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급성 괴사성 췌장염에서 발생한 결장 합병증 -1 예 보고-
손보성,정재희,송영택,Sohn, Bo-Sung,Jung, Jae-Hee,Song, Young-Tack 대한소아외과학회 2003 소아외과 Vol.9 No.2
We present a case of a colonic involvement associated with necrotizing pancreatitis, with a review of the literature. A 10 year old boy had an appendectomy at the local clinic ten days ago. On admission, he complained nausea, vomiting and severe constipation. His abdomen was distended and he had tenderness on the left abdomen. Laboratory and radiologic studies revealed findings consistent with acute pancreatitis with colonic complication. He was treated conservatively for 30 days but did not improve. On hospital 30th day, abdominal pain developed and his vital sign changed. Abdominal CT suggested ischemic change of the transverse colon. At laparotomy, the left colon showed stenosis. The greatly distended transverse colon was resected and a transverse end colostomy was done. He was discharged at postoperative 45th day with improvement and colostomy closure was performed 8 months later.
GISTs에서 증가된 Ki67 Index (>10%)와 p53 단백발현의 예후 인자로서의 유용성
손보성(Bo Sung Sohn),전해명(Hae Myung Jeon),성기영(Gi Young Sung),진형민(Hyung Min Jin),김욱(Wook Kim),박조현(Cho Hyun Park),박승만(Seung Man Park),임근우(Keun Woo Lim),박우배(Woo Bae Park),김승남(Seung Nam Kim),이교영(Kyo Young Lee 대한외과학회 2004 Annals of Surgical Treatment and Research(ASRT) Vol.66 No.2
손보성(Bo Sung Sohn),조정은(Chung Eun Cho),박일영(Il Young Park) 대한외과학회 2009 Annals of Surgical Treatment and Research(ASRT) Vol.77 No.4
The von Hippel-Lindau (VHL) disease is an autosomal dominant disorder by germline mutation of VHL tumor suppressor gene. The affected patients mainly develop cancers of the central nervous system, renal cell carcinoma, pheochromocytoma, and pancreatic cysts. Pancreatic involvement was observed 12∼77% in VHL patients and included true cysts, serous cystadenomas, and neuroendocrine tumors. We experienced two cases of pancreatic cyst of the von Hippel-Lindau disease and reviewed associated literatures.
손보성 ( Bo Sung Sohn ),류영욱 ( Young Wook Ryoo ),정재봉 ( Jae Bong Jung ),김병천 ( Byung Chun Kim ),이규석 ( Kyu Suk Lee ),송준영 ( Joon Young Song ) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.5
Infantile digital fibromatosis is a rare benign tumor on the fingers and toes of infants and childhood which is characterized by fibroblastic proliferation. Usually the lesions occur singly or severally on the dorsal or lateral aspects of the distal phalanges of the toes and fingers. The thumb and great toe are usually spared. These asymptomatic, firm, red, smooth nodules, some lcm diameter, occur during the first year of life. Forty-seven percent occur in the first month of life. This disease can occur after trauma. The lesions do not metastasize. Occasionally, spontaneous regression has been reported. After excision, recurrence can be possible. A 2 years old female infant had three large bean sized erythematous masses on the left 2,3,4th fingers. The erythematous aacule was developed at 6 months old and grew slowly. We could find inclusion body stained bright red with Massons trichrome and purple with PTAH in cytoplasm of fibroblast. The patient was treated with a simple excision followed by a skin graft. During 5 rnonths after operation, recurrence was not occurred. (Kor J Dermatol 1995;33(5): 978-982)
Composite Large Cell Neuroendocrine Carcinoma and Adenocarcinoma of the Ampulla of Vater
Bo Sung Sohn(손보성),Yu Hee Nam(남유희),Jin A Lee(이진아),Il Young Park(박일영),Nam Ik Han(한남익),Hee Jeong Lee(이희정) 한국간담췌외과학회 2009 한국간담췌외과학회지 Vol.13 No.2
Large Cell Neuroendocrine Tumors (LCNEC) in the ampulla of Vater are extremely rare. This report addresses a case of concurrent LCNEC and adenocarcinoma in the ampulla of Vater. A 60-year-old male patient experienced fever, body chills and jaundice. He had a periampullary ulcerative lesion and underwent radical pancreaticoduodenectomy. Histopathologically, the tumor consisted of an LCNEC component and an adenocarcinoma component. Simultaneous LCNEC and adenocarcinoma has been reported in a few cases. Our patient had a coexisting LCNEC and an adenocarcinoma of the ampulla of Vater. We also present a review of the literature.
