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온리약인 부자, 건강, 육계, 오수유의 면역조절효과 비교
손길현,신상우,권영규,김상찬,박종현,Son, Gil-Hyun,Shin, Sang-Woo,Kwon, Young-Kyu,Kim, Sang-Chan,Park, Jong-Hyun 대한동의생리학회 2005 동의생리병리학회지 Vol.19 No.3
This study was carried out to investigate the comparison of immunomodualtory effects of water-extracted Aconiti lateralis Preparata Radix(PR), Zingiberis Rhizoma(ZR), Cinnamomi Cortex(CC) and Evodiae Fructus(EF). The parameter examined to assess apparent immunomodulatory effect of the water-extracted PR, ZR, CC and EF included the regulation of Nitric oxide (NO). Also, ZR and EF represent the expression of Th1/Th2 type cytokine, the change of B cell phenotype. The water-extracted PR, ZR, CC and EF inhibited NO production and iNOS protein expression in LPS stimulated RAW 264.7 macrophage cells. In the Th1 and Th2 cytokine expression, the water-extracted ZR and EF induced IL-2, IFNr and IL-10 mRNA gene expression. Therefore, it seems that the water-extracted ZR and EF have a inducing effect of Th1 and Th2 type cytokines. In the Flow cytometry analysis, the water-extracted ZR and EF changed B cell phenotype (CD45R/B220), did NOT in PR and CC. The water-extracted PR, ZR, CC and EF have a reducing effect of immune suppression cause by Methotrexate (MTX), an agent of immune suppression. These results suggest that the immunomodulatory effects of the water-extracted ZR and EF may be, in part, associated with the inducing IL-2 and IFNr mRNA gene expression In and regulation of NO production in macrophage cells.
孫桔鉉,金先熙,嚴賢燮 대한동의병리학회 1990 동의생리병리학회지 Vol.5 No.-
The present study was done to investigate analgesic, anticonvulsion and anti-inflammatory effects of Soo Jeom San and Kami Soo Jeom San in rats and mice. 1. Kami Soo Jeom San produced more prominently analgesic effects than Soo Jeom San in actic acid-treated mice. 2. In anti-convulsant action against strychnine-induced convulsions, both onset time of Soo Jeom San and that of Kami Soo Jeom San were significantly delayed, whereas death of animals tested was significantly delayed by Kami Soo Jeom San treatment. 3. Onset time and death of animals tested were delayed on picrotoxin-induced convulsion after Kami Soo Jeom San treatment. 4. Anti-inflammatory action of Soo Jeom San was more predominant than that of Kami Soo Jeom San on carrageenin-induced edema. From conclusions as mentioned above, these conclusions indicate that analgesic effect and anti-convulsant action of Kami Soo Jeom San were more significant than those of Soo Jeom San.