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Celecoxib 유도체인 PCX-계열 화합물의 항염증 및 혈관신생 억제 작용
소지현,안은경,전혜진,임은주,박은희 숙명여자대학교 약학연구소 2005 약학논문집-숙명여자대학교 Vol.22 No.-
This study aimed to evaluate the pharmacological efficacies of PCX-series compounds, which were synthesized as prodrugs of celecoxib, a COX-2 selective inhibitor. Celecoxib, PCX-1, PCX-2, PCX-3, PCX-7, PCX-15 and PCX-16 provide potent anti-angiogenic activity in chorioallantoic membrane (CAM) assay. In addition, celecoxib, PCX-2, and PCX-16 showed anti-angiogenic activity in a dose-dependent manner. PCX-2 inhibited swelling in the carrageenan-induced rat paw edema test 24 hours after the administration. In the acetic acid-induced writhing test, PCX-7 and PCX-15 were verified to provide more potent analgesic effect than celecoxib 12 hours after the administration, and PCX-2 showed potent analgesic effect 24 hours after the administration. In the carrageenan-induced rat air pouch model, PCX-2 significantly decreased exudate volume, number of leukocyte and NO level. In the ulcerogenic activity test, PCX-2, PCX-7, PCX-15, and PCX-16 showed significantly less ulcer formation than indomethacin. Especially, PCX-7 showed the highest safety in the GI safety test. These findings provide novel pharmacological knowledge on pharmacological actions of celecoxib and its PCX-series compouds.
First report of Stellaria sessiliflora Y. Yabe (Caryophyllaceae) from Korea
소지현,김대홍,구애숙,김명준,이남숙 한국식물분류학회 2015 식물 분류학회지 Vol.45 No.2
Stellaria sessiliflora Y. Yabe (Caryophyllaceae), which is known to be distributed throughout Japan excluding Okinawa, was recently found on Jeju Island in Korea. Reports on the Japanese flora state that this spe- cies is distributed on Jeju Island, and a photograph of one specimen (Slide No. 6294) collected from Jeju Island by Ohwi in May 1935 confirms this. Additionally, specimens at the National Arboretum and Korea Forest Research Institute indicate that S. sessiliflora has occurred on Jeju Island for a considerable amount of time. However, the species has never been officially listed in the flora of Korea. Stellaria sessiliflora is distinguished from S. media by having broader leaves with a slightly undulate margin, petiolate leaves on the upper part of the stem, and 10 stamens. The local name ‘Geu-Neul-Byeol-Kkot’ is given to the species based on its shady habitat under deciduous broadleaf forest. Details of the morphological characters, an illustration, the type specimen, voucher specimen data, and photographs of Stellaria sessiliflora in Korea are presented.
Triadenum breviflorum (Hypericaceae): First report in Korea
소지현,이남숙,김명준 한국식물분류학회 2011 식물 분류학회지 Vol.41 No.3
Triadenum breviflorum (Wallich ex Dyer) Y. Kimura in Nakai & Honda (Hypericaceae), previously known only in northeast India, China and Taiwan, was found in a few wetlands of Jeju Island in 2008. Additionally, some images online of T. breviflorum suggest that it exists in other places on the Korean peninsula but that it has been misidentified as Triadenum japonicum. This species is distinguished from the latter by white petals, inflorescence from nodes 6-11, linear to narrowly elliptic leaves, and an attenuated base. The local name Huin-kkot-mul-go-chu-na-mul implies a white flower rather than the flesh-pink color of T. japonicum. The morphological characteristics of the species are provided with photographs of the habitat.
First record of Neottia japonica (Orchidaceae) from Korea
소지현,정미숙,정영순,이남숙 한국식물분류학회 2013 식물 분류학회지 Vol.43 No.3
Neottia japonica (Blume) Szlach. (Orchidaceae), previously known to be native in southern part of Japan and Taiwan, was found in Seogwipo-si, Jeju-do, Korea. This species is distinguished from the related taxa of Neottia pinetorum (Lindle.) Szlach and N. nipponica (Makino) Szlach. by smaller plant, lip with T-shaped lamella and auricles embracing column, and flowering in the spring. The local name was given as “A-gi-ssangnip-nan-cho” based on the cuter and smaller plant than N. pinetorum. The description and illustrations of the species on morphological characters, voucher specimens, and photograph at the habitat are provided.
Phylogenetic analysis of Neottia japonica (Orchidaceae) based on ITS and matK regions
소지현,이남숙 한국식물분류학회 2020 식물 분류학회지 Vol.50 No.4
To elucidate the molecular phylogeny of Neottia japonica, which is a terrestrial orchid distributed in East Asia, the internal transcribed spacer (ITS) of nuclear DNA and the matK of chloroplast DNA were used. A total 22 species of 69 accessions for ITS and 21 species of 114 accessions for matK phylogeny were analyzed with the maximum parsimony and Bayesian methods. In addition, we sought to establish a correlation between the distribution, morphology of the auricles and genetic association of N. japonica with phylogenetic data. The phylogenetic results suggest that N. japonica is monophyletic and sister to N. suzukii in ITS phylogeny, while it is paraphyletic with N. suzukii in matK phylogeny. Neottia japonica and N. suzukii show similar morphologies of the lip and column. They both flower in April, and are distributed sympatrically in Taiwan. Therefore, it appears to be clear that N. japonica and N. suzukii are close taxa within Neottia, although there is incongruence between the nrDNA and cpDNA phylogenies of N. japonica. The incongruence between the two datasets may have various causes, meaning that further studies are needed to confirm the evolutionary process of N. japonica. The phylogenetic status of N. kiusiana, which was not included in previous studies, was as a sister to N. nidus-avis. Meanwhile, the ITS and matK phylogenies are unsuitable for identifying genetic associations with the characteristic of auricles. The phylogenetic topologies of Korean, Taiwanese and mainland Chinese individuals suggest that the populations of N. japonica in Korea originated from China’s mainland and island areas. The characterization of regional gene differences could provide useful preliminary data for future studies.