}B$ activated diseases.

        • 原著(원저) : 西瓜皮(서과피)의 전염증성 cytokine 억제효과

          손진원 ( Jin Won Son ),지선영 ( Seon Young Jee ),금수연 ( Soo Yeon Kem ) 대구한의대학교 제한동의학술원 2013 제한동의학술원논문집 Vol.11 No.1

          Exocarpium Citrulli is the cortex of Fructus Citrulli. In Korean traditional medicine, it has been used to treat edema, dysuria, mouth and tongue sores. Although Exocarpium Citrulli has been known to possess anti-cancer activity, it has been rarely conducted to evaluate the anti-inflammatory activity. The present study was examined to evaluate the anti-inflammatory effects of the Exocarpium Gitrulli EtOH extracts (ECE) in vitro. Inflammatory mediators were detected after the addition of LPS with or without ECE in Raw 264.7 macrophage cell lines. LPS plays a key role in leading to the massive production of pro-inflammatory cytokines, such as TNF-a, 1L-1β and IL-6 in macrophages. In this study, cell viability assay (MTT assay) was conducted to determine the non-cytotoxic concentration of ECE. The dosages (0.1 and 0.3 mg/ml of ECE used in this study had no significant cytotoxicity during the experimental period. The relative level of NO was measured with Griess reagent. Pro-inflammatory cytokines were detected by EUSA assay. The cell was treated with 1 μg/ml of LPS 1 h before adding ECE. The level of NO and cytokines (TNF-a, IL-1β) in culture medium was increased by LPS application. However, these increases were attenuated by treatment with ECE.

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