손보성,송준영,정재봉,김병천,이상숙,류영욱,이규석 啓明大學校 醫科大學 1994 계명의대학술지 Vol.13 No.4
Papulonecrotic tuberculid is an eruption of necrotizing papules, particularly affecting the extremities and occurring in more or less symmetrical crops, and responding to antituberculosis therapy. Individual lesions heal with scarring. Histologically, vascular involvement is seen in early lesions. Late lesions are divided into two forms. In superficial forms, wedge shaped area of necrosis forms in epidermis and upper dermis. Epithelial and lymphoid cells gather around its periphery. In deep forms, with no epidermal change, granulomatous changes surrounded by well defined palisading histiocyte and lymphoid, epithelioid cells are seen. In mid-dermis and perivascular area, vessel shows vasculitis. In the first case, leukocytoclastic vasculitis and early granuloma formation were seen. In the second case, palisading granuloma formation was seen. In the third case, tuberculoid granuloma formation was seen. We report three cases of papulonecrotic tuberculid showing three different stages of histological finding, in individual cases.
피부종양에서 Single-strand Conformation Polymorphisms 법에 의한 p53 유전자 돌연변이 검색
류영욱,손보성,권호준,이규석,송준영 啓明大學校 醫科大學 1995 계명의대학술지 Vol.14 No.4
The tumor suppressor gene p53, located on the short arm of chromosome 17, encodes for nuclear protein which regulates cell proliferation by inhibiting cells entering S-phase. Mutation in p53 gene are the most frequent genetic alteration found in human cancers to date. This study was examined mutant p53 gene mutation using PCR-SSCP method and mutant p53 oncoprotein expression using avidin biotin peroxidase complex method immunohistochemically, in 2 seborrheic keratosis, 3 basal cell carcinoma, 3 squamous cell carcinoma and 1 metaststic squamous cell carcinoma cases. With PCR-SSCP methods in exon 5 and 7, no genetic mutation of p53 gene was observed in 2 seborrheic keratosis, 3 basal cell carcinoma, 3 squamous cell carcinoma, and 1 metaststic squamous cell carcinoma cases. With immunohistochemical staining with ABC method, a case of squamous cell carcinoma developed on lower lip was positive but another were all negative. This result means that p53 gene mutation on skin tumor may develope in squamous cell carcinoma developed on sun exposed area and this mutation on squamous cell carcinoma can develope other exonal site except exon 5 and 7.
손보성,권건영,이상숙,송홍석,김병천,이규석,송준영 啓明大學校 醫科大學 1995 계명의대학술지 Vol.14 No.1
The malignant lymphoma in malignant tumor derived from B or T lymphocyte, rarely histiocyte. Generally, the disease can invade lymph node, spleen, liver, digestive system, kidney and skin, The prevalent age is between thirties and eighties. We experienced a 74 years old man with two asymptomatic rapid growing protruding mass with centeral oozing and ulcerative lesion on the jaw for 3 months. Histologically, the tumor is composed of diffuse infilterated large tumor cells similar with histiocyte morphologically throughout the dermis. In immunohistochemical stain with leukocyte common antigen, many yellowish stained atypical tumor cells were seen in the dermis. For evaluation about the origin of tumor cell, immunohistochemical stains with UCHL-1, L-26, CD4, CD8, CD20 were done but all negative. The patient died after 3 months in spite of 8th days of chemotherapy, probably due to brain metastasis.