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손종구,이준우,김은선,박동운,박영서 한국생체재료학회 2003 생체재료학회지 Vol.7 No.4
Tissue engineering products, which have created a sensation in the medical industry, are expected to grow into a large market. From among artificial organs manufactured using tissue engineering technologies, artificial skin is expected to be introduced into the market first. With the overall and rapid aging of human society, the number of patients suffering from diabetic or decubitus ulcers, the greatest users of artificial skin, is expected to increase dramatically. Consequently, the future of artificial skin is bright. Studied only over the last decade, artificial skin has been a new field. The artificial skin market of Japan is expected to amount to ¥1 billion in 2003, ¥3 billion in 2005, and ¥10 billion in 2007. Although the domestic market itself is as yet unformed, artificial skin is expected to be marketed in Korea in 2003 or 2004 at the earliest. The subsequent market is expected to amount to ₩2 billion in 2004, 즹3.5 billion in 2005, and 즹17.5 billion in 2007. At current technological levels, however, there exist several problems including high prices, difficulty of mass production, and short clinical testing periods. Coupled with high prices, the smallness of the domestic market itself is hindering market expansion. In addition, artificial skin may create problems in terms of its biocompatibility if applied to actual surgical operations. Despite tremendous progress in the artificial skin technology, problems including the possibility of side effects as well as the reduction of production costs, construction of a mass production system, and heightened public awareness of artificial skin must be resolved first for further market expansion.
손종구,조제열,전승표,이준우 한국생체재료학회 2010 생체재료학회지 Vol.14 No.2
Conventionally, any physical or physiological index such as blood pressure or blood glucose was referred to as a biomarker. Currently, this term is identified with molecular or biological indicators and is an umbrella of genes and genetic variations, and expression differences in RNA, proteins and metabolites. Biomarkers as quantitative measures strongly impact issues of cost, access, toxicity, and the complete value of novel therapeutics. These indicators of disease are important in being able to diagnose and assess the disease condition, as well as to monitor response to treatment. Biomarkers can also form the foundation of therapy by assisting in decision making during early and late drug development stages, and monitoring clinical outcomes. Consequently, biomarker research and acceptance in clinical practice should attract greater funding and better awareness amongst the clinical community.
손종구,이준우,유재영,정병옥,방영서 한국생체재료학회 2006 생체재료학회지 Vol.10 No.4
One of the most promising new technologies designed to quickly analyze large amounts of genomic information is the DNA chip. DNA chip array assays have an advantage over traditional molecular biology assays because the nucleic acids are bound to a reusable solid support allowing for improvements in automation and data analysis. The DNA chip technology allows biomedical researchers to study entire genes and gather information about expression and gene mutation patterns. DNA chip technology requires hybridization of an unknown nucleotide sequence to an ordered array of known DNA immobilized onto a glass slide or silicon chip. The hybridization results are detected by fluorescence and analyzed by pattern recognition. According to Freedonia Group, DNA chip market is embryonic and promising indeed. The global market is expected to amount to approx. 575 million dollars by 2013, thus attaining 230% in growth rate compared with that in 2003. Among Bio-related businesses in Korea, DNA chip will show high growth rate by 2009. Based on focus group interviews and literature review, it is expected that DNA chip market will generate 23 million dollars in 2006 and 35 million dollars in 2009.
손종구,경갑수,유관재,박진은 한국강구조학회 2022 韓國鋼構造學會 論文集 Vol.34 No.4
In this study, the relationship between bridge design parameter and rating factor(R.F.) by the ASD method was investigated and analyzed using the safety diagnosis report of the steel box girder bridges for the analysis bridges of 116 and the verification bridges of 30. From this, a simple evaluation method that can easily evaluate the R.F. from the design stage was proposed, and the validity and efficiency of the proposed method were verified. As the 1st design factor, the maximum span length was found to have a high relationship with the R.F.. Also, using the relationship between stress for fixed load in center span(support) and the theoretical R.F. in center span(support), it is judged that the theoretical R.F. can be estimated with high precision in design process. 이 연구에서는 116개의 분석교량 및 30개의 검증교량에 대한 강박스거더교량의 안전진단보고서를 활용하여 ASD 기법에의한 내하율과 교량설계인자와의 관계를 조사, 분석하였다. 이로부터 설계단계부터 용이하게 내하율을 평가할 수 있는 단순 평가방법을 제안하는 것과 함께 제안 방법의 타당성 및 효율성 검증을 실시하였다. 1차 설계인자로는 최대경간장이 내하율과 관계가 높은 것으로 나타났으며, 또한 중앙부 고정하중 응력 - 중앙부 계산내하율, 지점부 고정하중 응력 - 지점부 계산내하율의 관계를 활용하면, 설계과정 중에 이론적인 내하율을 정밀도 높게 추정할 수 있을 것으로 판단된다.